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Multiplexing information in light's fundamental attributes to create supplementary orthogonal data channels has been well heralded as an effective means for optical data storage with greatly enhanced capacities. However, robust decoding methods against inevitable crosstalks associated with experimental noise and writing imperfections as the increase of multiplexing dimensions represent a major hurdle preventing the effective practice of multi-dimensional optical recording. Here, we propose a deep-learning-based retrieval approach for robust decoding multiplexed information. An artificial neural network is trained to learn the crosstalks from multiplexed recording in disordered gold nanorod aggregates with loosened orthogonality constraints. The acquired raw readout images are analyzed by the trained neural network, which allows quick, high-fidelity, and reliable information retrieval from polarization-, wavelength-, and 3D spatially multiplexed data. The smart decoding protocol paves the way toward the mass-production ready and wide-spread application of high-capacity multi-dimensional optical storage. [ABSTRACT FROM AUTHOR]

During the ignition process of a solid rocket motor, the pressure changes dramatically and the ignition process is very complex as it includes multiple reactions. Successful completion of the ignition process is essential for the proper operation of solid rocket motors. However, the measurement of pressure becomes extremely challenging due to several issues such as the enormity and high cost of conducting tests on solid rocket motors. Therefore, it needs to be investigated using numerical calculations and other methods. Currently, the fundamental theories concerning the ignition process have not been fully developed. In addition, numerical simulations require significant simplifications. To address these issues, this study proposes a solid rocket motor pressure prediction method based on bidirectional long short-term memory (CBiLSTM) combined with adaptive Gaussian noise (AGN). The method utilizes experimental pressure data and simulated pressure data as inputs for co-training to predict pressure data under new operating conditions. By comparison, the AGN-CBiLSTM method has a higher prediction accuracy with a percentage error of 3.27% between the predicted and actual data. This method provides an effective way to evaluate the performance of solid rocket motors and has a wide range of applications in the aerospace field. [ABSTRACT FROM AUTHOR]

Urban emergency shelters are a special type of public service facility, and their planning and construction are directly related to the safety of urban residents' lives and property, as well as to the sustainable development of the city. Existing research on the site selection of shelters is not ideal when dealing with large‐scale scenarios and fails to accurately reflect the actual situation. To address this issue, this study proposes an emergency shelter site selection model based on deep reinforcement learning, IAM‐PPO. This model constructs the site selection problem as a Markov Decision Process and uses deep learning to extract information from the site selection scenario. It finds the final solution for shelter locations through continuous exploration and learning. To improve the training efficiency of the model, the action masking process is innovatively applied to the model. The research results and ablation experiments using Shanghai as a case study prove that, owing to the diversity of shelter service ranges and action masking mechanism, the model proposed in this study can provide efficient and accurate shelter location services. Moreover, the customizability of this model provides meaningful reference value for other public facility location problems. [ABSTRACT FROM AUTHOR]

Background: Accurate pancreas and pancreatic tumor segmentation from abdominal scans is crucial for diagnosing and treating pancreatic diseases. Automated and reliable segmentation algorithms are highly desirable in both clinical practice and research. Purpose: Segmenting the pancreas and tumors is challenging due to their low contrast, irregular morphologies, and variable anatomical locations. Additionally, the substantial difference in size between the pancreas and small tumors makes this task difficult. This paper proposes an attention‐enhanced multiscale feature fusion network (AMFF‐Net) to address these issues via 3D attention and multiscale context fusion methods. Methods: First, to prevent missed segmentation of tumors, we design the residual depthwise attention modules (RDAMs) to extract global features by expanding receptive fields of shallow layers in the encoder. Second, hybrid transformer modules (HTMs) are proposed to model deep semantic features and suppress irrelevant regions while highlighting critical anatomical characteristics. Additionally, the multiscale feature fusion module (MFFM) fuses adjacent top and bottom scale semantic features to address the size imbalance issue. Results: The proposed AMFF‐Net was evaluated on the public MSD dataset, achieving 82.12% DSC for pancreas and 57.00% for tumors. It also demonstrated effective segmentation performance on the NIH and private datasets, outperforming previous State‐Of‐The‐Art (SOTA) methods. Ablation studies verify the effectiveness of RDAMs, HTMs, and MFFM. Conclusions: We propose an effective deep learning network for pancreas and tumor segmentation from abdominal CT scans. The proposed modules can better leverage global dependencies and semantic information and achieve significantly higher accuracy than the previous SOTA methods. [ABSTRACT FROM AUTHOR]

Individual Tree Detection-and-Counting (ITDC) is among the important tasks in town areas, and numerous methods are proposed in this direction. Despite their many advantages, still, the proposed methods are inadequate to provide robust results because they mostly rely on the direct field investigations. This paper presents a novel approach involving high-resolution imagery and the Canopy-Height-Model (CHM) data to solve the ITDC problem. The new approach is studied in six urban scenes: farmland, woodland, park, industrial land, road and residential areas. First, it identifies tree canopy regions using a deep learning network from high-resolution imagery. It then deploys the CHM-data to detect treetops of the canopy regions using a local maximum algorithm and individual tree canopies using the region growing. Finally, it calculates and describes the number of individual trees and tree canopies. The proposed approach is experimented with the data from Shanghai, China. Our results show that the individual tree detection method had an average overall accuracy of 0.953, with a precision of 0.987 for woodland scene. Meanwhile, the R2 value for canopy segmentation in different urban scenes is greater than 0.780 and 0.779 for canopy area and diameter size, respectively. These results confirm that the proposed method is robust enough for urban tree planning and management. [ABSTRACT FROM AUTHOR]

Introduction: Immune dysregulation plays a major role in cancer progression. The quantification of lymphocytic spatial inflammation may enable spatial system biology, improve understanding of therapeutic resistance, and contribute to prognostic imaging biomarkers. Methods: In this paper, we propose a knowledge-guided deep learning framework to measure the lymphocytic spatial architecture on human H&E tissue, where the fidelity of training labels is maximized through single-cell resolution image registration of H&E to IHC. We demonstrate that such an approach enables pixel-perfect ground-truth labeling of lymphocytes on H&E as measured by IHC. We then experimentally validate our technique in a genetically engineered, immune-compromised Rag2 mouse model, where Rag2 knockout mice lacking mature lymphocytes are used as a negative experimental control. Such experimental validation moves beyond the classical statistical testing of deep learning models and demonstrates feasibility of more rigorous validation strategies that integrate computational science and basic science. Results: Using our developed approach, we automatically annotated more than 111,000 human nuclei (45,611 CD3/CD20 positive lymphocytes) on H&E images to develop our model, which achieved an AUC of 0.78 and 0.71 on internal hold-out testing data and external testing on an independent dataset, respectively. As a measure of the global spatial architecture of the lymphocytic microenvironment, the average structural similarity between predicted lymphocytic density maps and ground truth lymphocytic density maps was 0.86 ± 0.06 on testing data. On experimental mouse model validation, we measured a lymphocytic density of 96.5 ± %1% in a Rag2+/- control mouse, compared to an average of 16.2 ± %5% in Rag2-/- immune knockout mice (p<0.0001, ANOVA-test). Discussion: These results demonstrate that CD3/CD20 positive lymphocytes can be accurately detected and characterized on H&E by deep learning and generalized across species. Collectively, these data suggest that our understanding of complex biological systems may benefit from computationally-derived spatial analysis, as well as integration of computational science and basic science. [ABSTRACT FROM AUTHOR]

Product configurators are recognised as critical toolkits enabling customers to co-create products with companies. Most available product configurators require customers to select suitable product attributes from predefined options. However, customers usually find the selection processes frustrating due to their lack of product knowledge. In view of the fact that customers often express their needs in imprecise and vague natural language, we define a new needs-based configuration mechanism and propose an implementation approach based on text embeddings and multilayer perceptron. Specifically, we leverage the massive amount of product reviews by encoding them into text embeddings. A multilayer perceptron is trained to map text embeddings to product attribute options. Experiment results indicate that the mapping has good generalisation capability to map customer needs into product configurations. The performance of our approach is comparable to that of deep learning-based approaches but with much higher efficiency in terms of computational complexity. Our needs-based configuration thus provides a quick and effective means of facilitating product customisation. It also demonstrates an innovative way of utilising customer resources in unstructured text to co-create products with companies. [ABSTRACT FROM AUTHOR]

In recent years, deep learning technology has developed significantly in the judicial field. More and more scholars are introducing deep learning to solve problems in the judicial field and improve the efficiency of judicial agencies in handling cases. An important task of judicial work is to identify the key elements of complex cases, establish the relationship between entities in the document, accurately grasp the development of the case, provide a basis for the understanding, analysis, and ruling of the case, and increase the interpretability of the case results. However, judging from the actual application situation, the application of deep learning technology in the judicial field is not yet mature and still faces huge challenges. On the one hand, the existing legal text element identification methods only consider the identification of core elements and ignore the basic elements. However, the basic elements contain necessary legal-related information, which is basic case information unique to the legal field and has important reference value for judicial staff to analyze cases. On the other hand, the traditional method of identifying key elements does not consider the contextual semantic relationship and ignores the element semantic information and global semantic information is lost, resulting in poor recognition of key elements of legal text. Therefore, in the identification of key elements of legal texts, not only the core elements and basic elements must be considered, but also the semantic features of sentences and the semantic features of elements must be comprehensively considered, thereby improving the effect of identifying key elements of legal texts and promoting the efficiency of judicial organs in handling cases. Aiming at the problem of identifying the basic elements of legal texts, this paper proposes a model for identifying the basic elements of legal texts based on dynamic representation. This algorithm uses the dynamic representation capability of the BERT model to vectorize text and considers global domain semantic information during the pre-training process to achieve a more comprehensive vector representation. Secondly, the memory component of the bidirectional long short-term memory network is used to integrate all the feature information between long-distance words in the legal text, effectively express the meaning of the word in the context, and realize the recognition of the basic elements of the legal text. In addition, the conditional random field model is used to learn the transfer rules of labels between entities and output the label sequence that best conforms to the actual rules. Finally, the basic element identification model proposed in this article has been significantly improved by comparing it with the current better methods. [ABSTRACT FROM AUTHOR]

The article introduces a new model called APF-GAN that improves upon existing generative adversarial network (GAN)-based models for image semantic segmentation. The model incorporates various strategies such as asymmetric pre-training and fine-tuning, progressive growth training, and semantic spatially-guided noise to enhance image quality and training efficiency. Experimental results demonstrate that the APF-GAN outperforms other models in terms of segmentation accuracy and aesthetics. The article also provides examples of images generated by the APF-GAN and discusses potential areas for future research. [Extracted from the article]

Machine learning (ML) has been broadly applied for vadose zone applications in recent years. This article provides a comprehensive review of such developments. ML applications for variables corresponding to different complex vadose zone processes are summarized mostly in a prediction context. By analyzing and assessing these applications, we discovered extensive usages of classic ML models with relatively limited applications of deep learning (DL) approaches in general. We also recognized a lack of benchmark datasets for soil property research as well as limited integration of physics‐based vadose zone principles into the ML approaches. To facilitate this interdisciplinary research of ML in vadose zone characterization and processes, a paradigm of knowledge‐guided machine learning is suggested along with other data‐driven and ML model‐based research suggestions to advance future research. Core Ideas: Random forest and artificial neural network are two widely applied machine learning options for predicting vadose zone studies.A benchmark dataset is missing in soil property studies.We suggest vadose zone scientists explore more deep learning options and expand knowledge‐guided machine learning implementations. [ABSTRACT FROM AUTHOR]

Background: In radiotherapy, real‐time tumor tracking can verify tumor position during beam delivery, guide the radiation beam to target the tumor, and reduce the chance of a geometric miss. Markerless kV x‐ray image‐based tumor tracking is challenging due to the low tumor visibility caused by tumor‐obscuring structures. Developing a new method to enhance tumor visibility for real‐time tumor tracking is essential. Purpose: To introduce a novel method for markerless kV image‐based tracking of lung tumors via deep learning‐based target decomposition. Methods: We utilized a conditional Generative Adversarial Network (cGAN), known as Pix2Pix, to build a patient‐specific model and generate the synthetic decomposed target image (sDTI) to enhance tumor visibility on the real‐time kV projection images acquired by the onboard kV imager equipped on modern linear accelerators. We used 4DCT simulation images to generate the digitally reconstructed radiograph (DRR) and DTI image pairs for model training. We augmented the training dataset by randomly shifting the 4DCT in the superior‐inferior, anterior‐posterior, and left‐right directions during the DRR and DTI generation process. We performed real‐time 2D tumor tracking via template matching between the DTI generated from the CT simulation and the sDTI generated from the real‐time kV projection images. We validated the proposed method using nine patients' datasets with implanted beacons near the tumor. Results: The sDTI can effectively improve the image contrast around the lung tumors on the kV projection images for the nine patients. With the beacon motion as ground truth, the tracking errors were on average 0.8 ± 0.7 mm in the superior‐inferior (SI) direction and 0.9 ± 0.8 mm in the in‐plane left‐right (IPLR) direction. The percentage of successful tracking, defined as a tracking error less than 2 mm in the SI direction, is 92.2% on the 4312 tested images. The patient‐specific model took approximately 12 h to train. During testing, it took approximately 35 ms to generate one sDTI, and 13 ms to perform the tumor tracking using template matching. Conclusions: Our method offers the potential solution for nearly real‐time markerless lung tumor tracking. It achieved a high level of accuracy and an impressive tracking rate. Further development of 3D lung tumor tracking is warranted. [ABSTRACT FROM AUTHOR]

The spatial resolution of precipitation predicted by general circulation models is too coarse to meet current research and operational needs. Downscaling is one way to provide finer resolution data at local scales. The single-image super-resolution method in the computer vision field has made great strides lately and has been applied in various fields. In this article, we propose a novel reference-based and gradient-guided deep learning model (RBGGM) to downscale daily precipitation considering the discontinuity of precipitation and ill-posed nature of downscaling. Global Precipitation Measurement Mission (GPM) precipitation data, variables in ERA5 re-analysis data, and topographic data are selected to perform the downscaling, and a residual dense attention block is constructed to extract features of them. By exploring the discontinuous feature of precipitation, we introduce gradient feature to reconstruct precipitation distribution. We also extract the feature of high-resolution monthly precipitation as a reference feature to resolve the ill-posed nature of downscaling. Extensive experimental results on benchmark data sets demonstrate that our proposed model performs better than other baseline methods. Furthermore, we construct a daily precipitation downscaling data set based on GPM precipitation data, ERA5 re-analysis data and topographic data.

The main objective of this study was to build a rich and high-quality thyroid ultrasound image database (TUD) for computer-aided diagnosis (CAD) systems to support accurate diagnosis and prognostic modeling of thyroid disorders. Because most of the raw thyroid ultrasound images contain artificial markers, which seriously affect the robustness of CAD systems because of their strong prior location information, we propose a marker mask inpainting (MMI) method to erase artificial markers and improve image quality. First, a set of thyroid ultrasound images were collected from the General Hospital of the Northern Theater Command. Then, two modules were designed in MMI, namely, the marker detection (MD) module and marker erasure (ME) module. The MD module detects all markers in the image and stores them in a binary mask. According to the binary mask, the ME module erases the markers and generates an unmarked image. Finally, a new TUD based on the marked images and unmarked images was built. The TUD is carefully annotated and statistically analyzed by professional physicians to ensure accuracy and consistency. Moreover, several normal thyroid gland images and some ancillary information on benign and malignant nodules are provided. Several typical segmentation models were evaluated on the TUD. The experimental results revealed that our TUD can facilitate the development of more accurate CAD systems for the analysis of thyroid nodule-related lesions in ultrasound images. The effectiveness of our MMI method was determined in quantitative experiments. The rich and high-quality resource TUD promotes the development of more effective diagnostic and treatment methods for thyroid diseases. Furthermore, MMI for erasing artificial markers and generating unmarked images is proposed to improve the quality of thyroid ultrasound images. Our TUD database is available at https://github.com/NEU-LX/TUD-Datebase. [ABSTRACT FROM AUTHOR]

Realistic image composition aims to composite new images by fusing a source object into a target image. It is a challenging problem due to the complex multi-task framework, including sensible object placement, appearance consistency, shadow generation, etc. Most existing researchers attempt to address one of the issues. Especially before compositing, there is no matching assignment between the source object and target image, which often leads to unreasonable results. To address the issues above, we consider image composition as an image generation problem and propose a deep adversarial learning network via spatial position analysis. We target the analysis network segment and classify the objects in target images. A spatial alignment network matches the segmented objects with the source objects, and predicts a sensible placement position, and an adversarial network generates a realistic composite image with the shadow and reflection of the source object. Furthermore, we use the classification information of target objects to filter out unreasonable image compositing. Moreover, we introduce a new test set to evaluate the network generalization for our multi-task image composition dataset. Extensive experimental results of the SHU (Shanghai University) dataset demonstrate that our deep spatial position analysis network remarkably enhances the compositing performance in realistic, shadow, and reflection generations. [ABSTRACT FROM AUTHOR]

SUMMARY: Spartina alterniflora is a halophyte that can survive in high‐salinity environments, and it is phylogenetically close to important cereal crops, such as maize and rice. It is of scientific interest to understand why S. alterniflora can live under such extremely stressful conditions. The molecular mechanism underlying its high‐saline tolerance is still largely unknown. Here we investigated the possibility that high‐affinity K+ transporters (HKTs), which function in salt tolerance and maintenance of ion homeostasis in plants, are responsible for salt tolerance in S. alterniflora. To overcome the imprecision and unstable of the gene screening method caused by the conventional sequence alignment, we used a deep learning method, DeepGOPlus, to automatically extract sequence and protein characteristics from our newly assemble S. alterniflora genome to identify SaHKTs. Results showed that a total of 16 HKT genes were identified. The number of S. alterniflora HKTs (SaHKTs) is larger than that in all other investigated plant species except wheat. Phylogenetically related SaHKT members had similar gene structures, conserved protein domains and cis‐elements. Expression profiling showed that most SaHKT genes are expressed in specific tissues and are differentially expressed under salt stress. Yeast complementation expression analysis showed that type I members SaHKT1;2, SaHKT1;3 and SaHKT1;8 and type II members SaHKT2;1, SaHKT2;3 and SaHKT2;4 had low‐affinity K+ uptake ability and that type II members showed stronger K+ affinity than rice and Arabidopsis HKTs, as well as most SaHKTs showed preference for Na+ transport. We believe the deep learning‐based methods are powerful approaches to uncovering new functional genes, and the SaHKT genes identified are important resources for breeding new varieties of salt‐tolerant crops. Significance Statement: The great potential of deep learning‐based methods for uncovering the HKT genes in S. alterniflora was demonstrated, which opens the door for utilizing SaHKTs in a wide range of species to increase the stress resilience of staple crops. [ABSTRACT FROM AUTHOR]

(1) Background: Cell proliferation (Ki-67) has important clinical value in the treatment and prognosis of non-small cell lung cancer (NSCLC). However, current detection methods for Ki-67 are invasive and can lead to incorrect results. This study aimed to explore a deep learning classification model for the prediction of Ki-67 and the prognosis of NSCLC based on FDG-PET/CT images. (2) Methods: The FDG-PET/CT scan results of 159 patients with NSCLC confirmed via pathology were analyzed retrospectively, and the prediction models for the Ki-67 expression level based on PET images, CT images and PET/CT combined images were constructed using Densenet201. Based on a Ki-67 high expression score (HES) obtained from the prediction model, the survival rate of patients with NSCLC was analyzed using Kaplan–Meier and univariate Cox regression. (3) Results: The statistical analysis showed that Ki-67 expression was significantly correlated with clinical features of NSCLC, including age, gender, differentiation state and histopathological type. After a comparison of the three models (i.e., the PET model, the CT model, and the FDG-PET/CT combined model), the combined model was found to have the greatest advantage in Ki-67 prediction in terms of AUC (0.891), accuracy (0.822), precision (0.776) and specificity (0.902). Meanwhile, our results indicated that HES was a risk factor for prognosis and could be used for the survival prediction of NSCLC patients. (4) Conclusions: The deep-learning-based FDG-PET/CT radiomics classifier provided a novel non-invasive strategy with which to evaluate the malignancy and prognosis of NSCLC. [ABSTRACT FROM AUTHOR]

This paper proposes a novel domain-generation-algorithm detection framework based on statistical learning that integrates the detection capabilities of multiple heterogeneous models. The framework includes both traditional machine learning methods based on artificial features and deep learning methods, comprehensively analyzing 34 artificial features and advanced features extracted from deep neural networks. Additionally, the framework evaluates the predictions of the base models based on the fit of the samples to each type of sample set and a predefined significance level. The predictions of the base models are statistically analyzed, and the final decision is made using strategies such as voting, confidence, and credibility. Experimental results demonstrate that the DGA detection framework based on statistical learning achieves a higher detection rate compared to the underlying base models, with accuracy, precision, recall, and F1 scores reaching 0.979, 0.977, 0.981, and 0.979, respectively. The framework also exhibits a stronger adaptability to unknown domains and a certain level of robustness against concept drift attacks. [ABSTRACT FROM AUTHOR]

In the era of deep learning, representational text-matching algorithms based on BERT and its variant models have become mainstream and are limited by the sentence vectors generated by the BERT model, and the SimCSE algorithm proposed in 2021 has improved the sentence vector quality to a certain extent. In this paper, to address the problem that the SimCSE algorithm has—that the greater the difference in sentence length, the smaller the probability that the sentence pairs are similar—an EdaCSE algorithm is proposed to perturb the sentence length using a simple data enhancement method without affecting the semantics of the sentences. The perturbation is applied to the sentence length by adding meaningless English punctuation marks to the original sentence so that the model no longer tends to recognise sentences of similar length as similar sentences. Based on the BERT series of models, experiments were conducted on five different datasets, and the experiments proved that the EdaCSE method improves an average of 1.67, 0.84, and 1.08 on the five datasets. [ABSTRACT FROM AUTHOR]

Background: X‐ray image quality is critical for accurate intrafraction motion tracking in radiation therapy. Purpose: This study aims to develop a deep‐learning algorithm to improve kV image contrast by decomposing the image into bony and soft tissue components. In particular, we designed a priori attention mechanism in the neural network framework for optimal decomposition. We show that a patient‐specific prior cross‐attention (PCAT) mechanism can boost the performance of kV image decomposition. We demonstrate its use in paraspinal SBRT motion tracking with online kV imaging. Methods: Online 2D kV projections were acquired during paraspinal SBRT for patient motion monitoring. The patient‐specific prior images were generated by randomly shifting and rotating spine‐only DRR created from the setup CBCT, simulating potential motions. The latent features of the prior images were incorporated into the PCAT using multi‐head cross attention. The neural network aimed to learn to selectively amplify the transmission of the projection image features that correlate with features of the priori. The PCAT network structure consisted of (1) a dual‐branch generator that separates the spine and soft tissue component of the kV projection image and (2) a dual‐function discriminator (DFD) that provides the realness score of the predicted images. For supervision, we used a loss combining mean absolute error loss, discriminator loss, perceptual loss, total variation, and mean squared error loss for soft tissues. The proposed PCAT approach was benchmarked against previous work using the ResNet generative adversarial network (ResNetGAN) without prior information. Results: The trained PCAT had improved performance in effectively retaining and preserving the spine structure and texture information while suppressing the soft tissues from the kV projection images. The decomposed spine‐only x‐ray images had the submillimeter matching accuracy at all beam angles. The decomposed spine‐only x‐ray significantly reduced the maximum errors to 0.44 mm (<2 pixels) in comparison to 0.92 mm (∼4 pixels) of ResNetGAN. The PCAT decomposed spine images also had higher PSNR and SSIM (p‐value < 0.001). Conclusion: The PCAT selectively learned the important latent features by incorporating the patient‐specific prior knowledge into the deep learning algorithm, significantly improving the robustness of the kV projection image decomposition, and leading to improved motion tracking accuracy in paraspinal SBRT. [ABSTRACT FROM AUTHOR]

In recent years, artificial intelligence (AI) technology has been used in most if not all domains and has greatly benefited our lives. While AI can accurately extract critical features and valuable information from large amounts of data to help people complete tasks faster, there are growing concerns about the non-transparency of AI in the decision-making process. The emergence of explainable AI (XAI) has allowed humans to better understand and control AI systems, which is motivated to provide transparent explanations for the decisions made by AI. This article aims to present a comprehensive overview of recent research on XAI approaches from three well-defined taxonomies. We offer an in-depth analysis and summary of the status and prospects of XAI applications in several key areas where reliable explanations are urgently needed to avoid mistakes in decision-making. We conclude by discussing XAI's limitations and future research directions. [ABSTRACT FROM AUTHOR]

The optical microscope is customarily an instrument of substantial size and expense but limited performance. Here we report an integrated microscope that achieves optical performance beyond a commercial microscope with a 5×, NA 0.1 objective but only at 0.15 cm3 and 0.5 g, whose size is five orders of magnitude smaller than that of a conventional microscope. To achieve this, a progressive optimization pipeline is proposed which systematically optimizes both aspherical lenses and diffractive optical elements with over 30 times memory reduction compared to the end-to-end optimization. By designing a simulation-supervision deep neural network for spatially varying deconvolution during optical design, we accomplish over 10 times improvement in the depth-of-field compared to traditional microscopes with great generalization in a wide variety of samples. To show the unique advantages, the integrated microscope is equipped in a cell phone without any accessories for the application of portable diagnostics. We believe our method provides a new framework for the design of miniaturized high-performance imaging systems by integrating aspherical optics, computational optics, and deep learning. Traditional optical microscope, while bulky, often fails to deliver optimal performance. Here, the authors have engineered an integrated microscope of 0.15 cm3 in volume and a weight of 0.5 g, which outperforms a commercial microscope and can be seamlessly integrated with a smartphone. [ABSTRACT FROM AUTHOR]