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Introduction: Multi-channel electrophysiology systems for recording of neuronal activity face significant data throughput limitations, hampering real-time, data-informed experiments. These limitations impact both experimental neurobiology research and next-generation neuroprosthetics., Methods: We present a novel solution that leverages the high integration density of 22nm fully-depleted silicon-on-insulator technology to address these challenges. The proposed highly integrated programmable System-on-Chip (SoC) comprises 68-channel 0.41 μW/Ch recording frontends, spike detectors, 16-channel 0.87-4.39 μW/Ch action potentials and 8-channel 0.32 μW/Ch local field potential codecs, as well as a multiply-accumulate-assisted power-efficient processor operating at 25 MHz (5.19 μW/MHz). The system supports on-chip training processes for compression, training, and inference for neural spike sorting. The spike sorting achieves an average accuracy of 91.48 or 94.12% depending on the utilized features. The proposed programmable SoC is optimized for reduced area (9 mm 2 ) and power. On-chip processing and compression capabilities free up the data bottlenecks in data transmission (up to 91% space saving ratio), and moreover enable a fully autonomous yet flexible processor-driven operation., Discussion: Combined, these design considerations overcome data-bottlenecks by allowing on-chip feature extraction and subsequent compression., Competing Interests: The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest., (Copyright © 2024 Guo, Weiße, Zeinolabedin, Schüffny, Stolba, Ma, Wang, Scholze, Dixius, Berthel, Partzsch, Walter, Ellguth, Höppner, George and Mayr.)

Cardiovascular diseases have been the leading cause of global mortality and disability. In addition to traditional drug and surgical treatment, more and more studies investigate tissue engineering therapeutic strategies in cardiovascular medicine. Collagen interweaves in the form of trimeric chains to form the physiological network framework of the extracellular matrix of cardiac and vascular cells, possessing excellent biological properties (such as low immunogenicity and good biocompatibility) and adjustable mechanical properties, which renders it a vital tissue engineering biomaterial for the treatment of cardiovascular diseases. In recent years, promising advances have been made in the application of collagen materials in blood vessel prostheses, injectable cardiac hydrogels, cardiac patches, and hemostatic materials, although their clinical translation still faces some obstacles. Thus, we reviewed these findings and systematically summarizes the application progress as well as problems of clinical translation of collagen biomaterials in the cardiovascular field. The present review contributes to a comprehensive understanding of the application of collagen biomaterials in cardiovascular medicine. [ABSTRACT FROM AUTHOR]

Additive Manufacturing (AM) has revolutionized the production industry by offering design freedom with shorter lead times and reduced material wastage. However, the damage tolerance (DT) of AM parts is a significant concern due to their microstructural and geometric complexities, which affect their mechanical performance. This article aims to provide a comprehensive overview of the manufacturing parameters affecting the components produced by AM specifically selective laser melting (SLM). Detailed discussions are presented on the effects of manufacturing attributes on the microstructure, defects, and mechanical characteristics of AM parts. Depending on these aspects, basic concepts are studied and critically explained specifically for AM materials. The basic criterion for damage‐tolerant component design, the criterion for fatigue and fracture properties, and the effect of the defects on fatigue life are critically presented. In addition, the effect of different types of gradation on the crack growth behavior of samples processed by SLM is also investigated in depth. There is currently a lack of a specific review study in the literature that establishes a connection between process attributes and metallographic properties, and their impact on the damage behavior of additively manufactured parts. This gap in research highlights the need for a comprehensive review to bridge this knowledge deficit and provide valuable insights for understanding the relationships between manufacturing processes, material characteristics, and the structural integrity of additively manufactured components. This review concludes by addressing the challenges and opportunities in designing and qualifying AM parts for damage tolerance. [ABSTRACT FROM AUTHOR]

Parkinson's disease (PD) is a prevalent neurodegenerative disease in which treatment often includes an exercise regimen. Exercise is neuroprotective in animal models of PD, and, more recently, human clinical studies have verified exercise's disease-modifying effect. Aerobic exercise and resistance training improve many of PD's motor and non-motor symptoms, while neuromotor therapy and stretching/flexibility exercises positively contribute to the quality of life in people with PD. Therefore, understanding the role of exercise in managing this complex disorder is crucial. Exerkines are bioactive substances that are synthesized and released during exercise and have been implicated in several positive health outcomes, including neuroprotection. Exerkines protect neuronal cells in vitro and rodent PD models in vivo. Aerobic exercise and resistance training both increase exerkine levels in the blood, suggesting a role for exerkines in the neuroprotective theory. Many exerkines demonstrate the potential for protecting the brain against pathological missteps caused by PD. Every person (people) with Parkinson's (PwP) needs a comprehensive exercise plan tailored to their unique needs and abilities. Here, we provide an exercise template to help PwP understand the importance of exercise for treating PD, describe barriers confronting many PwP in their attempt to exercise, provide suggestions for overcoming these barriers, and explore the role of exerkines in managing PD. In conclusion, exercise and exerkines together create a powerful neuroprotective system that should contribute to slowing the chronic progression of PD. [ABSTRACT FROM AUTHOR]

Encapsulating antiepileptic drugs (AEDs), including ethosuximide (Etho), into nanoparticles shows promise in treating epilepsy. Nanomedicine may be the most significant contributor to addressing this issue. It presents several advantages compared to traditional drug delivery methods and is currently a prominent area of focus in cancer research. Incorporating Etho into bismuth ferrite (BFO) nanoparticles within diverse controlled drug delivery systems is explored to enhance drug efficacy. This approach is primarily desired to aid in targeted drug delivery to the brain's deepest regions while limiting transplacental permeability, reducing fetal exposure, and mitigating associated adverse effects. In this investigation, we explored Etho, an antiepileptic drug commonly employed for treating absence seizures, as the active ingredient in BFO nanoparticles at varying concentrations (10 and 15 mg). Characterization of the drug-containing BFO nanoparticles involved scanning electron microscopy (SEM) and elemental analysis. The thermal properties of the drug-containing BFO nanoparticles were evaluated via differential scanning calorimetry (DSC) analysis. Cytotoxicity evaluations using the MTT assay were conducted on all nanoparticles, and human neuroblastoma cell line cultures (SH-SY5Y) were treated with each particle over multiple time intervals. Cell viability remained at 135% after 7 days when exposed to 15 mg of Etho in BFO nanoparticles. Additionally, in vitro drug release kinetics for Etho revealed sustained release lasting up to 5 hours with a drug concentration of 15 mg. [ABSTRACT FROM AUTHOR]

Background: Hypertension is a significant chronic disease globally, and lifestyle modifications are crucial for the prevention of this disease. We conducted a longitudinal analysis of the associations between lifestyle factors and the incidence of hypertension, stratified by sociodemographic characteristics. Methods: We analyzed 113,022 adults (65,315 men), aged 20 years or older from the Korean National Health Insurance Service-National Sample Cohort 2.0 who participated in health screening between 2002 and 2003. Lifestyle factors (smoking, drinking, physical activity) were assessed at baseline using self reports, and incident hypertension was defined based on physician diagnoses. Cox proportional hazards regression models were used to assess associations. Results: During an 11.6-year follow-up, 26,812 new cases of hypertension were identified. The risk of hypertension was high among men and women who smoked over 20 cigarettes daily (men: hazard ratio [HR]: 1.15; 95% confidence interval [CI], 1.08–1.21; women: HR: 1.62; 95% CI 1.17–2.25) and those who drank over 1.5 bottles of alcohol daily (men, HR: 1.18; 95% CI, 1.12–1.24; women, HR: 1.23; 95% CI 1.02–1.47). These associations tended to be high in high-income men (HR: 1.09; 95% CI, 1.04–1.14), low-income women (HR: 1.19; 95% CI, 1.05–1.35) and non-obese women (HR: 1.13; 95% CI, 1.01–1.27) who currently smoked. Physical activity was inversely associated with incident hypertension in men (HR: 0.96; 95% CI, 0.93–0.99). Conclusions: Unhealthy lifestyle factors, such as heavy smoking and drinking, was associated with an increased risk of hypertension, with variations by income, BMI, and sex. These findings underscore the importance of tailored, population-specific prevention strategies to address hypertension disparities. [ABSTRACT FROM AUTHOR]

Training helps to maintain and improve sufficient muscle function, body control, and body coordination. These are important to reduce the risk of fracture incidents caused by falls, especially for the elderly or people recovering from injury. Virtual reality training can offer a cost-effective and individualized training experience. We present an application for the HoloLens 2 to enable musculoskeletal training for elderly and impaired persons to allow for autonomous training and automatic progress evaluation. We designed a virtual downhill skiing scenario that is controlled by body movement to stimulate balance and body control. By adapting the parameters of the ski slope, we can tailor the intensity of the training to individual users. In this work, we evaluate whether the movement data of the HoloLens 2 alone is sufficient to control and predict body movement and joint angles during musculoskeletal training.We record the movements of 10 healthy volunteers with external tracking cameras and track a set of body and joint angles of the participant during training. We estimate correlation coefficients and systematically analyze whether whole body movement can be derived from the movement data of the HoloLens 2. No participant reports movement sickness effects and all were able to quickly interact and control their movement during skiing. Our results show a high correlation between HoloLens 2 movement data and the external tracking of the upper body movement and joint angles of the lower limbs. [ABSTRACT FROM AUTHOR]

Currently, an increasing number of Chinese urban citizens are participating in daily physical exercise. Existing research has shown that physical exercise can increase life satisfaction. However, some studies also suggest that the relationship between the two is unstable. The purposes of this study are to examine physical exercise and to test its correlation with life satisfaction of urban residents in China. Data are obtained from the 2018 China Family Panel Studies, and we focus on urban residents. Our overall sample size is 7423 people, including 3641 females (49.05%) and 3782 males (50.95%), with an average age of 49.55 years old. Because the dependent variables are continuous variables, the multiple linear regression model is used for data analysis. We find that the life satisfaction of Chinese urban residents is on the high side. Our core discovery is that there is a significant positive relationship between the frequency and duration of physical exercise and life satisfaction. Our further discovery is that the frequency of physical exercise affects life satisfaction by influencing popularity and positive emotions. Similarly, the duration of physical exercise affects life satisfaction by influencing popularity and positive emotions. Whether it is the frequency or the duration of physical exercise, it can reflect the residents' attention to physical exercise. Physical exercise habits not only promote physical health by strengthening physical fitness but also promote mental health by alleviating depression and promote social communication by increasing social activities in the Chinese context. All of these can improve people's life satisfaction. Our research suggests that the improvement in life satisfaction not only needs the abundance of external material conditions but also needs the individual to improve their physical and mental health through physical exercise. [ABSTRACT FROM AUTHOR]

Introduction: Physical activity (PA) and exercise (EX) participation rates have not been increasing among older adults, with many not meeting recommended guidelines. This qualitative descriptive study examined factors influencing engagement in PA within and outside an older adult fitness club context, using self-determination theory (SDT). Methods: Thirty-seven community-dwelling adults 65 years and older participated in focus groups or telephone interviews. Two researchers independently coded and analyzed transcript data inductively and deductively using SDT. Results: Two broad themes, The Spectrum of Motivating Factors and Facilitators and Barriers, and nine sub-themes, Physical Activity and Exercise Brings Me Joy; Meaningful Personal Impetuses; I Get Active with a Little Help from my Spouse and Others; I See Changes and Improvements (Theme 1); I Can Do This; Connections and Sense of Belonging; I Cannot Do This; Setting, Environment, and People Supports; and Pragmatics (Theme 2), emerged from the data. All participants discussed several motivating factors: enjoyment, managing health conditions, being held 'to account' by others, opportunities for socialization, and seeing improvements in health and well-being. A lack of supportive environments, knowledgeable staff and suitable settings and programs were cited as barriers by participants who were not older adult fitness club members. Discussion: Factors along the extrinsic to intrinsic regulation continuum facilitated or hindered community-dwelling older adults to engage in and sustain PA within and outside an older adult fitness club context. The findings underscore the need for programs, settings, environments, and related components to be expressly older-adult-tailored to enhance motivation through competence, autonomy, and relatedness support for maximal engagement and participation in PA or EX. [ABSTRACT FROM AUTHOR]

To validate range shifts in proton therapy, we investigated the potential of using the temporal information of prompt gamma rays as an indicator. We simulated the proton transport process using Monte Carlo simulations and used a geometric scorer to obtain the location and timing of prompt gamma ray production. By using a homogeneous target material in the simulation model, we established a fitted relationship between the range of 90-210 MeV protons and the corresponding temporal spectral width. Additionally, by introducing air cavities of 2-20 mm in simulations of inhomogeneous target materials, we observed significant correlations between the range offsets and the temporal spectral widths. These correlations were fitted to derive a functional relationship between the two variables. [ABSTRACT FROM AUTHOR]

In recent years, the incidence of chronic pancreatitis has increased significantly. Pancreatic calculi obstruct the pancreatic duct and induce abdominal pain in the patients. Pancreatic duct stenting is the major treatment option for chronic pancreatitis with calculi. In this study, a new kind of drug-eluting stent, a pancreatic stent coated by methacrylated gelatin (GelMA) hydrogel loaded with citric acid (CA), was designed for the interventional treatment of pancreatic duct calculi. The CA loading capacity reached up to 0.7 g CA/g hydrogel-coated stent. The GelMA hydrogel coating has higher mechanical strength and lower swelling performance after loading with CA. The in vitro experiments of stents exhibited good performance in CA sustained release and the calculi can be dissolved in almost 3 days. The stents also showed good blood compatibility and cell compatibility. This research has important clinical value in the treatment of chronic pancreatitis with pancreatic calculi. [ABSTRACT FROM AUTHOR]

Background: Population aging is a global trend, and the number of older adults living alone is increasing. Tai chi, a traditional Chinese exercise, has been shown to improve the physical and mental health of older adults. Aim: To investigate the effects of tai chi on death anxiety in older adults living alone and the role of social support and psychological capital in this relationship. Method: A cross-sectional study of 493 older adults living alone in four cities in southwestern China. Participants were assessed using questionnaires on tai chi practice, social support, psychological capital, and death anxiety. Results: Tai chi practice significantly reduced death anxiety in older adults living alone. It also positively correlated with social support and psychological capital, both of which negatively correlated with death anxiety. Social support and psychological capital mediated the relationship between tai chi practice and death anxiety, suggesting that tai chi may reduce death anxiety through these factors. These findings encourage older adults living alone to practice tai chi, as it may improve their mental and physical health and reduce their risk of death anxiety. Conclusion: Tai chi practice may reduce death anxiety in older adults living alone through the chain-mediated effects of social support and psychological capital. This suggests that tai chi may be a beneficial intervention for older adults living alone. [ABSTRACT FROM AUTHOR]

The COVID-19 pandemic negatively influenced individuals' physical activity levels (PALs) and particularly the PAL of the elderly. However, few studies have examined the correlates of PALs in this population during the pandemic. This study aimed to evaluate the residence-specific correlates of PALs in elderly people from Croatia and Bosnia and Herzegovina during the COVID-19 pandemic. The participants were 211 persons older than 65 years (101 females), of whom 111 were community-dwelling residents, and 110 were nursing home residents (71.11 ± 3.11 and 72.22 ± 4.01 years of age, respectively; t-test = 0.91, p < 0.05). The variables included health status, residential status sociodemographic factors, anthropometrics (body mass, height, and body mass index), and PAL. PAL was evaluated using a translated version of the Physical Activity Scale for the Elderly (PASE), and was validated in this study. PASE showed good test–retest reliability (51% of the common variance) and validity (57% of the common variance, with the step count measured using pedometers). Apart from participants' health status and age, PAL was positively correlated with (i) community-dwelling residence (OR = 1.93, 95% CI: 1.60–2.23), and (ii) a lower BMI (OR = 0.85, 95% CI = 0.71–0.98). The pre-pandemic physical activity was positively correlated with the PAL of the nursing home residents (OR = 1.2, 95% CI: 1.02–1.45). A higher education level was positively correlated with the PAL of community-dwelling residents (OR = 1.31, 95% CI: 1.04–1.66). This study evidenced the residence-specific correlates of PALs, and enabled the identification of specific groups that are at risk of having low PALs during the pandemic. Future studies examining this problem during a non-pandemic period are warranted. [ABSTRACT FROM AUTHOR]

A phytochorological and ecobiological study of the nine species, two subspecies and two varieties of the genera Aeonium and Greenovia in La Gomera is carried out, with special attention to F1 hybridization in nature. To the ten hybrids already described on the island, seven new hybrids were discovered, which are the subject of a separate publication. In all the known hybrids I determined whether the parents were sympatric or allopatric. The geographical coincidence of the parents was a sine qua non requirement for hybridization to occur in all the hybrids known so far, since pollen transfer by biotic and abiotic agents does not function between disjunct areas. The two prezygotic reproductive barriers that currently prevent interspecific hybridization in Aeonium or intergeneric hybridization between Aeonium and Greenovia are the geographic separation of populations and the different flowering times. The ability to survive and reproduce successfully of F1 hybrids in Aeonium and Greenovia is usually lower than that of the parent species and they generally disappear from the environment in the first filial generation without leaving offspring. The fundamental principles that govern F1 hybridization in La Gomera are extracted, and after verifying that they were also fulfilled in the other mountainous islands, they were synthesized in eight principles, which provide an updated vision of hybridization in the genus Aeonium. Citation: Arango O. 2024: Principles governing F1 hybridization in the genera Aeonium and Greenovia in La Gomera, Canary Islands. – Willdenowia 53: 257–268 Version of record first published online on 23 January 2024. [ABSTRACT FROM AUTHOR]

The purpose of this study was to examine the associations of social support factors with leisure-time physical activity (LTPA) of older people in Fuwen village. A cross-sectional study included 523 randomly selected elderly people (60+ years) whose LTPA levels were determined using the shortened version of the International Physical Activity Questionnaire (IPAQ-S). A modified version of the Physical Activity Social Support Scale (PASSS) was operated to gather perceived scores of the social support factors. A multivariate linear regression was performed to locate associations of perceived scores of social supports with leisure-time walking (LTW) and moderate and vigorous physical activity (MVPA). The results indicated that social support from family was positively and significantly related to LTW and MVPA in both models. The community factor was positively and significantly correlated with MVPA in both models. The sport club factor was related to LTW and MVPA to some extent. The results suggest that social support from family is the most important motivator for older people's LTW and MVPA in the village of Fuwen. Social support from the community is the motivator for older people's MVPA. The sport club factor has some effects on older people's LTW and MVPA as well. More future studies are needed to extend the database of the relationship between social support and rural older people's physical activity. [ABSTRACT FROM AUTHOR]

This retrospective observational study describes the results of an ad-hoc designated prevention protocol aimed at containing the spread of the scabies infestation among healthcare workers (HCWs) of a large University Hospital in Italy. The outbreak started on October 2022 and a preventive protocol was set up thanks to a multidisciplinary approach. HCWs at high scabies risk were defined as subjects working in Operative Units with a scabies prevalence higher than 2%, close contacts of a confirmed case of scabies, or HCWs with signs and symptoms of the disease. All cases at high scabies risk underwent a dermatological examination, and the infested HCWs were suspended from work until definitive healing. Mass drug administration was established for all HCWs working in Operative Units with a scabies prevalence higher than 2%. Until March 2023, out of 183 screening dermatological examinations, 21 (11.5%) were diagnostic for scabies. Between 11 October 2022 (date of the first diagnosed scabies case) and 6 March 2023 (the end of incubation period related to the last case detected), the frequency of scabies was 0.35% (21 scabies cases/6000 HCWs). The duration of the outbreak in our hospital was 14.7 weeks. Statistical analysis shows a significant association between scabies and being a nurse and having an allergy to dust mites. We obtained a low frequency of scabies infection, limiting the duration of the outbreak and the related economic burden. [ABSTRACT FROM AUTHOR]

(1) Background: Green and open spaces are conducive to physical activity for the elderly. However, it is unclear how different landscape characteristics relate to the physical activity of the elderly. (2) Methods: following the PRISMA method, this study reviewed the existing literature on the landscape characteristics correlated with the elderly's physical activity (PA) from Web of Science, Scopus, and PubMed. We conducted a systematic full-text review of 25 eligible reports and studies related to the linkage between the characteristics of green and open spaces and the elderly's physical activity (PA); (3) Results: Nature/greenery, safety, road/path conditions, aesthetics, PA facilities, accessibility, amenity, water, and elderly accessibility facilities were found to be positively associated with elderly's PA. Pavement conditions (gravel), the presence of water, poor maintenance, neighborhood aesthetics, and GVI are negatively correlated with the elderly's PA; (4) Conclusions: We close the paper by making a few recommendations for future policy-making, practice, and research. It is suggested that the landscape characteristics be applied in evidence-based policy-making and design, and in tackling health inequality. Future research should be more specific about the impact of site-scale factors, include landscape characteristics specifically needed by the elderly to conduct PA, and involve a wider scope of green and open space on top of neighborhood green and open space and parks. Additionally, these studies should take into consideration different cultural settings and geographical scales to reveal the different effects of various aspects of green and open space. [ABSTRACT FROM AUTHOR]

This work analyses damage formation within the bulk of basalt fiber-reinforced polymers (BFRP) by means of open-source Digital Volume Correlation (DVC). Volumetric image data were obtained from conventional in-situ X-Ray computed micro-tomography (µCT) of samples loaded in tension. The open-source image registration toolkit Elastix was employed to obtain full 3D displacement fields from the image data. We assessed the accuracy of the DVC results using the method of manufactured solution and showed that the approach followed here can detect deformation with a magnitude in the order of a fiber diameter which in the present case is 17 µm. The beneficial influence of regularization on DVC results is presented on the manufactured solution as well as on real in-situ tensile testing CT data of a BFRP sample. Results of the correlation showed that conventional µCT equipment in combination with DVC can be used to detect defects which could previously only be visualized using synchrotron facilities or destructive methods. [ABSTRACT FROM AUTHOR]

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BACKGROUND: There is limited evidence for emergency physicians and emergency trauma surgeons regarding the determinants of early and rapid assessment of older adult in-hospital mortality due to earthquakes. This study explored factors related to the early and rapid assessment of the mortality among older adult earthquake trauma patients (OAETPs) and created a screening model. METHODS: Data on 7,308 OAETPs from the West China Earthquake Patients Database were analyzed retrospectively. The 35 variables that can be obtained rapidly on arrival at the hospital were collected. Least absolute shrinkage and selection operator (LASSO) regression analysis was performed. Then, the nomogram for assessing the mortality of OAETPs was constructed. RESULTS: We identified 10 independent mortality-related factors that contributed to the inhospital mortality of OAETPs. The 10 factors included age (odds ratio [OR]=1.061, 95% confidence interval [CI]:1.031–1.090), dementia (OR=5.146, 95%CI: 1.169–17.856), coronary heart disease (CHD; OR=23.441, 95%CI: 4.799–83.927), malignant tumor (OR=8.497, 95%CI: 3.583–17.967), deep vein thrombosis (DVT; OR=7.110, 95%CI: 1.369–27.168), chronic kidney disease(CKD; OR=11.783, 95%CI: 5.419–24.407), pulse rate (PR; OR=1.036, 95%CI: 1.022–1.048), mean artery pressure (MAP; OR=0.960, 95%CI: 0.945–0.975), Glasgow Coma Scale (GCS; OR=0.864, 95%CI: 0.760–0.972), and Triage Revised Trauma Score (T-RTS, OR=0.485, 95%CI: 0.351–0.696). CONCLUSION: The 10 mortality-related factors could be quickly obtained on hospital arrival and should be the focal point of future earthquake response strategies regarding hospitalized older adults with trauma. A nomogram was constructed based on the factors for screening OAETPs with a higher risk of in-hospital mortality. [ABSTRACT FROM AUTHOR]

Chronic tendon ruptures are common disorders in orthopedics. The conventional surgical methods used to treat them often require the support of implants. Due to the non-availability of suitable materials, 3D-printed polycaprolactone (PCL) scaffolds were designed from two different starting materials as suitable candidates for tendon-implant applications. For the characterization, mechanical testing was performed. To increase their biocompatibility, the PCL-scaffolds were plasma-treated and coated with fibronectin and collagen I. Cytocompatibility testing was performed using L929 mouse fibroblasts and human-bone-marrow-derived mesenchymal stem cells. The mechanical testing showed that the design adaptions enhanced the mechanical stability. Cell attachment was increased in the plasma-treated specimens compared to the control specimens, although not significantly, in the viability tests. Coating with fibronectin significantly increased the cellular viability compared to the untreated controls. Collagen I treatment showed an increasing trend. The desired cell alignment and spread between the pores of the construct was most prominent on the collagen-I-coated specimens. In conclusion, 3D-printed scaffolds are possible candidates for the development of tendon implants. Enhanced cytocompatibility was achieved through surface modifications. Although adaptions in mechanical strength still require alterations in order to be applied to human-tendon ruptures, we are optimistic that a suitable implant can be designed. [ABSTRACT FROM AUTHOR]

Polycaprolactone (PCL) scaffold is a common biological material for tissue engineering, owing to its good biocompatibility, biodegradability and plasticity. However, it is not suitable for osteoblast adhesion and regeneration of bone tissue due to its non-biological activity, poor mechanical strength, slow degradation speed, smooth surface and strong hydrophobicity. To improve the mechanical properties and biocompatibility of PCL scaffold, the PCL/nHA scaffolds were prepared by melting and blending different proportions of nano-hydroxyapatite (nHA) with PCL by the near-field direct-writing melt electrospinning technology in this study. The morphology, porosity, mechanical properties and in vitro biocompatibility of the PCL/nHA scaffolds were studied. The results showed that when the proportion of nHA was less than or equal to 25%, PCL/nHA composite scaffolds were easily formed in which bone marrow mesenchymal stem cells proliferated successfully. When the proportion of nHA was 15%, the PCL/nHA composite scaffolds had excellent structural regularity, good fiber uniformity, outstanding mechanical stability and superior biocompatibility. The PCL/nHA composite scaffolds were ideal scaffold materials, which would broaden their applications for bone tissue engineering. [ABSTRACT FROM AUTHOR]

Background: In the context of the ageing of the French population, physical activity becomes a principal means for maintaining good health. International organisations are thus giving increasing importance to physical activity in programmes of disease-prevention. In parallel with these concerns, studies have shown the impact of sedentary activities (in particularly as a result of the seated position and screen time) on health. Objective: To show the links between physical activity, sedentarism and health indicators and to identify the socio-demographic variables by which they are influenced (particularly gender). Study design: This is a transversal epidemiological study conducted among the French population between 2014 and 2016 by Santé publique France, the national public health agency. Methods: The RPAQ (Recent Physical Activity Questionnaire) was used to measure the physical activity and sedentary lifestyle of individuals. The analyses focus on the behaviours among the population of older adults (55–74 years old, n = 1155). Results: A third of French older adults does not meet the WHO recommended physical activity levels, particularly so among women. The results of this survey point to significant links between health indicators (especially overweight and obesity) and the physical activity level and sedentarity of older adults. From the age of 60, energy expenditure linked to physical activity increases before decreasing from the age of 65. Older adults spend almost 6 hours per day in sedentary activities. The combinations between physical activity and sedentarism highlight four profiles of older adults. The most active profile is the one with the best health indicators. Conclusion: The links between health, sedentarity and physical activity are unequivocal: people who achieve the WHO recommendations for physical activity and spend less than 7 hours each day in sedentary activities are those who also have the best health indicators. These results vary with sociographic characteristics and reveal significant links with health indicators. [ABSTRACT FROM AUTHOR]

In this paper, near-field direct-writing melt electrospinning technology was employed to fabricate a polycaprolactone/nano-hydroxyapatite (PCL/nHA) scaffold for future applications in tissue engineering. The influences of different fabrication parameters on the structural characteristics, mechanical properties, and thermal stability of the scaffolds were discussed. It was found that the moving speed of the receiving plate had the most significant effect on the scaffold performance, followed by the receiving distance and spinning voltage. The results also showed that these process parameters affected the fiber diameter, corresponding coefficient of variation, porosity of the composite scaffolds, and mechanical properties of the samples, including the tensile strength and fiber peeling strength. Moreover, the process parameters could influence the thermal degradation performance and melting process. Although the mass loss of the composite scaffolds was not obvious after degradation, the mechanical performance degraded severely. It was concluded that the more appropriate process parameters for preparing PCL/nHA scaffolds were a spinning voltage of −4 kV, receiving distance of 4 mm, moving speed of receiving plate of 5 mm/s, and melt temperature of 130 °C. This study proved that near-field direct-writing melt electrospinning technology is a good method to obtain PCL/nHA composite scaffolds with an excellent mechanical properties and desired morphology for future tissue engineering applications. [ABSTRACT FROM AUTHOR]

The low toxicity and high adsorption capacities of clay minerals make them attractive for controlled delivery applications. However, the number of controlled-release studies in the literature using clay minerals is still scarce. In this work, three different clays from the smectite group (Kunipia F, montmorillonite; Sumecton SA, saponite; and Sumecton SWN, hectorite) were successfully loaded with rhodamine B dye and functionalized with oleic acid as a gatekeeper to produce organonanoclays for active and controlled payload-release. Moreover, hematin and cyanocobalamin have also been encapsulated in hectorite gated clay. These organonanoclays were able to confine the entrapped cargos in an aqueous environment, and effectively release them in the presence of surfactants (as bile salts). A controlled delivery of 49 ± 6 μg hematin/mg solid and 32.7 ± 1.5 μg cyanocobalamin/mg solid was reached. The cargo release profiles of all of the organonanoclays were adjusted to three different release-kinetic models, demonstrating the Korsmeyer–Peppas model with release dependence on (i) the organic–inorganic hybrid system, and (ii) the nature of loaded molecules and their interaction with the support. Furthermore, in vitro cell viability assays were carried out with Caco-2 cells, demonstrating that the organonanoclays are well tolerated by cells at particle concentrations of ca. 50 μg/mL. [ABSTRACT FROM AUTHOR]

National governments are increasingly exploring how the routine collection of subjective well-being data can be a valuable tool for improving public policy. In particular, health satisfaction is an indicator of subjective well-being which can be helpful in evaluating and improving of health policy. This study aimed to examine patterns and determinants of health satisfaction across provinces, considering how its measurement can help governments to deliver more effective health policy. We used secondary data using Happiness Level Assessment Survey conducted by the Central Statistics Agency of Indonesia involved respondents aged 18 to 98 with response rate in 2014 was 94.2%, while in 2017 was 96.4%. To this end, an analysis was performed on 45,881 responses to the 2014 and 2017 Happiness Level Assessment Survey performed by the Central Agency of Statistics. The results showed that there was a significant difference in health satisfaction in 2017 compared with 2014, with health satisfaction in 2017 is higher than that in 2014. Overall, 12 out of 34 provinces experienced a substantial rise in health satisfaction. Subsequently, multi-level modeling was used to explore the extent to which health satisfaction was associated with different individual-level and provincial-level explanatory variables. Here, the analyses showed that health satisfaction among Indonesians is associated with whether individuals live in urban or rural areas, demographic factors, health-related factors, social capital, and leisure time. Overall, the study helps to illuminate the status of health satisfaction across Indonesia, leading to numerous suggestions for improving health policy. [ABSTRACT FROM AUTHOR]

Musculoskeletal disorders are a significant burden on the global economy and public health. Hydrogels have significant potential for enhancing the repair of damaged and injured musculoskeletal tissues as cell or drug delivery systems. Hydrogels have unique physicochemical properties which make them promising platforms for controlling cell functions. Gelatin methacryloyl (GelMA) hydrogel in particular has been extensively investigated as a promising biomaterial due to its tuneable and beneficial properties and has been widely used in different biomedical applications. In this review, a detailed overview of GelMA synthesis, hydrogel design and applications in regenerative medicine is provided. After summarising recent progress in hydrogels more broadly, we highlight recent advances of GelMA hydrogels in the emerging fields of musculoskeletal drug delivery, involving therapeutic drugs (e.g., growth factors, antimicrobial molecules, immunomodulatory drugs and cells), delivery approaches (e.g., single-, dual-release system), and material design (e.g., addition of organic or inorganic materials, 3D printing). The review concludes with future perspectives and associated challenges for developing local drug delivery for musculoskeletal applications. [ABSTRACT FROM AUTHOR]

Physical activity is one of the most efficacious pathways to promoting mental and physical health, preventing disease, and, most important during the COVID-19 pandemic, bolstering a stronger immune system. Efforts to "flatten the curve" have resulted in the temporary closure of exercise facilities and gyms, suspension of sport activities, and advisories to avoid public recreational spaces. All of these changes have made traditional opportunities to be physically active difficult to access. These changes have also exacerbated existing disparities in access to social and environmental supports for physical activity, potentially contributing to a widening gap in physical activity participation among those at greatest risk for COVID-19. Physical activity can play a special role in reducing the inequitable consequences of COVID-19; however, expansion and better targeting of evidence-informed interventions are needed that address the unique barriers present in communities that have been economically and socially marginalized to achieve health equity in COVID-19 outcomes. This review highlights effective and feasible strategies that provide more equitable access to physical activity programs and spaces across the United States. With a renewed investment in physical activity, this behavior can play a crucial role in improving population health and reducing disparities during the COVID-19 pandemic and beyond. [ABSTRACT FROM AUTHOR]

Introduction: It is important to sustain mobility in order to maintain functionality and physical independence in the elderly. The aim was to evaluate the perception of exercise in the elderly in terms of the benefits of and barriers to exercise and determine the related factors. Materials and Method: 138 elderly people aged 65 and over were included in the study. Demographics, ambulation status and duration, history of falls, spontaneous/low-energy fractures, exercise/walking activities were recorded. Depression states, benefits and barriers of exercise, risk of falling, balance and Daily activities were evaluated. Results: The average age of the patients was 71.59±6.21 years and 52.2% were female. Only a quarter (24.6%) reported regular exercise, 50.7% had history of falling, and 18.8% had a fracture history. Only 24.6% of the patients walked for exercise purposes and 44.2% did exercise. The perception of exercise benefit was significantly higher in those with a history of falling (p=0.012) and significantly lower in those who walked for exercise purposes and did exercise (p<0.001 and p<0.001). Perception of exercise benefit was positively correlated with depression, negatively correlated with Lawton-Brody, and perception of obstacle was negatively correlated with balance (r=0.333, r=-0.375, r=-0.383, respectively). Depression level, perceived benefit of exercise, risk of falling were higher in women whereas balance disorder was higher in men (p<0.001, p=0.049, p=0.004, respectively). Conclusion: In the elderly, exercise is associated with the perception of benefit/obstacle, depression, risk of falling/fracture, balance and functional dependence. Active life should be supported by strengthening the perception of benefit and reducing the perception of obstacles. [ABSTRACT FROM AUTHOR]

Background: Older adults are the least active population in the U.S. Low-income communities have fewer physical activity (PA) resources, contributing to less PA and increased chronic disease risk. This study assessed the effect of the multilevel, peer-led, Peer Empowerment Program 4 Physical Activity (PEP4PA) on moderate-to-vigorous PA (MVPA) and health outcomes, over 2 years of follow up. Methods: In a cluster-randomized controlled trial, 12 senior or community centers serving low-income older adults were assigned to a PA intervention (n = 6) or usual programming (n = 6) condition. PEP4PA included self-monitoring, health coaching, group walks, social support, and community advocacy to improve walking conditions. The primary outcome was daily minutes of MVPA (7-day accelerometer). Secondary outcomes included Perceived Quality of Life (PQoL), 6-Minute Walk Test (6-MWT), blood pressure (BP), and depressive symptoms at baseline, 6, 12, 18 and 24 months. Mixed effects regression models estimated the effects on outcomes between groups over time and included random effects for repeated measures and center clustering. Effect modification by sex and income status was assessed. We calculated the incremental cost per daily minute of MVPA gained in the intervention group relative to the control group to assess cost effectiveness. Results: We enrolled 476 older adults (50 + years). Participants were on average 71 years old, 76% female, 60% low income, and 38% identified as racial or ethnic minorities. Compared to the control group, intervention participants sustained roughly a 10 min/day increase in MVPA from baseline at all time points and increased mean PQoL scores from unsatisfied at baseline to satisfied at 12, 18 and 24 months. Males and higher-income groups had greater improvements in MVPA. No significant effects were observed for 6-MWT or depressive symptoms, and BP results were mixed. The incremental cost per minute MVPA gained per person was $0.25, $0.09, $0.06, and $0.05 at 6, 12, 18 and 24 months, respectively. Conclusions: PEP4PA achieved increases in MVPA and PQoL in low-income older adults, over 2 years of follow up. The peer-led, community-based intervention provides a sustainable and cost-effective model to improve health behaviors in underserved, aging populations. Trial registration: ClinicalTrials.gov (NCT02405325) March 20, 2015. [ABSTRACT FROM AUTHOR]

Much of current artificial intelligence (AI) and the drive toward artificial general intelligence (AGI) focuses on developing machines for functional tasks that humans accomplish. These may be narrowly specified tasks as in AI, or more general tasks as in AGI – but typically these tasks do not target higher-level human cognitive abilities, such as consciousness or morality; these are left to the realm of so-called "strong AI" or "artificial consciousness." In this paper, we focus on how a machine can augment humans rather than do what they do, and we extend this beyond AGI-style tasks to augmenting peculiarly personal human capacities, such as wellbeing and morality. We base this proposal on associating such capacities with the "self," which we define as the "environment-agent nexus"; namely, a fine-tuned interaction of brain with environment in all its relevant variables. We consider richly adaptive architectures that have the potential to implement this interaction by taking lessons from the brain. In particular, we suggest conjoining the free energy principle (FEP) with the dynamic temporo-spatial (TSD) view of neuro-mental processes. Our proposed integration of FEP and TSD – in the implementation of artificial agents – offers a novel, expressive, and explainable way for artificial agents to adapt to different environmental contexts. The targeted applications are broad: from adaptive intelligence augmenting agents (IA's) that assist psychiatric self-regulation to environmental disaster prediction and personal assistants. This reflects the central role of the mind and moral decision-making in most of what we do as humans. [ABSTRACT FROM AUTHOR]

Vimentin, a type III intermediate filament protein, is found in most cells along with microfilaments and microtubules. It has been shown that the head domain folds back to associate with the rod domain and this association is essential for filament assembly. The N-terminally tagged vimentin has been widely used to label the cytoskeleton in live cell imaging. Although there is previous evidence that EGFP tagged vimentin fails to form filaments but is able to integrate into a pre-existing network, no study has systematically investigated or established a molecular basis for this observation. To determine whether a tag would affect de novo filament assembly, we used vimentin fused at the N-terminus with two different sized tags, AcGFP (239 residues, 27 kDa) and 3 × FLAG (22 residues; 2.4 kDa) to assemble into filaments in two vimentin-deficient epithelial cells, MCF-7 and A431. We showed that regardless of tag size, N-terminally tagged vimentin aggregated into globules with a significant proportion co-aligning with β-catenin at cell–cell junctions. However, the tagged vimentin aggregates could form filaments upon adding untagged vimentin at a ratio of 1:1 or when introduced into cells containing pre-existing filaments. The resultant filament network containing a mixture of tagged and untagged vimentin was less stable compared to that formed by only untagged vimentin. The data suggest that placing a tag at the N-terminus may create steric hinderance in case of a large tag (AcGFP) or electrostatic repulsion in case of highly charged tag (3 × FLAG) perhaps inducing a conformational change, which deleteriously affects the association between head and rod domains. Taken together our results shows that a free N-terminus is essential for filament assembly as N-terminally tagged vimentin is not only incapable of forming filaments, but it also destabilises when integrated into a pre-existing network. [ABSTRACT FROM AUTHOR]

The family of room temperature atomic scale magnetometers is currently limited to nitrogen-vacancy centers in diamond. However, nitrogen-vacancy centers are insensitive to strong off-axis magnetic fields. In this work, we show that the well-known TR12 radiative defect in diamond, exhibits strong optically detected magnetic resonance (ODMR) signal under optical saturation. We also demonstrate that the spin system responsible for the magnetic resonance is an excited triplet state that can be coherently controlled at room temperature on a single defect level. The high optically detected magnetic resonance contrast, which is maintained even for strong off-axis magnetic fields, suggests that TR12 centers can be used for vector magnetometry even at high field. [ABSTRACT FROM AUTHOR]

The aim of this study was to examine the effect of built environment (BE) elements on older people's (OP) leisure-time physical activity (LTPA) and leisure-time walking (LTW) level in the city of Ningbo. Older participants numbering 312 were randomly recruited using cross-sectional survey in 2019. International Physical Activity Questionnaire-short version (IPAQ-S) and Neighborhood Environment Walkability Scale—abbreviated (NEWS-A)—were used to gather LTPA data and the perceive scores of BE, respectively. Liner regression analysis was performed to investigate the association relationship between the perceived scores of BE and OP's LTW and LTPA. The study's results showed that, when not considering different sex groups, OP's LTW was significantly related with the perceived scores of access to services (AE, p = 0.045), walking/cycling facilities (W/CF, p = 0.007), aesthetics, and land use mix diversity (LUMD, p = 0.04). OP's LTPA was significantly related with AE (p = 0.04) and aesthetics (p < 0.001). The association relationships of BE with LTW and LTPA varied in different sex groups. Three elements (AE, W/CF, and LUMD) and one element (pedestrian/traffic safety and P/TS) of BE were found be related with older male and older female's LTW, respectively. One element (aesthetics) and two elements (aesthetics, LUMD) of BE were found be related with older male and older female's LTPA, respectively. The results indicated that the effects of BE on OP's LTW and the effects of BE on OP's LTPA were different. The effect also varied in different sex groups. More studies are needed to confirm the effect of BE on OP's LTW and LTPA in different sex groups to globally enrich the scientific data base. [ABSTRACT FROM AUTHOR]

Systemic environmental disadvantage relates to a host of health and functional outcomes. Specific structural factors have seldom been linked to neural structure, however, clouding understanding of putative mechanisms. Examining relations during childhood/preadolescence, a dynamic period of neurodevelopment, could aid bridge this gap. A total of 10,213 youth were recruited from the Adolescent Brain and Cognitive Development study. Self‐report and objective measures (Census and Federal bureau of investigation metrics extracted using geocoding) of environmental exposures were used, including stimulation indexing lack of safety and high attentional demands, discrepancy indexing social exclusion/lack of belonging, and deprivation indexing lack of environmental enrichment. Environmental measures were related to cortical thickness, surface area, and subcortical volume regions, controlling for other environmental exposures and accounting for other brain regions. Self‐report (|β| =.04–.09) and objective (|β| =.02–.06) environmental domains related to area/thickness in overlapping (e.g., insula, caudal anterior cingulate), and unique regions (e.g., for discrepancy, rostral anterior and isthmus cingulate, implicated in socioemotional functions; for stimulation, precuneus, critical for cue reactivity and integration of environmental cues; and for deprivation, superior frontal, integral to executive functioning). For stimulation and discrepancy exposures, self‐report and objective measures showed similarities in correlate regions, while deprivation exposures evidenced distinct correlates for self‐report and objective measures. Results represent a necessary step toward broader work aimed at establishing mechanisms and correlates of structural disadvantage, highlighting the relevance of going beyond aggregate models by considering types of environmental factors, and the need to incorporate both subjective and objective measurements in these efforts. [ABSTRACT FROM AUTHOR]

The endothelium plays an important role in the transcytosis of lipoproteins. According to one of the theories, endothelial injury is a triggering factor for the development of atherosclerosis, and intracellular structures, including components of the endotheliocyte cytoskeleton (microtubules, actin, and intermediate filaments), are involved in its development. In contrast to the proteins of tubulin-based microtubules and actin microfilaments, intermediate filaments are comprised of various tissue-specific protein members. Vimentin, the main protein of endothelial intermediate filaments, is one of the most well-studied of these and belongs to type-III intermediate filaments, commonly found in cells of mesenchymal origin. Vimentin filaments are linked mechanically or by signaling molecules to microfilaments and microtubules by which coordinated cell polarisation and migration are carried out, as well as control over several endotheliocyte functions. Moreover, the soluble vimentin acts as an indicator of the state of the cardiovascular system, and the involvement of vimentin in the development and course of atherosclerosis has been demonstrated. Here we discuss current concepts of the participation of vimentin filaments in the vital activity and functioning of endothelial cells, as well as the role of vimentin in the development of inflammatory processes and atherosclerosis. [ABSTRACT FROM AUTHOR]

Background: Older adult women are at risk for negative health outcomes that engaging in sustained physical activity can help prevent. However, promoting long-term maintenance of physical activity in this population has proven to be a challenge. Increasing autonomous motivations (ie, intrinsic, integrated, and identified regulations) for physical activity may facilitate enduring behavior change. Digitally delivered games for health that take a celebratory technology approach, that is, using technology to create new ways to experience valued behaviors and express valued beliefs, may be a useful way to target autonomous motivations for physical activity. Formative research with the target population is needed to design compelling intervention content. Objective: The objective of this study is to investigate older adult women’s reactions to and thoughts about a photography-based, social media walking game targeting autonomous motivations for physical activity. Methods: During an individual semistructured interview, a moderator solicited feedback from 20 older adult women (age range 65-74 years) as part of formative research to develop a social media game featuring weekly walking challenges. The challenges were designed to target autonomous motivations for physical activity. Interviews were audio-recorded and transcribed verbatim. Two reviewers conducted thematic content analysis on interview transcripts. Results: We identified 3 overarching themes in qualitative data analysis. These reflected the playful experiences, value, and acceptability associated with the intervention challenges. Generally, participants understood what the challenges were asking them to do, proffered appropriate example responses, and indicated that the challenges would be enjoyable. Participants reported that the intervention content afforded many and varied playful experiences (eg, competition, discovery, exploration, expression, fellowship, humor, nurture, sensation). Further, participants indicated that the intervention increased their motivation for physical activity, occasioned meaningful shifts in perspective, increased their knowledge of various topics of interest, provided an opportunity to create valued connection with others, and provided health-related benefits. Participants suggested the intervention emphasize local history, nature, and cultural events. Conclusions: The photography-based, social media walking game with relatively simple game mechanics was well received and judged to be apt to bring about a wide variety of emotive experiences. A clear, geographically specific identity emerged as a key driver of interest for intervention content. Taking a celebratory technology approach holds promise for targeting autonomous motivations for physical activity in older adult women. [ABSTRACT FROM AUTHOR]

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Introduction: Improvements in physical, mental, and overall quality of life are well documented in younger HIV populations who exercise. Exercise guidelines exist for younger HIV populations, but none for older people living with HIV (OPLWH), especially 50 years of age and older. Our aim was to map the existing literature on the effects of exercise and physical activity prescriptions for OPLWH. Methods: We conducted a scoping review using the methodological framework proposed by the Joanna Briggs Institute. Online searches on five research databases yielded 503 published articles. Fifteen studies met the study's inclusion criteria. Results: The most commonly used parameters of exercise included aerobic and strength training, as well as a combination of both. The physical, psychological and Quality of Life (QoL) impact of physical activity and its effect on OPLWH is evidently beneficial. Overall, a positive correlation between exercise and physical, mental and functional status was observed. No adverse side effects, or safety and efficacy concerns, during the use of exercise were reported. Conclusion: This review confirms the dearth of evidence on physical activity and exercise in the context of OPLWH. Of greater concern is the fact that there were no studies conducted in sub-Saharan Africa, the global region with by far the highest HIV burden. [ABSTRACT FROM AUTHOR]