24 results
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2. Considerations for paediatric student‐led telepractice in speech‐language therapy: A pilot observational study from South Africa.
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Watermeyer, Jennifer, Nattrass, Rhona, Beukes, Johanna, Madonsela, Sonto, and Scott, Megan
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SPEECH therapists , *QUALITATIVE research , *OCCUPATIONAL adaptation , *MEDICAL technology , *RESEARCH funding , *HEALTH occupations students , *PILOT projects , *SCIENTIFIC observation , *UNIVERSITIES & colleges , *DIGITAL divide , *SOCIAL role , *DESCRIPTIVE statistics , *PEDIATRICS , *STUDENTS , *TELEMEDICINE , *THEMATIC analysis , *CLIENT relations , *INFORMATION literacy , *RESEARCH , *RESOURCE-limited settings , *SOCIAL support , *INTERNET service providers , *SPEECH therapy , *VIDEO recording - Abstract
Background: COVID‐19 necessitated emergency telepractice for student‐led speech‐language therapy clinical practicals in training institutions, with limited preparation and evidence‐based guidelines. Beyond the pandemic, practitioners and university training sites are likely to continue to offer telepractice necessitating thorough preparation for telepractice services underpinned by a comprehensive understanding of the complexities involved in online therapy. Aims: Adopting realist evaluation principles, our aim in this paper was to explore broadly what works and does not work in a set of student‐led telepractice sessions in a diverse, resource‐limited context. The broader goal of this project was to provide evidence‐based support to enhance the efficiency and success of telepractice sessions in student clinical training contexts. Methods & Procedures: We used qualitative observational methods with reflexive thematic analysis to analyse 28 video recordings and 61 observation notes of student‐led paediatric telepractice sessions from a South African university clinic as part of a pilot study. Outcomes & Results: We identified four overarching considerations for student‐led telepractice: (1) additional, specific preparation is required, (2) with greater management of technology and adaptation of tasks, especially during times of poor connectivity; (3) telepractice relies heavily on caregiver input and collaboration; and (4) promoting engagement online, holding a client's attention, building rapport and offering reinforcement are critical skills that are complicated by the lack of face‐to‐face contact. Conclusions & Implications: Our findings indicate that telepractice pedagogy needs to be explicitly taught and students require practical assistance as they learn how to use this service delivery approach effectively. There are some aspects peculiar to telepractice that require unique consideration and planning, especially in contexts where service providers and users may be unfamiliar with this form of service provision. The findings of this pilot study can be used by clinical educators and student clinicians to enhance clinical training opportunities involving telepractice. WHAT THIS PAPER ADDS: What is already known on this subject: Many speech‐language therapy (SLT) student clinicians had to transition quickly to telepractice service provision during COVID‐19 with limited existing guidelines and support, especially in contexts where teletherapy is typically non‐existent or difficult to access. Although there is some literature available on experiences of telepractice, there is very little evidence‐based research which explores the mechanics of such sessions in real‐time and which offers practical support to student clinicians and clinical educators engaging in this mode of service delivery. What this study adds: This pilot study examined video‐recorded, student‐led, paediatric, speech‐language teletherapy sessions to understand challenges and considerations involved in using telepractice as a clinical training tool. Findings show that additional preparation for telepractice sessions is required, particularly in contexts of poor digital literacy; students must learn to manage technology, especially when connectivity poses a challenge, and adapt therapy tasks for online work with clients; telepractice relies heavily on caregiver input and collaboration, more so than in in‐person consultations, and this relationship requires careful management; and promoting engagement online, holding a client's attention, building rapport and offering reinforcement are critical yet challenging skills in telepractice. What are the potential or actual clinical implications of this work?: Our findings highlight a need to teach telepractice pedagogy explicitly and support students practically in learning how to provide therapy effectively via this mode of service delivery. Observational methods for studying practices in recorded telepractice sessions can be used as part of a reflective approach to clinical training. Using already available data allowed us to unpack the 'messy reality' of clinical training using telepractice. [ABSTRACT FROM AUTHOR]
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- 2024
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3. Oral manifestations in patients with coronavirus disease 2019 (COVID-19) identified using text mining: an observational study.
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Guauque-Olarte, Sandra, Cifuentes-C, Laura, and Fong, Cristian
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ORAL manifestations of general diseases , *COVID-19 , *TEXT mining , *OPEN scholarship , *SCIENTIFIC observation - Abstract
Text mining enables search, extraction, categorisation and information visualisation. This study aimed to identify oral manifestations in patients with COVID-19 using text mining to facilitate extracting relevant clinical information from a large set of publications. A list of publications from the open-access COVID-19 Open Research Dataset was downloaded using keywords related to oral health and dentistry. A total of 694,366 documents were retrieved. Filtering the articles using text mining yielded 1,554 oral health/dentistry papers. The list of articles was classified into five topics after applying a Latent Dirichlet Allocation (LDA) model. This classification was compared to the author's classification which yielded 17 categories. After a full-text review of articles in the category "Oral manifestations in patients with COVID-19", eight papers were selected to extract data. The most frequent oral manifestations were xerostomia (n = 405, 17.8%) and mouth pain or swelling (n = 289, 12.7%). These oral manifestations in patients with COVID-19 must be considered with other symptoms to diminish the risk of dentist-patient infection. [ABSTRACT FROM AUTHOR]
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- 2023
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4. The psychological well‐being of people in a COVID‐19 supervised quarantine facility: A mixed methods study.
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Mitchell, David, Bressington, Daniel, Esler, Danielle, Straube, Kylie, Noel‐Gough, Laura, Vermeulen, Lisa, and Stephens, Dianne
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WELL-being , *STATISTICS , *COVID-19 , *SCIENTIFIC observation , *CONFIDENCE intervals , *ANALYSIS of variance , *QUARANTINE , *RESEARCH methodology , *CROSS-sectional method , *COMMUNITY health services , *INTERVIEWING , *PSYCHOLOGICAL tests , *T-test (Statistics) , *DESCRIPTIVE statistics , *DATA analysis software , *DATA analysis , *THEMATIC analysis , *PSYCHOLOGICAL distress - Abstract
Accessible summary: What is known on the subject?: Supervised Quarantine has been shown to impact the psychological well‐being of those in quarantine both during the COVID‐19 pandemic and in previous pandemics.There are few studies regarding the psychological impact of supervised quarantine for the purpose of COVID‐19 mitigation.There is little research regarding the psychological well‐being of professionals maintaining quarantine, despite the fact they risk potential psychological distress. What the paper adds to existing knowledge?: This paper addresses the paucity of knowledge regarding the psychological well‐being of those undergoing quarantine in a purpose‐built facility.The quarantined study population involved uniquely domestic arrivals and also professionals maintaining quarantine.Lack of control, isolation and miscommunication were perceived as challenging mental well‐being. What are the implications for practice?: Although psychological distress in Domestic arrivals appeared low, there are still identifiable stresses on mental well‐being.Mental health workers need to be cognizant that point entry to COVID‐19 quarantine (Domestic vs. International as well as specific regions) may influence risk of psychological distress.Mental Health nurses supporting those in quarantine should afford quarantined individuals a degree of choice, establish regular clear communication and consider how to establish peer support mechanisms within the quarantine environment. Introduction: Supervised quarantine may compromise psychological well‐being. There is equivocal evidence regarding psychological distress in compulsory supervised quarantine facilities. Aims: To evaluate the mental well‐being of people undergoing and working in a supervised COVID‐19 quarantine facility. Method: Mixed methodology was used, including a cross‐sectional analysis of psychological distress (DASS‐21) and individual semi‐structured interviews (10 professionals maintaining quarantine and 10 quarantined persons). Results: Overall levels of psychological distress were low. Those quarantining from Victoria had significantly lower depression scores compared to all other departure points. Qualitative analysis identified distress being linked to a lack of control, isolation and miscommunication. Discussion: Quarantine was associated with low levels of psychological distress. This was lower in people travelling from Victoria, a state where there were higher rates of infections and restrictions. Interviews showed that psychological distress was conceptualized as being associated with supervised quarantine, but participants recognized the overall importance of quarantine. Implications for Practice: Mental health professionals supporting quarantined people should consider original departure points may predict levels of psychological distress. Implementing ways of gaining control through affording choice, improving communication channels and establishing peer support networks within quarantine settings may help maintain mental well‐being. [ABSTRACT FROM AUTHOR]
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- 2023
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5. Treatment suspension due to the coronavirus pandemic and mental health of infertile patients: a systematic review and meta-analysis of observational studies.
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Iranifard, Elnaz, Yas, Atefeh, Mansouri Ghezelhesari, Elahe, Taghipour, Ali, Mahmoudinia, Malihe, and Latifnejad Roudsari, Robab
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COVID-19 pandemic , *MENTAL health , *MENTAL illness , *RANDOM effects model , *SCIENTIFIC observation - Abstract
Background: Access to fertility treatments is considered a reproductive right, but because of the quarantine due to the coronavirus pandemic most infertility treatments were suspended, which might affect the psychological and emotional health of infertile patients. Therefore, this study was conducted to review the mental health of infertile patients facing treatment suspension due to the coronavirus pandemic. Methods: This study was conducted based on the Meta-analysis Of Observational Studies in Epidemiology (MOOSE) guideline. The Web of Science, PubMed, Embase, Scopus, and Cochrane library databases were searched by two independent researchers, without time limitation until 31 December 2022. All observational studies regarding the mental health of infertile patients facing treatment suspension including anxiety, depression, and stress were included in the study. Qualitative studies, editorials, brief communications, commentaries, conference papers, guidelines, and studies with no full text were excluded. Quality assessment was carried out using Newcastle–Ottawa Scale by two researchers, independently. The random effects model was used to estimate the pooled prevalence of mental health problems. Meta-regression and subgroup analysis were used to confirm the sources of heterogeneity. Results: Out of 681 studies, 21 studies with 5901 infertile patients were systematically reviewed, from which 16 studies were included in the meta-analysis. The results of all pooled studies showed that the prevalence of anxiety, depression, and stress in female patients was 48.4% (95% CI 34.8–62.3), 42% (95% CI 26.7–59.4), and 55% (95% CI 45.4–65), respectively. Additionally, 64.4% (95% CI 50.7–76.1) of patients wished to resume their treatments despite the coronavirus pandemic. Conclusion: Treatment suspension due to the coronavirus pandemic negatively affected the mental health of infertile patients. It is important to maintain the continuity of fertility care, with special attention paid to mental health of infertile patients, through all the possible measures even during a public health crisis. [ABSTRACT FROM AUTHOR]
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- 2024
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6. The impact of pandemics on medical research publication trend: Tested on PubMed as an example through the COVID-19 era.
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Al Nemer, Areej
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PUBLISHING , *ONLINE information services , *KRUSKAL-Wallis Test , *SCIENTIFIC observation , *SERIAL publications , *CROSS-sectional method , *COMPARATIVE studies , *DESCRIPTIVE statistics , *MEDLINE , *COVID-19 pandemic , *MEDICAL research - Abstract
Introduction: COVID-19 pandemic negatively influenced the entire life globally including various aspects of patients' care. Its effect on medical research production is not known. The aim of this study is to assess the impact of COVID-19 pandemic on medical research reporting trend. Methods: Advanced search on PubMed was performed over 2011- August, 2021. Monthly comparison was done for the years 2019, 2020, and 2021. Kruskal Wallis test was used to compare continuous distributions. Results: The total publication count showed constant increment over the study period. Faster rise was noticed on 2020 (15.7%). A steady growth in publications over the years and through the pandemic was also seen in seven studied countries with variable, both in total and also after exclusion of COVID-19 related papers. Italy and India have the highest proportions of COVID-19 related publications in comparison to the total papers in 2020, but USA has the highest quantity. Statistically significant differences exist between the first eight months of the last three years with and without counting COVID-19 related publications (p-values=0.0003907 and 0.001084, respectively). Conclusion: Our results reflect that investigators world-wide succeeded to reconfigure their work style and utilize the spared time induced by the lockdown to enrich the medical research platform. [ABSTRACT FROM AUTHOR]
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- 2022
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7. The impact of the COVID-19 pandemic on recovery from cardiac surgery: 1-year outcomes.
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Sanders, Julie, Bueser, Teofila, Beaumont, Emma, Dodd, Matthew, Murray, Sarah E, Owens, Gareth, Berry, Alan, Hyde, Edward, Clayton, Tim, and Oo, Aung Ye
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CARDIAC surgery , *MEDICAL quality control , *PREOPERATIVE care , *SCIENTIFIC observation , *SOCIAL support , *CONFIDENCE intervals , *CONVALESCENCE , *POSTOPERATIVE care , *RETROSPECTIVE studies , *ACQUISITION of data , *TREATMENT effectiveness , *COMPARATIVE studies , *QUESTIONNAIRES , *DESCRIPTIVE statistics , *MENTAL depression , *MEDICAL records , *ANXIETY , *COVID-19 pandemic , *LONGITUDINAL method , *EVALUATION - Abstract
Aims The outbreak of COVID-19 was potentially stressful for everyone and possibly heightened in those having surgery. We sought to explore the impact of the pandemic on recovery from cardiac surgery. Methods and results A prospective observational study of 196 patients who were ≥18years old undergoing cardiac surgery between March 23 and July 4, 2020 (UK lockdown) was conducted. Those too unwell or unable to give consent/complete the questionnaires were excluded. Participants completed (on paper or electronically) the impact of event [Impact of Events Scale-revised (IES-R)] (distress related to COVID-19), depression [Centre for Epidemiological Studies Depression Scale (CES-D)], and EQ-5D-5L [(quality of life, health-related quality of life (HRQoL)] questionnaires at baseline, 1 week after hospital discharge, and 6 weeks, 6 months and 1 year post-surgery. Questionnaire completion was >75.0% at all timepoints, except at 1 week (67.3%). Most participants were male [147 (75.0%)], white British [156 (79.6%)] with an average age 63.4years. No patients had COVID-19. IES-R sand CES-D were above average at baseline (indicating higher levels of anxiety and depression) decreasing over time. HRQoL pre-surgery was high, reducing at 1 week but increasing to almost pre-operative levels at 6 weeks and exceeding pre-operative levels at 6 months and 1 year. IES-R and CES-D scores were consistently higher in women and younger patients with women also having poorer HRQoL up to 1-year after surgery. Conclusions High levels of distress were observed in patients undergoing cardiac surgery during the COVID-19 pandemic with women and younger participants particularly affected. Psychological support pre- and post-operatively in further crises or traumatic times should be considered to aid recovery. Registration Clinicaltrials.gov ID:NCT04366167. [ABSTRACT FROM AUTHOR]
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- 2023
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8. Epidemiological Profile of Hospitalized Patients with Cystic Fibrosis in Brazil Due to Severe Acute Respiratory Infection during the COVID-19 Pandemic and a Systematic Review of Worldwide COVID-19 in Those with Cystic Fibrosis.
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Marques, Leonardo Souza, Boschiero, Matheus Negri, Sansone, Nathália Mariana Santos, Brienze, Letícia Rulli, and Marson, Fernando Augusto Lima
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CYSTIC fibrosis diagnosis ,INTENSIVE care units ,ONLINE information services ,COMPUTER software ,KRUSKAL-Wallis Test ,COVID-19 ,SCIENTIFIC observation ,CONFIDENCE intervals ,SYSTEMATIC reviews ,CLASSIFICATION ,AGE distribution ,CARDIOMYOPATHIES ,LUNG transplantation ,RESPIRATORY infections ,PATIENTS ,OXYGEN saturation ,HEALTH outcome assessment ,FISHER exact test ,MANN Whitney U Test ,CYSTIC fibrosis ,DYSPNEA ,ARTIFICIAL respiration ,HOSPITAL care ,DESCRIPTIVE statistics ,CHI-squared test ,RESEARCH funding ,MEDLINE ,DATA analysis software ,ODDS ratio ,POLYMERASE chain reaction ,COMORBIDITY ,COVID-19 pandemic ,PHENOTYPES ,ALGORITHMS ,SYMPTOMS ,DISEASE complications - Abstract
Since the onset of the coronavirus disease, COVID-19 pandemic, concern arose for those who might be at higher risk of a worse COVID-19 prognosis, such as those with cystic fibrosis (CF). In this context, we evaluated the features of hospitalized patients with CF due to severe acute respiratory infection (SARI) in Brazil and we also performed a systematic review including all the studies published from the beginning of the first case of COVID-19 (17 November 2019) to the date of this search (23 May 2022) which included, concomitantly, patients with CF and COVID-19 in the worldwide population. In our Brazilian data, we evaluated the period from December 2019 to March 2022, and we included 33 demographical and clinical patients' features. We classified the patients into groups: (G1) SARI due to another viral infection than severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) (23; 5.4%), (G2) SARI due to an unknown etiological agent (286; 67.1%), and (G3) SARI due to SARS-CoV-2 infection (117; 27.5%). The individuals in G3 tended to be older, especially over 50 years old, and presented a higher prevalence of dyspnea, peripheral capillary oxygen saturation (SpO
2 ) <95%, and cardiopathy. The highest prevalence for intensive care unit (ICU) treatment (52; 44.4%) and invasive mechanical ventilation (29; 24.8%) was for patients in G3. Almost half of the patients in G3 died (51; 43.6%); in contrast, none in G1 died. However, we observed 43 (15.0%) deaths in G2. In addition, 12 (4.2%) and one (0.9%) death not associated with SARI occurred, respectively, in the G2 and G3. The patients who died due to SARS-CoV-2 infection had a higher frequency of SpO2 <95% (46; 90.2%), ICU treatment (34; 66.7%), and invasive mechanical ventilation (27; 52.9%) when compared to those who recovered. The systematic review comprised a total of 31 papers published as observational studies. These studies comprised 661,386 patients in total, including children, adults, and elderly age groups. However, only 19,150 (2.9%) patients were diagnosed with CF and, from these patients, 2523 (0.4%) were diagnosed with both CF and COVID-19. It was observed that the most common outcome was the need for hospitalization (n = 322 patients with CF), and the need for oxygen support (n = 139 patients with CF). One hundred patients with CF needed intensive care units, fifty patients needed non-invasive mechanical ventilation support, and only three patients were described as receiving invasive mechanical ventilation support. Deaths were described in 38 patients with CF. Importantly, lung-transplanted patients with CF represented an increased risk of death in one publication; in accordance, another study described that lung transplantation and moderate to severe lung disease were independent risk factors for severe outcomes after SARS-CoV-2 infection. In contrast with the literature, in conclusion, Brazilian patients in G3 presented a severe phenotype, even though most of the other studies did not observe worse outcomes in patients with CF and COVID-19. [ABSTRACT FROM AUTHOR]- Published
- 2023
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9. Dynamics of COVID-19 epidemic via two different fractional derivatives.
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Kumar, Pushpendra, Erturk, Vedat Suat, Govindaraj, V., Inc, Mustafa, Abboubakar, Hamadjam, and Nisar, Kottakkaran Sooppy
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COVID-19 pandemic ,COVID-19 ,SARS-CoV-2 ,CORONAVIRUSES ,SCIENTIFIC observation ,DISEASE outbreaks - Abstract
In December 2019, the novel Coronavirus, also known as 2019-nCoV or SARS-CoV-2 or COVID-19, was first recognized as a deadly disease in Wuhan, China. In this paper, we analyze two different nonclassical Coronavirus models to observe the outbreaks of this disease. Caputo and Caputo–Fabrizio (C–F) fractional derivatives are considered to simulate the given epidemic models by using two separate methods. We perform all required graphical simulations with the help of real data to demonstrate the behavior of the proposed systems. We observe that the given schemes are highly effective and suitable to analyze the dynamics of Coronavirus. We find different natures of the given model classes for both Caputo and C-F derivative sense. The main contribution of this study is to propose a novel framework of modeling to show how the fractional-order solutions can describe disease dynamics much more clearly as compared to integer-order operators. The motivation to use two different fractional derivatives, Caputo (singular-type kernel) and Caputo–Fabrizio (exponential decay-type kernel) is to explore the model dynamics under different kernels. The applications of two various kernel properties on the same model make this study more effective for scientific observations. [ABSTRACT FROM AUTHOR]
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- 2023
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10. Impact of COVID-19 Pandemic on Treatment and Outcome of Fragility Hip Fractures In Non-COVID Patients: Comparison Between the Lockdown Period, a Historical Series and the "Pandemic Normality" in a Single Institution.
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Troiano, Elisa, De Sensi, Alice Giulia, Zanasi, Francesco, Facchini, Andrea, De Marco, Giulia, Colasanti, Giovanni Battista, Mondanelli, Nicola, and Giannotti, Stefano
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TRAUMA surgery ,KRUSKAL-Wallis Test ,HOSPITAL emergency services ,SCIENTIFIC observation ,TIME ,HIP fractures ,SURGERY ,PATIENTS ,RETROSPECTIVE studies ,OSTEOPOROSIS ,TREATMENT effectiveness ,COMPARATIVE studies ,HOSPITAL mortality ,CHI-squared test ,DESCRIPTIVE statistics ,STAY-at-home orders ,DATA analysis software ,SOCIAL distancing ,COVID-19 pandemic ,BONE fractures ,COMORBIDITY ,ELDER care ,OLD age - Abstract
Introduction: The COVID-19 pandemic has affected and is still deeply affecting all aspects of public life. World governments have been forced to enact restrictive measures to stem the contagion which have led to a decrease in the movement of people within national territory and to a redirection of health care resources with a suspension of non-urgent procedures. In Italy, a lockdown was imposed from March 9
th to May 3rd , 2020. As a result, a significant reduction in the overall operative volume of orthopedic trauma was expected, but it was not possible to predict a similar trend regarding fragility fractures of the proximal femur in the elderly. Methods: The aim of this paper was to examine the impact of COVID-19 on the operating volume for trauma surgeries and to determine how the pandemic affected the management of fragility hip fractures (FHFs) in non-COVID patients at a single Institution. Results: The first result was a statistically significant reduction in the overall operative volume of orthopedic trauma during the period of the first lockdown and an increase in the mean age of patients undergoing surgery, as expected. As regard to the second aim, the incidence of FHFs remained almost unchanged during the periods analysed. The population examined were superimposable in terms of demographics, comorbidities, type of fracture, peri-operative complications, percentage of operations performed within 48 hours from hospitalization and 1-year outcome. Discussion: Our results are in line with those already present in the Literature. Conclusions: Our study revealed a significant impact of the restrictive anti-contagion measures on the overall orthopedic surgical volume, but, at the same time, we could affirm that the pandemic did not affect the management of FHFs in non-COVID patients, and their results. [ABSTRACT FROM AUTHOR]- Published
- 2023
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11. Jusvinza, an anti-inflammatory drug derived from the human heat-shock protein 60, for critically ill COVID-19 patients. An observational study.
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Venegas-Rodríguez, Rafael, Serrano-Díaz, Anabel, Peña-Ruiz, Ruben, Santana-Sánchez, Raul, Hernández-Cedeño, Mabel, Rittoles Navarro, Aliusha, Grecesqui-Cruz, Inti, Pérez-Aguilera, Liam, Segura-Fernández, Anadys, Rosario-Cruz, Leticia, Martínez-Donato, Gilliam, Guillén-Nieto, Gerardo, and Domínguez- Horta, Maria del Carmen
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COVID-19 , *CRITICALLY ill , *ANTI-inflammatory agents , *MEDICAL records , *SCIENTIFIC observation - Abstract
This paper presents the results of an observational and retrospective study on the therapeutic effects of Jusvinza, an immunomodulatory peptide with anti-inflammatory properties for critically ill COVID-19 patients. This peptide induces regulatory mechanisms on the immune response in experimental systems and in patients with Rheumatoid Arthritis. Exploratory research in COVID-19 patients revealed that Jusvinza promotes clinical and radiological improvement. The aim of this study is to describe the clinical outcome and variations of several inflammatory biomarkers in a cohort of critically ill COVID-19 patients, divided into two groups during the observational research: one group received Jusvinza and the other did not. Research physicians extracted the patients´ data from their hospital's clinical records. The study analyzed 345 medical records, and 249 records from critically ill patients were included. The data covered the demographic characteristics, vital signs, ventilatory parameters and inflammatory biomarkers. Survival outcome was significantly higher in the group receiving Jusvinza (90.4%) compared to the group without Jusvinza (39.5%). Furthermore, in patients treated with Jusvinza there was a significant improvement in ventilatory parameters and a reduction in inflammation and coagulation biomarkers. Our findings show that Jusvinza could control the extent of inflammation in COVID-19 patients. This study indicates that Jusvinza is a helpful drug for the treatment of diseases characterized by hyperinflammation. [ABSTRACT FROM AUTHOR]
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- 2023
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12. Successful aging after elective surgery II: Study design and methods.
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Hshieh, Tammy T., Schmitt, Eva M., Fong, Tamara G., Arnold, Steve, Cavallari, Michele, Dickerson, Bradford C., Dillon, Simon T., Jones, Richard N., Libermann, Towia A., Marcantonio, Edward R., Pascual‐Leone, Alvaro, Shafi, Mouhsin M., Touroutoglou, Alexandra, Travison, Thomas G., Gou, Ray Yun, Tommet, Douglas, Abdeen, Ayesha, Earp, Brandon, Kunze, Lisa, and Lange, Jeffrey
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ELECTIVE surgery , *BIOMARKERS , *COGNITION disorders , *EXPERIMENTAL design , *STATISTICS , *AMYLOID , *PROFESSIONS , *ALZHEIMER'S disease , *COVID-19 , *SCIENTIFIC observation , *ELECTROENCEPHALOGRAPHY , *CONFIDENCE intervals , *PATHOLOGICAL physiology , *INFLAMMATION , *TRANSCRANIAL magnetic stimulation , *SURGICAL complications , *COGNITION , *MAGNETIC resonance imaging , *DEMENTIA patients , *AGING , *DELIRIUM , *DEMENTIA , *HOSPITAL care , *INDEPENDENT living , *POSITRON emission tomography , *DESCRIPTIVE statistics , *QUALITY assurance , *RESEARCH funding , *LONGITUDINAL method , *GOAL (Psychology) , *NEURORADIOLOGY , *DISEASE complications ,RESEARCH evaluation - Abstract
Background: The Successful Aging after Elective Surgery (SAGES) II study was designed to increase knowledge of the pathophysiology and linkages between delirium and dementia. We examine novel biomarkers potentially associated with delirium, including inflammation, Alzheimer's disease (AD) pathology and neurodegeneration, neuroimaging markers, and neurophysiologic markers. The goal of this paper is to describe the study design and methods for the SAGES II study. Methods: The SAGES II study is a 5‐year prospective observational study of 400–420 community dwelling persons, aged 65 years and older, assessed prior to scheduled surgery and followed daily throughout hospitalization to observe for development of delirium and other clinical outcomes. Delirium is measured with the Confusion Assessment Method (CAM), long form, after cognitive testing. Cognitive function is measured with a detailed neuropsychologic test battery, summarized as a weighted composite, the General Cognitive Performance (GCP) score. Other key measures include magnetic resonance imaging (MRI), transcranial magnetic stimulation (TMS)/electroencephalography (EEG), and Amyloid positron emission tomography (PET) imaging. We describe the eligibility criteria, enrollment flow, timing of assessments, and variables collected at baseline and during repeated assessments at 1, 2, 6, 12, and 18 months. Results: This study describes the hospital and surgery‐related variables, delirium, long‐term cognitive decline, clinical outcomes, and novel biomarkers. In inter‐rater reliability assessments, the CAM ratings (weighted kappa = 0.91, 95% confidence interval, CI = 0.74–1.0) in 50 paired assessments and GCP ratings (weighted kappa = 0.99, 95% CI 0.94–1.0) in 25 paired assessments. We describe procedures for data quality assurance and Covid‐19 adaptations. Conclusions: This complex study presents an innovative effort to advance our understanding of the inter‐relationship between delirium and dementia via novel biomarkers, collected in the context of major surgery in older adults. Strengths include the integration of MRI, TMS/EEG, PET modalities, and high‐quality longitudinal data. [ABSTRACT FROM AUTHOR]
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- 2023
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13. The NICU during COVID-19 Pandemic: Impact on Maternal Pediatric Medical Traumatic Stress (PMTS).
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Raho, Laura, Bucci, Silvia, Bevilacqua, Francesca, Grimaldi, Teresa, Dotta, Andrea, Bagolan, Pietro, and Aite, Lucia
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MOTHERS , *NEONATAL intensive care , *ATTITUDES of mothers , *SCIENTIFIC observation , *SOCIAL support , *NEONATAL intensive care units , *PATIENTS , *CASE-control method , *HOSPITAL admission & discharge , *FAMILY-centered care , *DECISION making , *DESCRIPTIVE statistics , *MANAGEMENT , *WOUNDS & injuries , *COVID-19 pandemic , *OUTPATIENT services in hospitals , *PSYCHOLOGICAL stress , *CHILDREN - Abstract
Objective The objective of this paper was to assess how hospital and outpatient clinic policies changes due to the coronavirus disease 2019 (COVID-19) pandemic impact pediatric medical traumatic stress (PMTS) symptoms in mothers of newborns admitted in a neonatal intensive care unit (NICU). Study Design Observational case-control study included the comparison between mothers of infants admitted in the NICU at birth during the COVID-19 pandemic and mothers of infants admitted in the NICU before the COVID-19 pandemic. The control group was selected matching 1:1 with the study group for the following infants' clinical variables: gender, type of pathology, gestational age, weight at birth, day of recovery, ventilator time days, and associated malformations. The Italian version of the Impact of Event Scale—Revised (IES-R) was used as a measure of PMTS. Result Mothers of the study group (50) scored significantly higher than mothers of the control group on three of four scales of IES-R ("IES-R total": F = 6.70; p = 0.011; IES-R subscale "intrusion": F = 7.45; p = 0.008; IES-R subscale "avoidance": F = 8.15; p = 0.005). A significantly higher number of mothers in the study group scored above the IES-R total clinical cut-off compared with mothers of control group (72 vs. 48%; Chi 2 = 6.00; p = 0.012). Conclusion The COVID-19 pandemic acted as superimposed stress in mothers of newborns admitted in the NICU at birth determining high levels of PMTS. Clinicians and researchers should identify and implement novel strategies to provide family-centered care during the COVID-19 pandemic and beyond. Key Points COVID-19 acted as superimposed stress on NICU population. PMTS in mothers got significantly worse during the COVID-19 pandemic. Alert on long-term consequences on child development. [ABSTRACT FROM AUTHOR]
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- 2022
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14. The Impact of the COVID-19 Pandemic on Ophthalmic Outpatient Care in a Tertiary Care Center in Riyadh.
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Alkharashi, Majed S., Alsharif, Heba M., Altahan, Faisal A., Alrashed, Ahmad W., and Abdulghani, Moath
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SCIENTIFIC observation ,TERTIARY care ,QUANTITATIVE research ,RETROSPECTIVE studies ,DESCRIPTIVE statistics ,OPHTHALMOLOGY ,STAY-at-home orders ,COVID-19 pandemic ,OUTPATIENT services in hospitals - Abstract
In this paper, we measured the impact of a full COVID-19 lockdown on ophthalmic patients after a period of lockdown in Saudi Arabia, from March to September 2020. A cross-sectional analytical study was carried out on 180 patients who had their appointments delayed or canceled due to the lockdown. Data was collected from electronic medical records and patients via voice calls using a validated questionnaire that were analyzed using a multivariable binary regression analysis. The results show no statistically significant mean difference in visual acuity when comparing pre- and post-lockdown measurements. The median number of appointment cancellations/delays per patient was two, and the estimated delay for the first canceled appointments was equal to 178.8 days. Of the cohort studied, 15.4% of patients faced delays in necessary surgical and therapeutic interventions; 22.1% of patients sought eye care at other institutions due to the delay, and 15% of those were seen by doctors unspecialized in ophthalmology. The odds of dissatisfaction with care were higher in patients who experienced cancellations in a surgical procedure and patients who experienced difficulty in obtaining medications. In conclusion, the pandemic hampered ophthalmic patients' access to medications. Subjective visual outcomes of patients were also negatively affected; however, the change in objective visual parameters was not statistically significant. [ABSTRACT FROM AUTHOR]
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- 2022
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15. Mortality rates among COVID-19 patients hospitalised during the first three waves of the epidemic in Milan, Italy: A prospective observational study.
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Giacomelli, Andrea, Ridolfo, Anna Lisa, Pezzati, Laura, Oreni, Letizia, Carrozzo, Giorgia, Beltrami, Martina, Poloni, Andrea, Caloni, Beatrice, Lazzarin, Samuel, Colombo, Martina, Pozza, Giacomo, Pagano, Simone, Caronni, Stefania, Fusetti, Chiara, Gerbi, Martina, Petri, Francesco, Borgonovo, Fabio, D'Aloia, Fabiana, Negri, Cristina, and Rizzardini, Giuliano
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COVID-19 , *DEATH rate , *LONGITUDINAL method , *SEX (Biology) , *SCIENTIFIC observation , *HOSPITAL mortality , *COMORBIDITY - Abstract
Introduction: This paper describes how mortality among hospitalised COVID-19 patients changed during the first three waves of the epidemic in Italy. Methods: This prospective cohort study used the Kaplan-Meier method to analyse the time-dependent probability of death of all of the patients admitted to a COVID-19 referral centre in Milan, Italy, during the three consecutive periods of: 21 February-31 July 2020 (first wave, W1), 1 August 2020–31 January 2021 (second wave, W2), and 1 February-30 April 2021 (third wave, W3). Cox models were used to examine the association between death and the period of admission after adjusting for age, biological sex, the time from symptom onset to admission, disease severity upon admission, obesity, and the comorbidity burden. Results: Of the 2,023 COVID-19 patients admitted to our hospital during the study period, 553 (27.3%) were admitted during W1, 838 (41.5%) during W2, and 632 (31.2%) during W3. The crude mortality rate during W1, W2 and W3 was respectively 21.3%, 23.7% and 15.8%. After adjusting for potential confounders, hospitalisation during W2 or W3 was independently associated with a significantly lower risk of death than hospitalisation during W1 (adjusted hazard ratios [AHRs]: 0.75, 95% confidence interval [CI] 0.59–0.95, and 0.58, 95% CI 0.44–0.77). Among the patients aged >75 years, there was no significant difference in the probability of death during the three waves (AHRs during W2 and W3 vs W1: 0.93, 95% CI 0.65–1.33, and 0.88, 95% CI 0.59–1.32), whereas those presenting with critical disease during W2 and W3 were at significantly lower risk of dying than those admitted during W1 (AHRs 0.61, 95% CI 0.43–0.88, and 0.44, 95% CI 0.28–0.70). Conclusions: Hospitalisation during W2 and W3 was associated with a reduced risk of COVID-19 death in comparison with W1, but there was no difference in survival probability in patients aged >75 years. [ABSTRACT FROM AUTHOR]
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- 2022
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16. The frequency of nutrition impact symptoms and reduced oral intake among consecutive COVID-19 patients from an Australian health service.
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De Groot, Lynette and Vivanti, Angela
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PREVENTION of malnutition , *APPETITE , *MATHEMATICAL statistics , *NONPARAMETRIC statistics , *STATISTICS , *LENGTH of stay in hospitals , *COVID-19 , *BODY weight , *RESPIRATORY insufficiency , *SCIENTIFIC observation , *PARAMETERS (Statistics) , *NUTRITION disorders , *DIETITIANS , *INGESTION , *MEDICAL screening , *RETROSPECTIVE studies , *COMMUNITY health services , *MANN Whitney U Test , *FISHER exact test , *RISK assessment , *DIET therapy , *CONTINUUM of care , *T-test (Statistics) , *PEARSON correlation (Statistics) , *MALNUTRITION , *DISEASE prevalence , *PSYCHOSOCIAL factors , *DESCRIPTIVE statistics , *MEDICAL referrals , *ELECTRONIC health records , *BODY mass index , *DATA analysis software , *DATA analysis , *NUTRITIONAL status , *DIETETICS , *DISEASE risk factors - Abstract
COVID-19 symptoms range from severe respiratory failure to mild anorexia, cough and smell and taste alterations, adversely impacting nutritional intake. The aim of this paper was to establish malnutrition risk, Nutrition Impact Symptoms (NIS) and associations with reduced oral intake. A retrospective observational cohort of all people testing positive for COVID-19 was conducted. Malnutrition risk, nutritional status, weight, reduced oral intake and NIS on and during admission were collected. Dietetic consultation frequency and mode were captured. Some 80% (48/60) of participants reported at least one NIS, and 58% (25/60) reported two or more. Most frequent reported symptoms were cough (60%), sore throat (35%) and reduced appetite (28%). Significant associations existed between ≥2 NIS (p=0.006), reduced appetite (p=0.000) and reduced oral intake, with 20% requiring ongoing nutrition support and consultation. High NIS prevalence confirms systematised nutrition support pathways are indicated through incorporation into standard care across the healthcare continuum, including community care. [ABSTRACT FROM AUTHOR]
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- 2022
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17. Measures to prevent nosocomial transmissions of COVID-19 based on interpersonal contact data.
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Cheng, Tao, Liu, Jiaxing, Liu, Yunzhe, Zhang, Xianghui, and Gao, Xiaowei
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CROSS infection prevention , *COVID-19 , *HOSPITAL medical staff , *SCIENTIFIC observation , *RISK assessment , *INTERPERSONAL relations , *CONTACT tracing , *WORKING hours , *SOCIAL distancing - Abstract
Background: With the global spreading of Coronavirus disease (COVID-19), many primary care medical workers have been infected, particularly in the early stages of this pandemic. Although extensive studies have explored the COVID-19 transmission patterns and (non-) pharmaceutical intervention to protect the general public, limited research has analysed the measures to prevent nosocomial transmission based upon detailed interpersonal contacts between medical staff and patients. Aim: This paper aims to develop and evaluate proactive prevention measures to contain the nosocomial transmission of COVID-19. The specific objectives are (1) to understand the virus transmission via interpersonal contacts among medical staff and patients; (2) to define proactive measures to reduce the risk of infection of medical staff and (3) evaluate the effectiveness of these measures to control the COVID-19 epidemic in hospitals. Methods: We observed the operation of a typical primary hospital in China to understand the interpersonal contacts among medical staff and patients. We defined effective distance as the indicator for risk of transmission. Then three proactive measures were proposed based upon the observations, including a medical staff rotation system, the establishment of a separate fever clinic and medical staff working alone. Finally, the impacts of these measures are evaluated with a modified Susceptible-Exposure-Infected-Removed model accommodating the situation of hospitals and asymptomatic and latent infection of COVID-19. The case study was conducted with the hospital observed in December 2019 and February 2020. Findings: The implementation of the medical staff rotation system has the most significant impact on containing the epidemic. The establishment of a separate fever clinic and medical staff working alone also benefits from inhibiting the epidemic outbreak. The simulation finds that if effective prevention and control measures are not taken in time, it will lead to a surge of infection cases in all asymptomatic probabilities and incubation periods. [ABSTRACT FROM AUTHOR]
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- 2022
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18. Knowledge and Attitudes Toward Covid-19 and Vaccines Among a New York Haredi-Orthodox Jewish Community.
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Carmody, Ellie R., Zander, Devon, Klein, Elizabeth J., Mulligan, Mark J., and Caplan, Arthur L.
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SCIENTIFIC observation , *CONFIDENCE intervals , *ATTITUDE (Psychology) , *COVID-19 vaccines , *CROSS-sectional method , *INTELLECT , *INDEPENDENT living , *DESCRIPTIVE statistics , *SCALE analysis (Psychology) , *CHI-squared test , *RESEARCH funding , *DATA analysis software , *ODDS ratio , *ORTHODOX Jews - Abstract
The Covid-19 pandemic has exposed the difficulty of the US public health system to respond effectively to vulnerable subpopulations, causing disproportionate rates of morbidity and mortality. New York Haredi-Orthodox Jewish communities represent a group that have been heavily impacted by Covid-19. Little research has examined their experience or perceptions toward Covid-19 and vaccines. We conducted a cross-sectional, observational study to explore the experience of Covid-19 among Haredim. Paper surveys were self-administered between December 2020 and January 2021 in Haredi neighborhood pediatricians' offices in Brooklyn, New York. Of 102 respondents, 43% reported either a positive SARS-CoV-2 viral or antibody test. Participants trusted their physicians, Orthodox medical organizations, and rabbinic leaders for medical information. Knowledge of Covid-19 transmission and risk was good (69% answered ≥ 4/6 questions correctly). Only 12% of respondents would accept a Covid-19 vaccine, 41% were undecided and 47% were strongly hesitant. Independent predictors of strong vaccine hesitancy included believing natural infection to be better than vaccination for developing immunity (adjusted odds ratio [aOR] 4.28; 95% confidence interval [CI] 1.23–14.86), agreement that prior infection provides a path toward resuming communal life (aOR 4.10; 95% CI 1.22–13.77), and pandemic-related loss of trust in physicians (aOR 5.01; 95% CI 1.05–23.96). The primary disseminators of health information for self-protective religious communities should be stakeholders who understand these groups' unique health needs. In communities with significant Covid-19 experience, vaccination messaging may need to be tailored toward protecting infection-naïve individuals and boosting natural immunity against emerging variants. [ABSTRACT FROM AUTHOR]
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- 2021
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19. Dementia care from behind the mask? Maintaining well‐being during COVID‐19 pandemic restrictions: Observations from Dementia Care Mapping on NHS mental health hospital wards in Wales.
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Page, Sean, Davies‐Abbott, Ian, and Jones, Adrian
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TREATMENT of dementia , *WELL-being , *PSYCHIATRIC nursing , *VISITING the sick , *COVID-19 , *SCIENTIFIC observation , *SOCIAL support , *PREVENTION of communicable diseases , *PATIENTS' attitudes , *DEMENTIA patients , *NATIONAL health services , *NURSE-patient relationships , *CRITICAL care medicine , *SOCIAL distancing , *PERSONAL protective equipment , *DATA analysis software , *HAND washing , *PSYCHIATRIC treatment , *OLD age - Abstract
Accessible summary: What is known on the subject?: Coronavirus disease 2019 (COVID‐19) is a new infectious disease that has spread across the world and infected a large number of people many of whom have died.People with moderate to severe dementia are at very high risk of becoming infected as the disease mainly impacts on older people with other health problems and once infected the person with dementia is more likely to become seriously ill than other people.To prevent infection, people are required to wear masks and isolate from contact with others. It is believed that these measures can reduce the quality of life and general well‐being of people with moderate to severe dementia in hospital or social care. This belief has not yet been demonstrated by research. What does this paper add to the existing knowledge?: We show that people with moderate to severe dementia receiving care on mental health hospital wards and subject to strict infection prevention measures can still achieve high levels of well‐being.We show that mental health nurses alter the focus of their care to deliberately overcome the challenges and particularly the restrictions on visiting by families. What are the implications for practice?: We believe that the changes in practice we observed can occur in other healthcare and social care settings and that whilst restrictions remain in place care staff can protect and possibly enhance well‐being for people with moderate to severe dementia. Introduction: The effect of coronavirus (COVID‐19) on people living with dementia is potentially severe in its clinical impacts. More widely, for this vulnerable group, the social restrictions to limit the spread of infection may be emotionally and psychologically damaging. Aim: To explore the impact of restrictions on well‐being for people with moderate to severe dementia in acute mental health hospital care. Method: "Dementia Care Mapping" was the observational tool used to determine well‐ or ill‐being. Observations were undertaken in two mental health hospital wards during a time of restrictions and the use of personal protective equipment. Results: We report levels of well‐being that are higher than might be expected alongside a change in the focus of psychological care delivered through mental health nursing interventions aimed at enhancing well‐being. Discussion—We postulate that mental health nurses faced with an unprecedented challenge respond by changing practice to mitigate for infection prevention measures and to compensate for family absence. Implications for practice: We suggest that the desirable enhancing actions by nursing staff which raise well‐being in these hospital settings are readily transferable to other settings that are aiming to maintain well‐being but also practising under COVID‐19 restrictions. [ABSTRACT FROM AUTHOR]
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- 2021
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20. Beliefs and practices among primary care physicians during the first wave of the COVID-19 pandemic in Baden-Wuerttemberg (Germany): an observational study.
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Roth, Catharina, Breckner, Amanda, Moellinger, Sophia, Schwill, Simon, Peters-Klimm, Frank, Szecsenyi, Joachim, Stengel, Sandra, and Wensing, Michel
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GENERAL practitioners , *SCIENTIFIC observation , *PROFESSIONS , *CONFIDENCE , *FAMILY medicine , *CROSS-sectional method , *FEAR , *SELF-efficacy , *PRIMARY health care , *PSYCHOSOCIAL factors , *HEALTH attitudes , *QUESTIONNAIRES , *DESCRIPTIVE statistics , *COVID-19 pandemic - Abstract
Background: During the first wave of the COVID-19 pandemic various ambulatory health care models (SARS-CoV-2 contact points: Subspecialised Primary Care Practices, Fever Clinics, and Special Places for Corona-Testing) were organised in a short period in Baden-Wuerttemberg, a region in Southern Germany. The aim of these SARS-CoV-2 contact points was to ensure medical treatment for patients with (suspected) and without SARS-CoV-2 infection. The present study aimed to assess the beliefs and practices of primary care physicians who either led a Subspecialised Primary Care Practice or a Primary Care Practice providing care as usual in Baden-Wuerttemberg during the first wave of the COVID-19 pandemic. Methods: This cross-sectional study was based on a paper-based questionnaire in primary care physicians during the first wave of the pandemic. Participants were identified via the web page of the Association of Statutory Health Insurance Physicians Baden-Wuerttemberg. The questionnaire was distributed in June and July 2020. It measured knowledge, practices, self-efficacy and fears towards SARS-CoV-2, using newly developed questions. Data was descriptively analysed. Results: One hundred fifty-five participants (92 leads of SARS-CoV-2 contact points/ 63 leads of primary care practices) completed the questionnaire. Out of 92 leads of SARS-CoV-2 contact points 74 stated to lead n Subspecialised Primary Care Practices. About half participants of both groups did not fear an own infection with the novel virus (between 50.8% and 62.2%), however about 75% feared financial loss. Knowledge was gained using various sources; main sources were the Association of Statutory Health Insurance Physicians (between 82.5% and 83.8%) and the German Society for Hygiene and Microbiology (RKI) (between 88.9% and 95.9%). Leads of Subspecialised Primary Care Practice felt more confident to perform anamnestic/diagnostic procedures (p < 0.001). The same was found for the confidence level regarding decision-making concerning the further treatment (p < 0.001). Several prevention measures to contain the spread of SARS-CoV-2 were adopted. Subspecialised Primary Care Practice had treated on average more patients with (suspected) COVID-19 (mean 408.12) than primary care practices (mean 83.8) (p < 0.001). Conclusion: The results of this study suggest that the Subspecialised Primary Care Practice that were implemented during the first wave of the SARS-CoV-2 pandemic contributed containment of the pandemic. Leads of Subspecialised Primary Care Practice indicated that physical separation of patients with potential SARS-CoV-2 infection was easier compared to those who continued working in their own practice. Additionally, leads of Subspecialised Primary Care Practice felt more confident in dealing with patients with SARS-CoV-2 infection. Trial registration: The study has been prospectively registered at the German Clinical Trial Register (DRKS00022224). [ABSTRACT FROM AUTHOR]
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- 2021
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21. Depressive symptoms and perception of risk during the first wave of the COVID‐19 pandemic: A web‐based cross‐country comparative survey.
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Terraneo, Marco, Lombi, Linda, and Bradby, Hannah
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MENTAL depression risk factors , *SCIENTIFIC observation , *ATTITUDE (Psychology) , *CROSS-sectional method , *MEDICAL care costs , *MENTAL health , *RISK perception , *RISK assessment , *COMPARATIVE studies , *MEDICAL care use , *MENTAL depression , *QUESTIONNAIRES , *STATISTICAL sampling , *COVID-19 pandemic - Abstract
Evidence is accumulating of the negative impact of the COVID‐19 pandemic and related public health measures on mental health. In this emergent field, there has been little research into the role of risk perception on depressive symptoms and the contribution of health‐care resources to model risk perception and mental health. The aim of this paper is to describe the relationship between individual‐level perception of risk and depression, controlling for a set of confounders and for country‐level heterogeneity. A cross‐sectional and observational online survey was conducted using a non‐probability snowball sampling technique. We use data on 11,340 respondents, living in six European countries (Italy, Sweden, United Kingdom, France, Poland, Czech Republic) who completed survey questionnaires during the first months of the pandemic. We used a fixed‐effect approach, which included individual and macro‐level variables. The findings suggest that a high proportion of people suffering from depression and heightened risk perception is positively associated with reporting depressive symptoms, even if this relationship varies significantly between countries. Moreover, the association is moderated by contextual factors including health‐care expenditure as a percentage of Gross Domestic Product, hospital beds for acute care, and number of medical specialists per head of population. Investment in health care offers a concrete means of protecting the mental health of a population living under pandemic restrictions. [ABSTRACT FROM AUTHOR]
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- 2021
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22. Real-world effectiveness of BNT162b2 mRNA vaccine: a meta-analysis of large observational studies.
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Kow, Chia Siang and Hasan, Syed Shahzad
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VACCINE safety , *COVID-19 vaccines , *RANDOM effects model , *VACCINE effectiveness , *COVID-19 , *SCIENTIFIC observation - Abstract
This paper aims to summarize through meta-analyses the overall vaccine effectiveness of the BNT162b2 mRNA vaccine from observational studies. A systematic literature search with no language restriction was performed in electronic databases to identify eligible observational studies which reported the adjusted effectiveness of the BNT162b2 mRNA vaccine to prevent RT-PCR confirmed COVID-19. Meta-analyses with the random-effects model were used to calculate the pooled hazard ratio (HR) and pooled incidence rate ratio (IRR) at 95% confidence intervals, and the vaccine effectiveness was indicated as (pooled HR − 1)/HR or (pooled IRR − 1)/IRR. Nineteen studies were included for this meta-analysis. The meta-analysis revealed significant protective effect against RT-PCR confirmed COVID-19 ≥ 14 days after the first dose, with vaccine effectiveness of 53% (95% confidence interval 32–68%), and ≥ 7 days after the second dose, with vaccine effectiveness of 95% (95% confidence interval: 96–97%). Despite its effectiveness, reporting vaccine safety data by relevant stakeholders should be encouraged as BNT162b2 mRNA is a new vaccine that has not gained full approval. There have been limited data about vaccine effectiveness among immunocompromised patients; thus, the vaccine should be used cautiously in this patient population. [ABSTRACT FROM AUTHOR]
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- 2021
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23. COVID-19 related immunization disruptions in Rajasthan, India: A retrospective observational study.
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Jain, Radhika, Chopra, Ambika, Falézan, Camille, Patel, Mustufa, and Dupas, Pascaline
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COVID-19 , *IMMUNIZATION , *ABANDONED children , *IMMUNIZATION of children , *SCIENTIFIC observation , *MOTOR homes - Abstract
• Disruptions during the COVID-19 lockdown caused children to miss immunizations. • Government catch-up efforts substantially reversed these effects. • Yet, children that were due vaccinations during the lockdown remained 10–15% less likely to be immunized 4–5 months later. • Catch-up was more likely to be incomplete among children of low socioeconomic status. • Ensuring all children are fully immunized requires careful tracking and disaggregated data. Governments around the world suspended immunization outreach to control COVID-19 spread. Many have since resumed services with an emphasis on catch-up vaccinations. This paper evaluated immunization disruptions during India's March-May 2020 lockdown and the extent to which subsequent catch-up efforts reversed them in Rajasthan, India. In this retrospective observational study, we conducted phone surveys to collect immunization details for 2,144 children that turned one year old between January and October 2020. We used logistic regressions to compare differences in immunization timeliness and completed first-year immunization status among children that were due immunizations just before (unexposed), during (heavily exposed), and after (post-exposure) the lockdown. Relative to unexposed children, heavily exposed children were significantly less likely to be immunized at or before 9 months (OR 0.550; 95% CI 0.367–0.824; p = 0.004), but more likely to be immunized at 10–12 months (OR 1.761; 95% CI 1.196–2.591; p = 0.004). They were also less likely to have completed their key first-year immunizations (OR 0.624; 95% CI 0.478–0.816; p = 0.001) by the time of survey. In contrast, post-exposure children showed no difference in timeliness or completed first-year immunizations relative to unexposed children, despite their younger age. First-year immunization coverage among heavily exposed children decreased by 6.9 pp to 10.4 pp (9.7% to 14.0%). Declines in immunization coverage were larger among children in households that were poorer, less educated, lower caste, and residing in COVID red zones, although subgroup comparisons were not statistically significant. Disruptions to immunization services resulted in children missing immunization during the lockdown, but catch-up efforts after it was eased ensured many children were reached at later ages. Nevertheless, catch-up was incomplete and children due their immunizations during the lockdown remained less likely to be fully immunized 4–5 months after it lifted, even as younger cohorts due immunizations in June or later returned to pre-lockdown schedules. [ABSTRACT FROM AUTHOR]
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- 2021
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24. Update on geographical variation and distribution of SARS-nCoV-2: A systematic review.
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Prajapat, Manisha, Handa, Vrishbhanu, Sarma, Phulen, Prakash, Ajay, Kaur, Hardeep, Sharma, Saurabh, Bhattacharyya, Anusuya, Kumar, Subodh, Sharma, Amit, Avti, Pramod, and Medhi, Bikash
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SARS-CoV-2 , *COVID-19 , *VACCINE development , *DRUG development , *SCIENTIFIC observation - Abstract
Knowledge of a new mutant strain of SARS-coronavirus (CoV-2) is enormously essential to identify a targeted drug and for the development of the vaccine. In this article, we systematically reviewed the different mutation strains (variant of concern [VOC] and variant of interest [VOI]) which were found in different countries such as the UK, Singapore, China, Germany, Vietnam, Western Africa, Dublin, Ireland, Brazil, Iran, Italy, France, America, and Philippines. We searched four literature databases (PubMed, EMBASE, NATURE, and Willey online library) with suitable keywords and the time filter was November 2019 to June 16, 2021. To understand the worldwide spread of variants of SARS-CoV-2, we included a total of 27 articles of case reports, clinical and observational studies in the systematic review. However, these variants mostly spread because of their ability to increase transmission, virulence, and escape immunity. So, in this paper is we found mutated strains of SARS-CoV-2 like VOCs that are found in different regions across the globe are ALPHA strain in the U.K, BETA strain in South Africa, GAMMA strain in Brazil, Gamma and Beta strains in European Countries, and some VOIs like Theta variant in the Philippines. [ABSTRACT FROM AUTHOR]
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- 2021
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