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Objective: This study aims to evaluate the effectiveness of the Online Psycho-Oncology Counseling (OPC) in reducing distress levels among cancer patients. Methods: The research employs a paired sample t-test analysis to compare distress scores before and after the intervention. The study includes 30 solid tumor patients aged 30-59, undergoing cancer treatment. Distress levels were measured using the Distress Thermometer before and after the OPC intervention. Paired distress scores were computed for each participant, and a paired sample t-test was conducted to assess the statistical significance of the observed changes. Result: A statistically significant reduction in distress scores post-OPC intervention (t-value = 3.657, df = 29, p < 0.05) was observed. The mean distress score decreased from 5.67 ± 1.093 before OPC to 4.77 ± 1.675 after OPC. Importantly, 26.6% of participants shifted from high to low distress levels. The findings suggest that the Online Psycho-Oncology Intervention is effective in alleviating distress among cancer patients. The paired sample t-test provides robust statistical evidence supporting the positive impact of OPC on psychological well-being. Additionally, semi structured interview schedule was followed to explore the feasibility and satisfaction of the OPC program. Likert scale and thematic analysis was followed to analyze the qualitative data. Conclusion: Further research with larger cohorts and extended follow-up periods is recommended to enhance the understanding of the long-term effectiveness of psycho-oncology interventions in the digital realm. [ABSTRACT FROM AUTHOR]