201. Exploring the Surge in Paediatric Type 2 Diabetes in an Inner-City London Centre—A Decade-Long Analysis of Incidence, Outcomes, and Transition.
- Author
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Abdelhameed, Farah, Giuffrida, Anna, Thorp, Ben, Moorthy, Myuri K., and Gevers, Evelien F.
- Subjects
GLYCOSYLATED hemoglobin ,HYPERTENSION ,AUTOANTIBODIES ,ALBUMINS ,CARDIOVASCULAR diseases risk factors ,TRANSITION to adulthood ,CHILDHOOD obesity ,FATTY liver ,TRANSITIONAL care ,DISEASE incidence ,RETROSPECTIVE studies ,ACQUISITION of data ,CARDIOVASCULAR diseases ,MANN Whitney U Test ,BLOOD sugar ,PRADER-Willi syndrome ,TYPE 2 diabetes ,NATIONAL health services ,METABOLIC disorders ,TREATMENT failure ,HYPERLIPIDEMIA ,T-test (Statistics) ,INSULIN ,TREATMENT effectiveness ,SEVERITY of illness index ,DISEASE prevalence ,MEDICAL records ,DESCRIPTIVE statistics ,CHI-squared test ,SLEEP apnea syndromes ,AGE factors in disease ,RESEARCH funding ,METROPOLITAN areas ,BODY mass index ,DATA analysis software ,COMORBIDITY ,INTELLECTUAL disabilities ,LONGITUDINAL method ,DISEASE complications ,CHILDREN ,ADOLESCENCE - Abstract
The rising prevalence of paediatric type 2 diabetes (T2D) is concerning, particularly with limited medical intervention despite evidence of accelerated disease progression. This study of a Barts Health NHS Trust cohort from 2008 to 2022 aims to elucidate the incidence, clinical outcomes, and complications associated with paediatric T2D. A retrospective analysis utilising electronic and paper records identified 40 patients with T2D. The incidence doubled from 2.6/year in 2008–2013 to 5.4/year in 2014–2018. Sixty-eight percent exhibited co-morbidities, notably learning disabilities. At diagnosis, the mean BMI was 32.4 ± 6.71 kg/m
2 , with no gender-based disparity and no significant change over a two-year follow-up. The initial HbA1c was 75.2 ± 21.0 mmol/mol, decreasing to 55.0 ± 17.4 mmol/mol after three months (p = 0.001) and then rising to 63.0 ± 25.5 mmol/mol at one year (p = 0.07). While 22/37 patients achieved HbA1c < 48 mmol/mol, only 9 maintained this for a year. Several metabolic and cardiovascular complications were observed at diagnosis and follow-up, with no significant change in frequency. In 2022, 15 patients transitioned to adult services. HbA1c at transition was 74.7 ± 27.6 mmol/mol, showing no change one year post-transition (71.9 ± 26.9 mmol/mol, p = 0.34). This study highlights substantial therapeutic failure, with current management falling short in achieving a sustained reduction in BMI or HbA1c. Novel treatment approaches are needed to improve clinical outcomes and address the high burden of co-morbidities and complications. [ABSTRACT FROM AUTHOR]- Published
- 2024
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