5 results on '"Mosimann, Pascal J"'
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2. Radiological Outcome of Middle Meningeal Artery Embolization in Relation to Chronic Subdural Hematoma Cause and Architecture.
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Abdelghafar, Ahmed, Falzon, Andrew, Hendriks, Eef J., Radovanovic, Ivan, Andrade, Hugo, Schaafsma, Joanna D., and Mosimann, Pascal J.
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SUBDURAL hematoma ,COMPUTED tomography ,PSEUDOPOTENTIAL method ,STATISTICAL correlation ,COHORT analysis - Abstract
Background/Objectives: MMAE (middle meningeal artery embolization) has emerged as a potential effective treatment for cSDH (chronic subdural hematoma). In this study, MMAE efficiency with regards to cSDH cause and architecture was explored. The comparability of cSDH thickness and volume as parameters for cSDH pre- and post-MMAE assessment was also analyzed. Methods: In this retrospective cohort study, 52 consecutive cSDH patients treated with MMAE in a single tertiary center were included. The cohort was divided into two group pairs pertaining to cSDH cause (spontaneous or traumatic) and cSDH architecture (non-mature or mature). The radiological outcome was compared in each group before and after MMAE and between each group pair using CT imaging. A correlation analysis between cSDH thickness and volume before and after MMAE was also performed. Results: A statistically significant positive linear association between cSDH thickness and volume at admission and at each follow-up interval (1–3, 3–6, 6–12 months) was noticed. cSDH thickness and volume reduction in each group was statistically significant, except for a traumatic cSDH volume reduction at 6–12 months. There was no statistically significant difference between each group pair in the cSDH thickness and volume reduction difference at all the follow-up intervals. Conclusions: A comparable efficiency of MMAE may be achieved in non-mature and mature as well as in spontaneous and traumatic cSDH, with an advantage for spontaneous cSDH at 6–12 months follow-up compared to traumatic cSDH. Traumatic cSDH may require a relatively long-term follow-up post-MMAE. cSDH thickness and volume, as parameters for pre- and post-MMAE cSDH evaluation, appear similar. [ABSTRACT FROM AUTHOR]
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- 2024
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3. LVIS EVO stent-through-balloon after hydrocoil embolization of intracranial aneurysms: One-year results
- Author
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Mosimann, Pascal J, primary, Yamac, Elif, additional, Wallocha, Marta, additional, Ayad, Ahmed, additional, and Chapot, René, additional
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- 2022
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4. Mechanical thrombectomy for acute ischemic stroke in COVID-19 patients: multicenter experience in 111 cases
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Styczen, Hanna, Maus, Volker, Goertz, Lukas, Koehrmann, Martin, Kleinschnitz, Christoph, Fischer, Sebastian, Moehlenbruch, Markus, Muehlen, Iris, Kallmuenzer, Bernd, Dorn, Franziska, Lakghomi, Asadeh, Gawlitza, Matthias, Kaiser, Daniel, Klisch, Joachim, Lobsien, Donald, Rohde, Stefan, Ellrichmann, Gisa, Behme, Daniel, Thormann, Maximilian, Flottmann, Fabian, Winkelmeier, Laurens, Gizewski, Elke R., Mayer-Suess, Lukas, Boeckh-Behrens, Tobias, Riederer, Isabelle, Klingebiel, Randolf, Berger, Bjoern, Schlunz-Hendann, Martin, Grieb, Dominik, Khanafer, Ali, de Rochemont, Richard du Mesnil, Arendt, Christophe, Altenbernd, Jens, Schlump, Jan-Ulrich, Ringelstein, Adrian, Sanio, Vivian Jean Marcel, Loehr, Christian, Dahlke, Agnes Maria, Brockmann, Carolin, Reder, Sebastian, Sure, Ulrich, Li, Yan, Muehl-Benninghaus, Ruben, Rodt, Thomas, Kallenberg, Kai, Durutya, Alexandru, Elsharkawy, Mohamed, Stracke, Paul, Schumann, Mathias Gerhard, Bock, Alexander, Nikoubashman, Omid, Wiesmann, Martin, Henkes, Hans, Mosimann, Pascal J., Chapot, Rene, Forsting, Michael, Deuschl, Cornelius, Styczen, Hanna, Maus, Volker, Goertz, Lukas, Koehrmann, Martin, Kleinschnitz, Christoph, Fischer, Sebastian, Moehlenbruch, Markus, Muehlen, Iris, Kallmuenzer, Bernd, Dorn, Franziska, Lakghomi, Asadeh, Gawlitza, Matthias, Kaiser, Daniel, Klisch, Joachim, Lobsien, Donald, Rohde, Stefan, Ellrichmann, Gisa, Behme, Daniel, Thormann, Maximilian, Flottmann, Fabian, Winkelmeier, Laurens, Gizewski, Elke R., Mayer-Suess, Lukas, Boeckh-Behrens, Tobias, Riederer, Isabelle, Klingebiel, Randolf, Berger, Bjoern, Schlunz-Hendann, Martin, Grieb, Dominik, Khanafer, Ali, de Rochemont, Richard du Mesnil, Arendt, Christophe, Altenbernd, Jens, Schlump, Jan-Ulrich, Ringelstein, Adrian, Sanio, Vivian Jean Marcel, Loehr, Christian, Dahlke, Agnes Maria, Brockmann, Carolin, Reder, Sebastian, Sure, Ulrich, Li, Yan, Muehl-Benninghaus, Ruben, Rodt, Thomas, Kallenberg, Kai, Durutya, Alexandru, Elsharkawy, Mohamed, Stracke, Paul, Schumann, Mathias Gerhard, Bock, Alexander, Nikoubashman, Omid, Wiesmann, Martin, Henkes, Hans, Mosimann, Pascal J., Chapot, Rene, Forsting, Michael, and Deuschl, Cornelius
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Background Data on the frequency and outcome of mechanical thrombectomy (MT) for large vessel occlusion (LVO) in patients with COVID-19 is limited. Addressing this subject, we report our multicenter experience. Methods A retrospective cohort study was performed of consecutive acute stroke patients with COVID-19 infection treated with MT at 26 tertiary care centers between January 2020 and November 2021. Baseline demographics, angiographic outcome and clinical outcome evaluated by the modified Rankin Scale (mRS) at discharge and 90 days were noted. Results We identified 111 out of 11 365 (1%) patients with acute or subsided COVID-19 infection who underwent MT due to LVO. Cardioembolic events were the most common etiology for LVO (38.7%). Median baseline National Institutes of Health Stroke Scale score and Alberta Stroke Program Early CT Score were 16 (IQR 11.5-20) and 9 (IQR 7-10), respectively. Successful reperfusion (mTICI >= 2b) was achieved in 97/111 (87.4%) patients and 46/111 (41.4%) patients were reperfused completely. The procedure-related complication rate was 12.6% (14/111). Functional independence was achieved in 20/108 (18.5%) patients at discharge and 14/66 (21.2%) at 90 days follow-up. The in-hospital mortality rate was 30.6% (33/108). In the subgroup analysis, patients with severe acute COVID-19 infection requiring intubation had a mortality rate twice as high as patients with mild or moderate acute COVID-19 infection. Acute respiratory failure requiring ventilation and time interval from symptom onset to groin puncture were independent predictors for an unfavorable outcome in a logistic regression analysis. Conclusion Our study showed a poor clinical outcome and high mortality, especially in patients with severe acute COVID-19 infection undergoing MT due to LVO.
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- 2022
5. LVIS EVO stent-through-balloon after hydrocoil embolization of intracranial aneurysms: One-year results
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Mosimann, Pascal J, Yamac, Elif, Wallocha, Marta, Ayad, Ahmed, and Chapot, René
- Abstract
Background and purpose To evaluate the durability and safety of complete intracranial aneurysm occlusion at one year using the low-profile braided intracranial LVIS EVO stent.Materials and methods This is a retrospective, monocentric, observational study of unruptured wide-necked intracranial aneurysms treated with the LVIS EVO stent-through-balloon technique after balloon-assisted hydrocoil embolization. Imaging and clinical data were assessed by two blinded independent neuroradiologists and neurologists, respectively. Primary endpoint was complete angiographic occlusion on day 0 and at 12 months. Secondary endpoints included clinical safety using the modified Rankin scale (mRS), ischemic and hemorrhagic adverse events, parent vessel stenosis > 50% or occlusion and retreatment rate.Results 103 aneurysms in 103 patients were included (53 years-old, 77% women). Mean aneurysm size and neck were 7 and 4 mm, respectively. Complete occlusion was 97% initially and 90% at 12 months, with pending follow up in 17.5% patients. Five patients (5%) with partially stented necks were retreated with a second stent in a T-configuration. Two stents failed to open initially and were immediately retrieved. Asymptomatic parent vessel occlusion and severe in-stent stenosis occurred in 1% and 3%, respectively. The 12-month procedure-related permanent neurological deficit and mortality rates (mRS 3–6) were 2% and 1%, respectively. There was one fatal bleeding but no large ischemic complications.Conclusion Delivering the LVIS EVO stent through a dual lumen balloon after balloon-assisted hydrocoil embolization yields a high and stable rate of complete aneurysm occlusion at one year with a reasonable immediate and delayed complication rate.
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- 2024
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