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• The South Orogen underwent early post-collision during 1.90–1.85 Ga, followed by late post-collision during 1.80–1.73 Ga. • The North Orogen experienced early post-collision at 1.80–1.73 Ga and then entered the late post-collision at 1.67–1.60 Ga. • Finally, the South Orogen and North Orogen simultaneously entered the initial breakup stage during 1.55–1.47 Ga. The Tarim Craton located in the northwest of China, where the Paleo-Mesoproterozoic extensional magmatism related to the Columbia supercontinent is widely developed. However, the process and time of the extension and initial breakup of the Tarim Craton are still controversial during Paleo-Mesoproterozoic era. In this contribution, we present a systematic petrographic, geochemical, and zircon U-Pb-Hf investigation on Aketashitage granite dykes, Wulan granitic gneisses and Astingbulake metadiabases from the Tarim Craton. Results from our study indicate that the ca. 1.88–1.86 Ga Aketashitage granite dykes belong to I-type granites, which were probably derived from low degree partial melting of thickened Archean crust during early post-collisional setting. The ca. 1.55 Ga Wulan granitic gneisses also show the characteristics of I-type granites, which mainly came from partial melting of mafic lower crust with minor mantle-derived magma input during the rift setting. The ca. 1.55 Ga protoliths of Astingbulake metadiabases show affinity to ocean island basalts and/or continental flood basalts and were produced by partial melting of enriched continental lithospheric mantle under continental rifting setting. In conjunction with previous studies, it can be concluded that the Tarim Craton experienced episodic extension to initial breakup: the South Orogen underwent early post-collisional extension during ca. 1.90–1.85 Ga, followed by late post-collisional extension during ca. 1.80–1.73 Ga; the North Orogen experienced early post-collisional extension at ca. 1.80–1.73 Ga and then entered the late post-collisional extension at ca. 1.67–1.60 Ga; finally, the South Orogen and North Orogen simultaneously entered the initial breakup stage during ca. 1.55–1.47 Ga. Based on a comparison of the global Mesoproterozoic (ca. 1.58–1.45 Ga) magmatic activities as a response to the initial break up of the Columbia supercontinent, we suggest that the Tarim Craton (including the Oulongbuluke Block) and North China Craton were close to India, Australia, Yangtze, Siberia, Congo, São Francisco and West African. [ABSTRACT FROM AUTHOR]