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Objectives: To report the outcomes of pediatric patients who underwent allogeneic hematopoietic stem cell transplant (HSCT) in single rooms without high-efficiency particulate air (HEPA) filters, laminar air flow or positive pressure at our centre and discuss the adaptations of a high-volume government centre. Methods: Data of the first 20 children who underwent allogeneic HSCT between May 2019 and July 2023 in adaptive settings were reviewed retrospectively. All patients were managed in in single rooms without HEPA filters, positive pressure or laminar air flow. Supportive care in the form of antimicrobial prophylaxis, veno-occlusive disease prophylaxis, anti-epileptics (with busulfan) and irradiated blood products were provided. Trained manpower including multi-specialty consultations were readily available. All complications including infections were managed as per standard guidelines. Results: The median (range) of children included was 6 (1–20) years. For eight patients we used alternate donors. The mean (SD) time to neutrophil and platelet engraftment were 17.0 (8.07) days and 18.8 (10.1) days, respectively. The mean (SD) time to discharge from the hospital was 30.9 (10.04) days. There were no deaths within 30 days. Six children each developed acute and chronic graft-versus-host disease (GVHD). The overall survival at a median follow-up of 292 days was 70% (n = 14). Conclusions: With certain adaptations in the existing infrastructure in resource-limited settings, allogeneic HSCT can be performed with good outcomes, provided experienced, dedicated and adequate personnel, comprehensive supportive care, multidisciplinary consultative support and isolation are provided. [ABSTRACT FROM AUTHOR]

This present investigation unveils a novel insight into the dominant airmass flows originating from both continental and maritime sources, shaping the characteristics of the raindrop size distribution (DSD), atmospheric instabilities, and cloud effective radius over Delhi (28.62°N, 77.17°E), the capital city of India. The investigation employs the Hybrid Single-Particle Lagrangian Integrated Trajectory model to analyze airmass back trajectories corresponding to days featuring rain events within the study area. An observable pattern emerges: days with rainfall driven by continental (maritime) activities experience higher (lower) atmospheric instabilities, which is validated by radiosonde measurements. This enhanced atmospheric instability leads to the prevalence of larger raindrops during continental-influenced rain events, in contrast to days marked by maritime airflow, as estimated from surface-based disdrometer measurements. Furthermore, observations from the INSAT 3D/3DR satellite indicate a tendency towards a smaller cloud effective radius associated with continental airmass inflow, as opposed to maritime inflow. Notably, a category of rain events characterized by ambiguous airmass back trajectories, referred to as mixed types, is identified. These mixed events showcase intermediary variations in the investigated atmospheric parameters, positioning them between the continental and maritime scenarios. The discernible differences in DSD characteristics between rain events influenced by continental and maritime activities yield fluctuations in the radar reflectivity-rain rate (Z-R) power law relations, which bear significance for the application of rain radar remote sensing. Hence, this investigation underscores the critical implication of incorporating airmass source information while characterizing rain features and related atmospheric parameters over a capital metropolis like Delhi. [ABSTRACT FROM AUTHOR]

Common walls between houses are a major reason for improper ventilation in apartment buildings. They make a compulsion for improper positioning of doors/windows. The shape of the house also affects the airflow distribution patterns inside the house. In this work, the effect of various shapes of the house on the ventilation inside the rooms is investigated with a cross-flow ventilation configuration, where the total floor area of the house is maintained as 1000 square feet. Moreover, work also has been performed to investigate the airflow inside a square-shaped house with different door/window configurations for various inlet airflow directions. Besides that, the impact of inlet airflow velocity on the ventilation process has also been investigated. From the investigation, it has been observed that with an increase in air volume flow rate, the area covered with low-velocity air (< 1 m/s) decreases and the area covered with high-velocity air ( > 2 m/s) increases irrespective of the shape of the house but does not follow any pattern for the comfort condition airflow velocity. The airflow pattern is not changed significantly with increase in inlet airflow velocity, but the airflow velocity regions are changed significantly. For a square shape house, 78% area is covered with a low air velocity region (< 1 m/s) is the highest with N & E door/window configuration. 62% area covered with high air velocity region (> 2 m/s) is the highest with N & S door/window configuration. 26% area covered with comfort flow condition (between 1-2 m/s) is the highest with N & S door/window configuration. [ABSTRACT FROM AUTHOR]

Introduction: In India smoking is a common habit prevalent in both urban and rural areas irrespective of mode of smoking i.e., cigarettes, bidis, pipes, cigar, hookah etc., Spirometry can be helpful to determine effects of smoking on pulmonary functions. We aimed to study the effect of smoking on the pulmonary function tests. Materials and Methods: This study was conducted on 300 subjects including 150 smokers and 150 non-smokers aged between 25 and 60 years attending a tertiary health care center in northern part of our country. Quantification of tobacco smoking was performed by calculating smoking index. All the study subjects underwent spirometry. Results: All the spirometric variables (FVC, FEV1, PEFR, FEF 25-75%) were lower in smokers as compared to non-smokers and this difference was statistically significant. 76% of the smokers had obstructive, 10.7% had normal, 6.7% had restrictive, and 6.7% had mixed pattern on spirometry. 65.3% of the non-smokers had normal, 28.7% had obstructive and 6% had restrictive pattern on spirometry. Conclusion: Almost all the pulmonary function parameters were significantly reduced in smokers compared to non-smokers and obstructive impairment was common amongst smokers. As early quitting is associated with improved survival, it is important that these asymptomatic smokers are identified early and helped to quit. Primary care physicians being the first point of contact, can play a major role. [ABSTRACT FROM AUTHOR]

As per the objective of the present experimental investigation, influence of various configurations of manifolds for optimum flow distribution in concentric glass tube solar air collector (CGTSAC) has been analyzed for transient conditions. Based on the previous studies it was found that the performance of solar air collector is robustly dependent on the flow distribution and decreases with non-uniform flow distribution. For evaluating four different flow distribution arrangements, the experimental setup of CGTSAC is installed at N.I.T., Kurukshetra (29°58′ (latitude) North and 76°53′ (longitude) East), India, and tested with various configurations of manifolds at different operating conditions. The experimental data have been recorded and found that the maximum exit air temperature is 53.1 and 52.9 °C, and the average values of COPt are 0.2731 and 0.2943 at air mass flow rate of 26.6 and 34.2 kg/h respectively with series flow arrangement. Also, the circular fin is introduced in CGTSAC to enhance the performance of the series flow arrangement by increasing the heat transfer. [ABSTRACT FROM AUTHOR]

Secondary aerosols constitute a significant fraction of atmospheric aerosols, yet our understanding of their formation mechanism and fate is very limited. In this work, the secondary organic aerosol (SOA) formation and aging of ambient air of Delhi are studied using a potential aerosol mass (PAM) reactor, an oxidation flow reactor (OFR), coupled with aerosol chemical speciation monitor (ACSM), proton transfer reaction time of flight mass spectrometer (PTR-ToF-MS), and scanning mobility particle sizer with counter (SMPS + C). The setup mimics atmospheric aging of up to several days with the generation of OH radicals. Variations in primary volatile organic compounds (VOCs) and oxygenated volatile organic compounds (OVOCs) as a function of photochemical age were investigated. Primary VOCs such as benzene, toluene, xylene, trimethyl benzene, etc. decrease and OVOCs like formic acid, formaldehyde, acetone, ethanol, etc. increase substantially upon oxidation in OFR. The highest organic aerosol (OA) enhancement was observed for the 4.2 equivalent photochemical days of aging i.e., 1.84 times the ambient concentration, and net OA loss was observed at very high OH exposure, typically after 8.4 days of photochemical aging due to heterogeneous oxidation followed by fragmentation/evaporation. In ambient air, OA enhancement is highest during nighttime due to the high concentrations of precursor VOCs in the atmosphere. SMPS + C results demonstrated substantial new particle formation upon aging and decrement in preexisting aerosol mass. This is the first experimental study conducting an in-situ evaluation of potential SOA mass generated from the ambient aerosols in India. [Display omitted] • The OA concentration first increases and then decreases at high OH exposure. • Concentration of Primary VOCs decreases and OVOCs increases upon aging. • Elevated O:C ratios highlights the formation of more oxidized compounds during aging. • Aging increases the new particle formation and decreased the mass of pre-existing aerosols. [ABSTRACT FROM AUTHOR]

In warm and hot climates, ceiling fans and/or air conditioners (ACs) are used to maintain thermal comfort. Ceiling fans provide air movement near the skin, which enhances the evaporation of sweat, reduces heat stress, and enhances thermal comfort. This is also called the cooling effect. However, AC usage behaviour and the effects of elevated air speed through the use of ceiling fans on indoor operative temperature during AC usage are not widely studied. This study investigated the optimum AC (cooling) set point temperature and air velocity necessary for maintaining thermal comfort while achieving energy conservation, in mixed-mode buildings in India, through field studies by using used custom-built Internet of Things (IOT) devices. In the current study, the results indicate a 79% probability that comfort conditions can be maintained by achieving a temperature drop of 3K. If this drop can be achieved, as much as possible, through passive measures, the duration of AC operation and its energy consumption are reduced, at least by 67.5 and 58.4%, respectively. During the air-conditioned period, there is a possibility that the cooing effect is reduced because of increase in operative temperature due to ceiling fan operation. Therefore, the optimum solution is to maintain the highest AC set point and minimum fan speed setting that are acceptable. [ABSTRACT FROM AUTHOR]