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Purpose. As a scientific field, bioinformatics has drawn remarkable attention from various fields, such as information technology, mathematics, and modern biological sciences, in recent years. The topic models originating from the field of natural language processing have become the focus of attention with the rapid accumulation of biological datasets. Thus, this research is aimed at modeling the topic content of the bioinformatics literature presented by Iranian researchers in the Scopus Citation Database. Methodology. This research was a descriptive-exploratory study, and the studied population included 3899 papers indexed in the Scopus database, which had been indexed in this database until March 9, 2022. The topic modeling was then performed on the abstracts and titles of the papers. A combination of LDA and TF-IDF was utilized for topic modeling. Findings. The data analysis with topic modeling resulted in identifying seven main topics "Molecular Modeling," "Gene Expression," "Biomarker," "Coronavirus," "Immunoinformatics," "Cancer Bioinformatics," and "Systems Biology." Moreover, "Systems Biology" and "Coronavirus" had the largest and smallest clusters, respectively. Conclusion. The present investigation demonstrated an acceptable performance for the LDA algorithm in classifying the topics included in this field. The extracted topic clusters indicated excellent consistency and topic connection with each other. [ABSTRACT FROM AUTHOR]

The quality of scientific publications can be measured by quantitative indices such as the h‐index, Source Normalized Impact per Paper, or g‐index. However, these measures lack to explain the function or reasons for citations and the context of citations from citing publication to cited publication. We argue that citation context may be considered while calculating the impact of research work. However, mining citation context from unstructured full‐text publications is a challenging task. In this paper, we compiled a data set comprising 9,518 citations context. We developed a deep learning‐based architecture for citation context classification. Unlike feature‐based state‐of‐the‐art models, our proposed focal‐loss and class‐weight‐aware BiLSTM model with pretrained GloVe embedding vectors use citation context as input to outperform them in multiclass citation context classification tasks. Our model improves on the baseline state‐of‐the‐art by achieving an F1 score of 0.80 with an accuracy of 0.81 for citation context classification. Moreover, we delve into the effects of using different word embeddings on the performance of the classification model and draw a comparison between fastText, GloVe, and spaCy pretrained word embeddings. [ABSTRACT FROM AUTHOR]

This paper reflects on the paradigmatic assumptions and ideologies that have shaped algorithmic management research. We identify two sets of assumptions: one about the "ontology of algorithms" (which holds that human resource management [HRM] algorithms are non‐human entities with material agency) and one about the "ontology of management" that HRM algorithms afford (which understands algorithmic management as a form of control for maximizing economic/shareholder value). We explain how these core assumptions underpin existing research of HRM algorithms, causing blind spots that hinder new ways of understanding and studying algorithmic management. After identifying and unpacking the assumptions and blind spots, we offer avenues to overcome these blind spots, allowing for future research based on new ideological assumption grounds that will help move algorithmic management scholarship further in significant ways. [ABSTRACT FROM AUTHOR]

We used quantitative text analysis to examine conversations in a series of online support groups attended by care partners of people living with rare dementias (PLWRD). We used transcripts of 14 sessions (>100,000 words) to explore patterns of communication in trained facilitators' (n = 2) and participants' (n = 11) speech and to investigate the impact of session agenda on language use. We investigated the features of their communication via Poisson regression and a clustering algorithm. We also compared their speech with a natural speech corpus. We found that differences to natural speech emerged, notably in emotional tone (d = −3.2, p < 0.001) and cognitive processes (d = 2.8, p < 0.001). We observed further differences between facilitators and participants and between sessions based on agenda. The clustering algorithm categorised participants' contributions into three groups: sharing experience, self-reflection, and group processes. We discuss the findings in the context of Social Comparison Theory. We argue that dedicated online spaces have a positive impact on care partners in combatting isolation and stress via affiliation with peers. We then discuss the linguistic mechanisms by which social support was experienced in the group. The present paper has implications for any services seeking insight into how peer support is designed, delivered, and experienced by participants. [ABSTRACT FROM AUTHOR]

Combining computational technologies and humanities is an ongoing effort aimed at making resources such as texts, images, audio, video, and other artifacts digitally available, searchable, and analyzable. In recent years, deep neural networks (DNN) dominate the field of automatic text analysis and natural language processing (NLP), in some cases presenting a super‐human performance. DNNs are the state‐of‐the‐art machine learning algorithms solving many NLP tasks that are relevant for Digital Humanities (DH) research, such as spell checking, language detection, entity extraction, author detection, question answering, and other tasks. These supervised algorithms learn patterns from a large number of "right" and "wrong" examples and apply them to new examples. However, using DNNs for analyzing the text resources in DH research presents two main challenges: (un)availability of training data and a need for domain adaptation. This paper explores these challenges by analyzing multiple use‐cases of DH studies in recent literature and their possible solutions and lays out a practical decision model for DH experts for when and how to choose the appropriate deep learning approaches for their research. Moreover, in this paper, we aim to raise awareness of the benefits of utilizing deep learning models in the DH community. [ABSTRACT FROM AUTHOR]

Simple Summary: Neuroblastoma is a rare type of cancer that usually affects children. The high-risk patients' expected survival rate is less than 50%. One reason is the lack of precision in the standard treatment protocol: a one-size-fits-all multi-modal therapy. The study presented in this paper was designed to address this deficit by optimising the use of two chemotherapeutic agents—vincristine and cyclophosphamide—during induction chemotherapy—the part of the protocol that shrinks the primary tumour before surgical removal. We combined a mathematical model and an optimisation algorithm to identify the best chemotherapy schedules for a cohort of virtual patients with different initial tumour compositions. Our results reveal novel strategies to exploit a pair of drugs with different levels of efficacy, provide a platform on which to individualise induction chemotherapy, and lay the foundation for a personalised therapy that leverages targeted therapies, multi-region sequencing, liquid biopsies, and modern computational methods to improve today's multi-modal therapy. Neuroblastoma is the most common extra-cranial solid tumour in children. Despite multi-modal therapy, over half of the high-risk patients will succumb. One contributing factor is the one-size-fits-all nature of multi-modal therapy. For example, during the first step (induction chemotherapy), the standard regimen (rapid COJEC) administers fixed doses of chemotherapeutic agents in eight two-week cycles. Perhaps because of differences in resistance, this standard regimen results in highly heterogeneous outcomes in different tumours. In this study, we formulated a mathematical model comprising ordinary differential equations. The equations describe the clonal evolution within a neuroblastoma tumour being treated with vincristine and cyclophosphamide, which are used in the rapid COJEC regimen, including genetically conferred and phenotypic drug resistance. The equations also describe the agents' pharmacokinetics. We devised an optimisation algorithm to find the best chemotherapy schedules for tumours with different pre-treatment clonal compositions. The optimised chemotherapy schedules exploit the cytotoxic difference between the two drugs and intra-tumoural clonal competition to shrink the tumours as much as possible during induction chemotherapy and before surgical removal. They indicate that induction chemotherapy can be improved by finding and using personalised schedules. More broadly, we propose that the overall multi-modal therapy can be enhanced by employing targeted therapies against the mutations and oncogenic pathways enriched and activated by the chemotherapeutic agents. To translate the proposed personalised multi-modal therapy into clinical use, patient-specific model calibration and treatment optimisation are necessary. This entails a decision support system informed by emerging medical technologies such as multi-region sequencing and liquid biopsies. The results and tools presented in this paper could be the foundation of this decision support system. [ABSTRACT FROM AUTHOR]

Fun and social affiliation are good predictors of long-term intention to use game-based interventions including those for motivating physical activity, yet current player matching algorithms are poor at facilitating social connectedness. In this paper, we report on the results of a study investigating how different player traits are associated with interest in social features of an exercise game for improving player experience through better player matching using common and complementary characteristics. Twelve conceptual scenarios were illustrated using storyboards and data was collected from 196 respondents who rated their attitudes and preferences towards gamification elements. Correlational results showed that all scenarios, except for cutting corners, were perceived as persuasive, enjoyable, engaging and are likely to increase future exercise intention for players who score high on Philanthropist- and Socialiser-oriented traits. Results also showed that many players favour the altruistic donation feature. Furthermore, qualitative results underscore that it is the player's partner that matters more than the players' personalities. We conclude with practical recommendations for designing more personalised exercise games that can include more socially engaging game mechanics in the future. [ABSTRACT FROM AUTHOR]

Background: The COVID‐19 pandemic has spread quickly, e‐learning became compulsory and disseminated throughout the world. During the pandemic, smartphones are frequently used to access e‐learning content, but connecting to technological tools increased the risk of cyberloafing during e‐courses. Currently, there are a limited number of studies on how e‐learning will evolve under compulsory conditions. Objectives: This study aimed to investigate the relationship between emotion regulation, e‐learning readiness, technology usage status (TUS), in‐class smartphone cyberloafing, and smartphone addiction (SA) of the students during the pandemic. Methods: In total 1294 students participated in this study. A research model was tested by structural equation modelling. Results and Conclusion: The findings of this study indicated that there is a relationship between TUS and SA. Emotion regulation was related to SA. E‐learning readiness levels can help to explain cyberloafing. This study presents a conceptual model of the variables that affect cyberloafing in the context of the e‐learning environment. Lay Description: What is already known about this topic: During the COVID‐19 pandemic smartphones are used frequently for e‐learning.Students could be distracted by technological tools such as smartphone, tablet PC, and so forth during online classes, which might disrupt learning.Students who are problematic smartphone users and cyberloafer turn to their smartphones to deal with the problem of emotional dysregulation.Cyberloafing behaviours of students may affect their personal and academic development, which will affect their academic success accordingly. What this paper adds: Emotion regulation was related to smartphone addiction.E‐learning readiness levels explain in class smartphone cyberloafing. Implications for practice: Learning experiences that will improve emotion‐regulation skills might be designed.Decreasing in‐class cyberloafing (and smartphone addiction in general) might help students to focus on their learning activities and learning goals.Student‐centred learning methods to be used during e‐learning, therefore the necessity of active participation in the lesson, student interaction, open cameras, and the use of smartphones to support the lesson during e‐learning can change cyberloafing behaviour. [ABSTRACT FROM AUTHOR]

The main semantic symbol systems for people to express their emotions include natural language and music. The analysis and establishment of semantic association between language and music is helpful to provide more accurate retrieval and recommendation services for text and music. Existing researches mainly focus on the surface symbolic features and association of natural language and music, which limits the performance and interpretability of applications based on semantic association of natural language and music. Emotion is the main meaning of music expression, and the semantic range of text expression includes emotion. In this paper, the semantic features of music are extracted from audio features, and the semantic matching model of audio emotion analysis is constructed to analyze ethnic music audio emotion through feature extraction ability of deep structure. The model is based on the framework of emotional semantic matching technology and realizes the emotional semantic matching of music fragments and words through semantic emotional recognition algorithm. Multiple experiments show that when W = 0.65 , the recognition rate of multichannel fusion model is 88.42%, and the model can reasonably realize audio emotion analysis. When the spatial dimension of music data changes, the classification accuracy reaches the highest when the spatial dimension is 25. Analysing the semantic association of audio promotes the application of folk music in occupational therapy. [ABSTRACT FROM AUTHOR]

This paper adopts the method of psychological data analysis to conduct in-depth research and analysis on the correlation between teachers' classroom teaching behaviors and students' knowledge acceptance. Firstly, this paper proposes a health factor prediction model, which is specifically divided into clustering and then classification model and a clustering and classification synthesis model. The classroom learning process is coded, sampled, and quantified to obtain data on students' learning behaviors, and a visualization system based on classroom students' learning behaviors is designed and developed to record and analyze students' behaviors in the classroom learning process and grasp students' classroom learning. These two models use algorithms to fine-grained divide the dataset from the perspective of subject users and mental health factors, respectively, and then use decision tree algorithms to classify and predict the mental health factor information by the subject user base information. Second, based on the collected datasets, we designed comparison experiments to validate the clustering-then-classification model and the integrated clustering-classification model and selected the optimal model for comparison. Teachers should increase effective praise and encouragement behaviors; teachers should increase meaningful teacher-student interaction behaviors; teachers should be proficient in teaching media technology to reduce unnecessary time wastage. Strategies to enhance teachers' TPACK include enriching teachers' knowledge base of CK, TK, and PK; developing teachers' integration thinking; and enriching teachers' types of activities for integrating technology. [ABSTRACT FROM AUTHOR]

This paper argues for a fluid approach to the study of agency in relation to algorithms, one that promotes crossing the boundaries of established analytical positions and breaking away from dualistic forms to frame its study. Building on various intellectual traditions, we develop three sensibilities for implementing such an approach: (a) working with tensions as an alternative to thinking about algorithmic power and human agency as an either/or binary; (b) examining mediations to reverse the tendency to treat algorithms as an ahistorical and universal force; and (c) exploring transversalities to navigate the spaces that emerge between various temporalities and levels of analysis. To make our case, we examine a crucial tension in the study of agency and algorithms, namely how scholars have either attributed power to algorithms or agency to users of algorithmic systems. The conclusion situates our argument for fluidity within larger historical debates in the study of technological power and human agency. [ABSTRACT FROM AUTHOR]

Accurate prostate segmentation in ultrasound images is crucial for the clinical diagnosis of prostate cancer and for performing image-guided prostate surgery. However, it is challenging to accurately segment the prostate in ultrasound images due to their low signal-to-noise ratio, the low contrast between the prostate and neighboring tissues, and the diffuse or invisible boundaries of the prostate. In this paper, we develop a novel hybrid method for segmentation of the prostate in ultrasound images that generates accurate contours of the prostate from a range of datasets. Our method involves three key steps: (1) application of a principal curve-based method to obtain a data sequence comprising data coordinates and their corresponding projection index; (2) use of the projection index as training input for a fractional-order-based neural network that increases the accuracy of results; and (3) generation of a smooth mathematical map (expressed via the parameters of the neural network) that affords a smooth prostate boundary, which represents the output of the neural network (i.e., optimized vertices) and matches the ground truth contour. Experimental evaluation of our method and several other state-of-the-art segmentation methods on datasets of prostate ultrasound images generated at multiple institutions demonstrated that our method exhibited the best capability. Furthermore, our method is robust as it can be applied to segment prostate ultrasound images obtained at multiple institutions based on various evaluation metrics. [ABSTRACT FROM AUTHOR]

In the field of higher education, generative artificial intelligence (GenAI) has become a revolutionary influence, shaping how students access and use library resources. This study explores the intricate balance of both positive and negative effects that GenAI might have on the academic library experience for higher education (HE) students. The key aspects of enhanced discovery and retrieval, personalization and engagement, streamlined research processes, and digital literacy and information evaluation potentially offered through using generative AI will be considered. These prospective advantages to HE students offered by using GenAI will be examined through will be examined through the theoretical framework of the Technological Acceptance Model (TAM) introduced by Davis et al. in 1986, which suggests that perceived usefulness and perceived ease of use are key factors in determining user acceptance and utilization of technology. The adoption of GenAI by higher education students will be analyzed from this viewpoint before assessing its impact on their use of library resources. [ABSTRACT FROM AUTHOR]

Objective: Bioinformatics analyses have been becoming important research tools in the field of life science since 2000. New tools have been developed for the detection of allergens in food sources. This study investigated potential allergen proteins similar to the endochitinase class 1(Pers a 1) protein found in avocado using bioinformatics analysis tools. Materials and Methods: The potential allergens were examined with four different in silico tools: Clustal W for multiple sequence comparison, Swiss-MODEL for homology modeling, ProtParam for comparing protein parameters, and AlgPred for allergen prediction. Results: In silico analyses revealed high rates of similarities in protein sequences among the studied species. The highest percent identity was found in Cinnamomum micranthum f. kanehirae as 97.55 while the lowest percent identity was found in Diospyros kaki as 70.23. It is very important to note that 9 of the 10 potential allergen species investigated are plats consumed in daily life and these species were identified as allergens. According to the algorithm of BLAST search on allergen representative peptides (ARPs), ARPs were found in eight potential allergen proteins except for Prunus avium and Citrus unshiu. The ARP sequence related to Persea americana is LQLTWNYNYGAAGNSIGFNGLSNP. Conclusion: People who are allergic to avocado (Persea americana) may be advised to be careful while consuming foods such as Phoenix dactylifera, Allium sativum, Citrus unshiu, Diospyros kaki, and Spinacia oleracea. The present paper can be considered as a model study for understanding allergens in foods by using in silico tools. [ABSTRACT FROM AUTHOR]

Brain tumors (BTs) are an uncommon but fatal kind of cancer. Therefore, the development of computer-aided diagnosis (CAD) systems for classifying brain tumors in magnetic resonance imaging (MRI) has been the subject of many research papers so far. However, research in this sector is still in its early stage. The ultimate goal of this research is to develop a lightweight effective implementation of the U-Net deep network for use in performing exact real-time segmentation. Moreover, a simplified deep convolutional neural network (DCNN) architecture for the BT classification is presented for automatic feature extraction and classification of the segmented regions of interest (ROIs). Five convolutional layers, rectified linear unit, normalization, and max-pooling layers make up the DCNN's proposed simplified architecture. The introduced method was verified on multimodal brain tumor segmentation (BRATS 2015) datasets. Our experimental results on BRATS 2015 acquired Dice similarity coefficient (DSC) scores, sensitivity, and classification accuracy of 88.8%, 89.4%, and 88.6% for high-grade gliomas. When it comes to segmenting BRATS 2015 BT images, the performance of our proposed CAD framework is on par with existing state-of-the-art methods. However, the accuracy achieved in this study for the classification of BT images has improved upon the accuracy reported in prior studies. Image classification accuracy for BRATS 2015 BT has been improved from 88% to 88.6%. [ABSTRACT FROM AUTHOR]

Interactive teaching is very popular in the field of education, especially in college preschool education teaching. In this study, the experimental performance of the evaluation system based on scientific emotion construction is analyzed by the machine learning algorithm. The experimental results show that the classification model realized by the machine learning algorithm is feasible and effective for the construction of an interactive design teaching evaluation system of preschool education in colleges and universities. The main research content of this experiment is for the teaching evaluation text, this paper intends to use NB, KNN, LR, and SVM algorithms as the meta-learning algorithm in the framework, the classification effect of the meta-classifier is ranked as SVM > LR > KNN > NB. From the above data comparison, the SVM meta-classifier in the algorithm in this paper has achieved the best classification effect. The SVM meta-classifier based on the algorithm in this paper performs well, and the classification accuracy rate reaches 92.1%. This shows that this model is very suitable for studying the. And the classification accuracy rate reaches 92.1%. This shows that this model is very suitable for studying the construction of interactive teaching evaluation systems under emotional education. • The experimental results show that the classification model realized by machine learning algorithm. • This shows that this model is very suitable for studying the construction of interactive teaching. • The main research content of this experiment is for the teaching evaluation text. • This paper intends to use NB, KNN, LR and SVM algorithms as the meta-learning algorithm. [ABSTRACT FROM AUTHOR]

The vulnerable children refer to the special group of children with deviation in the process of children's psychological development and personality formation due to growth dilemmas. This may incur a series of serious social and family problems. The vulnerable children mainly cover the children suffering from children's psychological problems, such as childhood autism, autism, social anxiety and hypersensitivity, fear, depression, and PTSD arising from other factors. At present, the research results at home and abroad mainly focus on the psychological dynamic correlation investigation and solution discussion of a certain kind of difficult factor in the children's psychological development based on statistical data by the experimental methods, such as scale and model, and there is a blind spot in the humanistic orientation theory construction of psychological treatment for vulnerable children, causing the social reflection on children's psychological predicament from the humanistic perspective cannot be performed in related researches and going against searching for universal and integral theoretical paradigm for solving related problems. Sophisticated technologies for the observations have emerged increasingly for enabling the psychological features of vulnerable children through developmental cognitive neuroscience experiments. This paper introduces humanistic art therapy theory, focuses on the construction of a theoretical paradigm, and verifies its effectiveness based on the experimental results on the psychological development of vulnerable children, with an efficient performance. This study mainly refers to children with difficulty in social inclusion and psychological development. The results showed that two kinds of art therapy can obviously improve the psychological disorders of vulnerable children. The goal was to enhance self-cognition, strengthen emotional interaction, and implement positive motivation. [ABSTRACT FROM AUTHOR]

With the rapid development of social platforms and human activities, people are now interested to solve their problems with the help of the social crowd-powered system. So, crowdsourcing has become a promising way of solving problems in a distributed manner within a specific time. Crowd workers pick up a task (simple or complex) and solve it with competing interest or collaboratively and receive an incentive (as monetary or non-monetary). In paid crowdsourcing platforms, crowd workers solve complex tasks and get remunerations through prior bidding or prior announcement of fee decided by the requester (task provider). For decomposable tasks, a single winner may not provide a significant solution to the requester due to the insufficient knowledge. So, we induce collaboration in competitive crowdsourcing markets to better handle decomposable-type tasks. In this paper, we propose an envelope game-based mechanism that ensures if the tasks are decomposable then the workers will be encouraged to collaborate with their subtasks and share their remunerations. This mechanism also increases the chance of receiving more number of cost-effective solutions. Thus both the requester and crowd workers get benefits from the system. The effectiveness of the proposed mechanism is evaluated through empirical analysis on simulated environments. [ABSTRACT FROM AUTHOR]

As the competition between enterprises intensifies, employees have witnessed a decline of psychological health year by year and severe anxiety and depression. To ensure the normal work of employees, it is important to implement psychological occupational therapy intervention (POTI). The previous studies on corporate occupational values focus on the behavioral variables and attitude variables related to occupations. The research paradigm does not suit a specific group of employees. Therefore, this paper explores the individual differences in POTI guided by the realization of occupational values. For a specific group of employees, the correlations of the psychological problems with job attitude, job involvement, and psychological health level were reasoned logically, a theoretical model was established, and the full-model map was plotted to illustrate the influence of the realization of occupational values over POTI. Then, the evaluation data on the psychological intervention effect of 2,800 employees were explored based on multikernel learning, and an individual difference prediction model was constructed through multikernel learning. Finally, the predicted results of different groups of employees were compared, revealing the effectiveness of our algorithm. [ABSTRACT FROM AUTHOR]

In this paper, we consider a stochastic optimization model for a surgical scheduling problem with a single operating room. The goal is to determine the optimal start times of multiple elective surgeries within a single day. The term "optimal" is defined as the largest surgically related utility value while achieving a given threshold defined by the performance variation of a reference solution. The optimization problem is analytically intractable because it involves quantities such as expectation and variance formulations. This implies that traditional mathematical programming techniques cannot be directly applied. We propose a decision support algorithm, which is a fully sequential procedure using variance screening in the first phase, and then employing multiple attribute utility theory to select the best solution in the second phase. The numerical experiments show that the proposed algorithm can find a promising solution in a reasonable amount of time. [ABSTRACT FROM AUTHOR]

Background & Aims: Cancer is one of the great human challenges in all countries, both advanced and developing. Cancer treatment management can include surgery, chemotherapy, or radiation therapy (1). Radiation therapy is done in two ways: Teletherapy and Brachytherapy. Brachytherapy involves the use of radiation sources to treat cancer by irradiating cancerous tissue from within the patient’s body (2). But the dose and how to use this method has always been questionable for researchers. Therefore, this study creates a new fuzzy approach to high-dose brachytherapy by optimizing the distribution of double roughness based on dosimetric criteria. The use of fuzzy logic itself has increased the accuracy of the mathematical model of the problem. This fuzzy model is a new study and innovation used in this paper. Due to the fuzzy nature of this method and its limitations, it is considered fuzzy. This makes the method more accurate and includes parameters such as the patient’s physical ability and age in the problem, which in itself increases the accuracy of the method for each patient. As a result, the obtained answer is improved and the executive program of brachytherapy method is more accurate. Methods: In the present study, the dose prescribed for an organ was evaluated by dosimetric indices listed in Table 1 (18). For the present study, data from 20 patients in the age range of 50 to 74 and mean age 62 years with a wide range of prostate volume between 23 and 103 cubic centimeters, and for the treatment of prostate cancer by brachytherapy from the Academic Medical Center (AMC, Amsterdam, the Netherlands) had participated. To compare brachytherapy programs with high interstitial dose, the dose rate was calculated with 192Ir beam with a radiation dose of 13 Gy, according to the standard protocol TG-43. To begin with, computed tomography (CT) scans or magnetic resonance imaging (MRI) were taken from the patients pelvis, and entered into the treatment planning software for use in treatment planning sessions. BT treatment planners and specialists then determined the input catheters, target volumes, and OARs obtained from the medical images. Depending on the size and exact location of the target volumes, between 14 and 20 catheters entered the patient’s body, reaching the target volumes. After designing and approving an acceptable treatment plan, the catheters inserted into the patient’s body were connected to a retractor 4 that controls the movement of the radiation source. After the treatment program, the source was returned to the retractor (8, 14). Then, an integer program model with fuzzy constraints was proposed for programming on high-dose brachytherapy. The description of infrastructures, parameters and variables in this model are in Table 2 (15 ). Finally, the dosimeter index is equal to the sum of all the index variables, as it turned out: The proposed model is a correct programming model called IP. In general, three evolutionary algorithms (EP), (GA) and (ES) were used in this research. The algorithms stopped after creating 20 generations of desirable answers and the best answer of each generation was determined on the chart as a point. The resulting set of answers were connected in the form of graphs, which are used to analyze the results. Each point on the graph identifies the best answer from each of the generations generated by the respective algorithms. These three algorithms were performed independently for each patient and the obtained answers were identified as dots on the chart. The graph obtained for each patient indicates the capability of each of these algorithms. Results: According to this study, each of the three algorithms (EP), (GA) and (ES) are each run independently for each of the patients with prostate cancer. At first, the genetic algorithm showed the ability to get closer to the desired answer sooner, but as the optimization process continues, the rate of convergence to the desired answer decreases, so if the time parameter is very important, the genetic algorithm can be useful. Especially for patients whose prostate volume was larger than other patients. In patients 15, 12, 8 and 9, due to their younger age than other patients and better physical condition, as well as prostate volume less than 80 ml, they had much more promising results than other patients. In contrast, for patients 4 and 19 with an age of over 70, the results were not as favorable as for other patients. The * sign in the table indicates that there is no answer through that patient-specific algorithm that covers 95 or even more of the tumor volume. Therefore, according to Table 2, it can be concluded that the best algorithm that can be considered for the case where the shortest time to reach the target coverage above 95% is the genetic algorithm. According to Table 2, it can be concluded that the best algorithm that can be considered for the case where the shortest time to reach the target coverage above 95% is the genetic algorithm. Therefore, according to Table 3, the ES algorithm has better answers than the other two algorithms for the case in which the largest volume of the tumor is covered. According to the results, the ES algorithm has obtained the best results for patients under 60 years of age and normal prostate volume. Conclusion: According to the obtained results, it can be stated that whether the main goal is the maximum coverage or the goal is the shortest possible time to reach the coverage above 95%, the best algorithm that can get a good answer for each patient is the evolutionary strategy algorithm. [ABSTRACT FROM AUTHOR]

Despite the potential importance of emotional aspects in information seeking, there is a lack of adequate attention to emotions' role in facilitating serendipitous information encountering. This paper contributes to this research gap by investigating the role of emotions during the process of perceiving and experiencing serendipitous information encountering in a controlled laboratory setting. The results show that applying a sketch game can stimulate participants' emotions. Our findings indicate that participants are more likely to experience serendipitous information encountering under the influence of positive emotions. This study contributes to an understanding of the relationship between emotions and the perception of serendipitous information encountering. The implications of the possibilities of facilitating positive emotions to induce serendipitous information encountering are discussed. [ABSTRACT FROM AUTHOR]

A New Family of Valid-Inequalities for Dantzig-Wolfe Reformulation of Mixed Integer Linear Programs In "Consistency Cuts for Dantzig-Wolfe Reformulation," Jens Vinther Clausen, Richard Lusby, and Stefan Ropke present a new family of valid inequalities to be applied to Dantzig-Wolfe reformulations with binary linking variables. They show that, for Dantzig-Wolfe reformulations of mixed integer linear programs that satisfy certain properties, it is enough to solve the linear programming relaxation of the Dantzig-Wolfe reformulation with all consistency cuts to obtain integer solutions. An example of this is the temporal knapsack problem; the effectiveness of the cuts is tested on a set of 200 instances of this problem, and the results are state-of-the-art solution times. For problems that do not satisfy these conditions, the cuts can still be used in a branch-and-cut-and-price framework. In order to show this, the cuts are applied to a set of generic mixed linear integer programs from the online library MIPLIB. These tests show the applicability of the cuts in general. This paper introduces a family of valid inequalities, which we term consistency cuts, to be applied to a Dantzig-Wolfe reformulation (or decomposition) with linking variables. We prove that these cuts ensure an integer solution to the corresponding Dantzig-Wolfe relaxation when certain criteria to the structure of the decomposition are met. We implement the cuts and use them to solve a commonly used test set of 200 instances of the temporal knapsack problem. We assess the performance with and without the cuts and compare further to CPLEX and other solution methods that have historically been used to solve the test set. By separating consistency cuts, we show that we can obtain optimal integer solutions much faster than the other methods and even solve the remaining unsolved problems in the test set. We also perform a second test on instances from the MIPLIB 2017 online library of mixed-integer programs, showing the potential of the cuts on a wider range of problems. [ABSTRACT FROM AUTHOR]

With the budding interests of structural and functional network characteristics as potential parameters for abnormal brains, an essential and thus simpler representation and evaluations have become necessary. Eigenvector centrality measure of functional magnetic resonance imaging (fMRI) offer region wise network representations through fMRI diagnostic maps. The article investigates the suitability of network node centrality values to discriminate ASD subject groups compared to typically developing controls following a boxplot formalism and a classification and regression tree model. Region wise differences between normal and ASD subjects primarily belong to the frontoparietal, limbic, ventral attention, default mode and visual networks. The reduced number of regions-of-interests (ROI) clearly suggests the benefit of automated supervised machine learning algorithm over the manual classification method. [ABSTRACT FROM AUTHOR]

Objective: Automated machine learning (autoML) platforms allow health care professionals to play an active role in the development of machine learning (ML) algorithms according to scientific or clinical needs. The aim of this study was to develop and evaluate such a model for automated detection and grading of distal hand osteoarthritis (OA). Methods: A total of 13,690 hand radiographs from 2,863 patients within the Swiss Cohort of Quality Management (SCQM) and an external control data set of 346 non‐SCQM patients were collected and scored for distal interphalangeal OA (DIP‐OA) using the modified Kellgren/Lawrence (K/L) score. Giotto (Learn to Forecast [L2F]) was used as an autoML platform for training two convolutional neural networks for DIP joint extraction and subsequent classification according to the K/L scores. A total of 48,892 DIP joints were extracted and then used to train the classification model. Heatmaps were generated independently of the platform. User experience of a web application as a provisional user interface was investigated by rheumatologists and radiologists. Results: The sensitivity and specificity of this model for detecting DIP‐OA were 79% and 86%, respectively. The accuracy for grading the correct K/L score was 75%, with a κ score of 0.76. The accuracy per DIP‐OA class differed, with 86% for no OA (defined as K/L scores 0 and 1), 71% for a K/L score of 2, 46% for a K/L score of 3, and 67% for a K/L score of 4. Similar values were obtained in an independent external test set. Qualitative and quantitative user experience testing of the web application revealed a moderate to high demand for automated DIP‐OA scoring among rheumatologists. Conversely, radiologists expressed a low demand, except for the use of heatmaps. Conclusion: AutoML platforms are an opportunity to develop clinical end‐to‐end ML algorithms. Here, automated radiographic DIP‐OA detection is both feasible and usable, whereas grading among individual K/L scores (eg, for clinical trials) remains challenging. [ABSTRACT FROM AUTHOR]

Objective: This study aimed to externally validate a reported model for identifying patients requiring extended stay following lower limb arthroplasty in a new setting. Design: External validation of a previously reported prognostic model, using retrospective data. Setting: Medium-sized hospital orthopaedic department, Australia. Participants: Electronic medical records were accessed for data collection between Sep-2019 and Feb-2020 and retrospective data extracted from 200 randomly selected total hip or knee arthroplasty patients. Intervention: Participants received total hip or knee replacement between 2-Feb-16 and 4-Apr-19. This study was a non-interventional retrospective study. Main measures: Model validation was assessed with discrimination, calibration on both original and adjusted forms of the candidate model. Decision curve analysis was conducted on the outputs of the adjusted model to determine net benefit at a predetermined decision threshold (0.5). Results: The original model performed poorly, grossly overestimating length of stay with mean calibration of −3.6 (95% confidence interval −3.9 to −3.2) and calibration slope of 0.52. Performance improved following adjustment of the model intercept and model coefficients (mean calibration 0.48, 95% confidence interval 0.16 to 0.80 and slope of 1.0), but remained poorly calibrated at low and medium risk threshold and net benefit was modest (three additional patients per hundred identified as at-risk) at the a-priori risk threshold. Conclusions: External validation demonstrated poor performance when applied to a new patient population and would provide limited benefit for our institution. Implementation of predictive models for arthroplasty should include practical assessment of discrimination, calibration and net benefit at a clinically acceptable threshold. [ABSTRACT FROM AUTHOR]

Cardiac digital twins provide a physics and physiology informed framework to deliver personalized medicine. However, high-fidelity multi-scale cardiac models remain a barrier to adoption due to their extensive computational costs. Artificial Intelligence-based methods can make the creation of fast and accurate whole-heart digital twins feasible. We use Latent Neural Ordinary Differential Equations (LNODEs) to learn the pressure-volume dynamics of a heart failure patient. Our surrogate model is trained from 400 simulations while accounting for 43 parameters describing cell-to-organ cardiac electromechanics and cardiovascular hemodynamics. LNODEs provide a compact representation of the 3D-0D model in a latent space by means of an Artificial Neural Network that retains only 3 hidden layers with 13 neurons per layer and allows for numerical simulations of cardiac function on a single processor. We employ LNODEs to perform global sensitivity analysis and parameter estimation with uncertainty quantification in 3 hours of computations, still on a single processor. [ABSTRACT FROM AUTHOR]

Introduction: The efficiency of The International Classification of Headache Disorders (ICHD-3) in reflecting patients' disability has recently been questioned. This prompts consideration that clinical features beyond pain may more accurately indicate the extent of underlying brain impairment than the mere frequency of headache days. Important cognitive dysfunctions and psychological impairment have been reported in burdensome cases of migraine, and the presence of these alterations has been associated with biological changes in the nervous system. This study aimed to compare migraine-related disability within a specific patient group, classified using ICHD-3 criteria or classified based on findings from a neuropsychological evaluation using machine learning. Additionally, a complementary voxel-based morphometry (VBM) comparison was conducted to explore potential neuroanatomical differences between the resulting groups. Patients and methods: The study included episodic and chronic migraine patients seeking consultation at a specialized headache department. A neuropsychological evaluation protocol, encompassing validated standardized tests for cognition, anxiety, depression, perceived stress, and headache-related impact (HIT-6) and disability (MIDAS), was administered. Results from this evaluation were input into an automated K-means clustering algorithm, with a predefined K=2 for comparative purposes. A supplementary Voxel-based Morphometry (VBM) evaluation was conducted to investigate neuroanatomical contrasts between the two distinct grouping configurations. Results: The study involved 111 participants, with 49 having chronic migraine and 62 having episodic migraine. Seventy-four patients were assigned to cluster one, and 37 patients were assigned to cluster two. Cluster two exhibited significantly higher levels of depression, anxiety, and perceived stress, and performed worse in alternating and focalized attention tests. Differences in HIT-6 and MIDAS scores between episodic and chronic migraine patients did not reach statistical significance (HIT-6: 64.39 (±7,31) vs 62.92 (±11,61); p= 0. 42 / MIDAS: 73.63 (±68,61) vs 84.33 (±63,62); p=0.40). In contrast, patients in cluster two exhibited significantly higher HIT-6 (62.32 (±10,11) vs 66.57 (±7,21); p=0.03) and MIDAS (68.69 (±62,58) vs 97.68 (±70,31); p=0.03) scores than patients in cluster one. Furthermore, significant differences in grey matter volume between the two clusters were noted, particularly involving the precuneus, while differences between chronic and episodic migraine patients did not withstand correction for multiple comparisons. Conclusions: The classification of migraine patients based on neuropsychological characteristics demonstrates a more effective separation of groups in terms of disability compared to categorizing them based on the chronic or episodic diagnosis of ICHD-3. These findings could reveal biological changes that might explain differences in treatment responses among apparently similar patients. [ABSTRACT FROM AUTHOR]

Parkinson's disease (PD) and essential tremor (ET) are prevalent movement disorders that mainly affect elderly people, presenting diagnostic challenges due to shared clinical features. While both disorders exhibit distinct speech patterns—hypokinetic dysarthria in PD and hyperkinetic dysarthria in ET—the efficacy of speech assessment for differentiation remains unexplored. Developing technology for automatic discrimination could enable early diagnosis and continuous monitoring. However, the lack of data for investigating speech behavior in these patients has inhibited the development of a framework for diagnostic support. In addition, phonetic variability across languages poses practical challenges in establishing a universal speech assessment system. Therefore, it is necessary to develop models robust to the phonetic variability present in different languages worldwide. We propose a method based on Gaussian mixture models to assess domain adaptation from models trained in German and Spanish to classify PD and ET patients in Czech. We modeled three different speech dimensions: articulation, phonation, and prosody and evaluated the models' performance in both bi-class and tri-class classification scenarios (with the addition of healthy controls). Our results show that a fusion of the three speech dimensions achieved optimal results in binary classification, with accuracies up to 81.4 and 86.2% for monologue and /pa-ta-ka/ tasks, respectively. In tri-class scenarios, incorporating healthy speech signals resulted in accuracies of 63.3 and 71.6% for monologue and /pa-ta-ka/ tasks, respectively. Our findings suggest that automated speech analysis, combined with machine learning is robust, accurate, and can be adapted to different languages to distinguish between PD and ET patients. [ABSTRACT FROM AUTHOR]

We prove that Simulated Annealing with an appropriate cooling schedule computes arbitrarily tight constant-factor approximations to the minimum spanning tree problem in polynomial time. This result was conjectured by Wegener (Automata, Languages and Programming, ICALP, Berlin, 2005). More precisely, denoting by n , m , w max , and w min the number of vertices and edges as well as the maximum and minimum edge weight of the MST instance, we prove that simulated annealing with initial temperature T 0 ≥ w max and multiplicative cooling schedule with factor 1 - 1 / ℓ , where ℓ = ω (m n ln (m)) , with probability at least 1 - 1 / m computes in time O (ℓ (ln ln (ℓ) + ln (T 0 / w min))) a spanning tree with weight at most 1 + κ times the optimum weight, where 1 + κ = (1 + o (1)) ln (ℓ m) ln (ℓ) - ln (m n ln (m)) . Consequently, for any ϵ > 0 , we can choose ℓ in such a way that a (1 + ϵ) -approximation is found in time O ((m n ln (n)) 1 + 1 / ϵ + o (1) (ln ln n + ln (T 0 / w min))) with probability at least 1 - 1 / m . In the special case of so-called (1 + ϵ) -separated weights, this algorithm computes an optimal solution (again in time O ((m n ln (n)) 1 + 1 / ϵ + o (1) (ln ln n + ln (T 0 / w min))) ), which is a significant speed-up over Wegener's runtime guarantee of O (m 8 + 8 / ϵ) . Our tighter upper bound also admits the result that in some situations a hybridization of simulated annealing and the (1 + 1) EA can lead to stronger runtime guarantees than either algorithm alone. [ABSTRACT FROM AUTHOR]

BACKGROUND: The cockpit of an aircraft is the main place where the pilot controls the aircraft on a mission. An excellent cockpit environment not only ensures the pilot's basic survival needs but also improves the comfort level and alleviates fatigue when performing missions. OBJECTIVE: On the basis of domestic and international airworthiness standards, a top-down refinement method is deployed to determine the initial goal, and the environmental criteria are fully discussed and balanced in a dynamic process to build a comprehensive evaluation system for environmental factors in the aircraft cockpit. METHODS: Based on the fuzzy comprehensive evaluation theory, an evaluation model for environmental factors is constructed by combining analytic hierarchical analysis (AHP) and particle swarm optimization (PSO). Then the feasibility of the evaluation model is verified by an illustrative example. RESULTS: The results suggest that the light environment gains the highest score among the 4 environmental criteria followed by the thermal environment, while both sound environment and microenvironment have relatively low scores. CONCLUSION: As for the 27 environmental sub-criteria, temperature, illumination, lighting clarity, light-color coordination, noise duration and pressure score the highest. The evaluation findings can provide important environmental control criteria for the subsequent environmental control system in the cockpit of the aircraft. [ABSTRACT FROM AUTHOR]

We aimed to explore managerial and project staff perceptions of the pilot implementation of an algorithm-supported care navigation model, targeting people at risk of hospital readmission. The pilot was implemented from May to November 2017 at a Victorian health service (Australia) and provided to sixty-five patients discharged from the hospital to the community. All managers and the single clinician involved participated in a semi-structured interview. Participants (n = 6) were asked about their perceptions of the service design and the enablers and barriers to implementation. Interviews were transcribed verbatim and analysed according to a framework approach, using inductive and deductive techniques. Constructed themes included the following: an algorithm alone is not enough, the health service culture, leadership, resources and the perceived patient experience. Participants felt that having an algorithm to target those considered most likely to benefit was helpful but not enough on its own without addressing other contextual factors, such as the health service's capacity to support a large-scale implementation. Deductively mapping themes to the integrated Promoting Action on Research Implementation in Health Services (i-PARIHS) framework highlighted that a formal facilitation would be essential for future sustainable implementations. The systematic identification of barriers and enablers elicited critical information for broader implementations of algorithm-supported models of care. [ABSTRACT FROM AUTHOR]

Background: Gastric cancer (GC) is a leading cause of cancer-related deaths, emphasizing the importance of timely diagnosis for effective treatment. Machine learning models have shown promise in assisting with GC diagnosis. Objectives: This study aimed at comparing the performance of various feature selection methods in identifying influential factors related to GC based on lifestyle using machine learning models. The ultimate goal was to enhance early detection and treatment of the disease. Methods: The data of patients from Shahid Ayatollah Modarres Hospital and Shohadaye Tajrish Hospital between 2013 and 2021 were utilized. Three feature selection methods (filter, wrapper, and filter-wrapper) were employed. The k-fold method validated each model. Four classifiers k Nearest Neighbor (kNN), Decision Tree (DT), Random Forest (RF), and Gradient-Boosted Decision Trees (GBDT) compared their outputs based on feature selection methods. Results: The filter-wrapper method outperformed others, achieving an area under the ROC curve and Fl score of 95.8% and 94.7%, respectively. GBDT also performed well. The wrapper and RF classifiers achieved an area under the ROC curve and Fl scores of 95.7% and 93.6%, respectively, after the filter-wrapper method. Without feature selection methods, the RF classifier had an area under the ROC curve and F1 scores of 95.6% and 91.7%, respectively, surpassing other classifiers. Conclusions: This study suggests that appropriate feature selection methods for identifying influential factors related to GC based on lifestyle can facilitate early diagnosis and treatment. The filter-wrapper method demonstrated the best performance in this regard. [ABSTRACT FROM AUTHOR]

Simple Summary: Acute myeloid leukemia (AML) is the second most frequent leukemia entity in children and adolescents, and definitely the most aggressive variant. Multiparameter flow-cytometry is one of the methodologies most useful to monitor the number of remaining leukemic cells in bone marrow (minimal residual disease, MRD) in AML patients, because it is widely available and applicable to most patients. However, AML flow cytometry data show very complex patterns and identifying leukemic cells in the data is subjective, time-consuming and requires experienced operators who are not available world-wide. In this paper, we approach automatic assessment of AML flow cytometry samples with a novel semi-supervised machine learning model, leveraging implicit expert knowledge stored in a collection of manually assessed samples. Because AML data exhibit a high degree of variability in the patterns of blast cell populations that is difficult to model, the model detects anomalies starting from the appearance of normal cell populations. Leukemia is the most frequent malignancy in children and adolescents, with acute lymphoblastic leukemia (ALL) and acute myeloid leukemia (AML) as the most common subtypes. Minimal residual disease (MRD) measured by flow cytometry (FCM) has proven to be a strong prognostic factor in ALL as well as in AML. Machine learning techniques have been emerging in the field of automated MRD quantification with the objective of superseding subjective and time-consuming manual analysis of FCM-MRD data. In contrast to ALL, where supervised multi-class classification methods have been successfully deployed for MRD detection, AML poses new challenges: AML is rarer (with fewer available training data) than ALL and much more heterogeneous in its immunophenotypic appearance, where one-class classification (anomaly detection) methods seem more suitable. In this work, a new semi-supervised approach based on the UMAP algorithm for MRD detection utilizing only labels of blast free FCM samples is presented. The method is tested on a newly gathered set of AML FCM samples and results are compared to state-of-the-art methods. We reach a median F 1 -score of 0.794, while providing a transparent classification pipeline with explainable results that facilitates inter-disciplinary work between medical and technical experts. This work shows that despite several issues yet to overcome, the merits of automated MRD quantification can be fully exploited also in AML. [ABSTRACT FROM AUTHOR]

Background. There is a narrow therapeutic window for sodium valproate, and the blood concentration is too low to control epilepsy, while it is easy to poison the body if the concentration is too high. It is therefore necessary to monitor drug concentration reasonably in order to control epilepsy. The purpose of this study was to establish a model for predicting concentrations of sodium valproate below 50 μg/mL in children with epilepsy. Methods. The clinical data and biochemical examination results of children with epilepsy treated in the pediatric outpatient department of our hospital from June 2019 to March 2022 were retrospectively collected and divided into a development group and a validation group according to a patient ratio of 8 to 2. Five machine learning algorithms were used to identify the key variable factors, and a risk prediction model for sodium valproate blood concentrations lower than the standard concentration was established. The area under the curve (AUC), calibration curve, GiViTi calibration band, and clinical influence curve were used to evaluate the diagnostic efficacy and clinical application value of the model. Results. A total of 525 children with epilepsy were enrolled. In the development group, the random forest algorithm performed best in predicting that the blood concentration of sodium valproate was lower than the standard concentration, showing the highest AUC (1.00). Six factors were determined as a nomogram to predict the incidence of low concentrations. In the validation group and the development group, the calibration curve, GiViTi calibration band, and clinical influence curve all performed well in the evaluation of the diagnostic efficacy and clinical application value of the model. Conclusions. This finding highlights the importance of examining biochemical indices in patients when data regarding the blood concentration of sodium valproate are lacking. [ABSTRACT FROM AUTHOR]

Sound scale construction is pivotal to the measurement of psychological constructs. Common item sampling procedures emphasize aspects of reliability to the disadvantage of aspects of validity, which are less tangible. We use a health knowledge test as an example to demonstrate how item sampling strategies that focus on either factor saturation or construct coverage influence scale composition and demonstrate how to find a trade-off between these two opposing needs. More specifically, we compile three 75-item health knowledge scales using Ant Colony Optimization, a metaheuristic algorithm that is inspired by the foraging behavior of ants, to optimize factor saturation, construct coverage, or a compromise of both. We demonstrate that our approach is well suited to balance out construct coverage and factor saturation when constructing a health knowledge test. Finally, we discuss conceptual problems with the modeling of declarative knowledge and provide recommendations for the assessment of health knowledge. [ABSTRACT FROM AUTHOR]

BACKGROUND: Although some research has been done in the Mexican manufacturing industry regarding mental workload, none has explored its association with physical fatigue, body weight gain, and human error simultaneously. OBJECTIVE: This research examines the association between mental workload and physical fatigue, body weight gain, and human error in employees from the Mexican manufacturing systems through a mediation analysis approach. METHODS: A survey named Mental Workload Questionnaire was developed by merging the NASA-TLX with a questionnaire containing the mental workload variables mentioned above. The Mental Workload Questionnaire was applied to 167 participants in 63 manufacturing companies. In addition, the mental workload was used as an independent variable, while physical fatigue and body weight gain were mediator variables, and human error was a dependent variable. Six hypotheses were used to measure the relationships among variables and tested using the ordinary least squares regression algorithm. RESULTS: Findings indicated that mental workload significantly correlates with physical fatigue and human error. Also, the mental workload had a significant total association with human error. The highest direct association with body weight gain was provided by physical fatigue, and body weight gain had an insignificant direct association with human error. Finally, all indirect associations were insignificant. CONCLUSION: Mental workload directly affects human error, which physical fatigue does not; however, it does affect body weight gain. Managers should reduce their employees' mental workload and physical fatigue to avoid further problems associated with their health. [ABSTRACT FROM AUTHOR]

Indirect methods for the indirect estimation of reference intervals are increasingly being used, especially for validation of reference intervals, as they can be applied to routine patient data. In this study, we compare three statistically different indirect methods for the verification and validation of reference intervals in eight laboratories distributed throughout Europe. The RefLim method is a fast and simple approach which calculates the reference intervals by extrapolating the theoretical 95 % of non-pathological values from the central linear part of a quantile-quantile plot. The Truncated Maximum Likelihood (TML) method estimates a smoothed kernel density function for the distribution of the mixed data, for which it is assumed that the "central" part of the distribution represents the healthy population. The refineR utilizes an inverse modelling approach. This algorithm identifies a model that best explains the observed data before transforming the data with the Box-Cox transformation. We show that the different indirect methods each have their advantages but can also lead to inaccurate or ambiguous results depending on the approximation of the mathematical model to real-world data. A combination of different methodologies can improve the informative value and thus the reliability of results. Based on routine measurements of four enzymes alkaline phosphatase (ALP), total amylase (AMY), cholinesterase (CHE) and gamma-glutamyl transferase (GGT) in adult women and men, we demonstrate that some reference limits taken from the literature need to be adapted to the laboratory's particular local and population characteristics. [ABSTRACT FROM AUTHOR]

This article introduces the research community to the power of machine learning over traditional approaches when analyzing longitudinal data. Although traditional approaches work well with small to medium datasets, machine learning models are more appropriate as the available data becomes larger and more complex. Additionally, machine learning methods are ideal for analyzing longitudinal data because they do not make any assumptions about the distribution of the dependent and independent variables or the homogeneity of the underlying population. They can also analyze cases with partial information. In this article, we use the Household, Income, and Labour Dynamics in Australia (HILDA) survey to illustrate the benefits of machine learning. Using a machine learning algorithm, we analyze the relationship between job‐related variables and neuroticism across 13 years of the HILDA survey. We suggest that the results produced by machine learning can be used to generate generalizable rules from the data to augment our theoretical understanding of the domain. With a technical guide, this article offers critical information and best‐practice recommendations that can assist social science researchers in conducting machine learning analysis with longitudinal data. [ABSTRACT FROM AUTHOR]

Background: Item response times in computerized assessments are frequently used to identify rapid guessing behaviour as a manifestation of response disengagement. However, non‐rapid responses (i.e., with longer response times) are not necessarily engaged, which means that response‐time‐based procedures could overlook disengaged responses. Therefore, the identification of disengaged responses could be improved by considering additional indicators of disengagement. We investigated the extent to which decreases in individuals' item solution probabilities over the course of a test reflect disengaged response behaviour. Objectives: To disentangle different types of possibly disengaged responses and better understand non‐effortful test‐taking behaviour, we augmented responses‐time‐based procedures for identifying rapid guessing with strategies for detecting disengaged responses on the basis of performance declines in non‐rapid responses. Methods: We combined item response theory (IRT) models for rapid guessing and test‐taking persistence to examine the capability of response times and item positions to capture response disengagement. We used a computerized assessment in which science items were randomly distributed across positions for each student. This allowed us to estimate individual differences in test‐taking persistence (i.e., the duration for which the initial level of performance is maintained) while accounting for rapid responses. Results and Conclusions: Response times did not fully explain disengagement; item responses reflected test‐taking persistence even when rapid responses were accounted for. This interpretation was supported by a strong correlation of test‐taking persistence with decreases in self‐reported test‐taking effort. Furthermore, our results suggest that IRT models for test‐taking persistence can effectively account for the undesirable impact of low test‐taking effort even when response times are unavailable. Practitioner Notes: Assessments of proficiencies that attempt to quantify what individuals know and can do lead to biased results when individuals provide disengaged responses.Item response times are frequently used to identify rapid guessing behaviour as a manifestation of response disengagement, but response‐time‐based procedures could overlook disengaged responses.To disentangle different types of possibly disengaged responses and better understand non‐effortful test‐taking behaviour, we augmented responses‐time‐based procedures for identifying rapid guessing with strategies for detecting disengaged responses on the basis of performance declines in non‐rapid responses.In a sample of fifth and sixth graders, we found that response times did not fully explain disengagement, as many students showed performance declines in non‐rapid item responses.Our results suggest that item response theory models for test‐taking persistence can effectively account for the undesirable impact of low test‐taking effort even when response times are unavailable. [ABSTRACT FROM AUTHOR]

In the literature of modern psychometric modeling, mostly related to item response theory (IRT), the fit of model is evaluated through known indices, such as χ2, M2, and root mean square error of approximation (RMSEA) for absolute assessments as well as Akaike information criterion (AIC), consistent AIC (CAIC), and Bayesian information criterion (BIC) for relative comparisons. Recent developments show a merging trend of psychometric and machine learnings, yet there remains a gap in the model fit evaluation, specifically the use of the area under curve (AUC). This study focuses on the behaviors of AUC in fitting IRT models. Rounds of simulations were conducted to investigate AUC's appropriateness (e.g., power and Type I error rate) under various conditions. The results show that AUC possessed certain advantages under certain conditions such as high-dimensional structure with two-parameter logistic (2PL) and some three-parameter logistic (3PL) models, while disadvantages were also obvious when the true model is unidimensional. It cautions researchers about the dangers of using AUC solely in evaluating psychometric models. [ABSTRACT FROM AUTHOR]

Rationale, Aims and Objectives: The development of clinical practice guidelines (CPG) suffers from the lack of an explicit and transparent framework for synthesising the key elements necessary to formulate practice recommendations. We matched deliberations of the American Society of Haematology (ASH) CPG panel for the management of pulmonary embolism (PE) with the corresponding decision‐theoretical constructs to assess agreement of the panel recommendations with explicit decision modelling. Methods: Five constructs were identified of which three were used to reformulate the panel's recommendations: (1) standard, expected utility threshold (EUT) decision model; (2) acceptable regret threshold model (ARg) to determine the frequency of tolerable false negative (FN) or false positive (FP) recommendations, and (3) fast‐and‐frugal tree (FFT) decision trees to formulate the entire strategy for management of PE. We compared four management strategies: withhold testing versus d‐dimer → computerized pulmonary angiography (CTPA) ('ASH‐Low') versus CTPA→ d‐dimer ('ASH‐High') versus treat without testing. Results: Different models generated different recommendations. For example, according to EUT, testing should be withheld for prior probability PE < 0.13%, a clinically untenable threshold which is up to 15 times (2/0.13) below the ASH guidelines threshold of ruling out PE (at post probability of PE ≤ 2%). Three models only agreed that the 'ASH low' strategy should be used for the range of pretest probabilities of PE between 0.13% and 13.27% and that the 'ASH high' management should be employed in a narrow range of the prior PE probabilities between 90.85% and 93.07%. For all other prior probabilities of PE, choosing one model did not ensure coherence with other models. Conclusions: CPG panels rely on various decision‐theoretical strategies to develop its recommendations. Decomposing CPG panels' deliberation can provide insights if the panels' deliberation retains a necessary coherence in developing guidelines. CPG recommendations often do not agree with the EUT decision analysis, widely used in medical decision‐making modelling. [ABSTRACT FROM AUTHOR]

(1) Objective: The objective of this study was to experimentally obtain the ideal pressure distribution model of buttock and thigh support for office workers in forward-leaning and upright sitting postures, reproduce the support provided by mesh materials with elastic materials, and propose an effective seat design scheme to improve the comfort of office workers. (2) Method: Based on the seven most popular mesh chairs on the market, pressure distribution experiments, and the fuzzy clustering algorithm, the relatively ideal body pressure distribution matrices were generated for office workers under two common sitting postures, and the corresponding partitioned sitting support surfaces were obtained. A prototype chair was created and validated by combining the ergonomics node coordinates and the physical properties of the materials. (3) Result: An ideal support model of four zones was constructed, and prototype pads were designed and produced according to this model. Subjects were recruited to test the ability of the prototypes to reproduce the ideal pressure distribution maps. (4) Conclusion: The four-zone ideal support model is capable of effectively representing the buttock and thigh support requirements in forward-leaning and upright sitting postures, and it is useful for the development of related products. Studying sitting postures and pressure values generated by different activities of office workers will help to refine the needs of office personnel and provide new ideas for the design of office chairs. [ABSTRACT FROM AUTHOR]

Ambient Assisted Living (AAL) is a medical surveillance system comprised of connected devices, healthcare sensor systems, wireless communications, computer hardware, and software implementations. AAL could be used for an extensive variety of purposes, comprising preventing, healing, as well as improving the health and wellness of elderly individuals. AAL intends to ensure the wellbeing of elderly persons while also spanning the number of years seniors can remain independent in their preferred surroundings. It also decreases the quantity of family caregivers by giving patients control over their health situations. To avert huge costs as well as possible adverse effects on standard of living, classifiers must be used to distinguish between adopters as well as nonadopters of such innovations. With the development of numerous classification algorithms, selecting the best classifier became a vital and challenging step in technology acceptance. Decision makers must consider several criteria from different domains when selecting the best classifier. Furthermore, it is critical to define the best multicriteria decision-making strategy for modelling technology acceptance. Considering the foregoing, this research reports the incorporation of the multicriteria decision-making (MCDM) method which is founded on the fuzzy method for order of preference by similarity to ideal solution (TOPSIS) to identify the top classifier for continuing toward supporting AAL implementation research. The results indicate that the classification algorithm KNN is the preferred technique among the collection of different classification algorithms for the ambient assisted living system. [ABSTRACT FROM AUTHOR]

A qubit lattice algorithm (QLA), which consists of a set of interleaved unitary collision-streaming operators, is developed for electromagnetic wave propagation in tensor dielectric media. External potential operators are required to handle gradients in the refractive indices, and these operators are typically non-unitary but sparse. A similar problem arises in the QLA for the Korteweg–de Vries equation, as the potential operator that models the KdV nonlinear term is also non-unitary. Several QLAs are presented here that avoid the need of this non-unitary potential operator by perturbing the collision operator. These QLAs are fully unitary. [ABSTRACT FROM AUTHOR]

In both popular and academic discussions of the use of algorithms in clinical practice, narratives often draw on the decisive potentialities of algorithms and come with the belief that algorithms will substantially transform healthcare. We suggest that this approach is associated with a logic of disruption. However, we argue that in clinical practice alongside this logic, another and less recognised logic exists, namely that of continuation : here the use of algorithms constitutes part of an established practice. Applying these logics as our analytical framing, we set out to explore how algorithms for clinical decision-making are enacted by political stakeholders, healthcare professionals, and patients, and in doing so, study how the legitimacy of delegating to an algorithm is negotiated and obtained. Empirically we draw on ethnographic fieldwork carried out in relation to attempts in Denmark to develop and implement Patient Reported Outcomes (PRO) tools – involving algorithmic sorting – in clinical practice. We follow the work within two disease areas: heart rehabilitation and breast cancer follow-up care. We show how at the political level, algorithms constitute tools for disrupting inefficient work and unsystematic patient involvement, whereas closer to the clinical practice, algorithms constitute a continuation of standardised and evidence-based diagnostic procedures and a continuation of the physicians' expertise and authority. We argue that the co-existence of the two logics have implications as both provide a push towards the use of algorithms and how a logic of continuation may divert attention away from new issues introduced with automated digital decision-support systems. [ABSTRACT FROM AUTHOR]

The article presents the discussion on competitiveness being a determining factor for the survival of businesses. Topics include sciences research to combine experimental approaches with theoretical modelling tools from systems theory, physics, engineering, computer science; and situation driven organizations on the search for simulation models.

Sarcoma, the second common type of solid tumor in children and adolescents, has a wide variety of subtypes that are often not properly diagnosed at an early stage, leading to late metastases and causing serious loss of life and property to patients and families. It exhibits a high degree of heterogeneity at the cellular, molecular, and epigenetic levels, where DNA methylation has been proposed to play a role in the diagnosis of sarcoma subtypes. Thus, this study is aimed at finding potential biomarkers at the DNA methylation level to distinguish different sarcoma subtypes. A machine learning process was designed to analyse sarcoma samples, each of which was represented by lots of methylation sites. Irrelevant sites were removed using the Boruta method, and remaining sites related to the target variables were kept for further analyses. Afterward, three feature ranking methods (LASSO, LightGBM, and MCFS) were adopted to rank these features, and six classification models were constructed by combining incremental feature selection and two classification algorithms (decision tree and random forest). Among these models, the performance of RF model was higher than that of DT model under all three ranking conditions. The specific expression of genes obtained from the annotation of highly correlated methylation site features, such as PRKAR1B, INPP5A, and GLI3, was proven to be associated with sarcoma by publications. Moreover, the quantitative rules obtained by decision tree algorithm helped us to understand the essential differences between various sarcoma types and classify sarcoma subtypes, providing a new means of clinical identification and determining new therapeutic targets. [ABSTRACT FROM AUTHOR]

Background: Physical activity (PA) is known to be beneficial for health, but adherence to international PA guidelines is low across different subpopulations. Interventions have been designed to stimulate PA of different target groups by influencing relevant psycho-social determinants, essentially based on a combination of the Integrated Model for Change, the Theory of Planned Behaviour, its successor the Reasoned Action Approach and the self-determination theory. The current study investigates the pathways through which interventions influence PA. Further, gender differences in pathways of change are studied. Methods: An integrated dataset of five different randomised controlled trial intervention studies is analysed by estimating a Bayesian network. The data include measurements, at baseline and at 3, 6 (short-term), and 12 (long-term) months after the baseline, of important socio-cognitive determinants of PA, demographic factors, and PA outcomes. A fragment is extracted from the Bayesian network consisting of paths between the intervention variable, determinants, and short- and long-term PA outcomes. For each relationship between variables, a stability indicator and its mutual information are computed. Such a model is estimated for the full dataset, and in addition such a model is estimated based only on male and female participants' data to investigate gender differences. Results: The general model (for the full dataset) shows complex paths, indicating that the intervention affects short-term PA via the direct determinants of intention and habit and that self-efficacy, attitude, intrinsic motivation, social influence concepts, planning and commitment have an indirect influence. The model also shows how effects are maintained in the long-term and that previous PA behaviour, intention and attitude pros are direct determinants of long-term PA. The gender-specific models show similarities as well as important differences between the structures of paths for the male- and female subpopulations. For both subpopulations, intention and habit play an important role for short-term effects and maintenance of effects in the long-term. Differences are found in the role of self-efficacy in paths of behaviour change and in the fact that attitude is relevant for males, whereas planning plays a crucial role for females. The average of these differences in subpopulation mechanisms appears to be presented in the general model. Conclusions: While previous research provided limited insight into how interventions influence PA through relevant determinants, the Bayesian network analyses show the relevance of determinants mentioned by the theoretical framework. The model clarifies the role that different determinants play, especially in interaction with each other. The Bayesian network provides new knowledge about the complex working mechanism of interventions to change PA by giving an insightful overview of influencing paths. Furthermore, by presenting subpopulation-specific networks, the difference between the influence structure of males and females is illustrated. These new insights can be used to improve interventions in order to enhance their effects. To accomplish this, we have developed a new methodology based on a Bayesian network analysis which may be applicable in various other studies. [ABSTRACT FROM AUTHOR]