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HanxBio has published a research paper titled "Narazaciclib, a novel multikinase inhibitor with potent activity against CSF1R, FLT3 and CDK6, shows strong anti-AML activity in defined preclinical models" in the journal Scientific Reports. The paper describes the preclinical evaluation of Narazaciclib (HX301) for the treatment of acute myeloid leukemia (AML). The researchers conducted comprehensive pharmacology characterization of HX301 using various preclinical experimental AML models, demonstrating its strong anti-leukemia activity and potential mechanisms of action. The study also investigated the pharmacodynamics and pharmacokinetics of HX301, providing valuable information for clinical dosage selection. The results of this study will guide the clinical development strategies for HX301 in the treatment of AML. [Extracted from the article]

A recent study conducted by GlaxoSmithKline plc highlights the transformative impact of microsampling and patient-centric sampling (PCS) techniques in drug development and clinical trials. These techniques have revolutionized pharmaceutical research by reducing sample volume requirements, allowing sample collection at home or nontraditional sites, and minimizing patient burden. The study also discusses the integration of liquid chromatography-mass spectrometry (LC-MS) strategies for analyzing PCS samples and addresses the challenges and future directions of implementing PCS. The aim of this research is to enhance patient care and treatment efficacy by fostering patient-centric approaches in pharmaceutical sciences. [Extracted from the article]

A patent application titled "Optimized Thermal Bottle" has been published online by the US Patent and Trademark Office. The inventor, Elvira GUALTIERI, filed the application on August 31, 2021, and the assignee is Pegaf S.R.L. The patent application describes an optimized thermal bottle that can independently manage multiple drinks or solid foods within separate compartments, allowing for different storage temperatures. The bottle consists of thermos compartments that are adjacent and can be closed with a cap. The invention aims to overcome the limitations of current thermal bottles and provide improved thermal insulation for each compartment. [Extracted from the article]

A patent has been issued for a carton designed to hold food products. The patent, filed by inventor John Murdick Holley Jr., describes a tray with multiple panels that form a rim, as well as foldable end flaps. The tray can be formed from a blank and includes features for product visibility. The patent was assigned to Graphic Packaging International LLC. [Extracted from the article]

A research paper titled "Evidence of a pan-tissue decline in stemness during human aging" has been published in the journal Aging. The study, conducted by researchers from the Universidade de Sao Paulo, University of Birmingham, and the University of Liverpool, used a machine learning method to analyze transcriptome data from healthy human tissues. The researchers found that approximately 60% of the tissues studied showed a negative correlation between age and stemness score, indicating a decline in stem cell function with aging. However, the uterus was an exception, showing increased stemness with age. The study suggests that stem cell deterioration may contribute to human aging. [Extracted from the article]

The downdraught of the helicopter's rotor blades, as it landed, blew her and her tripod sheer off the ground. Smoke from earth-shaking explosions shut down her view entirely. A trek [...]

Nelson Mandela voted for the first time in his life on April 27th 1994 in Inanda, a poor area on the hills above the city of Durban. The choice of [...]

BUYING: Look for firm peppers with a glossy sheen and zero soft spots.STORAGE: Place whole unwashed peppers in paper bag in crisper drawer of fridge for up to 7 days.FYI: [...]

Peanut Butter BlondiesSee page 73 for recipe. Poached Apricots with MascarponeSee page 73 for recipe.Flourless Chocolate CakeSee page 73 for recipe. Peanut Butter Blondies Active time: 45 min. Total time: [...]

REVITALIZE GARDEN SHEARS IN A SNIP Dull shears can make pruning both indoor and outdoor greenery quite the hassle. To get them working like new again, enlist the help of [...]

Jacksonville is known as a logistics hub, which includes railroads like CSX and Florida East Coast Railway, both headquartered there. Yet other railroads, like Norfolk Southern, also have a large [...]

Local efforts to find a buyer for the closed Foley Cellulose Paper Mill in Perry have been put on hold for another year while owner Georgia Pacific conducts a study [...]

From a humble start, attorney John Ruiz became Florida's richest person--on paper, for a moment. Now the medical claims recovery company that catapulted him to billionaire status is on the [...]

Fort Myers * Bonita Springs Estero * Cape Coral * Sanibel & Captiva Islands * Fort Myers Beach Pine Island * North Fort Myers Lehigh Acres * Boca Grande & [...]

Tait, Alice NO, NANCY, NO! A DOG CHASE IN NEW YORK Walker US/Candlewick (Children's None) $18.99 6, 4 ISBN: 9781536232714 A show-biz pooch leads a girl and her pup on [...]

Trempe, Melissa LADYBUG LAUNCH McElderry (Children's None) $18.99 4, 16 ISBN: 9781665930406 In this tale inspired by co-author Ojeda's personal experience, kindred spirits reach for the stars. Natalia, a young [...]

El-Rouby, Yasmin MISTY MOLE GETS NEW GLASSES Neem Tree Press (Children's None) $18.95 6, 11 ISBN: 9781915584182 Misty Mole realizes that her eyesight needs correcting. Misty's friend Sunny Squirrel says [...]

Schmuhl, Robert MR. CHURCHILL IN THE WHITE HOUSE Liveright/Norton (NonFiction None) $32.00 7, 2 ISBN: 9781324093428 A respected historian finds new things to say about the relationship between Franklin Roosevelt [...]

Scanlon, Liz Garton BIBSY CROSS AND THE BAD APPLE Knopf (Children's None) $16.99 6, 11 ISBN: 9780593644416 Trouble with an insensitive teacher threatens an enthusiastic 8-year-old's love of school in [...]

Davis, Amira Rose GO, WILMA, GO! Bloomsbury (Children's None) $18.99 7, 16 ISBN: 9781547612093 A tribute to the renowned Olympian and Civil Rights activist. Wilma Rudolph's youth and early successes [...]

Saller, Carol Fisher MADDIE'S GHOST (Fiction) $21.99 8, 15 ISBN: 9798986235387 In Saller's middle-grade novel, a tween and her friends race against time to restore her great-grandmother's good name. The [...]

Linsmeier, Amanda SIX OF SORROW Delacorte (Teen None) $19.99 6, 25 ISBN: 9780593707760 Six former best friends whose birthdays fall on the Day of Sorrow must defeat the supernatural evil [...]

Negley, Keith THE RUNNING MACHINE Balzer + Bray/HarperCollins (Children's None) $19.99 7, 23 ISBN: 9780063119826 A quick-witted young man decided that wheels and human legs might replace horses. When a [...]

Hollis, Lee MURDER AT THE SPELLING BEE Kensington (Fiction None) $8.99 5, 21 ISBN: 9781496736550 An unpleasant teacher gets what's coming to her when her Maine school district hosts a [...]

Choi, Yangsook A LETTER TO MY BEST FRIEND Farrar, Straus and Giroux (Children's None) $18.99 7, 9 ISBN: 9780374391294 A young Korean immigrant makes a new friend while reflecting on [...]

FUJIFILM X100VI MIRRORLESS DIGITAL CAMERA Social media is in love with https://fujifilm-x.com’s latest, and with good reason—it’s a small yet powerful camera that’s easy to use for novices but has [...]

BY DAN MOREN (IMAGE: APPLE) After years of the market complaining that Apple is “behind” on artificial intelligence, the company is poised to make a big push in the technology [...]

The drugs nalmefene and naltrexone show promise for treating compulsive gambling TWO medicines usually given to people who are addicted to opioid drugs also help with compulsive gambling. The finding [...]

WHEN a wasp comes across another, it uses certain brain cells to identify their face. What's more, these neurons seem similar to face-recognition cells in the brains of primates, including [...]

http://www.newscientist.com/topic/feedback is our weekly column of bizarre stories, implausible advertising claims, confusing instructions and more Chung To Kong found a way, in the spirit of unboiling an egg (https://www.newscientist.com/article/mg25534033-200-how-to-boil-an-egg-so-the-yolk-ends-up-on-the-outside-of-the-inside/ , [...]

As one of the federal government's oldest agencies, the U.S. Mint was established (via the Coinage Act) on April 2, 1792. The Mint currently operates production facilities in Denver, Colorado; [...]

INVESTING HAS CHANGED--A LOT. HERE'S WHAT THE EXPERTS HAVE TO SAY ABOUT MAKING YOUR MONEY WORK FOR YOU. Nothing ages like a good bourbon--except for a good investment. Now, you [...]

The Patent Office, in Washington, D.C., probably interests more people throughout the United States than any other bureau in the great departments located there. Beneath its vast roof are housed [...]

Chris Orzeehowski does not wear watches. But that didn't stop him from writing the copy for the luxury timepiece brand Filippo Loreti in 2016, a campaign that raked in more [...]

Title: Co-Founder and CEO Company: XTEN-AV Location: Washington, DC Overtime: One of his biggest passions is cricket--playing and watching--and the rest of his time is spent obsessed with his one-year-old [...]