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Your search keyword '"Leenhardt, Julien"' showing total 17 results
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17 results on '"Leenhardt, Julien"'

1. Regional CZT myocardial perfusion reserve for the detection of territories with simultaneously impaired CFR and IMR in patients without obstructive coronary artery disease: a pilot study

Author

Djaïleb, Loïc, De Leiris, Nicolas, Canu, Marjorie, Sy, Olivier Phan, Seiller, Alexandre, Leenhardt, Julien, Charlon, Clémence, Faure, Marine, Caillard, Jessica, Broisat, Alexis, Borel, Anne-Laure, Lablanche, Sandrine, Betry, Cécile, Ghezzi, Catherine, Vanzetto, Gérald, Fagret, Daniel, Riou, Laurent M., and Barone-Rochette, Gilles

Published
2023
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4. Validation of HPLC and TLC analytical methods to determine radiochemical purity of 99mTc-cAbVCAM1-5, a new experimental radiotracer

Author

Mutin, Juliette, primary, Orhon, Pauline, additional, Choisnard, Luc, additional, Lassiaz, Maxime, additional, Bacot, Sandrine, additional, Ahmadi, Mitra, additional, De Leiris, Nicolas, additional, Djaileb, Loic, additional, Broisat, Alexis, additional, Ghezzi, Catherine, additional, Bedouch, Pierrick, additional, Brunet, Marie-Dominique, additional, and Leenhardt, Julien, additional

Published
2024
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5. Comparison of Cadmium Zinc Telluride ECG-gated SPECT equilibrium radionuclide angiocardiography to magnetic resonance imaging to measure right ventricular volumes and ejection fraction in patients with cardiomyopathy

Author

Apert, Antoine, Canu, Marjorie, Jankowski, Adrien, Riou, Laurent, Broisat, Alexis, Charlon, Clemence, Augier, Caroline, Boignard, Aude, Leenhardt, Julien, Salvat, Muriel, Casset, Charlotte, Maurin, Marion, Saunier, Carole, Vanzetto, Gerald, Fagret, Daniel, Ghezzi, Catherine, Djaileb, Loic, and Barone-Rochette, Gilles

Published
2022
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11. Place of magistral preparations to continue the treatment if the drug is commercially stopped worldwide? A case report of a 10-year-old child with subacute sclerosing panencephalitis (SSPE) requiring inosiplex

Author

Le Cras, Renan, primary, Mazet, Roseline, additional, Dubois-Teklali, Fanny, additional, Sabourdy, Cécile, additional, Chanoine, Sébastien, additional, Lehmann, Audrey, additional, Morin, Agathe, additional, Leenhardt, Julien, additional, Durand, Marjorie, additional, Desruet, Marie-Dominique, additional, and Bedouch, Pierrick, additional

Published
2022
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16. Noninvasive assessment of coronary microvascular dysfunction using SPECT myocardial perfusion imaging and myocardial perfusion entropy quantification in a rodent model of type 2 diabetes

Author

Carabelli, Adrien, primary, Canu, Marjorie, additional, de Fondaumière, Marie, additional, Debiossat, Marlène, additional, Leenhardt, Julien, additional, Broisat, Alexis, additional, Ghezzi, Catherine, additional, Vanzetto, Gérald, additional, Fagret, Daniel, additional, Barone-Rochette, Gilles, additional, and Riou, Laurent M., additional

Published
2021
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17. Development and Validation of Analytical Methods for Radiochemical Purity of 177 Lu-PSMA-1.

Author

Orhon, Pauline, Desruet, Marie-Dominique, Piquemal, Marie, De Leiris, Nicolas, Djaileb, Loïc, Vuillez, Jean-Philippe, Bedouch, Pierrick, and Leenhardt, Julien

Subjects
RADIOCHEMICAL purification, HIGH performance liquid chromatography, CASTRATION-resistant prostate cancer, ANDROGEN receptors, NUCLEAR medicine, HORMONE therapy
Abstract

Prostate Specific Membrane Antigen (PSMA) is a highly relevant target in nuclear medicine due to its overexpression in prostate cancer. The 68Ga/177Lu-PSMA-1 combination is a theranostic agent for the detection and treatment of tumors overexpressing the PSMA target. Specifically, 177Lu-PSMA-1 is used in the treatment of castration-resistant prostate cancer that is ineffective or intolerant to the latest generation of chemotherapy and/or hormone therapy. This radiopharmaceutical is manufactured in a radiopharmaceutical synthesizing unit and must pass a quality control where the radiochemical purity (RCP) is assessed prior to release of the batch. RCP evaluation is performed by high-performance liquid chromatography (HPLC) and thin-layer chromatography (TLC). Since there is no monograph for 177Lu-PSMA-1 in the European Pharmacopoeia, we validate the analytical methods according to the EANM recommendations adapted from ICH Q2. Specificity, linearity, accuracy, precision, intermediate precision, limit of quantification (LOQ) and robustness were described for HPLC and TLC in this study. The results obtained demonstrated the robustness and reliability of the HPLC and TLC analytical methods for the evaluation of the RCP of 177Lu-PSMA-1. [ABSTRACT FROM AUTHOR]

Published
2022
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