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1. Annual (2023) taxonomic update of RNA-directed RNA polymerase-encoding negative-sense RNA viruses (realm Riboviria: kingdom Orthornavirae: phylum Negarnaviricota).

Author

Bukreyev, Alexander, Burt, Felicity, Büttner, Carmen, Calisher, Charles, Cao, Mengji, Casas, Inmaculada, Chandran, Kartik, Charrel, Rémi, Kumar Chaturvedi, Krishna, Chooi, Kar, Crane, Anya, Dal Bó, Elena, Carlos de la Torre, Juan, de Souza, William, de Swart, Rik, Debat, Humberto, Dheilly, Nolwenn, Di Paola, Nicholas, Di Serio, Francesco, Dietzgen, Ralf, Digiaro, Michele, Drexler, J, Duprex, W, Dürrwald, Ralf, Easton, Andrew, Elbeaino, Toufic, Ergünay, Koray, Feng, Guozhong, Firth, Andrew, Fooks, Anthony, Formenty, Pierre, Freitas-Astúa, Juliana, Gago-Zachert, Selma, Laura García, María, García-Sastre, Adolfo, Garrison, Aura, Gaskin, Thomas, Gong, Wenjie, Gonzalez, Jean-Paul, de Bellocq, JoëlleGoüy, Griffiths, Anthony, Groschup, Martin, Günther, Ines, Günther, Stephan, Hammond, John, Hasegawa, Yusuke, Hayashi, Kazusa, Hepojoki, Jussi, Higgins, Colleen, Hongō, Seiji, Horie, Masayuki, Hughes, Holly, Hume, Adam, Hyndman, Timothy, Ikeda, Kenichi, Jiāng, Dàohóng, Jonson, Gilda, Junglen, Sandra, Klempa, Boris, Klingström, Jonas, Kondō, Hideki, Koonin, Eugene, Krupovic, Mart, Kubota, Kenji, Kurath, Gael, Laenen, Lies, Lambert, Amy, Lǐ, Jiànróng, Li, Jun-Min, Liu, Ran, Lukashevich, Igor, MacDiarmid, Robin, Maes, Piet, Marklewitz, Marco, Marshall, Sergio, Marzano, Shin-Yi, McCauley, John, Mirazimi, Ali, Mühlberger, Elke, Nabeshima, Tomoyuki, Naidu, Rayapati, Natsuaki, Tomohide, Navarro, Beatriz, Navarro, José, Neriya, Yutaro, Netesov, Sergey, Neumann, Gabriele, Nowotny, Norbert, Nunes, Márcio, Ochoa-Corona, Francisco, Okada, Tomoyuki, Palacios, Gustavo, Pallás, Vicente, Papa, Anna, Paraskevopoulou, Sofia, Parrish, Colin, Pauvolid-Corrêa, Alex, Pawęska, Janusz, Pérez, Daniel, and Pfaff, Florian

Subjects
Aliusviridae, Arenaviridae, Articulavirales, Artoviridae, Aspiviridae, Bornaviridae, Bunyavirales, Crepuscuviridae, Discoviridae, Filoviridae, Fimoviridae, Goujianvirales, Hantaviridae, ICTV, International Committee on Taxonomy of Viruses, Jingchuvirales, Lispiviridae, Mononegavirales, Muvirales, Mymonaviridae, Myriaviridae, Nairoviridae, Natareviridae, Negarnaviricota, Nyamiviridae, Orthomyxoviridae, Orthornavirae, Paramyxoviridae, Peribunyaviridae, Phasmaviridae, Phenuiviridae, Pneumoviridae, Rhabdoviridae, Riboviria, Serpentovirales, Sunviridae, Tenuivirus, Tosoviridae, Tospoviridae, Tulasviridae, articulaviral, bunyaviral, bunyavirus, goujianviral, megaclassification, megataxonomy, mononegaviral, muviral, negarnaviricot, serpentoviral, virus classification, virus nomenclature, virus taxonomy, Negative-Sense RNA Viruses, RNA Viruses, RNA-Dependent RNA Polymerase
Abstract

In April 2023, following the annual International Committee on Taxonomy of Viruses (ICTV) ratification vote on newly proposed taxa, the phylum Negarnaviricota was amended and emended. The phylum was expanded by one new family, 14 new genera, and 140 new species. Two genera and 538 species were renamed. One species was moved, and four were abolished. This article presents the updated taxonomy of Negarnaviricota as now accepted by the ICTV.

Published
2023

2. 2022 taxonomic update of phylum Negarnaviricota (Riboviria: Orthornavirae), including the large orders Bunyavirales and Mononegavirales.

Author

Bukreyev, Alexander, Burt, Felicity, Büttner, Carmen, Calisher, Charles, Candresse, Thierry, Carson, Jeremy, Casas, Inmaculada, Chandran, Kartik, Charrel, Rémi, Chiaki, Yuya, Crane, Anya, Crane, Mark, Dacheux, Laurent, Bó, Elena, de la Torre, Juan, de Lamballerie, Xavier, de Souza, William, de Swart, Rik, Dheilly, Nolwenn, Di Paola, Nicholas, Di Serio, Francesco, Dietzgen, Ralf, Digiaro, Michele, Drexler, J, Duprex, W, Dürrwald, Ralf, Easton, Andrew, Elbeaino, Toufic, Ergünay, Koray, Feng, Guozhong, Feuvrier, Claudette, Firth, Andrew, Fooks, Anthony, Formenty, Pierre, Freitas-Astúa, Juliana, Gago-Zachert, Selma, García, María, García-Sastre, Adolfo, Garrison, Aura, Godwin, Scott, Gonzalez, Jean-Paul, de Bellocq, Joëlle, Griffiths, Anthony, Groschup, Martin, Günther, Stephan, Hammond, John, Hepojoki, Jussi, Hierweger, Melanie, Hongō, Seiji, Horie, Masayuki, Horikawa, Hidenori, Hughes, Holly, Hume, Adam, Hyndman, Timothy, Jiāng, Dàohóng, Jonson, Gilda, Junglen, Sandra, Kadono, Fujio, Karlin, David, Klempa, Boris, Klingström, Jonas, Koch, Michel, Kondō, Hideki, Koonin, Eugene, Krásová, Jarmila, Krupovic, Mart, Kubota, Kenji, Kuzmin, Ivan, Laenen, Lies, Lambert, Amy, Lǐ, Jiànróng, Li, Jun-Min, Lieffrig, François, Lukashevich, Igor, Luo, Dongsheng, Maes, Piet, Marklewitz, Marco, Marshall, Sergio, Marzano, Shin-Yi, McCauley, John, Mirazimi, Ali, Mohr, Peter, Moody, Nick, Morita, Yasuaki, Morrison, Richard, Mühlberger, Elke, Naidu, Rayapati, Natsuaki, Tomohide, Navarro, José, Neriya, Yutaro, Netesov, Sergey, Neumann, Gabriele, Nowotny, Norbert, Ochoa-Corona, Francisco, Palacios, Gustavo, Pallandre, Laurane, Pallás, Vicente, Papa, Anna, Paraskevopoulou, Sofia, and Parrish, Colin

Subjects
Humans, Mononegavirales, Phylogeny, Viruses
Abstract

In March 2022, following the annual International Committee on Taxonomy of Viruses (ICTV) ratification vote on newly proposed taxa, the phylum Negarnaviricota was amended and emended. The phylum was expanded by two new families (bunyaviral Discoviridae and Tulasviridae), 41 new genera, and 98 new species. Three hundred forty-nine species were renamed and/or moved. The accidentally misspelled names of seven species were corrected. This article presents the updated taxonomy of Negarnaviricota as now accepted by the ICTV.

Published
2022

3. 2021 Taxonomic update of phylum Negarnaviricota (Riboviria: Orthornavirae), including the large orders Bunyavirales and Mononegavirales

Author

Kuhn, Jens H, Adkins, Scott, Agwanda, Bernard R, Al Kubrusli, Rim, Alkhovsky, Sergey V, Amarasinghe, Gaya K, Avšič-Županc, Tatjana, Ayllón, María A, Bahl, Justin, Balkema-Buschmann, Anne, Ballinger, Matthew J, Basler, Christopher F, Bavari, Sina, Beer, Martin, Bejerman, Nicolas, Bennett, Andrew J, Bente, Dennis A, Bergeron, Éric, Bird, Brian H, Blair, Carol D, Blasdell, Kim R, Blystad, Dag-Ragnar, Bojko, Jamie, Borth, Wayne B, Bradfute, Steven, Breyta, Rachel, Briese, Thomas, Brown, Paul A, Brown, Judith K, Buchholz, Ursula J, Buchmeier, Michael J, Bukreyev, Alexander, Burt, Felicity, Büttner, Carmen, Calisher, Charles H, Cao, Mengji, Casas, Inmaculada, Chandran, Kartik, Charrel, Rémi N, Cheng, Qi, Chiaki, Yuya, Chiapello, Marco, Choi, Il-Ryong, Ciuffo, Marina, Clegg, J Christopher S, Crozier, Ian, Dal Bó, Elena, de la Torre, Juan Carlos, de Lamballerie, Xavier, de Swart, Rik L, Debat, Humberto, Dheilly, Nolwenn M, Di Cicco, Emiliano, Di Paola, Nicholas, Di Serio, Francesco, Dietzgen, Ralf G, Digiaro, Michele, Dolnik, Olga, Drebot, Michael A, Drexler, J Felix, Dundon, William G, Duprex, W Paul, Dürrwald, Ralf, Dye, John M, Easton, Andrew J, Ebihara, Hideki, Elbeaino, Toufic, Ergünay, Koray, Ferguson, Hugh W, Fooks, Anthony R, Forgia, Marco, Formenty, Pierre BH, Fránová, Jana, Freitas-Astúa, Juliana, Fu, Jingjing, Fürl, Stephanie, Gago-Zachert, Selma, Gāo, George Fú, García, María Laura, García-Sastre, Adolfo, Garrison, Aura R, Gaskin, Thomas, Gonzalez, Jean-Paul J, Griffiths, Anthony, Goldberg, Tony L, Groschup, Martin H, Günther, Stephan, Hall, Roy A, Hammond, John, Han, Tong, Hepojoki, Jussi, Hewson, Roger, Hong, Jiang, Hong, Ni, Hongo, Seiji, Horie, Masayuki, Hu, John S, Hu, Tao, Hughes, Holly R, and Hüttner, Florian

Subjects
Biotechnology, Humans, Mononegavirales, Viruses, Biological Sciences, Agricultural and Veterinary Sciences, Medical and Health Sciences, Virology
Abstract

In March 2021, following the annual International Committee on Taxonomy of Viruses (ICTV) ratification vote on newly proposed taxa, the phylum Negarnaviricota was amended and emended. The phylum was expanded by four families (Aliusviridae, Crepuscuviridae, Myriaviridae, and Natareviridae), three subfamilies (Alpharhabdovirinae, Betarhabdovirinae, and Gammarhabdovirinae), 42 genera, and 200 species. Thirty-nine species were renamed and/or moved and seven species were abolished. This article presents the updated taxonomy of Negarnaviricota as now accepted by the ICTV.

Published
2021

4. Surface Glycan Modification of Cellular Nanosponges to Promote SARS-CoV‑2 Inhibition

Author

Ai, Xiangzhao, Wang, Dan, Honko, Anna, Duan, Yaou, Gavrish, Igor, Fang, Ronnie H, Griffiths, Anthony, Gao, Weiwei, and Zhang, Liangfang

Subjects
Prevention, Lung, Vaccine Related, Bioengineering, Nanotechnology, Biodefense, Infectious Diseases, Pneumonia & Influenza, Emerging Infectious Diseases, Pneumonia, Infection, COVID-19, Heparin, Humans, Nanostructures, Polysaccharides, SARS-CoV-2, COVID-19 Drug Treatment, Chemical Sciences, General Chemistry
Abstract

Cellular binding and entry of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) are mediated by its spike glycoprotein (S protein), which binds with not only the human angiotensin-converting enzyme 2 (ACE2) receptor but also glycosaminoglycans such as heparin. Cell membrane-coated nanoparticles ("cellular nanosponges") mimic the host cells to attract and neutralize SARS-CoV-2 through natural cellular receptors, leading to a broad-spectrum antiviral strategy. Herein, we show that increasing surface heparin density on the cellular nanosponges can promote their inhibition against SARS-CoV-2. Specifically, cellular nanosponges are made with azido-expressing host cell membranes followed by conjugating heparin to the nanosponge surfaces. Cellular nanosponges with a higher heparin density have a larger binding capacity with viral S proteins and a significantly higher inhibition efficacy against SARS-CoV-2 infectivity. Overall, surface glycan engineering of host-mimicking cellular nanosponges is a facile method to enhance SARS-CoV-2 inhibition. This approach can be readily generalized to promote the inhibition of other glycan-dependent viruses.

Published
2021

6. Design and characterization of protective pan-ebolavirus and pan-filovirus bispecific antibodies

Author

Wirchnianski, Ariel S., primary, Nyakatura, Elisabeth K., additional, Herbert, Andrew S., additional, Kuehne, Ana I., additional, Abbasi, Shawn A., additional, Florez, Catalina, additional, Storm, Nadia, additional, McKay, Lindsay G. A., additional, Dailey, Leandrew, additional, Kuang, Erin, additional, Abelson, Dafna M., additional, Wec, Anna Z., additional, Chakraborti, Srinjoy, additional, Holtsberg, Frederick W., additional, Shulenin, Sergey, additional, Bornholdt, Zachary A., additional, Aman, M. Javad, additional, Honko, Anna N., additional, Griffiths, Anthony, additional, Dye, John M., additional, Chandran, Kartik, additional, and Lai, Jonathan R., additional

Published
2024
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8. IgG-like bispecific antibodies with potent and synergistic neutralization against circulating SARS-CoV-2 variants of concern

Author

Chang, Matthew R., Tomasovic, Luke, Kuzmina, Natalia A., Ronk, Adam J., Byrne, Patrick O., Johnson, Rebecca, Storm, Nadia, Olmedillas, Eduardo, Hou, Yixuan J., Schäfer, Alexandra, Leist, Sarah R., Tse, Longping V., Ke, Hanzhong, Coherd, Christian, Nguyen, Katrina, Kamkaew, Maliwan, Honko, Anna, Zhu, Quan, Alter, Galit, Saphire, Erica Ollmann, McLellan, Jason S., Griffiths, Anthony, Baric, Ralph S., Bukreyev, Alexander, and Marasco, Wayne A.

Published
2022
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9. Low-Input, High-Resolution 5′ Terminal Filovirus RNA Sequencing with ViBE-Seq.

Author

Ross, Stephen J., Hume, Adam J., Olejnik, Judith, Turcinovic, Jacquelyn, Honko, Anna N., McKay, Lindsay G. A., Connor, John H., Griffiths, Anthony, Mühlberger, Elke, and Cifuentes, Daniel

Subjects
MARBURG virus, RNA sequencing, EBOLA virus, NUCLEOTIDE sequencing, RNA viruses
Abstract

Although next-generation sequencing (NGS) has been instrumental in determining the genomic sequences of emerging RNA viruses, de novo sequence determination often lacks sufficient coverage of the 5′ and 3′ ends of the viral genomes. Since the genome ends of RNA viruses contain the transcription and genome replication promoters that are essential for viral propagation, a lack of terminal sequence information hinders the efforts to study the replication and transcription mechanisms of emerging and re-emerging viruses. To circumvent this, we have developed a novel method termed ViBE-Seq (Viral Bona Fide End Sequencing) for the high-resolution sequencing of filoviral genome ends using a simple yet robust protocol with high fidelity. This technique allows for sequence determination of the 5′ end of viral RNA genomes and mRNAs with as little as 50 ng of total RNA. Using the Ebola virus and Marburg virus as prototypes for highly pathogenic, re-emerging viruses, we show that ViBE-Seq is a reliable technique for rapid and accurate 5′ end sequencing of filovirus RNA sourced from virions, infected cells, and tissue obtained from infected animals. We also show that ViBE-Seq can be used to determine whether distinct reverse transcriptases have terminal deoxynucleotidyl transferase activity. Overall, ViBE-Seq will facilitate the access to complete sequences of emerging viruses. [ABSTRACT FROM AUTHOR]

Published
2024
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10. Monovalent SARS-COV-2 mRNA vaccine using optimal UTRs and LNPs is highly immunogenic and broadly protective against Omicron variants

Author

Ye, Zhongfeng, primary, Bonam, Srinivasa Reddy, additional, McKay, Lindsay G. A., additional, Plante, Jessica A., additional, Walker, Jordyn, additional, Zhao, Yu, additional, Huang, Changfeng, additional, Chen, Jinjin, additional, Xu, Chutian, additional, Li, Yamin, additional, Liu, Lihan, additional, Harmon, Joseph, additional, Gao, Shuliang, additional, Song, Donghui, additional, Zhang, Zhibo, additional, Plante, Kenneth S., additional, Griffiths, Anthony, additional, Chen, Jianzhu, additional, Hu, Haitao, additional, and Xu, Qiaobing, additional

Published
2023
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11. Monovalent SARS-COV-2 mRNA vaccine using optimal UTRs and LNPs is highly immunogenic and broadly protective against Omicron variants.

Author

Zhongfeng Ye, Bonam, Srinivasa Reddy, McKay, Lindsay G. A., Plante, Jessica A., Walker, Jordyn, Yu Zhao, Changfeng Huang, Jinjin Chen, Chutian Xu, Yamin Li, Lihan Liu, Harmon, Joseph, Shuliang Gao, Donghui Song, Zhibo Zhang, Plante, Kenneth S., Griffiths, Anthony, Jianzhu Chen, Haitao Hu, and Qiaobing Xu

Subjects
SARS-CoV-2, SARS-CoV-2 Omicron variant, COVID-19 vaccines, HUMORAL immunity
Abstract

The emergence of highly transmissible severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) variants of concern (VOCs) that are resistant to the current COVID-19 vaccines highlights the need for continued development of broadly protective vaccines for the future. Here, we developed two messenger RNA (mRNA)-lipid nanoparticle (LNP) vaccines, TU88mCSA and ALCmCSA, using the ancestral SARS-CoV-2 spike sequence, optimized 5' and 3' untranslated regions (UTRs), and LNP combinations. Our data showed that these nanocomplexes effectively activate CD4+ and CD8+ T cell responses and humoral immune response and provide complete protection against WA1/2020, Omicron BA.1 and BQ.1 infection in hamsters. Critically, in Omicron BQ.1 challenge hamster models, TU88mCSA and ALCmCSA not only induced robust control of virus load in the lungs but also enhanced protective efficacy in the upper respiratory airways. Antigen-specific immune analysis in mice revealed that the observed cross-protection is associated with superior UTRs [Carboxylesterase 1d (Ces1d)/adaptor protein-3β (AP3B1)] and LNP formulations that elicit robust lung tissue-resident memory T cells. Strong protective effects of TU88mCSA or ALCmCSA against both WA1/2020 and VOCs suggest that this mRNA-LNP combination can be a broadly protective vaccine platform in which mRNA cargo uses the ancestral antigen sequence regardless of the antigenic drift. This approach could be rapidly adapted for clinical use and timely deployment of vaccines against emerging and reemerging VOCs. [ABSTRACT FROM AUTHOR]

Published
2023
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12. A pan-variant mRNA-LNP T cell vaccine protects HLA transgenic mice from mortality after infection with SARS-CoV-2 Beta

Author

Carter, Brandon, primary, Huang, Pinghan, additional, Liu, Ge, additional, Liang, Yuejin, additional, Lin, Paulo J. C., additional, Peng, Bi-Hung, additional, McKay, Lindsay G. A., additional, Dimitrakakis, Alexander, additional, Hsu, Jason, additional, Tat, Vivian, additional, Saenkham-Huntsinger, Panatda, additional, Chen, Jinjin, additional, Kaseke, Clarety, additional, Gaiha, Gaurav D., additional, Xu, Qiaobing, additional, Griffiths, Anthony, additional, Tam, Ying K., additional, Tseng, Chien-Te K., additional, and Gifford, David K., additional

Published
2023
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13. Germline-encoded amino acid–binding motifs drive immunodominant public antibody responses

Author

Shrock, Ellen L., Timms, Richard T., Kula, Tomasz, Mena, Elijah L., West, Anthony P., Jr., Guo, Rui, Lee, I-Hsiu, Cohen, Alexander A., McKay, Lindsay G. A., Bi, Caihong, Rawat, Keerti, Leng, Yumei, Fujimura, Eric, Horns, Felix, Li, Mamie, Wesemann, Duane R., Griffiths, Anthony, Gewurz, Benjamin E., Bjorkman, Pamela J., and Elledge, Stephen J.

Subjects
Multidisciplinary
Abstract

INTRODUCTION. Antibodies are generated by a DNA recombination mechanism occurring in the immunoglobulin heavy and light chain genes in which modular VDJ (for heavy) and VJ (for light) gene segments are combinatorially assembled. The vast complexity of the antibody repertoire allows many species to generate antibodies against virtually any protein. However, when different individuals are exposed to a given pathogen they often mount antibody responses to the same precise protein regions—or epitopes—from the pathogen. The mechanisms underlying these recurrent antibody responses to immunodominant “public epitopes” are not well understood. RATIONALE. We set out to identify a collection of immunodominant public epitopes that would allow us to study mechanisms underlying recurrent antibody responses. We employed VirScan—a phage display platform programmed to display peptides covering the entire human virome—to identify the epitopes of antiviral antibodies from a large cohort of individuals in a high-throughput manner. Additionally, we isolated B cell receptors from different individuals that bound to model public epitopes in order to investigate their determinants of specificity. Finally, we performed a systematic analysis of antibody–antigen structures from the Protein Data Bank (PDB) to search for recurrent modes of antigen recognition. RESULTS. We mapped 376 immunodominant public epitopes from 51 viral species to single-amino-acid resolution. Antibodies from different individuals that recognized the same public epitope often (i) shared light chain isotype (kappa or lambda) and (ii) bound the same precise critical residues in the epitope. Public epitopes showed biased amino acid composition, including a striking enrichment of lysine at the borders of public epitopes recognized by antibodies with lambda light chains. We examined 50 B cell receptors recognizing three model public epitopes in detail and observed conserved V gene segment usage but almost no conservation of heavy chain CDR3 sequences, indicating that key specificity determinants lay within the V gene segments themselves. Structural analysis of antibody–antigen complexes in the PDB uncovered 18 human V gene segments that harbor germline-encoded amino acid–binding (GRAB) motifs that specifically bind to particular amino acids. Among these were a family of six closely related lambda V gene segments with similar GRAB motifs specific for border lysines. We confirmed that the GRAB motifs we identified were critical for antibody recognition of two model public epitopes. Analysis of murine antibody–antigen structures revealed 21 V gene segment–encoded GRAB motifs that only partially overlapped with the human GRAB motifs, which may explain why there is little overlap between the public epitopes recognized across species. Thus, there appears to be a structural basis underlying the notable convergence in humoral immune responses to immunodominant public epitopes across humans and the differing public epitope selection across species. CONCLUSION. Recurrent antibody responses to immunodominant public epitopes are a general feature of humoral immunity. We propose that they are driven by GRAB motifs, a germline-encoded component of the architecture of the antibody repertoire that predisposes antibodies to recognize particular structures and thus influences epitope selection and composition. Public epitopes likely arise in part because they are best aligned for recognition by GRAB motifs and can thus be bound by a relatively large precursor pool of B cells. GRAB motifs may have evolved to ensure efficient antibody responses to pathogens; the recurrent responses they engender across populations likely exert selective pressure on pathogens and influence host–pathogen coevolution.

Published
2023

14. The variable conversion of neutralizing anti-SARS-CoV-2 single-chain antibodies to IgG provides insight into RBD epitope accessibility

Author

Chang, Matthew R, primary, Ke, Hanzhong, additional, Losada Miguéns, Laura, additional, Coherd, Christian, additional, Nguyen, Katrina, additional, Kamkaew, Maliwan, additional, Johnson, Rebecca, additional, Storm, Nadia, additional, Honko, Anna, additional, Zhu, Quan, additional, Griffiths, Anthony, additional, and Marasco, Wayne A, additional

Published
2023
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17. Development of a Well-Characterized Cynomolgus Macaque Model of Sudan Virus Disease for Support of Product Development

Author

Alfson, Kendra J., primary, Goez-Gazi, Yenny, additional, Gazi, Michal, additional, Chou, Ying-Liang, additional, Niemuth, Nancy A., additional, Mattix, Marc E., additional, Staples, Hilary, additional, Klaffke, Benjamin, additional, Rodriguez, Gloria F., additional, Escareno, Priscilla, additional, Bartley, Carmen, additional, Ticer, Anysha, additional, Clemmons, Elizabeth A., additional, Dutton III, John W., additional, Griffiths, Anthony, additional, Meister, Gabe T., additional, Sanford, Daniel C., additional, Cirimotich, Chris M., additional, and Carrion, Ricardo, additional

Published
2022
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18. An introduction to the Marburg virus vaccine consortium, MARVAC

Author

Cross, Robert W., primary, Longini, Ira M., additional, Becker, Stephan, additional, Bok, Karin, additional, Boucher, David, additional, Carroll, Miles W., additional, Díaz, Janet V., additional, Dowling, William E., additional, Draghia-Akli, Ruxandra, additional, Duworko, James T., additional, Dye, John M., additional, Egan, Michael A., additional, Fast, Patricia, additional, Finan, Amy, additional, Finch, Courtney, additional, Fleming, Thomas R., additional, Fusco, Joan, additional, Geisbert, Thomas W., additional, Griffiths, Anthony, additional, Günther, Stephan, additional, Hensley, Lisa E., additional, Honko, Anna, additional, Hunegnaw, Ruth, additional, Jakubik, Jocelyn, additional, Ledgerwood, Julie, additional, Luhn, Kerstin, additional, Matassov, Demetrius, additional, Meshulam, Jeffrey, additional, Nelson, Emily V., additional, Parks, Christopher L., additional, Rustomjee, Roxana, additional, Safronetz, David, additional, Schwartz, Lauren M., additional, Smith, Dean, additional, Smock, Paul, additional, Sow, Ydrissa, additional, Spiropoulou, Christina F., additional, Sullivan, Nancy J., additional, Warfield, Kelly L., additional, Wolfe, Daniel, additional, Woolsey, Courtney, additional, Zahn, Roland, additional, Henao-Restrepo, Ana María, additional, Muñoz-Fontela, César, additional, and Marzi, Andrea, additional

Published
2022
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20. Development of a Well-Characterized Cynomolgus Macaque Model of Marburg Virus Disease for Support of Vaccine and Therapy Development

Author

Alfson, Kendra J., primary, Goez-Gazi, Yenny, additional, Gazi, Michal, additional, Chou, Ying-Liang, additional, Niemuth, Nancy A., additional, Mattix, Marc E., additional, Staples, Hilary M., additional, Klaffke, Benjamin, additional, Rodriguez, Gloria F., additional, Bartley, Carmen, additional, Ticer, Anysha, additional, Clemmons, Elizabeth A., additional, Dutton, John W., additional, Griffiths, Anthony, additional, Meister, Gabe T., additional, Sanford, Daniel C., additional, Cirimotich, Chris M., additional, and Carrion, Ricardo, additional

Published
2022
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21. An AAV-based, room-temperature-stable, single-dose COVID-19 vaccine provides durable immunogenicity and protection in non-human primates

Author

Zabaleta, Nerea, primary, Dai, Wenlong, additional, Bhatt, Urja, additional, Hérate, Cécile, additional, Maisonnasse, Pauline, additional, Chichester, Jessica A., additional, Sanmiguel, Julio, additional, Estelien, Reynette, additional, Michalson, Kristofer T., additional, Diop, Cheikh, additional, Maciorowski, Dawid, additional, Dereuddre-Bosquet, Nathalie, additional, Cavarelli, Mariangela, additional, Gallouët, Anne-Sophie, additional, Naninck, Thibaut, additional, Kahlaoui, Nidhal, additional, Lemaitre, Julien, additional, Qi, Wenbin, additional, Hudspeth, Elissa, additional, Cucalon, Allison, additional, Dyer, Cecilia D., additional, Pampena, M. Betina, additional, Knox, James J., additional, LaRocque, Regina C., additional, Charles, Richelle C., additional, Li, Dan, additional, Kim, Maya, additional, Sheridan, Abigail, additional, Storm, Nadia, additional, Johnson, Rebecca I., additional, Feldman, Jared, additional, Hauser, Blake M., additional, Contreras, Vanessa, additional, Marlin, Romain, additional, Tsong Fang, Raphaël Ho, additional, Chapon, Catherine, additional, van der Werf, Sylvie, additional, Zinn, Eric, additional, Ryan, Aisling, additional, Kobayashi, Dione T., additional, Chauhan, Ruchi, additional, McGlynn, Marion, additional, Ryan, Edward T., additional, Schmidt, Aaron G., additional, Price, Brian, additional, Honko, Anna, additional, Griffiths, Anthony, additional, Yaghmour, Sam, additional, Hodge, Robert, additional, Betts, Michael R., additional, Freeman, Mason W., additional, Wilson, James M., additional, Le Grand, Roger, additional, and Vandenberghe, Luk H., additional

Published
2021
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