1. Emerging roles of oxyntomodulin-based glucagon-like peptide-1/glucagon co-agonist analogs in diabetes and obesity.
- Author
-
Zhihong, Yao, Chen, Wang, Qianqian, Zhu, Lidan, Sun, Qiang, Zhou, Jing, Han, Wenxi, Wang, and Bhawal, Ruchika
- Subjects
- *
PEPTIDE receptors , *TYPE 2 diabetes , *GLUCAGON receptors , *METABOLIC disorders , *GASTRIC emptying , *PEPTIDE hormones , *DIABETES - Abstract
Oxyntomodulin (OXM) is an endogenous peptide hormone secreted from the intestines following nutrient ingestion that activates both glucagon-like peptide-1 (GLP-1) and glucagon receptors. OXM is known to exert various effects, including improvement in glucose tolerance, promotion of energy expenditure, acceleration of liver lipolysis, inhibition of food intake, delay of gastric emptying, neuroprotection, and pain relief. The antidiabetic and antiobesity properties have led to the development of biologically active and enzymatically stable OXM-based analogs with proposed therapeutic promise for metabolic diseases. Structural modification of OXM was ongoing to enhance its potency and prolong half-life, and several GLP-1/glucagon dual receptor agonist-based therapies are being explored in clinical trials for the treatment of type 2 diabetes mellitus and its complications. In the present article, we provide a brief overview of the physiology of OXM, focusing on its structural-activity relationship and ongoing clinical development. [Display omitted] • A brief pharmacological actions summary of oxyntomodulin. • The effect of chemical structure modifications on the half-life and biological activity of oxyntomodulin analogs. • The latest clinical progress of oxyntomodulin analogs. [ABSTRACT FROM AUTHOR]
- Published
- 2023
- Full Text
- View/download PDF