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BACKGROUND: Sand therapy is a non-pharmacological physiotherapy method that uses the natural environment and resources of Xinjiang to treat through the heat transfer and magnetic effects of sand. OBJECTIVE: Employing the two-phase flow-Casson blood flow model, we investigate the mechanism of atherosclerosis prevention via sand therapy, offering a biomechanical theoretical rationale for the prevention of atherosclerosis through sand therapy via the prism of computational fluid dynamics (CFD). METHODS: Sand therapy experiments were conducted to obtain popliteal artery blood flow velocity, and blood was considered as a two-phase flow composed of plasma and red blood cells, and CFD method was applied to analyze the hemodynamic effects of Casson's blood viscosity model before and after sand therapy. RESULTS: (1) The blood flow velocity increased by 0.24 m/s and 0.04 m/s at peak systolic and diastolic phases, respectively, after sand therapy; the axial velocity of blood vessels increased by 28.56% after sand therapy. (2) The average red blood cell viscosity decreased by 0.00014 Pa ⋅ s after sand therapy. (3) The low wall shear stress increased by 1.09 Pa and the high wall shear stress reached 41.47 Pa after sand therapy. (4) The time-averaged wall shear stress, shear oscillation index and relative retention time were reduced after sand therapy. CONCLUSION: The increase of blood flow velocity after sand therapy can reduce the excessive deposition of cholesterol and other substances, the decrease of erythrocyte viscosity is beneficial to the migration of erythrocytes to the vascular center, the increase of low wall shear stress has a positive effect on the prevention of atherosclerosis, and the decrease of time-averaged wall shear stress, shear oscillation index and relative retention time can reduce the occurrence of thrombosis. [ABSTRACT FROM AUTHOR]

The mechanics of bile flow in the biliary system plays an important role in studying bile stasis and gallstone formation. Bile duct stricture is an abnormal phenomenon that refers to the bile duct getting smaller or narrower. The main objective of this study is to study the influence of stricture on bile flow dynamics using numerical methods. We employed a numerical Computational Fluid Dynamics model of the bile flow within a strictured hepatic duct. We studied and compared the influence of stricture severity, stricture length, eccentricity, and bile flow property on the bile flow dynamics. The bile flow velocity, pressure distribution, pressure drop, and wall shear stress are provided in detail. The stricture alters the normal bile flow pattern and increases flow resistance. At the location upstream and downstream of the stricture, bile flow slows down. In the area of the stricture throat, bile flow is accelerated, and recirculation forms behind the stricture. The maximum pressure drop of the biliary system increases with the stricture length. The eccentricity makes the flow deflect away from the duct's centerline. The behavior of the deflected flow is significantly altered downstream of the stricture. Such bile flow behavior as deceleration and recirculation may lead to cholestasis. Stricture alters bile flow in the biliary tract, causing changes in biliary hydrodynamic indexes, which could potentially serve as an omen for gallstone formation and other related diseases. The consideration of the bile duct stricture could lead to better patient stratification. [ABSTRACT FROM AUTHOR]

Background: Abdominal aortic aneurysms (AAAs) present a formidable public health concern due to their propensity for localized, anomalous expansion of the abdominal aorta. These insidious dilations, often in their early stages, mask the life-threatening potential for rupture, which carries a grave prognosis. Understanding the hemodynamic intricacies governing AAAs is paramount for predicting aneurysmal growth and the imminent risk of rupture. Objective: Our extensive investigation delves into this complex hemodynamic environment intrinsic to AAAs, utilizing comprehensive numerical analyses of the physiological pulsatile blood flow and realistic boundary conditions to explore the multifaceted dynamics influencing aneurysm rupture risk. Our study introduces novel elements by integrating these parameters into the overall context of aneurysm pathophysiology, thus advancing our understanding of the intricate mechanics governing their evolution and rupture. Methods: Conservation of mass and momentum equations are used to model the blood flow in an AAAs, and these equations are solved using a finite volume-based ANSYS Fluent solver. Resistance pressure outlets following a three-element Windkessel model were imposed at each outlet to accurately model the blood flow and the AAAs' shear stress. Results: Our results uncover elevated blood flow velocities within an aneurysm, suggesting an augmented risk of future rupture due to increased stress in the aneurysm wall. During the systole phase, high wall shear stress (WSS) was observed, typically associated with a lower risk of rupture, while a low oscillatory shear index (OSI) was noted, correlating with a decreased risk of aneurysm expansion. Conversely, during the diastole phase, low WSS and a high OSI were identified, potentially weakening the aneurysm wall, thereby promoting expansion and rupture. Conclusion: Our study underscores the indispensable role of computational fluid dynamic (CFD) techniques in the diagnostic, therapeutic, and monitoring realms of AAAs. This body of research significantly advances our understanding of aneurysm pathophysiology, thus offering pivotal insights into the intricate mechanics underpinning their progression and rupture, informing clinical interventions and enhancing patient care. [ABSTRACT FROM AUTHOR]

Non-Newtonian fluid flow in pipe bends is inevitable in industrial applications. Previous researchers have extensively explored Newtonian flow through curved ducts. However, the non-Newtonian counterpart gets little attention. We study the turbulent flow of shear-dependent fluids obeying the Power-Law model in a pipe manifold containing an in-plane double bend. Ostwald-de Waele's power law is used to model the fluid's rheology. We utilize computational fluid dynamics (CFD) to solve Reynolds-averaged Navier-Stokes (RANS) equations with the k-ε turbulence model. We validate our numerical results with previous experimental results. The in-plane double bend perturbs the flow in the pipe manifold to develop a Prandtl's secondary flow of the first kind. A fully developed flow at the bend upstream is disturbed due to the bend's curvature and regains its fully developed characteristics upon a certain downstream length after the exit of the bend. We study the rheological characteristics of the secondary flow within the bend and the evolution of fluid flow at the bend downstream. We demonstrate that the centrifugal force-dominated secondary flow increases with a decrease of the non-Newtonian power-law index. We capture the camel'sback-shaped velocity profiles within the bend due to accelerating-decelerating flow. The study reveals that the average flow velocity increases along the bend with a corresponding pressure head loss. We quantify this velocity rise by a newly introduced non-dimensional number, viz. enhancement ratio. The double bend's enhancement ratio decreases with an increase in n. [ABSTRACT FROM AUTHOR]

The fracture network in fractured reservoirs is the main channel for fracturing fluid intrusion and gas flow, and the presence of liquid has a great influence on the gas flow pattern, and the gas flow shows more diversity in fluids with different properties such as fracturing fluid or formation water. In order to study the characteristics of gas-liquid two-phase flow in the microfracture network of the fractured gas reservoir, the topology of the microfracture network is simplified to T-junction and Y-junction. Based on the volume of fluid model, the gas-liquid two-phase flow interface is tracked. The model is solved by computational fluid dynamics software OpenFOAM, and the correctness of the model is verified by comparing it with laboratory microscopic experiment results. The flow characteristics of the gas phase in different fluids at the microscale and the influence of fluid parameters on flow pattern are analyzed. The results show that the properties of the liquid phase have a strong influence on the gas flow pattern, and the two-phase flow velocity and the properties of fluid parameters affect the gas flow to reach the stable state. The findings of this study can be used for reference to analyze the flow characteristics of gas in fracturing fluid and the flowback technology of fracturing gas well. • Numerical simulation for visualizing gas-liquid two-phase flow in micro-fracture using OpenFOAM. • Large and non-uniform bubbles in Newtonian fluids, small and uniform bubbles in non-Newtonian fluids. • Smaller the angle of gas-liquid velocity, the easier the two-phase flow to reach a stable state. • Increasing the wetting angle has little effect on the gas flow morphology at high velocity ratios. • Reduce the interfacial tension, the bubble deformation index becomes smaller, and the bubble edge presents an irregular shape. [ABSTRACT FROM AUTHOR]