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Your search keyword '"Schweighart, Elizabeth"' showing total 6 results
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6 results on '"Schweighart, Elizabeth"'

1. Epigenetic regulator genes direct lineage switching in MLL/AF4 leukemia

Author

Tirtakusuma, Ricky, Szoltysek, Katarzyna, Milne, Paul, Grinev, Vasily V., Ptasinska, Anetta, Chin, Paulynn S., Meyer, Claus, Nakjang, Sirintra, Hehir-Kwa, Jayne Y., Williamson, Daniel, Cauchy, Pierre, Keane, Peter, Assi, Salam A., Ashtiani, Minoo, Kellaway, Sophie G., Imperato, Maria R., Vogiatzi, Fotini, Schweighart, Elizabeth K., Lin, Shan, Wunderlich, Mark, Stutterheim, Janine, Komkov, Alexander, Zerkalenkova, Elena, Evans, Paul, McNeill, Hesta, Elder, Alex, Martinez-Soria, Natalia, Fordham, Sarah E., Shi, Yuzhe, Russell, Lisa J., Pal, Deepali, Smith, Alex, Kingsbury, Zoya, Becq, Jennifer, Eckert, Cornelia, Haas, Oskar A., Carey, Peter, Bailey, Simon, Skinner, Roderick, Miakova, Natalia, Collin, Matthew, Bigley, Venetia, Haniffa, Muzlifah, Marschalek, Rolf, Harrison, Christine J., Cargo, Catherine A., Schewe, Denis, Olshanskaya, Yulia, Thirman, Michael J., Cockerill, Peter N., Mulloy, James C., Blair, Helen J., Vormoor, Josef, Allan, James M., Bonifer, Constanze, Heidenreich, Olaf, and Bomken, Simon

Published
2022
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3. Increased Bone Marrow Uptake and Accumulation of Very-Late Antigen-4 Targeted Lipid Nanoparticles

Author

Swart, Laura E., primary, Fens, Marcel H. A. M., additional, Oort, Anita van, additional, Waranecki, Piotr, additional, Casimiro, L. Daniel Mata, additional, Tuk, David, additional, Hendriksen, Martijn, additional, Brink, Luca van den, additional, Schweighart, Elizabeth, additional, Seinen, Cor, additional, Nelson, Ryan, additional, Krippner-Heidenreich, Anja, additional, O’Toole, Tom, additional, Schiffelers, Raymond M., additional, Kooijmans, Sander, additional, and Heidenreich, Olaf, additional

Published
2023
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4. Case Report: Immune dysregulation associated with long-lasting regression of a (pre) leukemic clone.

Author

Koedijk, Joost B., van Beek, Thomas B., Vermeulen, Marijn A., Kester, Lennart A., Schweighart, Elizabeth K., Nierkens, Stefan, Belderbos, Mirjam E., Zwaan, C. Michel, Heitink-Pollé, Katja M. J., and Heidenreich, Olaf

Subjects
PRELEUKEMIA, GENE fusion, BLAST injuries, BONE marrow, DISEASE management, ACUTE myeloid leukemia, PREVENTIVE medicine
Abstract

Regression of leukemia in the absence of disease-modifying therapy remains poorly understood, although immunological mechanisms are thought to play a role. Here, we present a unique case of a 17-year-old boy with immune dysregulation and long-lasting regression of a (pre)leukemic clone in the absence of disease-modifying therapy. Using molecular and immunological analyses, we identified bone marrow features associated with disease control and loss thereof. In addition, our case reveals that detection of certain fusion genes with hardly any blasts in the bone marrow may be indicative of an accompanying oncogenic fusion gene, with implications for disease surveillance- and management in future patients. [ABSTRACT FROM AUTHOR]

Published
2023
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5. Inhibition of the Menin-MLL1 Interaction in MLL-Rearranged Primary Mixed-Phenotype Acute Leukemia Samples Promotes Leukemic Differentiation

Author

Szoltysek, Katarzyna, primary, Cameron, Rachel L., additional, Krippner-Heidenreich, Anja, additional, Rasouli, Milad, additional, Hehir-Kwa, Jayne Y., additional, Schweighart, Elizabeth K., additional, Ashtiani, Minoo, additional, Stutterheim, Janine, additional, Vormoor, Josef, additional, and Heidenreich, Olaf, additional

Published
2022
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6. Oncogenic RAS Signaling Promotes an Immunosuppressive Niche in Acute Lymphoblastic Leukemia

Author

Ferrao Blanco, Mauricio Nicolás, Schweighart, Elizabeth, Kester, Lennart, Hehir-Kwa, Jayne, Belderbos, Mirjam E., den Boer, Monique L., Heidenreich, Olaf, and Vormoor, Josef

Abstract

Emerging evidence suggests that genomic aberrations in cancer cells may impact the composition of the tumor microenvironment leading to a tumor-specific supporting niche. Previous genomic profiling studies have identified somatic alterations in RAS pathway genes that drive treatment resistance in B-cell acute lymphoblastic leukemia (B-ALL): yet it is unknown whether such genetic events may specifically hijack the leukemic niche.

Published
2023
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