10 results on '"Moran, C."'
Search Results
2. Effect of Aerobic Exercise in Chinese Adult Individuals at Risk for Type 2 Diabetes Mellitus (T2DM) with Low Salivary Amylase Gene (AMY1) Copy Number Variation
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Zhang X, Moran C, Wang R, and Zhou Y
- Subjects
salivary amylase gene ,copy number variation ,blood glucose ,insulin ,Specialties of internal medicine ,RC581-951 - Abstract
Xinming Zhang,1,* Colin Moran,2,* Ruiyuan Wang,3 Yue Zhou3 1School of Sport Science, Nantong University, Nantong City, Jiangsu Province, People’s Republic of China; 2School of Health Sciences and Sport, University of Stirling, Stirling, Scotland, The United Kingdom; 3School of Sport Science, Beijing Sport University, Beijing City, People’s Republic of China*These authors contributed equally to this workCorrespondence: Xinming Zhang, Nantong University, No. 9 Seyuan Road, Nantong, Jiangsu Province, People’s Republic of China, Tel +86 15901080090, Email smile-carrie@hotmail.comPurpose: Type 2 Diabetes mellitus (T2DM) has become a life-threatening health problem around the world. Studies have confirmed that aerobic exercise can prevent the risk of T2DM. Furthermore, recent research showed that salivary amylase gene (AMY1) copy number variation (CNV) could be one of the genetic factors that increased the risk of T2DM. To provide more evidence on how AMY1 CNV and exercise is correlated with the risk of T2DM, we designed this study to show the differences in postprandial carbohydrate metabolism between people with different AMY1 copy numbers, and how aerobic exercise can influence this process.Participants and Methods: Sixteen participants without cardiovascular disease were chosen, 8 with AMY1 CNV≥ 6 (High CNV group, HCNV), and 8 with AMY1 CNV ≤ 2 (Low CNV group, LCNV). All participants were Chinese, Han nationality, 18 to 40 years old, with fasting blood glucose lower than 6.1 mmol/L and normal blood pressure levels. They were asked to visit the laboratory in fasting state and drink a cup of solution with 75 grams of edible carbohydrate (glucose or starch). After carbohydrate intake, blood samples were taken at certain times at rest or after aerobic exercise. Blood glucose levels were tested with a portable blood glucose monitor, and insulin levels were tested with the enzyme-linked immunosorbent assay (ELISA).Results: The LCNV group had significantly higher resting insulin levels and homeostatic model assessment of insulin resistance (HOMA-IR) than the HCNV group. Compared to the HCNV group, postprandial blood glucose levels and insulin levels were insensitive to starch intake in the LCNV group. However, this difference disappeared after aerobic exercise was added as an intervention.Conclusion: Lower AMY1 CNV could be associated with higher risk of T2DM and complex carbohydrate metabolism disorder, while aerobic exercise can reduce the risk by increasing the carbohydrate utilization rate.Keywords: salivary amylase gene, copy number variation, blood glucose, insulin
- Published
- 2023
3. Impact of primary kidney disease on the effects of empagliflozin in patients with chronic kidney disease: secondary analyses of the EMPA-KIDNEY trial
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4. Effects of empagliflozin on progression of chronic kidney disease: a prespecified secondary analysis from the empa-kidney trial
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Staplin, N, Haynes, R, Judge, PK, Wanner, C, Green, JB, Emberson, J, Preiss, D, Mayne, KJ, Ng, SYA, Sammons, E, Zhu, D, Hill, M, Stevens, W, Wallendszus, K, Brenner, S, Cheung, AK, Liu, ZH, Li, J, Hooi, LS, Liu, WJ, Kadowaki, T, Nangaku, M, Levin, A, Cherney, D, Maggioni, AP, Pontremoli, R, Deo, R, Goto, S, Rossello, X, Tuttle, KR, Steubl, D, Petrini, M, Seidi, S, Landray, MJ, Baigent, C, Herrington, WG, Abat, S, Abd Rahman, R, Abdul Cader, R, Abdul Hafidz, MI, Abdul Wahab, MZ, Abdullah, NK, Abdul-Samad, T, Abe, M, Abraham, N, Acheampong, S, Achiri, P, Acosta, JA, Adeleke, A, Adell, V, Adewuyi-Dalton, R, Adnan, N, Africano, A, Agharazii, M, Aguilar, F, Aguilera, A, Ahmad, M, Ahmad, MK, Ahmad, NA, Ahmad, NH, Ahmad, NI, Ahmad Miswan, N, Ahmad Rosdi, H, Ahmed, I, Ahmed, S, Aiello, J, Aitken, A, AitSadi, R, Aker, S, Akimoto, S, Akinfolarin, A, Akram, S, Alberici, F, Albert, C, Aldrich, L, Alegata, M, Alexander, L, Alfaress, S, Alhadj Ali, M, Ali, A, Alicic, R, Aliu, A, Almaraz, R, 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- 2024
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5. [Translated article] Survey on the Management of Dysplastic Nevus by Dermatologists in the Center-Spain Section of the Spanish Academy of Dermatology and Venereology (AEDV)
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Baeza-Hernández, G., Rubio-Aguilera, R.F., Martínez-Morán, C., Álvarez-Garrido, H., Garrido-Ríos, A.A., and Borbujo, J.
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- 2023
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6. Encuesta sobre el manejo del nevus displásico por los dermatólogos de la sección Centro de la Academia Española de Dermatología y Venereología (AEDV)
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Baeza-Hernández, G., Rubio-Aguilera, R.F., Martínez-Morán, C., Álvarez-Garrido, H., Garrido-Ríos, A.A., and Borbujo, J.
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- 2023
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7. Effectiveness of interventions for informal caregivers of people with end-stage chronic illness: a systematic review.
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McGuigan, K., Laurente, G., Christie, A., Carswell, C., Moran, C., Yaqoob, M. M., Bolton, S., Mullan, R., Rej, S., Gilbert, P., McKeaveney, C., McVeigh, C., Tierney, C., Reid, J., Walsh, I., Forbes, T., and Noble, H.
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CAREGIVERS ,BURDEN of care ,QUALITY of life ,CHRONIC diseases ,CINAHL database - Abstract
Background: People living with advanced, non-malignant chronic conditions often have extensive and complex care needs. Informal or family caregivers often provide the care and support needed by those with advanced chronic conditions at home. These informal caregivers experience many challenges associated with their caring role, which can impact their own wellbeing. Whilst there is growing evidence around the impact on carers, guidance on support for informal caregivers of patients with advanced, non-malignant, chronic conditions is lacking, with little evidence available on effective psychosocial carer interventions. This systematic review explored existing interventions for caregivers of those with advanced, non-malignant, chronic illness, in order to assess the effectiveness of these interventions in improving psychosocial outcomes. Methods: Electronic databases, Medline, CINAHL, EMBASE, and PsycINFO, were searched up to the end of March 2023. Studies meeting the inclusion criteria, focusing on interventions to improve psychosocial outcomes, such as depression, anxiety, quality of life, and caregiver burden, in this cohort of caregivers were included. Data were extracted regarding study setting, design, methods, intervention components, and outcomes. Risk of bias and quality assessment were conducted. Results: A total of 5281 articles were screened, ultimately identifying 12 studies for inclusion, reported in 13 publications. A narrative synthesis revealed mixed results. Psychosocial interventions resulted in more significant improvements in psychosocial outcomes than psychoeducational or support interventions, with interventions for carer-patient dyads also reflecting more positive outcomes for caregivers. Evidence-based interventions, guided by an appropriate theoretical model, were reportedly more effective in improving caregiver outcomes. Differences in outcomes were related to intervention development, design, delivery, and outcome assessment. Conclusions: This review, to our knowledge, is the first to explore the effectiveness of interventions in improving psychosocial outcomes for caregivers of those with advanced, non-malignant, chronic conditions. The review highlights the need for more robust, sufficiently powered, high-quality trials of evidence-based interventions for caregivers of people with advanced chronic illness. Optimal intervention duration and frequency of sessions are unclear and need further exploration. [ABSTRACT FROM AUTHOR]
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- 2024
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8. Complicated Barrett's Lesions and Subsequent Endoscopic Eradication Therapy: A Single Centre Irish Experience.
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Lloyd, A., Moran, C., Mcdonald, C., and Murphy, T.
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ENDOSCOPIC surgery , *STATISTICAL association - Abstract
This article, titled "Complicated Barrett's Lesions and Subsequent Endoscopic Eradication Therapy: A Single Centre Irish Experience," discusses the use of endoscopic eradication therapy (EET) for the treatment of complex Barrett's lesions. The study reviewed the outcomes of 63 patients who underwent initial endoscopic mucosal resection (EMR) for visible lesions. The results showed that EMR with subsequent ablation achieved high deep margin clearance rates, leading to complete Barrett's eradication for the majority of patients within 20 months. The study also reported a procedure-related complication rate of 23.8%. [Extracted from the article]
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- 2024
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9. Caregiving style and quality of life in caregivers of patients with cardiovascular disease.
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Stragapede, E., Bouchard, K., Lalande, K., Moran, C., Greenman, P. S., Sztajerowska, K., and Tulloch, H.
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AbstractObjectivesMethodsResultsConclusionsCardiovascular disease (CVD), a leading cause of morbidity and mortality, frequently requires informal caregiving. Spousal caregivers may gain satisfaction while providing care, but there are associated risks, including reduced quality of life (QoL). Caregiving Style (CS; i.e. the ways one responds and is attentive towards their partner’s needs) may help explain why some caregivers experience worse QoL. This study investigated the relationship between CS and QoL among caregivers of patients with a diagnosed cardiac condition.Spousal caregivers recruited from a cardiac rehabilitation program at an academic teaching hospital completed a sociodemographic questionnaire, CS Questionnaire, and QoL Questionnaire for Cardiac Spouses. Multiple regression analyses were conducted, controlling for age, gender, and education.The sample consisted of 170 spousal caregivers (M age = 61.8; 74.3% female). The mean of the physical and social functioning scale was 59.4 (SD 10.3) and emotional scale was 71.5 (SD 14.4). Average scores for proximal, sensitive, controlling, and compulsive styles were 4.95, 4.33, 2.82, and 3.22, respectively. Spouses reporting compulsive caregiving (e.g. overprotection, providing intensive care) indicated poor physical/social (β=-0.42, SE=1.02, −7.19, −3.18,
p <.001), and emotional functioning (β=-0.41, SE = 1.41, −10.15, −4.60,p <.001). Those reporting sensitive caregiving (i.e. understanding patient needs and feelings) indicated better emotional functioning (β=.19, SE = 1.46, .10, 5.85,p =.04). No other CS was significantly associated with QoL.Spousal caregivers engaging in compulsive styles of care may be susceptible to poor QoL, whereas engaging in sensitive styles may promote better QoL. CS may be an important consideration in programming and services designed to support caregivers. [ABSTRACT FROM AUTHOR]- Published
- 2024
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10. IDF23-0169 Comparing fasting glucose and HbA1c when screening older people with or without chronic kidney disease for diabetes.
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Nalbandian, C., Zhou, Z., Curtis, A., Flanagan, Z., Spark, S., Wolfe, R., Kost, A., Gasevic, D., Moran, C., Nelson, M., Reid, C., and Zoungas, S.
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CHRONIC kidney failure , *OLDER people , *GLYCOSYLATED hemoglobin , *MEDICAL screening , *GLUCOSE - Published
- 2024
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