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Twenty-two compounds were isolated from the fruit of Albizia lebbeck including one unprecedented, rare amino acid-derived zwitterionic and one new flavone derivative. The isolation was performed on repeated column chromatography over silica gel and their structures were determined by 1D-, 2D-NMR and HR-ESI-MS spectra together with reported data in the literature. The chemophenetic significance is also discussed. Some isolated compounds were reported for the first time to be found in the species. Additionally, compound 2 showed antibacterial activity and compounds 1 and 2 revealed moderate cytotoxic activity against the Raw 264.7 cancer cell line with IC50 values of 37.19 µM and 29.36 µM, respectively. Furthermore, a proposed biosynthetic pathway of compound 1 is described. [ABSTRACT FROM AUTHOR]

Two new fatty acid esters of triterpenoids (1–2) together with eleven known compounds (3–13) were obtained after investigation of the CH2Cl2-MeOH (1:1) crude extract from the leaves of Schefflera barteri Harms. All these compounds (1–13) were isolated for the first time from this plant among which compounds 3, 4, 6 and 9–13 were also isolated from the genus Schefflera for the first time. The structures of the isolated compounds were elucidated by analyses of their spectroscopic data (1D and 2D NMR, and MS). The antibacterial and cytotoxic activities of crude extracts, fractions and compounds (1, 2, 5, 6, 8 and 9) were investigated against both Gram-negative and Gram-positive bacteria strains as well as on human cervix carcinoma and colon adenocarcinoma cancer cell lines, respectively. They showed weak to significant activity towards the strains and malignant cells used. [ABSTRACT FROM AUTHOR]

The chemical investigation of the CH 2 Cl 2 /MeOH (1:1) extract from the aerial part of Mussaenda erythrophylla Schumach. & Thonn. (Rubiaceae) resulted in the isolation of sixteen known compounds (1 – 16) distributed in coumarins, flavonoid glucosides, quinic acid derivatives, triterpenoids, monoglycerid, steroids, tetraterpenoid and polyol. The structures of the compounds were determined by spectrometric and spectroscopic analysis including MS and NMR data followed by their comparison with reported ones in the literature. The chemophenetic significance of the isolated compounds was discussed. The crude extract and some of the isolated compounds were assessed in vitro for their antileishmanial, cytotoxic and antiplasmodial activities. The crude extract of M. erythrophylla showed moderate antileishmanial activity (IC 50 = 61.6 μg/mL) while the hexane soluble fraction showed good antileishmanial activity (IC 50 = 31.06 μg/mL) compared to the reference drug amphotericin B (IC 50 = 0.11 μM). Compounds 11 and 9 also exhibited potent antileishmanial activity (IC 50 = 53.7–52.0 μM). The crude extract as well as the ethyl acetate soluble fraction also exhibited good antiplasmodial activity (IC 50 = 7.43 ± 0.00 μg/mL and 14.49 ± 2.96 μg/mL respectively), while compounds 11 , 15 and 16 showed weak activity with IC 50 > 20 μM compared to the reference drug artemisinin (IC 50 = 0.014 ± 0.001 μM). [Display omitted] • Sixteen compounds isolated from aerial of Mussaenda erythrophylla. • The chemophenetic significance of isolates were studied. • Structures were cleared by extensive NMR and MS techniques. • Isolates showed moderate to significant cytotoxicity towards the parasites. • Compounds were low to moderate active against the parasites. [ABSTRACT FROM AUTHOR]