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419 results on '"Ferreira, Fernando"'

1. Expected and unexpected routes to synchronization in a system of swarmalators

Author

Kongni, Steve J., Njougouo, Thierry, Louodop, Patrick, Tchitnga, Robert, Ferreira, Fernando F., and Cerdeira, Hilda A.

Subjects
Nonlinear Sciences - Adaptation and Self-Organizing Systems
Abstract

Systems of oscillators whose internal phases and spatial dynamics are coupled, swarmalators, present diverse collective behaviors which in some cases lead to explosive synchronization in a finite population as a function of the coupling parameter between internal phases. Near the synchronization transition, the phase energy of the particles is represented by the XY model, and they undergo a transition which can be of the first order or second depending on the distribution of natural frequencies of their internal dynamics. The first order transition is obtained after an intermediate state (Static Wings Phase Wave state (SWPW)) from which the nodes, in cascade over time, achieve complete phase synchronization at a precise value of the coupling constant. For a particular case of natural frequencies distribution, a new phenomenon of Rotational Splintered Phase Wave state (RSpPW) is observed and leads progressively to synchronization through clusters switching alternatively from one to two and for which the frequency decreases as the phase coupling increases.

Published
2024

2. Gut epithelial electrical cues drive differential localization of enterobacteria

Author

Sun, Yaohui, Ferreira, Fernando, Reid, Brian, Zhu, Kan, Ma, Li, Young, Briana M, Hagan, Catherine E, Tsolis, Renée M, Mogilner, Alex, and Zhao, Min

Subjects
Microbiology, Biological Sciences, Biodefense, Lung, Emerging Infectious Diseases, Foodborne Illness, Digestive Diseases, Cystic Fibrosis, Rare Diseases, Infectious Diseases, 2.2 Factors relating to the physical environment, 2.1 Biological and endogenous factors, Infection, Medical Microbiology
Abstract

Salmonella translocate to the gut epithelium via microfold cells lining the follicle-associated epithelium (FAE). How Salmonella localize to the FAE is not well characterized. Here we use live imaging and competitive assays between wild-type and chemotaxis-deficient mutants to show that Salmonella enterica serotype Typhimurium (S. Typhimurium) localize to the FAE independently of chemotaxis in an ex vivo mouse caecum infection model. Electrical recordings revealed polarized FAE with sustained outward current and small transepithelial potential, while the surrounding villus is depolarized with inward current and large transepithelial potential. The distinct electrical potentials attracted S. Typhimurium to the FAE while Escherichia coli (E. coli) localized to the villi, through a process called galvanotaxis. Chloride flux involving the cystic fibrosis transmembrane conductance regulator (CFTR) generated the ionic currents around the FAE. Pharmacological inhibition of CFTR decreased S. Typhimurium FAE localization but increased E. coli recruitment. Altogether, our findings demonstrate that bioelectric cues contribute to S. Typhimurium targeting of specific gut epithelial locations, with potential implications for other enteric bacterial infections.

Published
2024

3. Diabetic Ocular Surface Has Defects in Oxygen Uptake Revealed by Optic Fiber Microsensor

Author

Qin, Sun, Ma, Li, Ferreira, Fernando, Brown, Chelsea, Navedo, Manuel F, Reid, Brian, and Zhao, Min

Subjects
Biomedical and Clinical Sciences, Ophthalmology and Optometry, Eye Disease and Disorders of Vision, Diabetes, Autoimmune Disease, Eye, Metabolic and endocrine, Humans, Animals, Mice, Diabetes Mellitus, Experimental, Cornea, Conjunctiva, Corneal Diseases, Oxygen, cornea, diabetes, oxygen, microsensor, Biological Sciences, Medical and Health Sciences, Ophthalmology & Optometry, Ophthalmology and optometry
Abstract

PurposeDiabetes mellitus causes diabetic keratopathy (DK). This and other ocular surface disorders are underdiagnosed and problematic for affected patients as well as recipients of diabetic donor corneas. Thus, it is important to find noninvasive means to facilitate determination of the potentially vision-threatening DK. It has been reported that diabetic corneas uptake significantly less oxygen (O2) than healthy controls. However, an integral assessment of the ocular surface is missing.MethodsUsing an optic-fiber O2 micro-sensor (optrode) we demonstrated recently that the healthy ocular surface displays a unique spatiotemporal map of O2 consumption. We hypothesize that diabetes impairs the spatiotemporal profile of O2 uptake at the ocular surface.ResultsUsing streptozotocin (STZ)-induced diabetic mice, we found diminished O2 uptake and loss of the unique pattern across the ocular surface. A diabetic cornea consumes significantly less O2 at the bulbar conjunctiva and limbus, but not the central and peripheral cornea, compared to controls. Further, we show that, contrary to the healthy cornea, the diabetic cornea does not increase the O2 consumption at the limbus in the evening as the normal control.ConclusionsAltogether, our measurements reveal a previously unknown impairment in O2 uptake at the diabetic cornea, making it a potential tool to diagnose ocular surface abnormalities and suggesting a new etiology mechanism.

Published
2024

6. Multispecies and multibiomarker assessment of fish health from Iguaçu River reservoir, Southern Brazil

Author

Rubio-Vargas, Dámaso Angel, Morais, Tobias Pereira de, Randi, Marco Antonio Ferreira, Filipak Neto, Francisco, Ortolani-Machado, Cláudia Feijó, Martins, César de Castro, Oliveira, Andrea Pinto, Nazário, Mariana Gallucci, Ferreira, Fernando Cesar Alves da Silva, Opuskevitch, Iracema, Penner, Dieter, Esquivel-Muelbert, Juan, Mela Prodocimo, Maritana, de Souza, Claudemir, Choueri, Rodrigo Brasil, and de Oliveira Ribeiro, Ciro Alberto

Published
2024
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7. Electric field–guided collective motility initiation of large epidermal cell groups

Author

Sun, Yaohui, Reid, Brian, Zhang, Yan, Zhu, Kan, Ferreira, Fernando, Estrada, Alejandro, Sun, Yuxin, Draper, Bruce W, Yue, Haicen, Copos, Calina, Lin, Francis, Bernadskaya, YelenaY, Zhao, Min, and Mogilner, Alex

Subjects
Biochemistry and Cell Biology, Biological Sciences, Bioengineering, 1.1 Normal biological development and functioning, Animals, Zebrafish, Cell Movement, Phosphatidylinositol 3-Kinases, Medical and Health Sciences, Developmental Biology, Biochemistry and cell biology
Abstract

Recent research has elucidated mechanochemical pathways of single cell polarization, but much less is known about collective motility initiation in adhesive cell groups. We used galvanotactic assays of zebrafish keratocyte cell groups, pharmacological perturbations, electric field switches, particle imaging velocimetry, and cell tracking to show that large cell groups initiate motility in minutes toward the cathode. Interestingly, while PI3K-inhibited single cells are biased toward the anode, inhibiting PI3K does not affect the cathode-directed cell group migration. We observed that control groups had the fastest cathode-migrating cell at the front, while the front cells in PI3K-inhibited groups were the slowest. Both control and PI3K-inhibited groups rapidly repolarized when the electric field direction was reversed, and the group migration continued after the electric field was switched off. Inhibiting myosin disrupted the cohesiveness of keratocyte groups and abolished the collective directionality and ability to switch direction when the electric field is reversed. Our data are consistent with a model according to which cells in the group sense the electric field individually and mechanical integration of the cells results in coherent group motility.

Published
2023

8. Synchronization in a multilevel network using the Hamilton-Jacobi-Bellman (HJB) technique

Author

Njougouo, Thierry, Camargo, Victor, Louodop, Patrick, Ferreira, Fernando F, Talla, Pierre K., and Cerdeira, Hilda A.

Subjects
Mathematics - Optimization and Control, Nonlinear Sciences - Chaotic Dynamics, Physics - Computational Physics
Abstract

This paper presents the optimal control and synchronization problem of a multilevel network of R\"ossler chaotic oscillators. Using the Hamilton-Jacobi-Bellman (HJB) technique, the optimal control law with three-state variables feedback is designed such that the trajectories of all the R\"ossler oscillators in the network are optimally synchronized in each level. Furthermore, we provide numerical simulations to demonstrate the effectiveness of the proposed approach for the cases of one and three networks. A perfect correlation between the MATLAB and the PSPICE results was obtained, thus allowing the experimental validation of our designed controller and shows the effectiveness of the theoretical results.

Published
2022
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9. Critical Exponents of Master-Node Network Model

Author

Mihara, Antonio, Ferreira, Anderson A., Martins, André C. R., and Ferreira, Fernando F.

Subjects
Physics - Physics and Society
Abstract

The dynamics of competing opinions in social network play an important role in society, with many applications in diverse social contexts as consensus, elections, morality and so on. Here we study a model of interacting agents connected in networks to analyze their decision stochastic process. We consider a first-neighbor interaction between agents in a one-dimensional network with a shape of ring topology. Moreover, some agents are also connected to a hub, or master node, that has preferential choice or bias. Such connections are quenched. As the main results, we observed a continuous non-equilibrium phase transition to an absorbing state as a function of control parameters. By using the finite size scaling method, we analyzed the static and dynamic critical exponents to show that this model probably cannot match any universality class already known., Comment: 14 pages, 5 tables, 4 figures

Published
2022

10. Varieties of Lazy Magmas Characterized by Forbidden Substructure Theorems

Author

Araújo, João, Ferreira, Fernando Maia, and Kinyon, Michael

Subjects
Mathematics - Group Theory, Mathematics - Logic, 20N02, 20M07, 20M75
Abstract

A magma (or groupoid) is a set with a binary operation $(A,f)$. Roughly speaking, a magma is said to be lazy if compositions such as $f(x,f(f(y,z),u))$ depend on at most two variables. Recently, Kaprinai, Machida and Waldhauser described the lattice of all the varieties of lazy groupoids. A forbidden structure theorem is one that charcaterizes a smaller class $A$ inside a larger class $B$ as all the elements in $B$ that avoid some substructures. For example, a lattice is distributive (smaller class $A$) if and only if it is a lattice (larger class $B$) and avoids the pentagon and the diamond. In this paper we provide a characterization of all pairs of lazy groupoid varieties $A\le B$ by forbidden substructure theorems. Some of the results are straightforward, but some other are very involved. All of these results and proofs were found using a computational tool that proves theorems of this type (for many different classes of relational algebras) and that we make available to every mathematician.

Published
2022

11. Optic Fiber Microsensor Reveals Specific Spatiotemporal Oxygen Uptake Profiles at the Mammalian Ocular Surface

Author

Sun, Qin, Ma, Li, Ferreira, Fernando, Brown, Chelsea, Reid, Brian, and Zhao, Min

Subjects
Analytical Chemistry, Biochemistry and Cell Biology, Chemical Sciences, Biological Sciences, Eye Disease and Disorders of Vision, Rats, Mice, Animals, Cornea, Fiber Optic Technology, Optical Fibers, Oxygen, Mammals, cornea, oxygen uptake, spatiotemporal profile, self-referencing probe, oxygen sensor, optical fiber sensor, Biochemistry and cell biology, Analytical chemistry
Abstract

Oxygen (O2) uptake by cells and tissues is a critical indicator of metabolic demand, changes in microenvironment, and pathophysiology. O2 uptake from the atmosphere accounts for virtually all the O2 consumption in the avascular cornea; however, a detailed spatiotemporal profile of corneal O2 uptake (COU) remains undetermined. Here, we used a non-invasive self-referencing optical fiber O2 sensor-the scanning micro-optrode technique (SMOT)-to report the O2 partial pressure and flux variations at the ocular surface of rodents and non-human primates. In vivo spatial mapping in mice revealed a distinct COU, characterized by a centripetal gradient with a significantly higher O2 influx at the limbus and conjunctiva regions than at the center of the cornea. This regional COU profile was reproduced ex vivo in freshly enucleated eyes. The centripetal gradient was conserved across the following species analyzed: mice, rats, and rhesus monkeys. In vivo temporal mapping in mice showed a significant increase in the O2 flux in the limbus in the evening compared to other times. Altogether, the data unveiled a conserved centripetal COU profile, which may be associated with the limbal epithelial stem cells residing at the intersection of the limbus and conjunctiva. These physiological observations will serve as a useful baseline for comparative studies with contact lens wear, ocular disease, diabetes, etc. Moreover, the sensor may be applied to understand the responses of the cornea and other tissues to various insults, drugs, or changes in the environment.

Published
2023

16. Pollutant bioaccumulation in sentinel fish chronically exposed in Iguaçu river reservoirs (Southern Brazil) and human health risk of fish consumption

Author

Rubio-Vargas, Dámaso Angel, Morais, Tobias Pereira de, Randi, Marco Antônio Ferreira, Filipak Neto, Francisco, Martins, César de Castro, Oliveira, Andrea Pinto, Nazário, Mariana Gallucci, Ferreira, Fernando Cesar Alves da Silva, Opuskevitch, Iracema, Penner, Dieter, Esquivel-Muelbert, Juan, Prodocimo, Maritana Mela, Choueri, Rodrigo Brasil, and Oliveira Ribeiro, Ciro Alberto de

Published
2024
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19. Contextual and Individual Determinants of Anterior Open Bite in Adolescents

Author

Bastos Roosevelt-Silva, Pistelli Gustavo-Chab, Ferreira Fernando-Pedrin-Carvalho, Bastos José-Roberto-Magalhães, Janson Guilherme, and Ferreira Raquel-Conceição

Subjects
Open bite, Social determinants of health, Epidemiology, Dentistry, RK1-715
Abstract

Objective: Studying the broader determinants of anterior open bite (AOB) may guide more equitable policies.This study estimates the prevalence of AOB in Brazilian adolescents and its association with contextual and individual determinants. Methodology: The data for dentofacial anomalies in 15- to 19-year-olds from the National Oral Health Survey SBBrasil 2010 were analysed (N = 4748). AOB was based on the Dental Aesthetic Index (AOB = 0; AOB > 0); the contextual variables were the Human Development Index (HDI) and the Gini Index (2010). The individual sociodemographic variables included sex (male, female), self-reported skin colour/race (white, black, brown, and indigenous + yellow), family income (≥4 minimum wage [MW]; 0–3 MW), and educational attainment (ideal, delayed). The individual clinical variables were decayed, missing, and filled teeth (DMFT) (0, ≥1), first permanent molar loss (0, ≤3, 4), and molar relationship (normal, half cusp, full cusp). Multilevel logistic regression models with random intercepts and fixed slopes were used to estimate odds ratios (ORs) and confidence intervals (95% CIs). Results: AOB prevalence in Brazil was 8.78% (95% CI, 6.85–11.20) at 15 to 19 years of age. The lowest prevalence was in São Luis (2.63%; 95% CI, 0.58–11.03) and the highest was in João Pessoa (29.85%; 95% CI, 15.93–48.85), both capitals of the northeast Brazilian region. A higher prevalence of AOB (OR, 1.71; 95% CI, 1.04–2.80) was observed in municipalities with a lower HDI. Adolescents who declared their skin colour black, with lower family income, with delayed education, with DMFT ≥ 1, who lost 4 permanent first molars, and who had a complete molar cusp relationship were more likely to have AOB. Conclusions: AOB varied amongst Brazilian municipalities. The HDI plays an important role in the prevalence of AOB; individual social determinants have also been associated with AOB malocclusion in adolescents.

Published
2023
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35. Revealing the differential protein profiles behind the nitrogen use efficiency in popcorn (Zea mays var. everta)

Author

Khan, Shahid, Pinto, Vitor Batista, do Amaral Júnior, Antônio Teixeira, Gonçalves, Gabriel Moreno Bernardo, Corrêa, Caio Cézar Guedes, Ferreira, Fernando Rafael Alves, de Souza, Guilherme Augusto Rodrigues, Campostrini, Eliemar, Freitas, Marta Simone Mendonça, Vieira, Marlene Evangelista, de Oliveira Santos, Talles, de Lima, Valter Jário, Kamphorst, Samuel Henrique, do Amaral, José Francisco Teixeira, Mora-Poblete, Freddy, de Souza Filho, Gonçalo Apolinário, and Silveira, Vanildo

Published
2022
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37. A prospective observational study for a Federated Artificial Intelligence solution for moniToring mental Health status after cancer treatment (FAITH): study protocol

Author

Lemos, Raquel, Areias-Marques, Sofia, Ferreira, Pedro, O’Brien, Philip, Beltrán-Jaunsarás, María Eugenia, Ribeiro, Gabriela, Martín, Miguel, del Monte-Millán, María, López-Tarruella, Sara, Massarrah, Tatiana, Luís-Ferreira, Fernando, Frau, Giuseppe, Venios, Stefanos, McManus, Gary, and Oliveira-Maia, Albino J.

Published
2022
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38. AS TECNOLOGIAS CERÂMICAS DAS ESTRUTURAS DE TERRA DO ACRE.

Author

Pessoa, Cliverson, Freitas Costa, Angislaine, Pessôa Coelho, Jane, Frota, Raquel, Ferreira, Fernando, César Piccoli, Jacó, and Góes Neves, Eduardo

Subjects
ALLUVIAL plains, CERAMICS, SOCIAL change, EARTHWORK
Abstract

Copyright of Revista de Arqueologia is the property of Revista de Arqueologia and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Published
2024
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43. Camera trap surveys of Atlantic Forest mammals: A data set for analyses considering imperfect detection (2004–2020)

Author

Franceschi, Ingridi Camboim, primary, Dornas, Rubem Augusto da Paixão, additional, Lermen, Isabel Salgueiro, additional, Coelho, Artur Vicente Pfeifer, additional, Vilas Boas, Ademir Henrique, additional, Chiarello, Adriano Garcia, additional, Paglia, Adriano Pereira, additional, de Souza, Agnis Cristiane, additional, Borsekowsky, Alana Rafaela, additional, Rocha, Alessandro, additional, Bager, Alex, additional, de Souza, Alexander Zaidan, additional, Lopes, Alexandre Martins Costa, additional, de Moura, Aloysio Souza, additional, Ferreira, Aluane Silva, additional, García‐Olaechea, Alvaro, additional, Delciellos, Ana Cláudia, additional, Bacellar, Ana Elisa de Faria, additional, Campelo, Ana Kellen Nogueira, additional, Paschoal, Ana Maria Oliveira, additional, Rolim, Anderson Claudino, additional, da Silva, André Luiz Ferreira, additional, Lanna, Andre Monnerat, additional, da Silva, André Pereira, additional, Guimarães, Andresa, additional, Cardoso, Ângela, additional, Cassol, Angelica Soligo, additional, da Costa‐Pinto, Anna Ludmilla, additional, do Nascimento, Ariel Guilherme Santos, additional, Fernandes, Arthur Soares, additional, Clyvia, Aryanne, additional, Santos, Aureo Banhos dos, additional, Lima‐Silva, Barbara, additional, Beisiegel, Beatriz de Mello, additional, Luciano, Beatriz Fernandes Lima, additional, Leopoldo, Bernardo de Faria, additional, Krobel, Bruna Nunes, additional, Kubiak, Bruno Busnello, additional, Saranholi, Bruno Henrique, additional, Correa, Bruno Senna, additional, Sant Anna Teixeira, Caio, additional, Ayroza, Camila Rezende, additional, Cassano, Camila Righetto, additional, Benitez‐Riveros, Camilo, additional, Gestich, Carla Cristina, additional, Tedesco, Carla Denise, additional, Gheler‐Costa, Carla, additional, Hegel, Carla Grasiele Zanin, additional, Evangelista Junior, Carlito da Silva, additional, Ferreira, Carlos Eduardo Morando Faria, additional, Grelle, Carlos Eduardo Viveiros, additional, Esteves, Carolina Franco, additional, Espinosa, Caroline da Costa, additional, Leuchtenberger, Caroline, additional, Sanchéz‐Lalinde, Catalina, additional, Machado, Cauanne Iglesias Campos, additional, Andreazzi, Cecilia, additional, Bueno, Cecília, additional, Cronemberger de Faria, Cecilia, additional, Novaes, Claudio, additional, Widmer, Cynthia Elisa, additional, Santos, Cyntia Cavalcante, additional, Ferraz, Daniel da Silva, additional, Galiano, Daniel, additional, Bôlla, Daniela Aparecida Savariz, additional, Behs, Daniela, additional, Rodrigues, Daniele Pereira, additional, de Melo, Danielle Picão, additional, Ramos, Déborah Maria Soares, additional, de Mattia, Denise Lidório, additional, Pavei, Diego Dias, additional, Loretto, Diogo, additional, Huning, Douglas da Silva, additional, Dias, Douglas de Matos, additional, Paetzhold, Éder Ricardo, additional, Rios, Elaine, additional, Setz, Eleonore Zulnara Freire, additional, Cazetta, Eliana, additional, Cafofo Silva, Emanuel Giovani, additional, Pasa, Emanuelle, additional, Saito, Erica Naomi, additional, de Aguiar, Erick Francisco Silva, additional, Castro, Érika Paula, additional, Viveiros de Castro, Ernesto Bastos, additional, Pedó, Ezequiel, additional, Pereira, Fabiane de Aguiar, additional, Bolzan, Fábio, additional, Roque, Fábio de Oliveira, additional, Mazim, Fábio Dias, additional, Comin, Fábio Henrique, additional, Maffei, Fábio, additional, Peters, Felipe Bortolotto, additional, Fantacini, Felipe Moreli, additional, da Silva, Felipe Pessoa, additional, Machado, Felipe Santana, additional, Vélez‐Garcia, Felipe, additional, Lage, Fernanda Stussi Duarte, additional, Perini, Fernando Araújo, additional, Passos, Fernando Camargo, additional, Carvalho, Fernando, additional, de Azevedo, Fernando Cesar Cascelli, additional, Ferreira, Fernando, additional, de Pinho, Fernando Ferreira, additional, Chaves, Flávia Guimarães, additional, Miranda, Flavia Regina, additional, Rodrigues, Flavio Henrique Guimarães, additional, Ubaid, Flávio Kulaif, additional, Gabriel, Francisco Homem, additional, de Souza, Franco Leandro, additional, de Oliveira, Fred Victor, additional, Cupolillo, Gabriel, additional, Moreira, Gabriela de Araújo Pires, additional, Mette, Gabriela, additional, Duarte, Gabriela Teixeira, additional, Beca, Gabrielle, additional, Corso, Gilberto, additional, Perbiche‐Neves, Gilmar, additional, Souto, Glauber Henrique Borges de Oliveira, additional, Vilarroel, Glenda Jéssica da Silva, additional, Batista, Graziele O., additional, Ferreira, Guilherme Braga, additional, Toledo, Gustavo Alves da Costa, additional, Senger, Gustavo, additional, Bergallo, Helena de Godoy, additional, dos Santos, Hellen Cristina Pinheiro, additional, Gazola, Humberto Angelo, additional, Melo, Isabel, additional, Brack, Ismael Verrastro, additional, Veríssimo, Iuri, additional, Viana, Ivan Réus, additional, Laurentino, Izabela Costa, additional, Diehl, Jaime Luis, additional, Zocche, Jairo José, additional, Martins‐Silva, Jimi, additional, Just, João Paulo Gava, additional, Cherem, Jorge José, additional, Nascimento, Jorge Luiz, additional, Marinho, Jorge Reppold, additional, Dantas, José Oliveira, additional, de Matos, Jose Roberto, additional, Pires, José Salatiel Rodrigues, additional, Cerveira, Josi Fernanda, additional, Ruiz‐Esparza, Juan, additional, da Silva, Juliana Paulo, additional, Bogoni, Juliano André, additional, Molina, Karina Theodoro, additional, Pereira, Karla Dayane de Lima, additional, Ceron, Karoline, additional, de Vleeschouwer, Kristel, additional, Lautenschlager, Laís, additional, Bailey, Larissa, additional, Fornitano, Larissa, additional, Rampim, Lilian Elaine, additional, Sforza, Lorena, additional, Bissa, Luan Gonçalves, additional, Santucci, Luca Mattos, additional, da Silva, Lucas Gonçalves, additional, Perillo, Lucas Neves, additional, Correa, Lucas Ribeiro, additional, Hufnagel, Ludmila, additional, Alberti, Luis Fernando, additional, Recalde Mello, Luis Jose, additional, Bernardo, Luis Renato Rezende, additional, Oliveira‐Santos, Luiz Gustavo Rodrigues, additional, Guimarães, Luiza Neves, additional, Benchimol, Maíra, additional, Twardowschy, Manuela Catharina, additional, Ferreira‐Riveros, Marcela, additional, da Silva, Marcelo, additional, Jardim, Márcia Maria de Assis, additional, Fontes, Marco Aurélio Leite, additional, Tortato, Marcos Adriano, additional, do Nascimento, Marcos Tadeu, additional, Sekiama, Margareth Lumy, additional, Nascimento‐Costa, Maria Clara, additional, dos Santos, Maria Ester Bueno, additional, Morini, Maria Santina de Castro, additional, Nagy‐Reis, Mariana Baldy, additional, Kaizer, Mariane da Cruz, additional, Sant'Anna, Mariano José Ribeiro da Silva, additional, Hartmann, Marilia Teresinha, additional, Favarini, Marina Ochoa, additional, Olivo, Marina Oliveira, additional, Montes, Martín Alejandro, additional, Alvaréz, Martin Roberto del Valle, additional, Haddad, Matheus Feldstein, additional, Costa, Maurício Djalles, additional, Graipel, Maurício Eduardo, additional, Konzen, Mauricio Quoos, additional, Galetti, Mauro, additional, Almeida, Meyline de Oliveira Souza, additional, Faria, Michel Barros, additional, Luiz, Micheli Ribeiro, additional, Baptista, Michelle Noronha da Matta, additional, Marini, Miguel Ângelo, additional, Ribeiro, Milton Cezar, additional, Olifiers, Natalie, additional, de Albuquerque, Natasha Moraes, additional, Cantero, Nicolás, additional, Peroni, Nivaldo, additional, Zanella, Noeli, additional, Mendonça‐Furtado, Olívia, additional, Pays, Olivier, additional, Ferretti, Orlando Ednei, additional, Rocha‐Barbosa, Oscar, additional, Santos, Paloma Marques, additional, de Farias, Patrícia Menegaz, additional, da Rocha, Patrício Adriano, additional, Colas‐Rosas, Paul François, additional, Ribeiro‐Souza, Paula, additional, Ferracioli, Paula, additional, Hartmann, Paulo Afonso, additional, Antas, Paulo de Tarso Zuquim, additional, Ribeiro, Paulo, additional, Tomasi Sarti, Paulo, additional, Mônico, Paulo Ivo, additional, de Castilho, Pedro Volkmer, additional, Pereira, Peônia Brito de Moraes, additional, Crawshaw, Peter Gransden, additional, Renaud, Pierre‐Cyril, additional, Romagna, Rafael Spilere, additional, de Sousa, Rafael Turíbio Moraes, additional, Spagnol, Raíssa Soares, additional, Beltrão‐Mendes, Raone, additional, Mariano, Ravi Fernandes, additional, Rocha, Renata Reinoso, additional, Sousa‐Lima, Renata, additional, Pagotto, Renata Valls, additional, de Faria, Rhayssa Terra, additional, Arrais, Ricardo Corassa, additional, Moratelli, Ricardo, additional, Sartorello, Ricardo, additional, Bianchi, Rita de Cassia, additional, Guimarães, Roberto de Carvalho, additional, Massara, Rodrigo Lima, additional, Costa, Romulo Theodoro, additional, Marques, Rosane Vera, additional, Nunes, Ruan Márcio Ruas, additional, Hartz, Sandra Maria, additional, Silvestre de Sousa, Saulo Meneses, additional, Lima, Saulo Ramos, additional, Barbosa, Sergio Lutz, additional, Godoy, Silvia Neri, additional, Ferrari, Stephen Francis, additional, de Araújo‐Piovezan, Talita Guimarães, additional, Góes, Talita Laura, additional, Trigo, Tatiane Campos, additional, de Freitas, Thales R. O., additional, Maccarini, Thiago Bernardes, additional, de Castro, Thiago Marcial, additional, Bella, Thiago Ribas, additional, de Oliveira Junior, Tonny Marques, additional, Cunha, Uslaine Maciel, additional, Kanaan, Vanessa Tavares, additional, Pfannerstill, Vera, additional, Pimentel, Victor Siqueira, additional, Picinatto Filho, Vilmar, additional, Alves, Vinícius Nunes, additional, Rojas‐Bonzi, Viviana, additional, Mottin, Viviane, additional, Rocha, Vlamir José, additional, Kindel, Andreas, additional, and Coelho, Igor Pfeifer, additional

Published
2024
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45. Are Surgeons Going to Be Left Holding the Bag? Incisional Hernia Repair and Intra-Peritoneal Non-Absorbable Mesh Implant Complications

Author

Kirkpatrick, Andrew W., primary, Coccolini, Federico, additional, Tolonen, Matti, additional, Minor, Samual, additional, Catena, Fausto, additional, Celotti, Andrea, additional, Gois, Emanuel, additional, Perrone, Gennaro, additional, Novelli, Giuseppe, additional, Garulli, Gianluca, additional, Ioannidis, Orestis, additional, Sugrue, Michael, additional, De Simone, Belinda, additional, Tartaglia, Dario, additional, Lampella, Hanna, additional, Ferreira, Fernando, additional, Ansaloni, Luca, additional, Parry, Neil G., additional, Colak, Elif, additional, Podda, Mauro, additional, Noceroni, Luigi, additional, Vallicelli, Carlo, additional, Rezende-Netos, Joao, additional, Ball, Chad G., additional, McKee, Jessica, additional, Moore, Ernest E., additional, and Mather, Jack, additional

Published
2024
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48. Tumor-Infiltrating T Cells in Skin Basal Cell Carcinomas and Squamous Cell Carcinomas: Global Th1 Preponderance with Th17 Enrichment—A Cross-Sectional Study.

Author

Cunha, Daniela, Neves, Marco, Silva, Daniela, Silvestre, Ana Rita, Nunes, Paula Borralho, Arrobas, Fernando, Ribot, Julie C., Ferreira, Fernando, Moita, Luís F., Soares-de-Almeida, Luís, Silva, João Maia, Filipe, Paulo, and Ferreira, João

Subjects
BASAL cell carcinoma, T cells, SQUAMOUS cell carcinoma, REGULATORY T cells, T helper cells, IMMUNOLOGIC memory
Abstract

Basal cell carcinomas (BCCs) and squamous cell carcinomas (SCCs) are high-incidence, non-melanoma skin cancers (NMSCs). The success of immune-targeted therapies in advanced NMSCs led us to anticipate that NMSCs harbored significant populations of tumor-infiltrating lymphocytes with potential anti-tumor activity. The main aim of this study was to characterize T cells infiltrating NMSCs. Flow cytometry and immunohistochemistry were used to assess, respectively, the proportions and densities of T cell subpopulations in BCCs (n = 118), SCCs (n = 33), and normal skin (NS, n = 30). CD8+ T cells, CD4+ T cell subsets, namely, Th1, Th2, Th17, Th9, and regulatory T cells (Tregs), CD8+ and CD4+ memory T cells, and γδ T cells were compared between NMSCs and NS samples. Remarkably, both BCCs and SCCs featured a significantly higher Th1/Th2 ratio (~four-fold) and an enrichment for Th17 cells. NMSCs also showed a significant enrichment for IFN-γ-producing CD8+T cells, and a depletion of γδ T cells. Using immunohistochemistry, NMSCs featured denser T cell infiltrates (CD4+, CD8+, and Tregs) than NS. Overall, these data favor a Th1-predominant response in BCCs and SCCs, providing support for immune-based treatments in NMSCs. Th17-mediated inflammation may play a role in the progression of NMSCs and thus become a potential therapeutic target in NMSCs. [ABSTRACT FROM AUTHOR]

Published
2024
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