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Your search keyword '"Bezuglov, Vladimir"' showing total 6 results
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6 results on '"Bezuglov, Vladimir"'

1. The Interaction of the Endocannabinoid Anandamide and Paracannabinoid Lysophosphatidylinositol during Cell Death Induction in Human Breast Cancer Cells

Author

Akimov, Mikhail G., primary, Gretskaya, Natalia M., additional, Gorbacheva, Evgenia I., additional, Khadour, Nisreen, additional, Chernavskaya, Valeria S., additional, Sherstyanykh, Galina D., additional, Kovaleko, Tatiana F., additional, Fomina-Ageeva, Elena V., additional, and Bezuglov, Vladimir V., additional

Published
2024
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2. Multicomponent Lipid Nanoparticles for RNA Transfection

Author

Gretskaya, Nataliya, primary, Akimov, Mikhail, additional, Andreev, Dmitry, additional, Zalygin, Anton, additional, Belitskaya, Ekaterina, additional, Zinchenko, Galina, additional, Fomina-Ageeva, Elena, additional, Mikhalyov, Ilya, additional, Vodovozova, Elena, additional, and Bezuglov, Vladimir, additional

Published
2023
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5. Influence of N-Arachidonoyl Dopamine and N-Docosahexaenoyl Dopamine on the Expression of Neurotrophic Factors in Neuronal Differentiated Cultures of Human Induced Pluripotent Stem Cells under Conditions of Oxidative Stress

Author

Novosadova, Ekaterina, primary, Dolotov, Oleg, additional, Inozemtseva, Ludmila, additional, Novosadova, Ludmila, additional, Antonov, Stanislav, additional, Shimchenko, Darya, additional, Bezuglov, Vladimir, additional, Vetchinova, Anna, additional, Tarantul, Vyacheslav, additional, Grivennikov, Igor, additional, and Illarioshkin, Sergey, additional

Published
2022
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6. N -Acyl Dopamines Induce Apoptosis in Endometrial Stromal Cells from Patients with Endometriosis.

Author

Gamisonia, Alina M., Yushina, Marina N., Fedorova-Gogolina, Irina A., Akimov, Mikhail G., Eldarov, Chupalav M., Pavlovich, Stanislav V., Bezuglov, Vladimir V., Gretskaya, Natalia M., Sukhikh, Gennady T., and Bobrov, Mikhail Yu.

Subjects
ENDOMETRIOSIS, STROMAL cells, MITOCHONDRIAL membranes, MEMBRANE potential, REACTIVE oxygen species, NITRIC-oxide synthases
Abstract

Endometriosis is characterized by the formation and development of endometrial tissues outside the uterus, based on an imbalance between proliferation and cell death, leading to the uncontrolled growth of ectopic foci. The potential target for the regulation of these processes is the endocannabinoid system, which was found to be involved in the migration, proliferation, and survival of tumor cells. In this paper, we investigated the effect of endocannabinoid-like compounds from the N-acyl dopamine (NADA) family on the viability of stromal cells from ectopic and eutopic endometrium of patients with ovarian endometriosis. N-arachidonoyldopamine, N-docosahexaenoyldopamine, and N-oleoyldopamine have been shown to have a five-times-more-selective cytotoxic effect on endometrioid stromal cells. To study the mechanisms of the toxic effect, inhibitory analysis, measurements of caspase-3/9 activity, reactive oxygen species, and the mitochondrial membrane potential were performed. It was found that NADA induced apoptosis via an intrinsic pathway through the CB1 receptor and downstream serine palmitoyltransferase, NO synthase activation, increased ROS production, and mitochondrial dysfunction. The higher selectivity of NADA for endometriotic stromal cells and the current lack of effective drug treatment can be considered positive factors for further research of these compounds as possible therapeutic agents against endometriosis. [ABSTRACT FROM AUTHOR]

Published
2021
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