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139 results on '"Ma, Seong-Kwon"'

10. Circulating osteoprotegerin levels and cardiovascular outcomes in patients with pre-dialysis chronic kidney disease: results from the KNOW-CKD study.

Author

Suh, Sang Heon, Oh, Tae Ryom, Choi, Hong Sang, Kim, Chang Seong, Bae, Eun Hui, Ma, Seong Kwon, Oh, Kook-Hwan, Lee, Kyu-Beck, Jeong, Jong Cheol, Jung, Ji Yong, and Kim, Soo Wan

Subjects
CHRONIC kidney failure, MAJOR adverse cardiovascular events, OSTEOPROTEGERIN, DISEASE risk factors, TREATMENT effectiveness
Abstract

While the relationship between circulating osteoprotegerin (OPG) and cardiovascular events is well-established in the general population, its association with cardiovascular risks in chronic kidney disease (CKD) patients remains less robust. This study hypothesized that elevated circulating OPG levels might be associated with an increased risk of major adverse cardiac events (MACE) in CKD patients, a total of 2,109 patients with CKD stages 1 through pre-dialysis 5 from the KNOW-CKD cohort were categorized into quartiles based on serum OPG levels. The primary outcome of the study was 3-point MACE, defined as a composite of nonfatal myocardial infarction, nonfatal stroke, or cardiac death. The median follow-up duration was 7.9 years. The cumulative incidence of 3-point MACE significantly varied across serum OPG levels in Kaplan–Meier curve analysis (P < 0.001, log-rank test), with the highest incidence observed in the 4th quartile. Cox regression analysis indicated that, relative to the 1st quartile, the risk of 3-point MACE was significantly higher in the 3rd (adjusted hazard ratio 2.901, 95% confidence interval 1.009 to 8.341) and the 4th quartiles (adjusted hazard ratio 4.347, 95% confidence interval 1.410 to 13.395). In conclusion, elevated circulating OPG levels are associated with adverse cardiovascular outcomes in pre-dialysis CKD patients. [ABSTRACT FROM AUTHOR]

Published
2024
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20. Fatal Hypermagnesemia in Patients Taking Magnesium Hydroxide

Author

Jou, Da Hye, primary, Kim, Su In, additional, Choi, In Hong, additional, Song, Su Hyun, additional, Oh, Tae Ryom, additional, Suh, Sang Heon, additional, Choi, Hong Sang, additional, Kim, Chang Seong, additional, Kim, Soo Wan, additional, Bae, Eun Hui, additional, and Ma, Seong Kwon, additional

Published
2023
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26. Effects of Blood Pressure According to Age on End-Stage Renal Disease Development in Patients With Diabetes: A Nationwide Population-Based Cohort Study

Author

Bae, Eun Hui, primary, Lim, Sang Yeob, additional, Kim, Bongseong, additional, Oh, Tae Ryom, additional, Song, Su Hyun, additional, Suh, Sang Heon, additional, Choi, Hong Sang, additional, Yang, Eun Mi, additional, Kim, Chang Seong, additional, Ma, Seong Kwon, additional, Han, Kyung-Do, additional, and Kim, Soo Wan, additional

Published
2022
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30. Association Between Left Ventricular Geometry and Renal Outcomes in Patients With Chronic Kidney Disease: Findings From Korean Cohort Study for Outcomes in Patients With Chronic Kidney Disease Study

Author

Suh, Sang Heon, primary, Oh, Tae Ryom, additional, Choi, Hong Sang, additional, Kim, Chang Seong, additional, Bae, Eun Hui, additional, Oh, Kook-Hwan, additional, Lee, Joongyub, additional, Jung, Ji Yong, additional, Lee, Kyu-Beck, additional, Ma, Seong Kwon, additional, and Kim, Soo Wan, additional

Published
2022
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32. Association between serum osteoprotegerin level and renal prognosis in nondialysis patients with chronic kidney disease in the Korean Cohort Study for Outcomes in Patients with Chronic Kidney Disease (the KNOW-CKD Study)

Author

Oh, Tae Ryom, primary, Myeong, Chana, additional, Song, Su Hyun, additional, Choi, Hong Sang, additional, Suh, Sang Heon, additional, Kim, Chang Seong, additional, Bae, Eun Hui, additional, Chung, Wookyung, additional, Choi, Kyu Hun, additional, Oh, Kook Hwan, additional, Ma, Seong Kwon, additional, and Kim, Soo Wan, additional

Published
2022
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34. Additional file 1 of Inflammation-sensing catalase-mimicking nanozymes alleviate acute kidney injury via reversing local oxidative stress

Author

Choi, Hong Sang, Mathew, Ansuja Pulickal, Uthaman, Saji, Vasukutty, Arathy, Kim, In Jin, Suh, Sang Heon, Kim, Chang Seong, Ma, Seong Kwon, Graham, Sontyana Adonijah, Kim, Soo Wan, Park, In-Kyu, and Bae, Eun Hui

Subjects
endocrine system diseases
Abstract

Additional file 1: Figure S1. (A) Powder sample of prepared dMn3O4 (B) Schematic representation and (C) EDS analysis of dMn3O4. Figure S2. XPS analysis individual peaks in dMn3O4. Figure S3. NMR analysis (A) PTC and (B) PC. Figure S4. Low magnification FE-TEM images of (A) PTC (B) PC-M, PC-M + H2O2, PTC-M and PTC-M + H2O2. Figure S5. EDS elemental mapping of PTC-M. Figure S6. (A) Lyophilized sample of PTC-M (B) TGA analysis. Figure S7. (A) Hydrodynamic diameter and (B) zeta potential of PTC-M and PC-M before and after exposure to H2O2. Figure S8. (A) Hydrodynamic size distribution and (B) zeta potential of empty nanomicelles (PTC and PC) before and after treatment with H2O2. Figure S9. Stability of PTC-M in 10% FBS. Figure S10. Catalase like activity of PTC-M at different concentrations. Figure S11. (A) Disproportionation of H2O2 by PTC-M resulting in bubble formation (B) Dissolved oxygen production by dMn3O4 and PTC-M. Data is shown as mean ± SEM (n = 3 replicates). Statistics were performed by a one-way ANOVA (*P < 0.05, **P < 0.01, *** P < 0.001, and **** P < 0.0001). Figure S12. In vitro cell viability of the empty nanomicelles (PTC, PC) as well as dMn3O4 loaded nanomicelles (PTC-M, PC-M). Figure S13. Cellular uptake and intracellular IR780 release. High magnification images (Scalebar=75µm). Figure S14. (A) Ex-vivo images of organs at different time points post injection form I/R model mice administered with PC-IR780 and IR780 (B) NIRF signal intensity quantification from isolated kidneys of PTC-IR780, PC-IR780 and IR780 administered mice in I/R model at different time points. Figure S15. Ex-vivo images of major organs at different time points post injection form normal C57 mice administered with PTC-IR780. Figure S16. ICP-MS analysis of major organs, feces and urine collected from AKI mice administered with PTC-M at 72 h and 168h. Figure S17. H & E staining of all major organs (liver, lung, spleen, heart, and intestine) collected from the control and PTC-M treated AKI mice (at 72 h), scale bar = 200 μm. Table S1. List of primary and secondary antibodies for immunoblotting. Table S2. List of primer sequences for real-time qPCR. Table S3. List of primary and secondary antibodies for immunohistochemistry.

Published
2022
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38. Association of High Serum Adiponectin Level With Adverse Cardiovascular Outcomes and Progression of Coronary Artery Calcification in Patients With Pre-dialysis Chronic Kidney Disease

Author

Suh, Sang Heon, primary, Oh, Tae Ryom, additional, Choi, Hong Sang, additional, Kim, Chang Seong, additional, Lee, Joongyub, additional, Oh, Yun Kyu, additional, Jung, Ji Yong, additional, Lee, Kyu-Beck, additional, Oh, Kook-Hwan, additional, Ma, Seong Kwon, additional, Bae, Eun Hui, additional, and Kim, Soo Wan, additional

Published
2022
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42. Hypertension as a risk factor for retinal vein occlusion in menopausal women

Author

Oh, Tae Ryom, Han, Kyung-Do, Choi, Hong Sang, Kim, Chang Seong, Bae, Eun Hui, Ma, Seong Kwon, and Kim, Soo Wan

Subjects
Adult, Blood Glucose, Nitrates, hypertension, Alcohol Drinking, Age Factors, Observational Study, Blood Pressure, Comorbidity, Middle Aged, Triazoles, Cigarette Smoking, post-menopause, pre-menopause, Risk Factors, Republic of Korea, Retinal Vein Occlusion, Humans, Female, Menopause, Exercise, Research Article, Retrospective Studies
Abstract

Retinal vein occlusion (RVO) is an important cause of blindness. Hypertension is a well-known risk factor for RVO. Although the prevalence of hypertension increases in women after menopause, the relationship between blood pressure and RVO in women before and after menopause has not been studied in detail. We retrospectively analyzed 2,619,206 patients from the Korean National Health Insurance System database. A Cox proportional hazard regression model was used to evaluate the independent association between blood pressure and the risk of RVO development and identify differences between premenopausal and postmenopausal women. The incidence of RVO was higher among postmenopausal women than in premenopausal women. In the model adjusted for socioeconomic and clinical variables, there was an association between blood pressure and RVO development in premenopausal and postmenopausal women; however, this was stronger than premenopausal women. Both systolic and diastolic blood pressure are associated with an increased risk of RVO, and their effects are more potent in premenopausal women than postmenopausal women. Thus, comprehensive management of hypertension in premenopausal women is essential to reduce the risk of RVO.

Published
2021

45. Persistent Resistant Hypertension Has Worse Renal Outcomes in Chronic Kidney Disease than that Resolved in Two Years: Results from the KNOW-CKD Study

Author

Song, Su-Hyun, primary, Kim, Young-Jin, additional, Choi, Hong-Sang, additional, Kim, Chang-Seong, additional, Bae, Eun-Hui, additional, Ahn, Curie, additional, Oh, Kook-Hwan, additional, Park, Sue-Kyung, additional, Lee, Kyu-Beck, additional, Sung, Suah, additional, Han, Seung-Hyeok, additional, Ma, Seong-Kwon, additional, and Kim, Soo-Wan, additional

Published
2021
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47. Abdominal Aortic Calcification and Cardiovascular Outcomes in Chronic Kidney Disease: Findings from KNOW-CKD Study.

Author

Suh, Sang Heon, Oh, Tae Ryom, Choi, Hong Sang, Kim, Chang Seong, Bae, Eun Hui, Oh, Kook-Hwan, Lee, Joongyub, Oh, Yun Kyu, Jung, Ji Yong, Ma, Seong Kwon, and Kim, Soo Wan

Subjects
CHRONIC kidney failure, CALCIFICATION, AORTA, CHRONICALLY ill
Abstract

To investigate the association between abdominal aortic calcification score (AACS) assessed by plain radiograph of the lateral abdomen and the risk of cardiovascular (CV) events in patients with pre-dialysis chronic kidney disease (CKD), a total of 2090 pre-dialysis CKD patients from the Korean Cohort Study for Outcome in Patients with Chronic Kidney Disease (KNOW-CKD) were categorized by AACS into 0, 1–2, 3–4, 5–6, and ≥7. The primary outcome of the study was the composite CV events, defined as a composite of non-fatal CV events and all-cause death. The risk of composite CV events was significantly higher in the subjects with AACS ≥ 7 (adjusted hazard ratio (HR) 1.888, 95% confidence interval (CI) 1.219 to 2.923), compared to that of the subjects with AACS 0. The risks of fatal and non-fatal CV events (adjusted HR 1.052, 95% CI 1.030 to 1.073) and all-cause death (adjusted HR 1.949, 95% CI 1.073 to 3.539) were also significantly higher in the subjects with AACS ≥ 7. In conclusion, AACS assessed by plain radiograph is independently associated with adverse CV outcomes in patients with pre-dialysis CKD. A simple radiographic examination of the lateral abdomen may help CV risk stratification in this population. [ABSTRACT FROM AUTHOR]

Published
2022
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48. Underweight and Weight Change Increases End-Stage Renal Disease Risk in Patients with Diabetes: A Nationwide Population-Based Cohort Study.

Author

Bae, Eun Hui, Oh, Tae Ryom, Suh, Sang Heon, Yang, Eun Mi, Choi, Hong Sang, Kim, Chang Seong, Ma, Seong Kwon, Kim, Bongseong, Han, Kyung-Do, and Kim, Soo Wan

Abstract

Weight variability has known as a risk factor for cardiovascular events and mortality. However, its effect on end-stage renal disease (ESRD) development remains controversial. We investigated the relationship between weight change and ESRD risk. Overall, 97,029 patients with DM aged >20 years were selected from the Korean National Health Screening Program 2009–2012. Weight change was defined as differences in body weight from the index year to 2 years later. Newly diagnosed ESRD was observed until 2017 end. Over a 5.1-year median follow-up period, ESRD was newly diagnosed in 7932 (4.81%) DM patients. BMI < 18.5 kg/m2 and waist circumferences <85/80 and >100/95 cm were ESRD risk factors. ESRD risk increased with increasing weight change; ≥10% weight loss (hazard ratio [HR], 1.247) followed by ≥10% weight gain (1.247) was associated with a higher HR than ≤5% weight change after adjusting for several confounding factors. The association between weight change and ESRD risk in a subgroup analysis was significantly stronger in patients aged <65 years, without proteinuria, with BMI ≥ 25, with DM duration <5 years, and prescribed less than 3 classes of DM medication. Underweight patients showed higher ESRD risks than overweight patients. Weight loss >10% was associated with the fastest decline in renal function. [ABSTRACT FROM AUTHOR]

Published
2022
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49. Association of Circulating Osteoprotegerin Level with Blood Pressure Variability in Patients with Chronic Kidney Disease.

Author

Suh, Sang Heon, Oh, Tae Ryom, Choi, Hong Sang, Kim, Chang Seong, Oh, Kook-Hwan, Lee, Joongyub, Oh, Yun Kyu, Jung, Ji Yong, Choi, Kyu Hun, Ma, Seong Kwon, Bae, Eun Hui, and Kim, Soo Wan

Subjects
CHRONIC kidney failure, BLOOD pressure, DIASTOLIC blood pressure, OSTEOPROTEGERIN, CHRONICALLY ill
Abstract

Circulating osteoprotegerin (OPG) is a biomarker for cardiovascular complications that are closely related to chronic kidney disease (CKD). To investigate the association between circulating OPG level with long-term visit-to-visit blood pressure variability (BPV) in patients with pre-dialysis CKD, a total of 1855 subjects with CKD from stage 1 to pre-dialysis stage 5 from a prospective cohort were analyzed. Long-term visit-to-visit BPV was determined by average real variability (ARV), standard deviation (SD), and coefficient of variation (CoV) of systolic and diastolic blood pressure (SBP and DBP). ARV of SBP (Adjusted β coefficient 0.143, 95% confidence interval 0.021 to 0.264) was significantly associated with serum OPG level. Although SD and CoV of SBP were not significantly associated with serum OPG level in multivariate linear regression analyses, restricted cubic spline visualized the linear correlation of serum OPG level with all of ARV, SD, and CoV. The association between serum OPG level and DBP variability was not significant. Subgroup analyses revealed that the association of serum OPG with BPV is more prominent in the subjects with Charlson comorbidity index ≤3 and in the subjects without history of diabetes mellitus. In conclusion, circulating OPG level is potentially associated with long-term visit-to-visit BPV in patients with pre-dialysis CKD. [ABSTRACT FROM AUTHOR]

Published
2022
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50. Association of Urinary Potassium Excretion with Blood Pressure Variability and Cardiovascular Outcomes in Patients with Pre-Dialysis Chronic Kidney Disease.

Author

Suh, Sang Heon, Song, Su Hyun, Oh, Tae Ryom, Choi, Hong Sang, Kim, Chang Seong, Bae, Eun Hui, Oh, Kook-Hwan, Lee, Joongyub, Han, Seung Hyeok, Kim, Yeong Hoon, Chae, Dong-Wan, Ma, Seong Kwon, and Kim, Soo Wan

Abstract

Dietary potassium intake is a dilemma in patients with chronic kidney disease (CKD). We investigated the association of urine potassium excretion, a surrogate for dietary potassium intake, with blood pressure variability (BPV) and cardiovascular (CV) outcomes in patients with pre-dialysis CKD. A total of 1860 participants from a cohort of pre-dialysis CKD (KNOW-CKD) patients were divided into the quartiles by spot urine potassium-to-creatinine ratio. The first quartile (26.423 ± 5.731 mmol/gCr) was defined as low urine potassium excretion. Multivariate linear regression analyses revealed an independent association of low urine potassium excretion with high BPV (adjusted β coefficient 1.163, 95% confidence interval 0.424 to 1.901). Cox regression analyses demonstrated that, compared to high urine potassium excretion, low urine potassium excretion is associated with increased risk of CV events (adjusted hazard ratio 2.502, 95% confidence interval 1.162 to 5.387) but not with all-cause mortality. In conclusion, low urine potassium excretion is associated with high BPV and increased risk of CV events in patients with pre-dialysis CKD. The restriction of dietary potassium intake should be individualized in patients with pre-dialysis CKD. [ABSTRACT FROM AUTHOR]

Published
2021
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