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Thermoelastic stress analysis (TSA) can be used to determine the stress field of structures or materials under cyclic loadings through temperature under adiabatic conditions. So high-frequency cyclic loadings are considered as a fundamental condition. However, loading frequencies in many practical applications do not meet the adiabatic conditions. In order to improve the accuracy of TSA under low-frequency fatigue loadings, the non-adiabatic response in TSA was derived by combining the classical thermoelastic equation and heat conduction equation. This response was used to create a modified model that accounted for heat transfer and temperature distribution under low-frequency loading conditions. Otherwise, fatigue test and finite element method were used to evaluate the correctness of the modified model using epoxy resin material. The results showed that the temperature change obtained from the modified model were in good agreement with the experiment results. The modified model can effectively evaluate the structural stress under low-frequency fatigue loadings. [ABSTRACT FROM AUTHOR]

Background: Patients with symptomatic chronic internal carotid artery occlusion (ICAO) face a high risk of recurrent stroke despite receiving aggressive medical therapy. This study aimed to evaluate the effectiveness and safety of hybrid surgery in treating symptomatic chronic ICAO. Methods: This retrospective case series was conducted at a single center. From January 2019 to December 2022, patients with symptomatic chronic ICAO who underwent hybrid surgery were included. We collected baseline data, lesion characteristics, revascularization rates, perioperative complications, and follow-up outcomes. Results: The study enrolled 27 patients, comprising 22 males and 5 females, with symptomatic chronic ICAO. The hybrid surgery achieved a technical success rate of 100% for revascularization (n = 27), with a perioperative complication rate of 14.8% (n = 4). Following a median follow-up of 6.0 months (IQR, 4–10), 21 patients underwent a DSA or CT angiography reexamination, confirming a vascular patency rate of 90.5% (n = 19). One patient required surgery for severe in-stent restenosis, and another experienced asymptomatic occlusion. Clinical follow-ups were conducted for all 26 patients; no new strokes were reported in the qualifying artery territory, with 13 patients scoring 0, 12 scoring 1, and 1 scoring 2 on the mRS. Conclusion: Although hybrid surgery represent a promising option for treating chronic ICAO, they are also associated with a relatively high incidence of treatment-related complications. The application of composite surgery should be based on standardized technical guidelines and the careful selection of patients who are genuinely at high risk for recurrent strokes. [ABSTRACT FROM AUTHOR]

Simple Summary: The problem of low fertility in Tibetan pigs has a long history. In order to solve the problem of low fertility in Tibetan pigs, in this study, we successfully constructed cDNA libraries of the transcriptome from ovarian tissues of Tibetan and Yorkshire pigs using RNA-Seq technology, analyzed and screened the genes significantly enriched in the pathways closely related to the regulation of reproduction, and finally identified AR, CYP11A1, CYP17A1, INHBA, ARRB2, EGFR, ETS1, HSD17B1, IGF1R, MIF, SCARB1, and SMAD4 as important candidate genes. The 12 differentially expressed genes screened in relation to reproduction were validated using RT-qPCR. The results showed that six genes were highly significantly (p < 0.01) higher in expression in Tibetan pigs than in Yorkshire pigs, i.e., AR, CYP17A1, EGFR, ETS1, IGF1R, and SMAD4; on the other hand, six genes were highly significantly (p < 0.01) lower in expression in Tibetan pigs than in Yorkshire pigs, i.e., CYP11A1, INHBA, ARRB2, HSD17B, MIF, SCARB1. This study provides a theoretical basis for improving the regulatory genes in Tibetan pigs. The purpose of this study was to explore and verify genes that regulate the reproductive traits of Tibetan pigs at the mRNA level. The ovarian tissues of Tibetan pigs (TPs) and Yorkshire pigs (YPs) were selected as research objects, and cDNA libraries of the ovarian tissue transcripts of Tibetan pigs and Yorkshire pigs were successfully constructed by the RNA-Seq technique. A total of 651 differentially expressed genes (DEGs) were screened, including 414 up-regulated genes and 237 down-regulated genes. Through GO and KEGG enrichment analysis, it was found that these differentially expressed genes were significantly enriched in cell process, reproductive process, reproduction, cell proliferation, binding, and catalytic activity, as well as oxidative phosphorylation, endocrine resistance, thyroid hormone, Notch, and other signal transduction pathways. Genes significantly enriched in pathways closely related to reproductive regulation were analyzed and selected, and the AR, CYP11A1, CYP17A1, INHBA, ARRB2, EGFR, ETS1, HSD17B1, IGF1R, MIF, SCARB1, and SMAD4 genes were identified as important candidate genes. Twelve differentially expressed genes related to reproduction were verified by RT-qPCR. The results showed that the expression of the AR, CYP17A1, EGFR, ETS1, IGF1R, and SMAD4 genes was significantly higher in Tibetan pigs than in Yorkshire pigs, while the expression of the CYP11A1, INHBA, ARRB2, HSD17B, MIF, and SCARB1 genes in Tibetan pigs was significantly lower than in Yorkshire pigs. The purpose of this study is to provide a theoretical basis for exploring the molecular mechanism of reproductive trait effect genes and the application of molecular breeding in Tibetan pigs. [ABSTRACT FROM AUTHOR]

Pancreatic ductal adenocarcinoma (PDAC) is a highly malignant neoplasm characterized by a poor prognosis and limited therapeutic strategy. The PDAC tumor microenvironment presents a complex heterogeneity, where neutrophils emerge as the predominant constituents of the innate immune cell population. Leveraging the power of single-cell RNA-seq, spatial RNA-seq, and multi-omics approaches, we included both published datasets and our in-house patient cohorts, elucidating the inherent heterogeneity in the formation of neutrophil extracellular traps (NETs) and revealed the correlation between NETs and immune suppression. Meanwhile, we constructed a multi-omics prognostic model that suggested the patients exhibiting downregulated expression of NETs may have an unfavorable outcome. We also confirmed TLR2 as a potent prognosis factor and patients with low TLR2 expression had more effective T cells and an overall survival extension for 6 months. Targeting TLR2 might be a promising strategy to reverse immunosuppression and control tumor progression for an improved prognosis. [ABSTRACT FROM AUTHOR]

Serious solvation effect of zinc ions has been considered as the cause of the severe side reactions (hydrogen evolution, passivation, dendrites, and etc.) of aqueous zinc metal batteries. Even though the regulation of cationic solvation structure has been widely studied, effects of the anionic solvation structures on the zinc metal were rarely examined. Herein, co-reconstruction of anionic and cationic solvation structures was realized through constructing a new multi-component electrolyte (Zn(BF4)2-glycerol-boric acid-chitosan-polyacrylamide, simplified as ZGBCP), which incorporates double crosslinking network via the esterification, protonation and polymerization reactions, thereby combining multiple advantages of ‘liquid-like’ high conductivity, ‘gel-like’ robust interface, and ‘solid-like’ high Zn2+ transfer number. Based on the ZGBCP electrolyte, the Zn anodes achieve record-low polarization and stable cycling. Furthermore, the ZGBCP electrolyte renders the AZMBs ultrawide working temperature (−50 °C ~ +100 °C) and ultralong cycle life (30000 cycles), which further validates the feasibility of the dual solvation structure strategy and provides a innovative perspective for the development of high-performance AZMBs.Solvation effect of zinc ions has led to side reactions in aqueous zinc metal batteries. Here, the authors construct a multicomponent zinc gel polymer electrolyte and co-reconstruct the cationic/anionic solvation structures. [ABSTRACT FROM AUTHOR]

We investigate optimal project management in a setting plagued by an indefinite number of setbacks that are discovered en route to project completion. The contractor can cover up delays in progress due to shirking either by making false claims of setbacks or by postponing the reports of real ones. The sponsor optimally induces work and honest reporting via a soft deadline and a reward for completion that specifies a bonus for early delivery. Late‐stage setbacks trigger randomization between minimally feasible project extension and (inefficient) cancellation. Because extensions may be granted repeatedly, arbitrarily large overruns in schedule and budget are possible after which the project may still be canceled. [ABSTRACT FROM AUTHOR]

Membrane trafficking pathways mediate key microglial activities such as cell migration, cytokine secretion, and phagocytosis. However, the underlying molecular mechanism remains poorly understood. Previously, we found that synaptotagmin‐11 (Syt11), a non‐Ca2+‐binding Syt associated with Parkinson's disease (PD) and schizophrenia, inhibits cytokine release and phagocytosis in primary microglia. Here we reported the in vivo function of Syt11 in microglial immune responses using an inducible microglia‐specific Syt11‐conditional‐knockout (cKO) mouse strain. Syt11‐cKO resulted in activation of microglia and elevated mRNA levels of IL‐6, TNF‐α, IL‐1β, and iNOS in various brain regions under both resting state and LPS‐induced acute inflammation state in adult mice. In a PD mouse model generated by microinjection of preformed α‐synuclein fibrils into the striatum, a reduced number of microglia migrated toward the injection sites and an enhanced phagocytosis of α‐synuclein fibrils by microglia were found in Syt11‐cKO mice. To understand the molecular mechanism of Syt11 function, we identified its direct binding proteins vps10p‐tail‐interactor‐1a (vti1a) and vti1b. The linker domain of Syt11 interacted with both proteins and a peptide derived from it competitively inhibited the interaction of Syt11 with vti1a/vti1b in vitro and in cells. Importantly, application of this peptide induced more cytokine secretion in wild‐type microglia upon LPS treatment, phenocopying defects in Syt11 knockdown cells. Altogether, we propose that Syt11 inhibits microglial activation in vivo and regulates cytokine secretion through interactions with vti1a and vti1b. [ABSTRACT FROM AUTHOR]

Liver metastasis is a common cause of death in progressive colorectal cancer patients, but the molecular mechanisms remain unclear. Here, it is reported that a conserved and oxidative pentose phosphate pathway‐associated circular RNA, circNOLC1, plays a crucial role in colorectal cancer liver metastasis. It is found that circNOLC1 silencing reduces the oxidative pentose phosphate pathway‐related intermediate metabolites and elevates NADP+/NADPH ratio and intracellular ROS levels, thereby attenuating colorectal cancer cell proliferation, migration, and liver metastasis. circNOLC1 interacting with AZGP1 to activate mTOR/SREBP1 signaling, or sponging miR‐212‐5p to upregulate c‐Met expression, both of which can further induce G6PD to activate oxidative pentose phosphate pathway in colorectal cancer liver metastasis. Moreover, circNOLC1 is regulated by the transcription factor YY1 and specifically stabilized HuR induces its parental gene mRNA expression. The associations between circNOLC1 and these signaling molecules are validated in primary CRC and corresponding liver metastasis tissues. These findings reveal that circNOLC1 interacting with AZGP1 and circNOLC1/miR‐212‐5p/c‐Met axis plays a key role in oxidative pentose phosphate pathway‐mediated colorectal cancer liver metastasis, which may provide a novel target for precision medicine of colorectal cancer. [ABSTRACT FROM AUTHOR]

This paper proposed an improved potential rapidly exploring random tree star (P-RRT*) algorithm for unmanned aerial vehicles (UAV). The algorithm has faster expansion and convergence speeds and better path quality. Path planning is an important part of the UAV control system. Rapidly exploring random tree (RRT) is a path-planning algorithm that is widely used, including in UAV, and its altered body, P-RRT*, is an asymptotic optimal algorithm with bias sampling. The algorithm converges slowly and has a large random sampling area. To overcome the above drawbacks, we made the following improvements. First, the algorithm used the direction of the artificial potential field (APF) to determine whether to perform greedy expansion, increasing the search efficiency. Second, as the random tree obtained the initial path and updated the path cost, the algorithm rejected high-cost nodes and sampling points based on the heuristic cost and current path cost to speed up the convergence rate. Then, the random tree was pruned to remove the redundant nodes in the path. The simulation results demonstrated that the proposed algorithm could significantly decrease the path cost and inflection points, speed up initial path obtaining and convergence, and is suitable for the path planning of UAVs. [ABSTRACT FROM AUTHOR]

Aqueous Zn−Mn battery has been considered as the most promising scalable energy‐storage system due to its intrinsic safety and especially ultralow cost. However, the traditional Zn−Mn battery mainly using manganese oxides as cathode shows low voltage and suffers from dissolution/disproportionation of the cathode during cycling. Herein, for the first time, a high‐voltage and long‐cycle Zn−Mn battery based on a highly reversible organic coordination manganese complex cathode (Manganese polyacrylate, PAL−Mn) was constructed. Benefiting from the insoluble carboxylate ligand of PAL−Mn that can suppress shuttle effect and disproportionationation reaction of Mn3+ in a mild electrolyte, Mn3+/Mn2+ reaction in coordination state is realized, which not only offers a high discharge voltage of 1.67 V but also exhibits excellent cyclability (100 % capacity retention, after 4000 cycles). High voltage reaction endows the Zn−Mn battery high specific energy (600 Wh kg−1 at 0.2 A g−1), indicating a bright application prospect. The strategy of introducing carboxylate ligands in Zn−Mn battery to harness high‐voltage reaction of Mn3+/Mn2+ well broadens the research of high‐voltage Zn−Mn batteries under mild electrolyte conditions. [ABSTRACT FROM AUTHOR]

Aqueous zinc metal batteries (AZMBs) as one of the next-generation energy storage technologies have attracted both academic and industrial attention due to their high safety, low cost, and high specific energy, yet are facing interfacial challenges at the electrolyte/anode interface, e.g. uneven physical diffusion of Zn2+ flux, severe chemical corrosion, and disordered electrochemical deposition behavior of the zinc metal anode. To address these issues, herein, we propose a facile and effective electrolyte modulating strategy to construct a physico-chemo-electrochemically coupled stable interface between the aqueous electrolyte and zinc anode. The aqueous electrolyte modified using a tiny amount of water-soluble ionic liquid 1-ethyl-3-methylimidazolium tetrafluoroborate (EMIMBF4) can form a positively charged organic EMIM+ adsorption layer and a protective inorganic Zn2+-conducting layer through the in situ decomposition of BF4− on the zinc anode surface, thus effectively homogenizing the Zn2+ diffusion flux and decreasing the chemical corrosion rate. Moreover, EMIM+ provides an electrostatic shielding layer, leading to the preferential and ordered electrodeposition of Zn2+ along the Zn (002). Benefiting from this physico-chemo-electrochemically multifunctional interfacial layer, the Zn//Zn symmetric cells achieve a considerably extended lifespan of up to 1200 h at 5 mA cm−2 and 5 mA h cm−2, and more than 450 h even at an ultrahigh current density and large deposition capacity (10 mA cm−2 and 10 mA h cm−2). Zn//Cu asymmetric cells also exhibit excellent reversibility with a high coulombic efficiency of 99.75%. Furthermore, the physically, chemically, and electrochemically stabilized interface enables the AZMB with a quinone-based cathode to offer high specific capacity (256.9 mA h g−1) and a decent capacity retention rate (83.9% after 300 cycles). [ABSTRACT FROM AUTHOR]

In order to ensure the reliable interruption of high voltage direct current circuit breaker (HVDC CB), the breaking test of HVDC CB plays an important role in its performance verification. In this paper, the interruption process of the HVDC CB is analyzed, and the equivalent requirements for the breaking test of HVDC CB are summarized. In the breaking test of high voltage and high current, the transient interruption voltage (TIV) duration is short, which leads to insufficient voltage stress. A new synthetic test circuit for testing the interruption performance of HVDC CBs is proposed, which can solve the problem of insufficient TIV duration caused by insufficient test capacity. Subsequently, the working principle of the test circuit is introduced in detail and the design method of the circuit parameters is given. The short‐circuit current breaking test simulation of HVDC CB is carried out. The simulation results fit most well with the results of actual test cases, which verifies the universality of this test method. Finally, a test platform is built to verify the principle of the test circuit. TIV rose to 2.5 kV compared to the predetermined system voltage of 1.67 kV during the test, which means that the key stress provided by the test circuit can meet the expected requirements. [ABSTRACT FROM AUTHOR]

Relation extraction, a fundamental task in natural language processing, aims to extract entity triples from unstructured data. These triples can then be used to build a knowledge graph. Recently, pre-training models that have learned prior semantic and syntactic knowledge, such as BERT and ERNIE, have enhanced the performance of relation extraction tasks. However, previous research has mainly focused on sequential or structural data alone, such as the shortest dependency path, ignoring the fact that fusing sequential and structural features may improve the classification performance. This study proposes a concise approach using the fused features for the relation extraction task. Firstly, for the sequential data, we verify in detail which of the generated representations can effectively improve the performance. Secondly, inspired by the pre-training task of next-sentence prediction, we propose a concise relation extraction approach based on the fusion of sequential and structural features using the pre-training model ERNIE. The experiments were conducted on the SemEval 2010 Task 8 dataset and the results show that the proposed method can improve the F1 value to 0.902. [ABSTRACT FROM AUTHOR]

Chaotic secure communication schemes encounter a conflict of key space enhancement between the consistency and complexity of chaotic transceivers. In this paper, we propose a monolithically integrated multi-section semiconductor laser (MIMSL), used as a compact chaotic transceiver with an enhanced key space. The MIMSL consists of a distributed feedback (DFB) laser section, a semiconductor optical amplifier (SOA) section, two phase (P) sections and a passive optical waveguide. We simulate the dynamics of the MIMSL by applying the time-dependent coupled-wave equations for traveling-wave optical fields. Further, we numerically demonstrate a security enhancement of the unidirectional chaotic communication scheme using the MIMSL transceivers with independent high-speed modulation in the phase sections of the MIMSL. The security of our scheme depends not only on the difficulty of identifying the MIMSL structural parameters and the bias current of each section, but also on the phase shifts in two phase sections providing the additional dimension of security key space. Final simulation results show that a total of 248 key spaces can be achieved with a data rate of 2.5 Gb/s and an injection strength of 0.36. [ABSTRACT FROM AUTHOR]

Cellulose is the most abundant biopolymer on Earth, which is synthesized by plants, bacteria, and animals, with source-dependent properties. Cellulose containing β-1,4-linked D-glucoses further assembles into hierarchical structures in microfibrils, which can be processed to nanocellulose with length or width in the nanoscale after a variety of pretreatments including enzymatic hydrolysis, TEMPO-oxidation, and carboxymethylation. Nanocellulose can be mainly categorized into cellulose nanocrystal (CNC) produced by acid hydrolysis, cellulose nanofibrils (CNF) prepared by refining, homogenization, microfluidization, sonification, ball milling, and the aqueous counter collision (ACC) method, and bacterial cellulose (BC) biosynthesized by the Acetobacter species. Due to nontoxicity, good biodegradability and biocompatibility, high aspect ratio, low thermal expansion coefficient, excellent mechanical strength, and unique optical properties, nanocellulose is utilized to develop various cellulose nanocomposites through solution casting, Layer-by-Layer (LBL) assembly, extrusion, coating, gel-forming, spray drying, electrostatic spinning, adsorption, nanoemulsion, and other techniques, and has been widely used as food packaging material with excellent barrier and mechanical properties, antibacterial activity, and stimuli-responsive performance to improve the food quality and shelf life. Under the driving force of the increasing green food packaging market, nanocellulose production has gradually developed from lab-scale to pilot- or even industrial-scale, mainly in Europe, Africa, and Asia, though developing cost-effective preparation techniques and precisely tuning the physicochemical properties are key to the commercialization. We expect this review to summarise the recent literature in the nanocellulose-based food packaging field and provide the readers with the state-of-the-art of this research area. [ABSTRACT FROM AUTHOR]

Hollow nanoboxes structure have raised great attention as microwave absorption materials on account of their ultralow density and large specific area. By introducing an adjustable interior cavity structure, the dielectric loss and microwave absorption performance were affected by the tunable complex permittivity and impedance matching was improved. In our study, hollow CoS2 nanoboxes with designable interspaces were successfully fabricated based on the surfactant-assisted solution method and followed by an in situ ion-exchange process. The structure, elemental compositions and morphology of the products were characterized by XRD, XPS, EDX, SEM and TEM, respectively. In addition, microwave absorption performance and the intrinsic mechanism are investigated in-depth. The paraffin-based composites with 20 wt.% filling contents exhibited superior microwave absorption capacities in view of both maximum reflection loss value (RLmax, −54.48 dB) and effective absorption bandwidth (EAB, below −10 dB, 6.0 GHz), which can be ascribed to unique hollow structure and good impedance matching. With these considerations in mind, this study provides a reference for the construction of high-performance microwave absorbers with unique hollow structure. [ABSTRACT FROM AUTHOR]

Phytoplankton patterns have been observed widely in aquatic systems. Although pattern formation has been investigated based on many PDEs, discrete models on aquatic systems can provide more complex dynamics. A discrete toxic-phytoplankton–zooplankton model is studied in this paper, with the consideration of Allee effect and cross-diffusion. Focusing on Allee effect coefficient, flip and Neimark–Sacker bifurcation analyses are carried out. And focusing on cross-diffusion coefficient, Turing bifurcation analyses are carried out. Parameter conditions and bifurcation diagram of these bifurcations are obtained correspondingly. Numerical simulations are then performed which are consistent with results of theoretical analysis. Irregular patterns can be formed by flip bifurcation. Spirals can be formed by Neimark–Sacker bifurcation. Spots and stripes can be formed by Turing bifurcation. When Turing and flip, or Turing and Neimark–Sacker bifurcations both occur, special patterns can be obtained. [ABSTRACT FROM AUTHOR]

The transverse magnetic field (TMF) contacts generate a magnetic field through the structure and apply electromagnetic force to the arc to drive the arc to move on the surface of the contact. When the arc rotates on the surface of the spiral-type TMF contact, it needs to continuously cross the slots in the surface, so that the current is transferred between the contact arms. The structure of the slot not only determines the magnitude of the electromagnetic force of the arc during its movement, but also directly affects the arc’s appearance and speed during its motion. At present, most researches on spiral-type TMF contacts focus on increasing the strength of TMF and enhancing the force on the arc, but there is little research on the influence of the arc’s appearance during the slot crossing process. In this article, two spiral-type TMF contact structures are selected for experiments, the appearance of the arc in the slot crossing process is studied and analyzed, and the arc characteristics in different slot crossing processes are summarized. It is found that the anode plasma jets can keep moving with low concentration, which plays an important role in the slot crossing process and the current breaking. [ABSTRACT FROM AUTHOR]

Packet-level forward erasure correction (FEC) is effective for achieving low-latency transmissions in non-terrestrial networks (NTNs), which often contain lossy links with long propagation delay. This letter considers the problem of dynamically sending FEC coded packets based on delayed feedback to achieve fast in-order data delivery without retransmissions. We show that the problem can be formulated using reinforcement learning (RL) by tracking history feedback and system state. With carefully devised state space and reward signal, the RL scheme is shown to be effective for achieving high and smooth in-order goodput with low delay. For example, smooth goodput can be achieved at a FEC code rate of more than 90% of the capacity with the delay of all the packets being lower than 1.5 round-trip time, which would be incurred by a single packet loss if using retransmissions. [ABSTRACT FROM AUTHOR]