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9 results on '"Hayashi, Kenji"'

3. Scale-resolving simulations of the CRM high-lift configuration at high angles of attack

Author

Zauner, Markus, Sansica, Andrea, Kojima, Yoimi, Hayashi, Kenji, and Hashimoto, Atsusi

Abstract

Eighth Aerodynamics Prediction Challenge (APC-8) ワークショップ (2022年6月29日. アイーナいわて県民情報交流センター), 盛岡市, 岩手, Eighth Aerodynamics Prediction Challenge workshop (APC-8) (June 29, 2022. Aiina, Iwate Prefectural Information Exchange Center) , Morioka-shi, Iwate, Japan, 注記: 第54回流体力学講演会/第40回航空宇宙数値シミュレーション技術シンポジウム(ANSS)内で開催, 形態: カラー図版あり, Note: Workshop was held in The 54th Fluid Dynamics Conference / The 40th Aerospace Numerical Simulation Symposium, Physical characteristics: Original contains color illustrations, 資料番号: AA2230008002, レポート番号: JAXA-SP-22-003

Published
2022

6. UVSOR Synchrotron Facility Update

Author

Ota, Hiroshi, primary, Salehi, Elham, additional, Fujimoto, Masaki, additional, Hayashi, Kenji, additional, Horigome, Toshio, additional, Iwayama, Hiroshi, additional, Katoh, Masahiro, additional, Kondo, Naonori, additional, Makita, Seiji, additional, Matsui, Fumihiko, additional, Matsuda, Hiroyuki, additional, Mizukawa, Tetsunori, additional, Minakuchi, Aki, additional, Nakamura, Eiken, additional, Nagasaka, Masanari, additional, Okano, Yasuaki, additional, Ohigashi, Takuji, additional, Sakai, Masahiro, additional, Sugita, Kento, additional, Tanaka, Kiyohisa, additional, Taira, Yoshitaka, additional, Teshima, Fumitsuna, additional, Yamazaki, Jun-ichiro, additional, Yano, Takayuki, additional, Yuzawa, Hayato, additional, and Kera, Satoshi, additional

Published
2022
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7. FaSTARを用いた低速・高迎角条件におけるNASA-CRM解析の格子依存性調査

Author

HASHIMOTO, Atsushi, KOJIMA, Yoimi, KANAMORI, Masashi, MATSUZAKI, Tomoaki, NAKAMOTO, Keita, and HAYASHI, Kenji

Abstract

Seventh Aerodynamics Prediction Challenge (APC-7) ワークショップ (2021年6月30日. オンライン開催), Seventh Aerodynamics Prediction Challenge workshop (APC-7) (June 30, 2021. Online meeting), 注記: 第53回流体力学講演会/第39回航空宇宙数値シミュレーション技術シンポジウム(ANSS)オンライン内で開催, 形態: カラー図版あり, Note: Workshop was held in The 53rd Fluid Dynamics Conference / The 39th Aerospace Numerical Simulation Symposium Online, Physical characteristics: Original contains color illustrations, 資料番号: AA2130007003, レポート番号: JAXA-SP-21-002

Published
2021

8. Fasting period after Rybelsus administration influences clinical benefit

Author

Hayashi, Kenji, Bando, Hiroshi, Miki, Kazuya, Yasuoka, Eri, Kamoto, Asami, Yasuoka, Tatsuo, Hayashi, Kenji, Bando, Hiroshi, Miki, Kazuya, Yasuoka, Eri, Kamoto, Asami, and Yasuoka, Tatsuo

Abstract

Glucagon-like peptide 1 receptor agonists (GLP-1 RAs) have been attracted attention for various beneficial effects. Among them, oral semaglutide (Rybelsus) was developed using the absorption enhancer sodium N-(8-[2-hydroxybenzoyl] amino) caprylate (SNAC). The relationship between the bioavailability and post-dose fasting time period was analyzed. The results showed that i) its bioavailability with drinking 50mL and 120mL of water together was almost similar, ii) bioavailability for 240mL intake was about 2/3 of 50-120mL, iii) general availability would be about 1.4% for 50-120ml water, and 0.8% for 240mL of water. Tolerability and safety of Rybelsus showed similar results for healthy subjects, patients with renal and/or hepatic impairment. From mentioned above, Rybelsus has been one of the topic agents with characteristic mechanism of SNAC and clinical benefit of GLP-1RA. It will be expected to be applied widely in actual diabetic practice.

Published
2022

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