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11 results on '"Johnson, Newell W."'

7. The pathogenic interplay between periodontal disease and inflammatory bowel disease

Author

da Silva Figueredo, Carlos Marcelo, Lira-Junior, Ronaldo, Love, Robert M, Johnson, Newell W, Ervolino, Edilson, Martins De Mello Neto, Joao M, da Silva Figueredo, Carlos Marcelo, Lira-Junior, Ronaldo, Love, Robert M, Johnson, Newell W, Ervolino, Edilson, and Martins De Mello Neto, Joao M

Abstract

Aims: The present thesis aimed to study the interplay between periodontal disease and inflammatory bowel disease using a model where both diseases could co-exist in the same animal. Our specific aims were: 1) systematically review (SR) studies that evaluated the immunological traits of patients with both Inflammatory bowel disease (IBD) and periodontal disease; 2) investigate the impact of dextran sulphate sodium (DSS)-induced colitis (DIC) on histopathological and immunological outcomes in the periodontal tissues of Wistar rats; 3) investigate whether ligature-induced periodontitis (LIP) could affect the expression of Th1/Th2-related cytokines in the colon of Wistar rats; and 4) investigate the impact of non-surgical periodontal treatment (NSPT) on the expression of cytokines and chemokines in the intestine and gingival tissues of Wistar rats with DIC and LIP. [...], Thesis (PhD Doctorate), Doctor of Philosophy (PhD), School of Medicine & Dentistry, Griffith Health, Full Text

Published
2023

9. Economic cost of managing patients with oral potentially malignant disorders in Sri Lanka

Author

Amarasinghe, Hemantha, Jayasinghe, Ruwan D., Dharmagunawardene, Dilantha, Attygalla, Manjula, Kumara, Dinesh R., Kularatna, Sanjeewa, Johnson, Newell W., Amarasinghe, Hemantha, Jayasinghe, Ruwan D., Dharmagunawardene, Dilantha, Attygalla, Manjula, Kumara, Dinesh R., Kularatna, Sanjeewa, and Johnson, Newell W.

Abstract

Objectives: Cancer of the oral cavity is the leading malignancy amongst males in Sri Lanka, and eighth amongst women. Almost all malignancies are developed from a clinically visible precursor stage called an oral potentially malignant disorder (OPMD). The objective of this study was to estimate costs of managing patients with OPMD in Sri Lanka for a 12-month period from diagnosis. Methods: A hospital-based costing study was conducted in Sri Lanka in the years 2016-2017. Three selected treatment centres participated. For societal perspectives, healthcare, household and indirect costs were used. Costs to the healthcare system included clinic visits, diagnostic biopsy, consumables and drug costs. Capital costs included apportioned value of land, buildings, equipment and furniture. Household costs consisted of out-of-pocket expenditure and indirect costs of lost income. Results: Sixty-two patients were recruited (39 male and 23 female). The majority had awareness of oral potentially malignant disorders (OPMDs). Total average cost of managing a single patient with an OPMD for 1 year was SLR 19 547 (US$ 140) which includes a health system cost of SLR 7320 (US$ 52) and household cost of SLR 12 227 (US$ 87). Travel loss and income loss were a substantial burden to patients and their families. Conclusions: Managing patients with an OPMD, even with annual monitoring, is less costly than managing patients with oral cancer. Out-of-pocket costs are very high, and these could be reduced by revising the National Management Guidelines to allow care closer to home.

Published
2022

11. Salivary bacterial shifts in oral leukoplakia resemble the dysbiotic oral cancer bacteriome.

Author

Gopinath, Divya, Kunnath Menon, Rohit, Chun Wie, Chong, Banerjee, Moinak, Panda, Swagatika, Mandal, Deviprasad, Behera, Paresh Kumar, Roychoudhury, Susanta, Kheur, Supriya, George Botelho, Michael, and Johnson, Newell W.

Subjects
ORAL leukoplakia, ORAL cancer, PARTIAL least squares regression, DISCRIMINANT analysis, CARCINOMA, LEAST squares
Abstract

Objective: While some oral carcinomas appear to arise de novo, others develop within long-standing conditions of the oral cavity that have malignant potential, now known as oral potentially malignant disorders (OPMDs). The oral bacteriome associated with OPMD has been studied to a lesser extent than that associated with oral cancer. To characterize the association in detail we compared the bacteriome in whole mouth fluid (WMF) in patients with oral leukoplakia, oral cancer and healthy controls. Methods: WMF bacteriome from 20 leukoplakia patients, 31 patients with oral cancer and 23 healthy controls were profiled using the Illumina MiSeq platform. Sequencing reads were processed using DADA2, and taxonomical classification was performed using the phylogenetic placement method. Sparse Partial Least Squares Regression Discriminant Analysis model was used to identify bacterial taxa that best discriminate the studied groups. Results: We found considerable overlap between the WMF bacteriome of leukoplakia and oral cancer while a clearer separation between healthy controls and the former two disorders was observed. Specifically, the separation was attributed to 14 taxa belonging to the genera Megaspheara, unclassified enterobacteria, Prevotella, Porphyromonas, Rothia and Salmonella, Streptococcus, and Fusobacterium. The most discriminative bacterial genera between leukoplakia and oral cancer were Megasphaera, unclassified Enterobacteriae, Salmonella and Prevotella. Conclusion: Oral bacteria may play a role in the early stages of oral carcinogenesis as a dysbiotic bacteriome is associated with oral leukoplakia and this resembles that of oral cancer more than healthy controls. Our findings may have implications for developing oral cancer prevention strategies targeting early microbial drivers of oral carcinogenesis. [ABSTRACT FROM AUTHOR]

Published
2021
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