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22 results on '"Zhang, Guisen"'

5. Local auxin biosynthesis regulates brace root angle and lodging resistance in maize

Author

Zheng, Zhigang, primary, Wang, Baobao, additional, Zhuo, Chuyun, additional, Xie, Yurong, additional, Zhang, Xiaoming, additional, Liu, Yanjun, additional, Zhang, Guisen, additional, Ding, Hui, additional, Zhao, Binbin, additional, Tian, Manqing, additional, Xu, Miaoyun, additional, Kong, Dexin, additional, Shen, Rongxin, additional, Liu, Qing, additional, Wu, Guangxia, additional, Huang, Junfei, additional, and Wang, Haiyang, additional

Published
2023
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6. UB2/UB3/TSH4-anchored transcriptional networks regulate early maize inflorescence development in response to simulated shade

Author

Kong, Dexin, primary, Li, Changyu, additional, Xue, Weicong, additional, Wei, Hongbin, additional, Ding, Hui, additional, Hu, Guizhen, additional, Zhang, Xiaoming, additional, Zhang, Guisen, additional, Zou, Ting, additional, Xian, Yuting, additional, Wang, Baobao, additional, Zhao, Yongping, additional, Liu, Yuting, additional, Xie, Yurong, additional, Xu, Miaoyun, additional, Wu, Hong, additional, Liu, Qing, additional, and Wang, Haiyang, additional

Published
2022
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15. Effect of 0.01% Atropine on Accommodation in Myopic Teenagers

Author

Li, Huixia, primary, Zhang, Liying, additional, Tian, Hong, additional, Zhang, Song, additional, Zhang, Xueyan, additional, Zhang, Han, additional, Chen, Yujing, additional, Qi, Wenping, additional, Wu, Xiaoying, additional, Jiang, Hongmei, additional, Yang, Hailong, additional, Yang, Yajun, additional, Liu, Lei, additional, and Zhang, Guisen, additional

Published
2022
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21. Two Novel Palbociclib-Resorcinol and Palbociclib-Orcinol Cocrystals with Enhanced Solubility and Dissolution Rate.

Author

Duan, Chenxin, Liu, Wenwen, Tao, Yunwen, Liang, Feifei, Chen, Yanming, Xiao, Xinyi, Zhang, Guisen, Chen, Yin, and Hao, Chao

Subjects
SOLUBILITY, X-ray powder diffraction, DIFFERENTIAL scanning calorimetry, ACCELERATED life testing, CRYSTALLIZATION, DRUG solubility
Abstract

Palbociclib (PAL) is an effective anti-breast cancer drug, but its use has been partly restricted due to poor bioavailability (resulting from extremely low water solubility) and serious adverse reactions. In this study, two cocrystals of PAL with resorcinol (RES) or orcinol (ORC) were prepared by evaporation crystallization to enhance their solubility. The cocrystals were characterized by single crystal X-ray diffraction, Hirshfeld surface analysis, powder X-ray diffraction, differential scanning calorimetry, thermogravimetric analysis, Fourier transform infrared and scanning electron microscopy. The intrinsic dissolution rates of the PAL cocrystals were determined in three different dissolution media (pH 1.0, pH 4.5 and pH 6.8), and both cocrystals showed improved dissolution rates at pH 1.0 and pH 6.8 in comparison to the parent drug. In addition, the cocrystals increased the solubility of PAL at pH 6.8 by 2–3 times and showed good stabilities in both the accelerated stability testing and stress testing. The PAL-RES cocrystal also exhibited an improved relative bioavailability (1.24 times) than PAL in vivo pharmacokinetics in rats. Moreover, the in vitro cytotoxicity assay of PAL-RES showed an increased IC50 value for normal cells, suggesting a better biosafety profile than PAL. Co-crystallization may represent a promising strategy for improving the physicochemical properties of PAL with better pharmacokinetics. [ABSTRACT FROM AUTHOR]

Published
2022
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22. Evaluating the One-Year Efficacy of Combined Anti-VEGF and Dexamethasone Implant Treatment for Macular Edema in Retinal Vein Occlusions.

Author

Ren F, Gong H, Zhang H, Zhang X, Liu X, Li J, and Zhang G

Subjects
Humans, Intravitreal Injections, Retrospective Studies, Tomography, Optical Coherence, Treatment Outcome, Vascular Endothelial Growth Factors, Visual Acuity, Dexamethasone therapeutic use, Macular Edema drug therapy, Macular Edema etiology, Retinal Vein Occlusion complications, Retinal Vein Occlusion drug therapy
Abstract

BACKGROUND Retinal vein occlusion-induced macular edema (RVO-ME) is a significant global cause of vision loss, with the effectiveness of combined anti-vascular endothelial growth factor (anti-VEGF) drugs and dexamethasone implantation (DEX I) being a relevant, yet not thoroughly explored, area of interest.The aim of this study was to evaluate the 1-year clinical efficacy of combination therapy using anti-vascular endothelial growth factor (VEGF) drugs and dexamethasone implantation (DEX I) in the treatment of macular edema secondary to retinal vein occlusion (RVO-ME). MATERIAL AND METHODS This retrospective study analyzed data from 34 RVO-ME patients treated at the Inner Mongolia Chaoju Eye Hospital between January 2020 and December 2021. All patients underwent initial DEX I treatment, followed by the introduction of anti-VEGF drugs, and were observed for one year. Retinal structural and vascular changes were measured using spectral domain optical coherence tomography (SD-OCT) and OCT angiography (OCTA). The study also evaluated shifts in best corrected visual acuity (BCVA) throughout the observation period. RESULTS Following the combined therapy, patients showed significant improvements in BCVA, intraocular pressure (IOP), central retinal thickness (CRT), and retinal vessel density (VD) (all P<0.05). Upon stratifying the results by RVO type, patients with branch retinal vein occlusion (BRVO)-ME displayed more significant BCVA improvement and CRT reduction at various post-treatment intervals compared to those with central retinal vein occlusion (CRVO)-ME (all P<0.05). CONCLUSIONS The combined use of anti-VEGF drugs and DEX I showed promising one-year efficacy in treating RVO-ME, with greater improvements noted in patients with BRVO-ME compared to those with CRVO-ME. Despite the positive results, close monitoring of IOP elevation, a notable side effect, remains crucial.

Published
2023
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