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2. Annual (2023) taxonomic update of RNA-directed RNA polymerase-encoding negative-sense RNA viruses (realm Riboviria: kingdom Orthornavirae: phylum Negarnaviricota).

Author

Bukreyev, Alexander, Burt, Felicity, Büttner, Carmen, Calisher, Charles, Cao, Mengji, Casas, Inmaculada, Chandran, Kartik, Charrel, Rémi, Kumar Chaturvedi, Krishna, Chooi, Kar, Crane, Anya, Dal Bó, Elena, Carlos de la Torre, Juan, de Souza, William, de Swart, Rik, Debat, Humberto, Dheilly, Nolwenn, Di Paola, Nicholas, Di Serio, Francesco, Dietzgen, Ralf, Digiaro, Michele, Drexler, J, Duprex, W, Dürrwald, Ralf, Easton, Andrew, Elbeaino, Toufic, Ergünay, Koray, Feng, Guozhong, Firth, Andrew, Fooks, Anthony, Formenty, Pierre, Freitas-Astúa, Juliana, Gago-Zachert, Selma, Laura García, María, García-Sastre, Adolfo, Garrison, Aura, Gaskin, Thomas, Gong, Wenjie, Gonzalez, Jean-Paul, de Bellocq, JoëlleGoüy, Griffiths, Anthony, Groschup, Martin, Günther, Ines, Günther, Stephan, Hammond, John, Hasegawa, Yusuke, Hayashi, Kazusa, Hepojoki, Jussi, Higgins, Colleen, Hongō, Seiji, Horie, Masayuki, Hughes, Holly, Hume, Adam, Hyndman, Timothy, Ikeda, Kenichi, Jiāng, Dàohóng, Jonson, Gilda, Junglen, Sandra, Klempa, Boris, Klingström, Jonas, Kondō, Hideki, Koonin, Eugene, Krupovic, Mart, Kubota, Kenji, Kurath, Gael, Laenen, Lies, Lambert, Amy, Lǐ, Jiànróng, Li, Jun-Min, Liu, Ran, Lukashevich, Igor, MacDiarmid, Robin, Maes, Piet, Marklewitz, Marco, Marshall, Sergio, Marzano, Shin-Yi, McCauley, John, Mirazimi, Ali, Mühlberger, Elke, Nabeshima, Tomoyuki, Naidu, Rayapati, Natsuaki, Tomohide, Navarro, Beatriz, Navarro, José, Neriya, Yutaro, Netesov, Sergey, Neumann, Gabriele, Nowotny, Norbert, Nunes, Márcio, Ochoa-Corona, Francisco, Okada, Tomoyuki, Palacios, Gustavo, Pallás, Vicente, Papa, Anna, Paraskevopoulou, Sofia, Parrish, Colin, Pauvolid-Corrêa, Alex, Pawęska, Janusz, Pérez, Daniel, and Pfaff, Florian

Subjects
Aliusviridae, Arenaviridae, Articulavirales, Artoviridae, Aspiviridae, Bornaviridae, Bunyavirales, Crepuscuviridae, Discoviridae, Filoviridae, Fimoviridae, Goujianvirales, Hantaviridae, ICTV, International Committee on Taxonomy of Viruses, Jingchuvirales, Lispiviridae, Mononegavirales, Muvirales, Mymonaviridae, Myriaviridae, Nairoviridae, Natareviridae, Negarnaviricota, Nyamiviridae, Orthomyxoviridae, Orthornavirae, Paramyxoviridae, Peribunyaviridae, Phasmaviridae, Phenuiviridae, Pneumoviridae, Rhabdoviridae, Riboviria, Serpentovirales, Sunviridae, Tenuivirus, Tosoviridae, Tospoviridae, Tulasviridae, articulaviral, bunyaviral, bunyavirus, goujianviral, megaclassification, megataxonomy, mononegaviral, muviral, negarnaviricot, serpentoviral, virus classification, virus nomenclature, virus taxonomy, Negative-Sense RNA Viruses, RNA Viruses, RNA-Dependent RNA Polymerase
Abstract

In April 2023, following the annual International Committee on Taxonomy of Viruses (ICTV) ratification vote on newly proposed taxa, the phylum Negarnaviricota was amended and emended. The phylum was expanded by one new family, 14 new genera, and 140 new species. Two genera and 538 species were renamed. One species was moved, and four were abolished. This article presents the updated taxonomy of Negarnaviricota as now accepted by the ICTV.

Published
2023

3. 2022 taxonomic update of phylum Negarnaviricota (Riboviria: Orthornavirae), including the large orders Bunyavirales and Mononegavirales.

Author

Bukreyev, Alexander, Burt, Felicity, Büttner, Carmen, Calisher, Charles, Candresse, Thierry, Carson, Jeremy, Casas, Inmaculada, Chandran, Kartik, Charrel, Rémi, Chiaki, Yuya, Crane, Anya, Crane, Mark, Dacheux, Laurent, Bó, Elena, de la Torre, Juan, de Lamballerie, Xavier, de Souza, William, de Swart, Rik, Dheilly, Nolwenn, Di Paola, Nicholas, Di Serio, Francesco, Dietzgen, Ralf, Digiaro, Michele, Drexler, J, Duprex, W, Dürrwald, Ralf, Easton, Andrew, Elbeaino, Toufic, Ergünay, Koray, Feng, Guozhong, Feuvrier, Claudette, Firth, Andrew, Fooks, Anthony, Formenty, Pierre, Freitas-Astúa, Juliana, Gago-Zachert, Selma, García, María, García-Sastre, Adolfo, Garrison, Aura, Godwin, Scott, Gonzalez, Jean-Paul, de Bellocq, Joëlle, Griffiths, Anthony, Groschup, Martin, Günther, Stephan, Hammond, John, Hepojoki, Jussi, Hierweger, Melanie, Hongō, Seiji, Horie, Masayuki, Horikawa, Hidenori, Hughes, Holly, Hume, Adam, Hyndman, Timothy, Jiāng, Dàohóng, Jonson, Gilda, Junglen, Sandra, Kadono, Fujio, Karlin, David, Klempa, Boris, Klingström, Jonas, Koch, Michel, Kondō, Hideki, Koonin, Eugene, Krásová, Jarmila, Krupovic, Mart, Kubota, Kenji, Kuzmin, Ivan, Laenen, Lies, Lambert, Amy, Lǐ, Jiànróng, Li, Jun-Min, Lieffrig, François, Lukashevich, Igor, Luo, Dongsheng, Maes, Piet, Marklewitz, Marco, Marshall, Sergio, Marzano, Shin-Yi, McCauley, John, Mirazimi, Ali, Mohr, Peter, Moody, Nick, Morita, Yasuaki, Morrison, Richard, Mühlberger, Elke, Naidu, Rayapati, Natsuaki, Tomohide, Navarro, José, Neriya, Yutaro, Netesov, Sergey, Neumann, Gabriele, Nowotny, Norbert, Ochoa-Corona, Francisco, Palacios, Gustavo, Pallandre, Laurane, Pallás, Vicente, Papa, Anna, Paraskevopoulou, Sofia, and Parrish, Colin

Subjects
Humans, Mononegavirales, Phylogeny, Viruses
Abstract

In March 2022, following the annual International Committee on Taxonomy of Viruses (ICTV) ratification vote on newly proposed taxa, the phylum Negarnaviricota was amended and emended. The phylum was expanded by two new families (bunyaviral Discoviridae and Tulasviridae), 41 new genera, and 98 new species. Three hundred forty-nine species were renamed and/or moved. The accidentally misspelled names of seven species were corrected. This article presents the updated taxonomy of Negarnaviricota as now accepted by the ICTV.

Published
2022

5. 2021 Taxonomic update of phylum Negarnaviricota (Riboviria: Orthornavirae), including the large orders Bunyavirales and Mononegavirales

Author

Kuhn, Jens H, Adkins, Scott, Agwanda, Bernard R, Al Kubrusli, Rim, Alkhovsky, Sergey V, Amarasinghe, Gaya K, Avšič-Županc, Tatjana, Ayllón, María A, Bahl, Justin, Balkema-Buschmann, Anne, Ballinger, Matthew J, Basler, Christopher F, Bavari, Sina, Beer, Martin, Bejerman, Nicolas, Bennett, Andrew J, Bente, Dennis A, Bergeron, Éric, Bird, Brian H, Blair, Carol D, Blasdell, Kim R, Blystad, Dag-Ragnar, Bojko, Jamie, Borth, Wayne B, Bradfute, Steven, Breyta, Rachel, Briese, Thomas, Brown, Paul A, Brown, Judith K, Buchholz, Ursula J, Buchmeier, Michael J, Bukreyev, Alexander, Burt, Felicity, Büttner, Carmen, Calisher, Charles H, Cao, Mengji, Casas, Inmaculada, Chandran, Kartik, Charrel, Rémi N, Cheng, Qi, Chiaki, Yuya, Chiapello, Marco, Choi, Il-Ryong, Ciuffo, Marina, Clegg, J Christopher S, Crozier, Ian, Dal Bó, Elena, de la Torre, Juan Carlos, de Lamballerie, Xavier, de Swart, Rik L, Debat, Humberto, Dheilly, Nolwenn M, Di Cicco, Emiliano, Di Paola, Nicholas, Di Serio, Francesco, Dietzgen, Ralf G, Digiaro, Michele, Dolnik, Olga, Drebot, Michael A, Drexler, J Felix, Dundon, William G, Duprex, W Paul, Dürrwald, Ralf, Dye, John M, Easton, Andrew J, Ebihara, Hideki, Elbeaino, Toufic, Ergünay, Koray, Ferguson, Hugh W, Fooks, Anthony R, Forgia, Marco, Formenty, Pierre BH, Fránová, Jana, Freitas-Astúa, Juliana, Fu, Jingjing, Fürl, Stephanie, Gago-Zachert, Selma, Gāo, George Fú, García, María Laura, García-Sastre, Adolfo, Garrison, Aura R, Gaskin, Thomas, Gonzalez, Jean-Paul J, Griffiths, Anthony, Goldberg, Tony L, Groschup, Martin H, Günther, Stephan, Hall, Roy A, Hammond, John, Han, Tong, Hepojoki, Jussi, Hewson, Roger, Hong, Jiang, Hong, Ni, Hongo, Seiji, Horie, Masayuki, Hu, John S, Hu, Tao, Hughes, Holly R, and Hüttner, Florian

Subjects
Biotechnology, Humans, Mononegavirales, Viruses, Biological Sciences, Agricultural and Veterinary Sciences, Medical and Health Sciences, Virology
Abstract

In March 2021, following the annual International Committee on Taxonomy of Viruses (ICTV) ratification vote on newly proposed taxa, the phylum Negarnaviricota was amended and emended. The phylum was expanded by four families (Aliusviridae, Crepuscuviridae, Myriaviridae, and Natareviridae), three subfamilies (Alpharhabdovirinae, Betarhabdovirinae, and Gammarhabdovirinae), 42 genera, and 200 species. Thirty-nine species were renamed and/or moved and seven species were abolished. This article presents the updated taxonomy of Negarnaviricota as now accepted by the ICTV.

Published
2021

6. Surface Glycan Modification of Cellular Nanosponges to Promote SARS-CoV‑2 Inhibition

Author

Ai, Xiangzhao, Wang, Dan, Honko, Anna, Duan, Yaou, Gavrish, Igor, Fang, Ronnie H, Griffiths, Anthony, Gao, Weiwei, and Zhang, Liangfang

Subjects
Prevention, Lung, Vaccine Related, Bioengineering, Nanotechnology, Biodefense, Infectious Diseases, Pneumonia & Influenza, Emerging Infectious Diseases, Pneumonia, Infection, COVID-19, Heparin, Humans, Nanostructures, Polysaccharides, SARS-CoV-2, COVID-19 Drug Treatment, Chemical Sciences, General Chemistry
Abstract

Cellular binding and entry of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) are mediated by its spike glycoprotein (S protein), which binds with not only the human angiotensin-converting enzyme 2 (ACE2) receptor but also glycosaminoglycans such as heparin. Cell membrane-coated nanoparticles ("cellular nanosponges") mimic the host cells to attract and neutralize SARS-CoV-2 through natural cellular receptors, leading to a broad-spectrum antiviral strategy. Herein, we show that increasing surface heparin density on the cellular nanosponges can promote their inhibition against SARS-CoV-2. Specifically, cellular nanosponges are made with azido-expressing host cell membranes followed by conjugating heparin to the nanosponge surfaces. Cellular nanosponges with a higher heparin density have a larger binding capacity with viral S proteins and a significantly higher inhibition efficacy against SARS-CoV-2 infectivity. Overall, surface glycan engineering of host-mimicking cellular nanosponges is a facile method to enhance SARS-CoV-2 inhibition. This approach can be readily generalized to promote the inhibition of other glycan-dependent viruses.

Published
2021

7. 2022 taxonomic update of phylum Negarnaviricota (Riboviria: Orthornavirae), including the large orders Bunyavirales and Mononegavirales

Author

Kuhn, Jens H., Adkins, Scott, Alkhovsky, Sergey V., Avšič-Županc, Tatjana, Ayllón, María A., Bahl, Justin, Balkema-Buschmann, Anne, Ballinger, Matthew J., Bandte, Martina, Beer, Martin, Bejerman, Nicolas, Bergeron, Éric, Biedenkopf, Nadine, Bigarré, Laurent, Blair, Carol D., Blasdell, Kim R., Bradfute, Steven B., Briese, Thomas, Brown, Paul A., Bruggmann, Rémy, Buchholz, Ursula J., Buchmeier, Michael J., Bukreyev, Alexander, Burt, Felicity, Büttner, Carmen, Calisher, Charles H., Candresse, Thierry, Carson, Jeremy, Casas, Inmaculada, Chandran, Kartik, Charrel, Rémi N., Chiaki, Yuya, Crane, Anya, Crane, Mark, Dacheux, Laurent, Bó, Elena Dal, de la Torre, Juan Carlos, de Lamballerie, Xavier, de Souza, William M., de Swart, Rik L., Dheilly, Nolwenn M., Di Paola, Nicholas, Di Serio, Francesco, Dietzgen, Ralf G., Digiaro, Michele, Drexler, J. Felix, Duprex, W. Paul, Dürrwald, Ralf, Easton, Andrew J., Elbeaino, Toufic, Ergünay, Koray, Feng, Guozhong, Feuvrier, Claudette, Firth, Andrew E., Fooks, Anthony R., Formenty, Pierre B. H., Freitas-Astúa, Juliana, Gago-Zachert, Selma, García, María Laura, García-Sastre, Adolfo, Garrison, Aura R., Godwin, Scott E., Gonzalez, Jean-Paul J., de Bellocq, Joëlle Goüy, Griffiths, Anthony, Groschup, Martin H., Günther, Stephan, Hammond, John, Hepojoki, Jussi, Hierweger, Melanie M., Hongō, Seiji, Horie, Masayuki, Horikawa, Hidenori, Hughes, Holly R., Hume, Adam J., Hyndman, Timothy H., Jiāng, Dàohóng, Jonson, Gilda B., Junglen, Sandra, Kadono, Fujio, Karlin, David G., Klempa, Boris, Klingström, Jonas, Koch, Michel C., Kondō, Hideki, Koonin, Eugene V., Krásová, Jarmila, Krupovic, Mart, Kubota, Kenji, Kuzmin, Ivan V., Laenen, Lies, Lambert, Amy J., Lǐ, Jiànróng, Li, Jun-Min, Lieffrig, François, Lukashevich, Igor S., Luo, Dongsheng, Maes, Piet, Marklewitz, Marco, Marshall, Sergio H., Marzano, Shin-Yi L., McCauley, John W., Mirazimi, Ali, Mohr, Peter G., Moody, Nick J. G., Morita, Yasuaki, Morrison, Richard N., Mühlberger, Elke, Naidu, Rayapati, Natsuaki, Tomohide, Navarro, José A., Neriya, Yutaro, Netesov, Sergey V., Neumann, Gabriele, Nowotny, Norbert, Ochoa-Corona, Francisco M., Palacios, Gustavo, Pallandre, Laurane, Pallás, Vicente, Papa, Anna, Paraskevopoulou, Sofia, Parrish, Colin R., Pauvolid-Corrêa, Alex, Pawęska, Janusz T., Pérez, Daniel R., Pfaff, Florian, Plemper, Richard K., Postler, Thomas S., Pozet, Françoise, Radoshitzky, Sheli R., Ramos-González, Pedro L., Rehanek, Marius, Resende, Renato O., Reyes, Carina A., Romanowski, Víctor, Rubbenstroth, Dennis, Rubino, Luisa, Rumbou, Artemis, Runstadler, Jonathan A., Rupp, Melanie, Sabanadzovic, Sead, Sasaya, Takahide, Schmidt-Posthaus, Heike, Schwemmle, Martin, Seuberlich, Torsten, Sharpe, Stephen R., Shi, Mang, Sironi, Manuela, Smither, Sophie, Song, Jin-Won, Spann, Kirsten M., Spengler, Jessica R., Stenglein, Mark D., Takada, Ayato, Tesh, Robert B., Těšíková, Jana, Thornburg, Natalie J., Tischler, Nicole D., Tomitaka, Yasuhiro, Tomonaga, Keizō, Tordo, Noël, Tsunekawa, Kenta, Turina, Massimo, Tzanetakis, Ioannis E., Vaira, Anna Maria, van den Hoogen, Bernadette, Vanmechelen, Bert, Vasilakis, Nikos, Verbeek, Martin, von Bargen, Susanne, Wada, Jiro, Wahl, Victoria, Walker, Peter J., Whitfield, Anna E., Williams, John V., Wolf, Yuri I., Yamasaki, Junki, Yanagisawa, Hironobu, Ye, Gongyin, Zhang, Yong-Zhen, and Økland, Arnfinn Lodden

Published
2022
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8. Renaming of genera Ebolavirus and Marburgvirus to Orthoebolavirus and Orthomarburgvirus, respectively, and introduction of binomial species names within family Filoviridae

Author

Biedenkopf, Nadine, Bukreyev, Alexander, Chandran, Kartik, Di Paola, Nicholas, Formenty, Pierre B. H., Griffiths, Anthony, Hume, Adam J., Mühlberger, Elke, Netesov, Sergey V., Palacios, Gustavo, Pawęska, Janusz T., Smither, Sophie, Takada, Ayato, Wahl, Victoria, and Kuhn, Jens H.

Published
2023
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10. Design and characterization of protective pan-ebolavirus and pan-filovirus bispecific antibodies

Author

Wirchnianski, Ariel S., primary, Nyakatura, Elisabeth K., additional, Herbert, Andrew S., additional, Kuehne, Ana I., additional, Abbasi, Shawn A., additional, Florez, Catalina, additional, Storm, Nadia, additional, McKay, Lindsay G. A., additional, Dailey, Leandrew, additional, Kuang, Erin, additional, Abelson, Dafna M., additional, Wec, Anna Z., additional, Chakraborti, Srinjoy, additional, Holtsberg, Frederick W., additional, Shulenin, Sergey, additional, Bornholdt, Zachary A., additional, Aman, M. Javad, additional, Honko, Anna N., additional, Griffiths, Anthony, additional, Dye, John M., additional, Chandran, Kartik, additional, and Lai, Jonathan R., additional

Published
2024
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12. IgG-like bispecific antibodies with potent and synergistic neutralization against circulating SARS-CoV-2 variants of concern

Author

Chang, Matthew R., Tomasovic, Luke, Kuzmina, Natalia A., Ronk, Adam J., Byrne, Patrick O., Johnson, Rebecca, Storm, Nadia, Olmedillas, Eduardo, Hou, Yixuan J., Schäfer, Alexandra, Leist, Sarah R., Tse, Longping V., Ke, Hanzhong, Coherd, Christian, Nguyen, Katrina, Kamkaew, Maliwan, Honko, Anna, Zhu, Quan, Alter, Galit, Saphire, Erica Ollmann, McLellan, Jason S., Griffiths, Anthony, Baric, Ralph S., Bukreyev, Alexander, and Marasco, Wayne A.

Published
2022
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13. Correction to: 2021 Taxonomic update of phylum Negarnaviricota (Riboviria: Orthornavirae), including the large orders Bunyavirales and Mononegavirales

Author

Kuhn, Jens H., Adkins, Scott, Agwanda, Bernard R., Al Kubrusli, Rim, Alkhovsky, Sergey V., Amarasinghe, Gaya K., Avšič-Županc, Tatjana, Ayllón, María A., Bahl, Justin, Balkema-Buschmann, Anne, Ballinger, Matthew J., Basler, Christopher F., Bavari, Sina, Beer, Martin, Bejerman, Nicolas, Bennett, Andrew J., Bente, Dennis A., Bergeron, Éric, Bird, Brian H., Blair, Carol D., Blasdell, Kim R., Blystad, Dag-Ragnar, Bojko, Jamie, Borth, Wayne B., Bradfute, Steven, Breyta, Rachel, Briese, Thomas, Brown, Paul A., Brown, Judith K., Buchholz, Ursula J., Buchmeier, Michael J., Bukreyev, Alexander, Burt, Felicity, Büttner, Carmen, Calisher, Charles H., Cao, Mengji, Casas, Inmaculada, Chandran, Kartik, Charrel, Rémi N., Cheng, Qi, Chiaki, Yuya, Chiapello, Marco, Choi, Il-Ryong, Ciuffo, Marina, Clegg, J. Christopher S., Crozier, Ian, Dal Bó, Elena, de la Torre, Juan Carlos, de Lamballerie, Xavier, de Swart, Rik L., Debat, Humberto, Dheilly, Nolwenn M., Di Cicco, Emiliano, Di Paola, Nicholas, Di Serio, Francesco, Dietzgen, Ralf G., Digiaro, Michele, Dolnik, Olga, Drebot, Michael A., Drexler, J. Felix, Dundon, William G., Duprex, W. Paul, Dürrwald, Ralf, Dye, John M., Easton, Andrew J., Ebihara, Hideki, Elbeaino, Toufic, Ergünay, Koray, Ferguson, Hugh W., Fooks, Anthony R., Forgia, Marco, Formenty, Pierre B. H., Fránová, Jana, Freitas-Astúa, Juliana, Fu, Jingjing, Fürl, Stephanie, Gago-Zachert, Selma, Gāo, George Fú, García, María Laura, García-Sastre, Adolfo, Garrison, Aura R., Gaskin, Thomas, Gonzalez, Jean-Paul J., Griffiths, Anthony, Goldberg, Tony L., Groschup, Martin H., Günther, Stephan, Hall, Roy A., Hammond, John, Han, Tong, Hepojoki, Jussi, Hewson, Roger, Hong, Jiang, Hong, Ni, Hongo, Seiji, Horie, Masayuki, Hu, John S., Hu, Tao, Hughes, Holly R., Hüttner, Florian, Hyndman, Timothy H., Ilyas, M., Jalkanen, Risto, Jiāng, Dàohóng, Jonson, Gilda B., Junglen, Sandra, Kadono, Fujio, Kaukinen, Karia H., Kawate, Michael, Klempa, Boris, Klingström, Jonas, Kobinger, Gary, Koloniuk, Igor, Kondō, Hideki, Koonin, Eugene V., Krupovic, Mart, Kubota, Kenji, Kurath, Gael, Laenen, Lies, Lambert, Amy J., Langevin, Stanley L., Lee, Benhur, Lefkowitz, Elliot J., Leroy, Eric M., Li, Shaorong, Li, Longhui, Lǐ, Jiànróng, Liu, Huazhen, Lukashevich, Igor S., Maes, Piet, de Souza, William Marciel, Marklewitz, Marco, Marshall, Sergio H., Marzano, Shin-Yi L., Massart, Sebastien, McCauley, John W., Melzer, Michael, Mielke-Ehret, Nicole, Miller, Kristina M., Ming, Tobi J., Mirazimi, Ali, Mordecai, Gideon J., Mühlbach, Hans-Peter, Mühlberger, Elke, Naidu, Rayapati, Natsuaki, Tomohide, Navarro, José A., Netesov, Sergey V., Neumann, Gabriele, Nowotny, Norbert, Nunes, Márcio R. T., Olmedo-Velarde, Alejandro, Palacios, Gustavo, Pallás, Vicente, Pályi, Bernadett, Papa, Anna, Paraskevopoulou, Sofia, Park, Adam C., Parrish, Colin R., Patterson, David A., Pauvolid-Corrêa, Alex, Pawęska, Janusz T., Payne, Susan, Peracchio, Carlotta, Pérez, Daniel R., Postler, Thomas S., Qi, Liying, Radoshitzky, Sheli R., Resende, Renato O., Reyes, Carina A., Rima, Bertus K., Luna, Gabriel Robles, Romanowski, Víctor, Rota, Paul, Rubbenstroth, Dennis, Rubino, Luisa, Runstadler, Jonathan A., Sabanadzovic, Sead, Sall, Amadou Alpha, Salvato, Maria S., Sang, Rosemary, Sasaya, Takahide, Schulze, Angela D., Schwemmle, Martin, Shi, Mang, Shí, Xiǎohóng, Shí, Zhènglì, Shimomoto, Yoshifumi, Shirako, Yukio, Siddell, Stuart G., Simmonds, Peter, Sironi, Manuela, Smagghe, Guy, Smither, Sophie, Song, Jin-Won, Spann, Kirsten, Spengler, Jessica R., Stenglein, Mark D., Stone, David M., Sugano, Jari, Suttle, Curtis A., Tabata, Amy, Takada, Ayato, Takeuchi, Shigeharu, Tchouassi, David P., Teffer, Amy, Tesh, Robert B., Thornburg, Natalie J., Tomitaka, Yasuhiro, Tomonaga, Keizō, Tordo, Noël, Torto, Baldwyn, Towner, Jonathan S., Tsuda, Shinya, Tu, Changchun, Turina, Massimo, Tzanetakis, Ioannis E., Uchida, Janice, Usugi, Tomio, Vaira, Anna Maria, Vallino, Marta, van den Hoogen, Bernadette, Varsani, Arvind, Vasilakis, Nikos, Verbeek, Martin, von Bargen, Susanne, Wada, Jiro, Wahl, Victoria, Walker, Peter J., Wang, Lin-Fa, Wang, Guoping, Wang, Yanxiang, Wang, Yaqin, Waqas, Muhammad, Wèi, Tàiyún, Wen, Shaohua, Whitfield, Anna E., Williams, John V., Wolf, Yuri I., Wu, Jiangxiang, Xu, Lei, Yanagisawa, Hironobu, Yang, Caixia, Yang, Zuokun, Zerbini, F. Murilo, Zhai, Lifeng, Zhang, Yong-Zhen, Zhang, Song, Zhang, Jinguo, Zhang, Zhe, and Zhou, Xueping

Published
2021
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14. Low-Input, High-Resolution 5′ Terminal Filovirus RNA Sequencing with ViBE-Seq.

Author

Ross, Stephen J., Hume, Adam J., Olejnik, Judith, Turcinovic, Jacquelyn, Honko, Anna N., McKay, Lindsay G. A., Connor, John H., Griffiths, Anthony, Mühlberger, Elke, and Cifuentes, Daniel

Subjects
MARBURG virus, RNA sequencing, EBOLA virus, NUCLEOTIDE sequencing, RNA viruses
Abstract

Although next-generation sequencing (NGS) has been instrumental in determining the genomic sequences of emerging RNA viruses, de novo sequence determination often lacks sufficient coverage of the 5′ and 3′ ends of the viral genomes. Since the genome ends of RNA viruses contain the transcription and genome replication promoters that are essential for viral propagation, a lack of terminal sequence information hinders the efforts to study the replication and transcription mechanisms of emerging and re-emerging viruses. To circumvent this, we have developed a novel method termed ViBE-Seq (Viral Bona Fide End Sequencing) for the high-resolution sequencing of filoviral genome ends using a simple yet robust protocol with high fidelity. This technique allows for sequence determination of the 5′ end of viral RNA genomes and mRNAs with as little as 50 ng of total RNA. Using the Ebola virus and Marburg virus as prototypes for highly pathogenic, re-emerging viruses, we show that ViBE-Seq is a reliable technique for rapid and accurate 5′ end sequencing of filovirus RNA sourced from virions, infected cells, and tissue obtained from infected animals. We also show that ViBE-Seq can be used to determine whether distinct reverse transcriptases have terminal deoxynucleotidyl transferase activity. Overall, ViBE-Seq will facilitate the access to complete sequences of emerging viruses. [ABSTRACT FROM AUTHOR]

Published
2024
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15. ICTV Virus Taxonomy Profile: Filoviridae 2024

Author

Biedenkopf, Nadine, primary, Bukreyev, Alexander, additional, Chandran, Kartik, additional, Di Paola, Nicholas, additional, Formenty, Pierre B. H., additional, Griffiths, Anthony, additional, Hume, Adam J., additional, Mühlberger, Elke, additional, Netesov, Sergey V., additional, Palacios, Gustavo, additional, Pawęska, Janusz T., additional, Smither, Sophie, additional, Takada, Ayato, additional, Wahl, Victoria, additional, and Kuhn, Jens H., additional

Published
2024
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16. Efficient Hydrogen Evolution from Dimethylamine Borane, Ammonia Borane and Sodium Borohydride Catalyzed by Ruthenium and Platinum Nanoparticles Stabilized by an Amine Modified Polymer Immobilized Ionic Liquid: A Comparative Study*

Author

Doherty, Simon, primary, Alharbi, Adhwa A., additional, Wills, Corinne, additional, Dixon, Casey, additional, Arca, Elisabetta, additional, Chamberlain, Thomas W., additional, Griffiths, Anthony, additional, Collins, Sean M., additional, Wu, Kejun, additional, Yan, Han, additional, Bourne, Richard A., additional, and Knight, Julian G., additional

Published
2024
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17. Palladium Nanoparticle Deposition on Spherical Carbon Supports for Heterogeneous Catalysis in Continuous Flow

Author

Boyall, Sarah, primary, Berman, Phoebe, additional, Griffiths, Anthony, additional, Massey, Alexander F., additional, Dixon, Thomas M., additional, Shaw, Thomas, additional, Miller, Joanna, additional, White, Jonathan, additional, Menzel, Robert, additional, Clemens, Graeme, additional, Leslie, Kevin, additional, Muller, Frans L, additional, Bourne, Richard, additional, and Chamberlain, Thomas W., additional

Published
2024
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18. Monovalent SARS-COV-2 mRNA vaccine using optimal UTRs and LNPs is highly immunogenic and broadly protective against Omicron variants

Author

Ye, Zhongfeng, primary, Bonam, Srinivasa Reddy, additional, McKay, Lindsay G. A., additional, Plante, Jessica A., additional, Walker, Jordyn, additional, Zhao, Yu, additional, Huang, Changfeng, additional, Chen, Jinjin, additional, Xu, Chutian, additional, Li, Yamin, additional, Liu, Lihan, additional, Harmon, Joseph, additional, Gao, Shuliang, additional, Song, Donghui, additional, Zhang, Zhibo, additional, Plante, Kenneth S., additional, Griffiths, Anthony, additional, Chen, Jianzhu, additional, Hu, Haitao, additional, and Xu, Qiaobing, additional

Published
2023
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20. Monovalent SARS-COV-2 mRNA vaccine using optimal UTRs and LNPs is highly immunogenic and broadly protective against Omicron variants.

Author

Zhongfeng Ye, Bonam, Srinivasa Reddy, McKay, Lindsay G. A., Plante, Jessica A., Walker, Jordyn, Yu Zhao, Changfeng Huang, Jinjin Chen, Chutian Xu, Yamin Li, Lihan Liu, Harmon, Joseph, Shuliang Gao, Donghui Song, Zhibo Zhang, Plante, Kenneth S., Griffiths, Anthony, Jianzhu Chen, Haitao Hu, and Qiaobing Xu

Subjects
SARS-CoV-2, SARS-CoV-2 Omicron variant, COVID-19 vaccines, HUMORAL immunity
Abstract

The emergence of highly transmissible severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) variants of concern (VOCs) that are resistant to the current COVID-19 vaccines highlights the need for continued development of broadly protective vaccines for the future. Here, we developed two messenger RNA (mRNA)-lipid nanoparticle (LNP) vaccines, TU88mCSA and ALCmCSA, using the ancestral SARS-CoV-2 spike sequence, optimized 5' and 3' untranslated regions (UTRs), and LNP combinations. Our data showed that these nanocomplexes effectively activate CD4+ and CD8+ T cell responses and humoral immune response and provide complete protection against WA1/2020, Omicron BA.1 and BQ.1 infection in hamsters. Critically, in Omicron BQ.1 challenge hamster models, TU88mCSA and ALCmCSA not only induced robust control of virus load in the lungs but also enhanced protective efficacy in the upper respiratory airways. Antigen-specific immune analysis in mice revealed that the observed cross-protection is associated with superior UTRs [Carboxylesterase 1d (Ces1d)/adaptor protein-3β (AP3B1)] and LNP formulations that elicit robust lung tissue-resident memory T cells. Strong protective effects of TU88mCSA or ALCmCSA against both WA1/2020 and VOCs suggest that this mRNA-LNP combination can be a broadly protective vaccine platform in which mRNA cargo uses the ancestral antigen sequence regardless of the antigenic drift. This approach could be rapidly adapted for clinical use and timely deployment of vaccines against emerging and reemerging VOCs. [ABSTRACT FROM AUTHOR]

Published
2023
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21. Annual (2023) taxonomic update of RNA-directed RNA polymerase-encoding negative-sense RNA viruses (realm Riboviria: kingdom Orthornavirae: phylum Negarnaviricota)

Author

Kuhn, Jens H., primary, Abe, Junya, additional, Adkins, Scott, additional, Alkhovsky, Sergey V., additional, Avšič-Županc, Tatjana, additional, Ayllón, María A., additional, Bahl, Justin, additional, Balkema-Buschmann, Anne, additional, Ballinger, Matthew J., additional, Kumar Baranwal, Virendra, additional, Beer, Martin, additional, Bejerman, Nicolas, additional, Bergeron, Éric, additional, Biedenkopf, Nadine, additional, Blair, Carol D., additional, Blasdell, Kim R., additional, Blouin, Arnaud G., additional, Bradfute, Steven B., additional, Briese, Thomas, additional, Brown, Paul A., additional, Buchholz, Ursula J., additional, Buchmeier, Michael J., additional, Bukreyev, Alexander, additional, Burt, Felicity, additional, Büttner, Carmen, additional, Calisher, Charles H., additional, Cao, Mengji, additional, Casas, Inmaculada, additional, Chandran, Kartik, additional, Charrel, Rémi N., additional, Kumar Chaturvedi, Krishna, additional, Chooi, Kar Mun, additional, Crane, Anya, additional, Dal Bó, Elena, additional, Carlos de la Torre, Juan, additional, de Souza, William M., additional, de Swart, Rik L., additional, Debat, Humberto, additional, Dheilly, Nolwenn M., additional, Di Paola, Nicholas, additional, Di Serio, Francesco, additional, Dietzgen, Ralf G., additional, Digiaro, Michele, additional, Drexler, J. Felix, additional, Duprex, W. Paul, additional, Dürrwald, Ralf, additional, Easton, Andrew J., additional, Elbeaino, Toufic, additional, Ergünay, Koray, additional, Feng, Guozhong, additional, Firth, Andrew E., additional, Fooks, Anthony R., additional, Formenty, Pierre B. H., additional, Freitas-Astúa, Juliana, additional, Gago-Zachert, Selma, additional, Laura García, María, additional, García-Sastre, Adolfo, additional, Garrison, Aura R., additional, Gaskin, Thomas R., additional, Gong, Wenjie, additional, Gonzalez, Jean-Paul J., additional, de Bellocq, JoëlleGoüy, additional, Griffiths, Anthony, additional, Groschup, Martin H., additional, Günther, Ines, additional, Günther, Stephan, additional, Hammond, John, additional, Hasegawa, Yusuke, additional, Hayashi, Kazusa, additional, Hepojoki, Jussi, additional, Higgins, Colleen M., additional, Hongō, Seiji, additional, Horie, Masayuki, additional, Hughes, Holly R., additional, Hume, Adam J., additional, Hyndman, Timothy H., additional, Ikeda, Kenichi, additional, Jiāng, Dàohóng, additional, Jonson, Gilda B., additional, Junglen, Sandra, additional, Klempa, Boris, additional, Klingström, Jonas, additional, Kondō, Hideki, additional, Koonin, Eugene V., additional, Krupovic, Mart, additional, Kubota, Kenji, additional, Kurath, Gael, additional, Laenen, Lies, additional, Lambert, Amy J., additional, Lǐ, Jiànróng, additional, Li, Jun-Min, additional, Liu, Ran, additional, Lukashevich, Igor S., additional, MacDiarmid, Robin M., additional, Maes, Piet, additional, Marklewitz, Marco, additional, Marshall, Sergio H., additional, Marzano, Shin-Yi L., additional, McCauley, John W., additional, Mirazimi, Ali, additional, Mühlberger, Elke, additional, Nabeshima, Tomoyuki, additional, Naidu, Rayapati, additional, Natsuaki, Tomohide, additional, Navarro, Beatriz, additional, Navarro, José A., additional, Neriya, Yutaro, additional, Netesov, Sergey V., additional, Neumann, Gabriele, additional, Nowotny, Norbert, additional, Nunes, Márcio R. T., additional, Ochoa-Corona, Francisco M., additional, Okada, Tomoyuki, additional, Palacios, Gustavo, additional, Pallás, Vicente, additional, Papa, Anna, additional, Paraskevopoulou, Sofia, additional, Parrish, Colin R., additional, Pauvolid-Corrêa, Alex, additional, Pawęska, Janusz T., additional, Pérez, Daniel R., additional, Pfaff, Florian, additional, Plemper, Richard K., additional, Postler, Thomas S., additional, Rabbidge, Lee O., additional, Radoshitzky, Sheli R., additional, Ramos-González, Pedro L., additional, Rehanek, Marius, additional, Resende, Renato O., additional, Reyes, Carina A., additional, Rodrigues, Thaís C. S., additional, Romanowski, Víctor, additional, Rubbenstroth, Dennis, additional, Rubino, Luisa, additional, Runstadler, Jonathan A., additional, Sabanadzovic, Sead, additional, Sadiq, Sabrina, additional, Salvato, Maria S., additional, Sasaya, Takahide, additional, Schwemmle, Martin, additional, Sharpe, Stephen R., additional, Shi, Mang, additional, Shimomoto, Yoshifumi, additional, Kavi Sidharthan, Venkidusamy, additional, Sironi, Manuela, additional, Smither, Sophie, additional, Song, Jin-Won, additional, Spann, Kirsten M., additional, Spengler, Jessica R., additional, Stenglein, Mark D., additional, Takada, Ayato, additional, Takeyama, Sawana, additional, Tatara, Akio, additional, Tesh, Robert B., additional, Thornburg, Natalie J., additional, Tian, Xin, additional, Tischler, Nicole D., additional, Tomitaka, Yasuhiro, additional, Tomonaga, Keizō, additional, Tordo, Noël, additional, Tu, Changchun, additional, Turina, Massimo, additional, Tzanetakis, Ioannis E., additional, Maria Vaira, Anna, additional, van den Hoogen, Bernadette, additional, Vanmechelen, Bert, additional, Vasilakis, Nikos, additional, Verbeek, Martin, additional, von Bargen, Susanne, additional, Wada, Jiro, additional, Wahl, Victoria, additional, Walker, Peter J., additional, Waltzek, Thomas B., additional, Whitfield, Anna E., additional, Wolf, Yuri I., additional, Xia, Han, additional, Xylogianni, Evanthia, additional, Yanagisawa, Hironobu, additional, Yano, Kazutaka, additional, Ye, Gongyin, additional, Yuan, Zhiming, additional, Zerbini, F. Murilo, additional, Zhang, Guilin, additional, Zhang, Song, additional, Zhang, Yong-Zhen, additional, Zhao, Lu, additional, and Økland, Arnfinn Lodden, additional

Published
2023
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22. Amino‐Modified Polymer Immobilized Ionic Liquid Stabilized Ruthenium Nanoparticles: Efficient and Selective Catalysts for the Partial and Complete Reduction of Quinolines

Author

Alharbi, Adhwa, primary, Wills, Corinne, additional, Chamberlain, Thomas, additional, Bourne, Richard, additional, Griffiths, Anthony, additional, Collins, Sean, additional, Wu, Kejun, additional, Mueller, Pia, additional, Knight, Julian, additional, and Doherty, Simon, additional

Published
2023
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23. Germline-encoded amino acid–binding motifs drive immunodominant public antibody responses

Author

Shrock, Ellen L., primary, Timms, Richard T., additional, Kula, Tomasz, additional, Mena, Elijah L., additional, West, Anthony P., additional, Guo, Rui, additional, Lee, I-Hsiu, additional, Cohen, Alexander A., additional, McKay, Lindsay G. A., additional, Bi, Caihong, additional, Leng, Yumei, additional, Fujimura, Eric, additional, Horns, Felix, additional, Li, Mamie, additional, Wesemann, Duane R., additional, Griffiths, Anthony, additional, Gewurz, Benjamin E., additional, Bjorkman, Pamela J., additional, and Elledge, Stephen J., additional

Published
2023
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24. A pan-variant mRNA-LNP T cell vaccine protects HLA transgenic mice from mortality after infection with SARS-CoV-2 Beta

Author

Carter, Brandon, primary, Huang, Pinghan, additional, Liu, Ge, additional, Liang, Yuejin, additional, Lin, Paulo J. C., additional, Peng, Bi-Hung, additional, McKay, Lindsay G. A., additional, Dimitrakakis, Alexander, additional, Hsu, Jason, additional, Tat, Vivian, additional, Saenkham-Huntsinger, Panatda, additional, Chen, Jinjin, additional, Kaseke, Clarety, additional, Gaiha, Gaurav D., additional, Xu, Qiaobing, additional, Griffiths, Anthony, additional, Tam, Ying K., additional, Tseng, Chien-Te K., additional, and Gifford, David K., additional

Published
2023
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26. Amine-modified polyionic liquid supports enhance the efficacy of PdNPs for the catalytic hydrogenation of CO2 to formate.

Author

Paterson, Reece, Fahy, Luke E., Arca, Elisabetta, Dixon, Casey, Wills, Corinne Y., Yan, Han, Griffiths, Anthony, Collins, Sean M., Wu, Kejun, Bourne, Richard A., Chamberlain, Thomas W., Knight, Julian G., and Doherty, Simon

Subjects
CATALYTIC hydrogenation, POLYMERIZED ionic liquids, CONDUCTING polymers, IONIC liquids, BENZYLAMINE
Abstract

Palladium nanoparticles stabilised by aniline modified polymer immobilised ionic liquid is a remarkably active catalyst for the hydrogenation of CO2 to formate; the initial TOF of 500 h−1 is markedly higher than either unmodified catalyst or its benzylamine and N,N-dimethylaniline modified counterparts and is among the highest to be reported for a PdNP-based catalyst. [ABSTRACT FROM AUTHOR]

Published
2023
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27. Continuing decline of the common brushtail possum in central Australia.

Author

McDonald, Peter J., Portelli, Dean J., Schubert, Andrew T., Stewart, Alistair J., and Griffiths, Anthony D.

Subjects
GLOBAL warming, BIOLOGICAL extinction, ARID regions, HIGH temperatures, NATIONAL parks & reserves
Abstract

Australia's recent mammal declines have been most severe in the arid regions, with at least 14 species extinctions occurring therein. The common brushtail possum (Trichosurus vulpecula) is a semi-arboreal marsupial that historically occurred widely across arid Australia but has disappeared from much of this region. We surveyed the last known sites for the species in central Australia. In 2012, we detected possum scats from 3 of 19 sites in Tjoritja National Park in the Northern Territory. Presence sites were separated by <4 km and characterised by extreme ruggedness. Further scat surveys in 2016–17, and 10 499 camera-trap nights of targeted survey in 2020–21, resulted in no possum detections. Moreover, no possums were detected during >60 000 camera-trap nights at nearby monitoring sites targeting other species in 2016–22. The contraction of common brushtail possums to rugged refuges by 2012 is consistent with a decline driven by mammalian predators. The possible extirpation also coincided with or followed record years of high temperatures. The culturally significant common brushtail possum is a priority candidate species for reintroduction to parts of central Australia. Reintroduction attempts must manage mammalian predators and consider the suitability of source populations and translocation sites in the face of a rapidly warming climate. We surveyed the last known sites for the common brushtail possum in central Australia. Our data suggest that possums were extirpated from their last refuges in the MacDonnell Ranges after 2012. Any reintroduction attempts must manage mammalian predators and consider the suitability of source populations and translocation sites in the face of a rapidly warming climate. [ABSTRACT FROM AUTHOR]

Published
2023
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28. The variable conversion of neutralizing anti-SARS-CoV-2 single-chain antibodies to IgG provides insight into RBD epitope accessibility

Author

Chang, Matthew R, primary, Ke, Hanzhong, additional, Losada Miguéns, Laura, additional, Coherd, Christian, additional, Nguyen, Katrina, additional, Kamkaew, Maliwan, additional, Johnson, Rebecca, additional, Storm, Nadia, additional, Honko, Anna, additional, Zhu, Quan, additional, Griffiths, Anthony, additional, and Marasco, Wayne A, additional

Published
2023
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29. Amine-modified polyionic liquid supports enhance the efficacy of PdNPs for the catalytic hydrogenation of CO2 to formate

Author

Paterson, Reece, primary, Fahy, Luke E., additional, Arca, Elisabetta, additional, Dixon, Casey, additional, Wills, Corinne Y., additional, Yan, Han, additional, Griffiths, Anthony, additional, Collins, Sean M., additional, Wu, Kejun, additional, Bourne, Richard A., additional, Chamberlain, Thomas W., additional, Knight, Julian G., additional, and Doherty, Simon, additional

Published
2023
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32. Development of a Well-Characterized Cynomolgus Macaque Model of Sudan Virus Disease for Support of Product Development

Author

Alfson, Kendra J., primary, Goez-Gazi, Yenny, additional, Gazi, Michal, additional, Chou, Ying-Liang, additional, Niemuth, Nancy A., additional, Mattix, Marc E., additional, Staples, Hilary, additional, Klaffke, Benjamin, additional, Rodriguez, Gloria F., additional, Escareno, Priscilla, additional, Bartley, Carmen, additional, Ticer, Anysha, additional, Clemmons, Elizabeth A., additional, Dutton III, John W., additional, Griffiths, Anthony, additional, Meister, Gabe T., additional, Sanford, Daniel C., additional, Cirimotich, Chris M., additional, and Carrion, Ricardo, additional

Published
2022
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33. An introduction to the Marburg virus vaccine consortium, MARVAC

Author

Cross, Robert W., primary, Longini, Ira M., additional, Becker, Stephan, additional, Bok, Karin, additional, Boucher, David, additional, Carroll, Miles W., additional, Díaz, Janet V., additional, Dowling, William E., additional, Draghia-Akli, Ruxandra, additional, Duworko, James T., additional, Dye, John M., additional, Egan, Michael A., additional, Fast, Patricia, additional, Finan, Amy, additional, Finch, Courtney, additional, Fleming, Thomas R., additional, Fusco, Joan, additional, Geisbert, Thomas W., additional, Griffiths, Anthony, additional, Günther, Stephan, additional, Hensley, Lisa E., additional, Honko, Anna, additional, Hunegnaw, Ruth, additional, Jakubik, Jocelyn, additional, Ledgerwood, Julie, additional, Luhn, Kerstin, additional, Matassov, Demetrius, additional, Meshulam, Jeffrey, additional, Nelson, Emily V., additional, Parks, Christopher L., additional, Rustomjee, Roxana, additional, Safronetz, David, additional, Schwartz, Lauren M., additional, Smith, Dean, additional, Smock, Paul, additional, Sow, Ydrissa, additional, Spiropoulou, Christina F., additional, Sullivan, Nancy J., additional, Warfield, Kelly L., additional, Wolfe, Daniel, additional, Woolsey, Courtney, additional, Zahn, Roland, additional, Henao-Restrepo, Ana María, additional, Muñoz-Fontela, César, additional, and Marzi, Andrea, additional

Published
2022
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34. A pan-variant mRNA-LNP T cell vaccine protects HLA transgenic mice from mortality after infection with SARS-CoV-2 Beta

Author

Carter, Brandon, primary, Huang, Pinghan, additional, Liu, Ge, additional, Liang, Yuejin, additional, Lin, Paulo J.C., additional, Peng, Bi-Hung, additional, McKay, Lindsay, additional, Dimitrakakis, Alexander, additional, Hsu, Jason, additional, Tat, Vivian, additional, Saenkham-Huntsinger, Panatda, additional, Chen, Jinjin, additional, Kaseke, Clarety, additional, Gaiha, Gaurav D., additional, Xu, Qiaobing, additional, Griffiths, Anthony, additional, Tam, Ying K., additional, Tseng, Chien-Te K., additional, and Gifford, David K., additional

Published
2022
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36. IMM-BCP-01, a patient-derived anti–SARS-CoV-2 antibody cocktail, is active across variants of concern including Omicron BA.1 and BA.2

Author

Nikitin, Pavel A., primary, DiMuzio, Jillian M., additional, Dowling, John P., additional, Patel, Nirja B., additional, Bingaman-Steele, Jamie L., additional, Heimbach, Baron C., additional, Henriquez, Noeleya, additional, Nicolescu, Chris, additional, Polley, Antonio, additional, Sikorski, Eden L., additional, Howanski, Raymond J., additional, Nath, Mitchell, additional, Shukla, Halley, additional, Scheaffer, Suzanne M., additional, Finn, James P., additional, Liang, Li-Fang, additional, Smith, Todd, additional, Storm, Nadia, additional, McKay, Lindsay G. A., additional, Johnson, Rebecca I., additional, Malsick, Lauren E., additional, Honko, Anna N., additional, Griffiths, Anthony, additional, Diamond, Michael S., additional, Sarma, Purnanand, additional, Geising, Dennis H., additional, Morin, Michael J., additional, and Robinson, Matthew K., additional

Published
2022
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37. Development of a Well-Characterized Cynomolgus Macaque Model of Marburg Virus Disease for Support of Vaccine and Therapy Development

Author

Alfson, Kendra J., primary, Goez-Gazi, Yenny, additional, Gazi, Michal, additional, Chou, Ying-Liang, additional, Niemuth, Nancy A., additional, Mattix, Marc E., additional, Staples, Hilary M., additional, Klaffke, Benjamin, additional, Rodriguez, Gloria F., additional, Bartley, Carmen, additional, Ticer, Anysha, additional, Clemmons, Elizabeth A., additional, Dutton, John W., additional, Griffiths, Anthony, additional, Meister, Gabe T., additional, Sanford, Daniel C., additional, Cirimotich, Chris M., additional, and Carrion, Ricardo, additional

Published
2022
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38. Heteroatom modified polymer immobilized ionic liquid stabilized ruthenium nanoparticles: Efficient catalysts for the hydrolytic evolution of hydrogen from sodium borohydride

Author

Paterson, Reece, primary, Alharbi, Adhwa A., additional, Wills, Corinne, additional, Dixon, Casey, additional, Šiller, Lidja, additional, Chamberlain, Thomas W., additional, Griffiths, Anthony, additional, Collins, Sean M., additional, Wu, Kejun, additional, Simmons, Matthew D., additional, Bourne, Richard A., additional, Lovelock, Kevin R.J., additional, Seymour, Jake, additional, Knight, Julian G., additional, and Doherty, Simon, additional

Published
2022
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40. Structural basis for continued antibody evasion by the SARS-CoV-2 receptor binding domain

Author

Nabel, Katherine G., primary, Clark, Sarah A., additional, Shankar, Sundaresh, additional, Pan, Junhua, additional, Clark, Lars E., additional, Yang, Pan, additional, Coscia, Adrian, additional, McKay, Lindsay G. A., additional, Varnum, Haley H., additional, Brusic, Vesna, additional, Tolan, Nicole V., additional, Zhou, Guohai, additional, Desjardins, Michaël, additional, Turbett, Sarah E., additional, Kanjilal, Sanjat, additional, Sherman, Amy C., additional, Dighe, Anand, additional, LaRocque, Regina C., additional, Ryan, Edward T., additional, Tylek, Casey, additional, Cohen-Solal, Joel F., additional, Darcy, Anhdao T., additional, Tavella, Davide, additional, Clabbers, Anca, additional, Fan, Yao, additional, Griffiths, Anthony, additional, Correia, Ivan R., additional, Seagal, Jane, additional, Baden, Lindsey R., additional, Charles, Richelle C., additional, and Abraham, Jonathan, additional

Published
2022
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41. Efficient Hydrolytic Hydrogen Evolution from Sodium Borohydride Catalyzed by Polymer Immobilized Ionic Liquid‐Stabilized Platinum Nanoparticles

Author

Doherty, Simon, primary, Knight, Julian G., additional, Alharbi, Hussam Y., additional, Paterson, Reece, additional, Wills, Corinne, additional, Dixon, Casey, additional, Šiller, Lidija, additional, Chamberlain, Thomas W., additional, Griffiths, Anthony, additional, Collins, Sean M., additional, Wu, Kejun, additional, Simmons, Matthew D., additional, Bourne, Richard A., additional, Lovelock, Kevin R. J., additional, and Seymour, Jake, additional

Published
2022
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42. Heteroatom Modified Polymer Immobilized Ionic Liquid Stabilized Ruthenium Nanoparticles: Efficient Catalysts for the Hydrolytic Evolution of Hydrogen from Sodium Borohydride*

Author

Doherty, Simon, primary, Paterson, Reece, additional, Alharbi, Adhwa A., additional, Wills, Corinne, additional, Dixon, Casey, additional, Šiller, Lidja, additional, Chamberlain, Thomas W., additional, Griffiths, Anthony, additional, Collins, Sean M., additional, Wu, Kejun, additional, Simmons, Matthew D., additional, Bourne, Richard A., additional, Lovelock, Kevin R. J., additional, Seymour, Jake, additional, and Knight, Julian G., additional

Published
2022
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43. Highly Efficient and Selective Reduction of Nitroarenes to N-Arylhydroxylamines Catalysed by Phosphine Oxide-Decorated Polymer Immobilized Ionic Liquid Stabilized Ruthenium Nanoparticles

Author

Paterson, Reece, primary, Alharbi, Hussam, additional, Wills, Corinne, additional, Chamberlain, Thomas W., additional, Bourne, Richard A., additional, Griffiths, Anthony, additional, Collins, Sean M., additional, Wu, Kejun, additional, Simmons, Matthew D., additional, Knight, Julian G., additional, and Doherty, Simon, additional

Published
2022
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44. Preclinical Efficacy of IMM-BCP-01, a Highly Active Patient-Derived Anti-SARS-CoV-2 Antibody Cocktail

Author

Nikitin, Pavel A., primary, DiMuzio, Jillian M., additional, Dowling, John P., additional, Patel, Nirja B., additional, Bingaman-Steele, Jamie L., additional, Heimbach, Baron C., additional, Henriquez, Noeleya, additional, Nicolescu, Chris, additional, Polley, Antonio, additional, Howanski, Raymond J., additional, Nath, Mitchell, additional, Shukla, Halley, additional, Finn, James P., additional, Liang, Li-fang, additional, Smith, Todd, additional, Storm, Nadia, additional, McKay, Lindsay G. A., additional, Johnson, Rebecca I., additional, Malsick, Lauren E., additional, Honko, Anna N., additional, Griffiths, Anthony, additional, Sarma, Purnanand, additional, Geising, Dennis H., additional, Morin, Michael J., additional, and Robinson, Matthew K., additional

Published
2021
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45. A Modular Biomaterial Scaffold‐Based Vaccine Elicits Durable Adaptive Immunity to Subunit SARS‐CoV‐2 Antigens

Author

Langellotto, Fernanda, primary, Dellacherie, Maxence O., additional, Yeager, Chyenne, additional, Ijaz, Hamza, additional, Yu, Jingyou, additional, Cheng, Chi‐An, additional, Dimitrakakis, Nikolaos, additional, Seiler, Benjamin T., additional, Gebre, Makda S., additional, Gilboa, Tal, additional, Johnson, Rebecca, additional, Storm, Nadia, additional, Bardales, Sarai, additional, Graveline, Amanda, additional, White, Des, additional, Tringides, Christina M., additional, Cartwright, Mark J., additional, Doherty, Edward J., additional, Honko, Anna, additional, Griffiths, Anthony, additional, Barouch, Dan H., additional, Walt, David R., additional, and Mooney, David J., additional

Published
2021
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46. An AAV-based, room-temperature-stable, single-dose COVID-19 vaccine provides durable immunogenicity and protection in non-human primates

Author

Zabaleta, Nerea, primary, Dai, Wenlong, additional, Bhatt, Urja, additional, Hérate, Cécile, additional, Maisonnasse, Pauline, additional, Chichester, Jessica A., additional, Sanmiguel, Julio, additional, Estelien, Reynette, additional, Michalson, Kristofer T., additional, Diop, Cheikh, additional, Maciorowski, Dawid, additional, Dereuddre-Bosquet, Nathalie, additional, Cavarelli, Mariangela, additional, Gallouët, Anne-Sophie, additional, Naninck, Thibaut, additional, Kahlaoui, Nidhal, additional, Lemaitre, Julien, additional, Qi, Wenbin, additional, Hudspeth, Elissa, additional, Cucalon, Allison, additional, Dyer, Cecilia D., additional, Pampena, M. Betina, additional, Knox, James J., additional, LaRocque, Regina C., additional, Charles, Richelle C., additional, Li, Dan, additional, Kim, Maya, additional, Sheridan, Abigail, additional, Storm, Nadia, additional, Johnson, Rebecca I., additional, Feldman, Jared, additional, Hauser, Blake M., additional, Contreras, Vanessa, additional, Marlin, Romain, additional, Tsong Fang, Raphaël Ho, additional, Chapon, Catherine, additional, van der Werf, Sylvie, additional, Zinn, Eric, additional, Ryan, Aisling, additional, Kobayashi, Dione T., additional, Chauhan, Ruchi, additional, McGlynn, Marion, additional, Ryan, Edward T., additional, Schmidt, Aaron G., additional, Price, Brian, additional, Honko, Anna, additional, Griffiths, Anthony, additional, Yaghmour, Sam, additional, Hodge, Robert, additional, Betts, Michael R., additional, Freeman, Mason W., additional, Wilson, James M., additional, Le Grand, Roger, additional, and Vandenberghe, Luk H., additional

Published
2021
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50. Characterization of an Anti-Ebola Virus Hyperimmune Globulin Derived From Convalescent Plasma.

Author

Ciencewicki, Jonathan M, Herbert, Andrew S, Storm, Nadia, Josleyn, Nicole M, Huie, Kathleen E, McKay, Lindsay G A, Griffiths, Anthony, Dye, John M, Willis, Todd, and Arora, Vikram

Subjects
CONVALESCENT plasma, EBOLA virus disease, ANTIBODY titer, VIRUS diseases, ENZYME-linked immunosorbent assay, RESEARCH, ANIMAL experimentation, BLOOD plasma, EVALUATION research, EBOLA virus, INTRAVENOUS immunoglobulins, COMPARATIVE studies, RESEARCH funding, VIRAL antibodies, MICE
Abstract

Background: Convalescent plasma has been used to treat many viral diseases including Ebola. The manufacture of a purified anti-Ebola virus (EBOV) intravenous immunoglobulin (IVIG) from pooled convalescent plasma is described in this paper.Methods: An enzyme-linked immunosorbent assay (ELISA) targeting an EBOV surface glycoprotein antigen was used to determine the immunoglobulin titer of pooled plasma and purified anti-EBOV IVIG. Anti-EBOV IVIG was also tested in neutralization assays using a vesicular stomatitis virus pseudovirion expressing EBOV glycoprotein on its surface and with live EBOV. Finally, the efficacy of the anti-EBOV IVIG was assessed in a mouse model of EBOV infection.Results: In the ELISA, the anti-EBOV IVIG was shown to have a 7-fold increase in immunoglobulin G (IgG) titer over pooled convalescent plasma. In both the pseudovirion and live virus assays, the anti-EBOV IVIG showed approximately 5- to 6-fold increased potency over pooled plasma. Anti-EBOV IVIG also significantly improved survivability in mice infected with the virus when administered concurrently or 2 days after infection.Conclusions: These data support this purified anti-EBOV IVIG merits additional investigation and clinical trials for treatment and postexposure prophylaxis of Ebola virus disease. The experience gained can be applied to manufacture hyperimmune globulins against other emerging viruses. [ABSTRACT FROM AUTHOR]

Published
2022
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