Search

This work is a companion reproducible paper of a previous paper (Antol et al., 2021) in which we presented an alternative to the traditional paradigm of similarity searching in metric spaces called the Learned Metric Index. Inspired by the advance in learned indexing of structured data, we used machine learning models to replace index pivots, thus posing similarity search as a classification problem. This implementation proved to be more than competitive with the conventional methods in terms of speed and recall, proving the concept as viable. The aim of this publication is to make our source code, datasets, and experiments publicly available. For this purpose, we create a collection of Python3 software libraries, YAML reproducible experiment files, and JSON ground-truth files, all bundled in a Docker image – the Learned Metric Index Framework (LMIF) – which can be run using any Docker-compatible operating system on a CPU with Advanced vector extensions (AVX). We introduce a reproducibility protocol for our experiments using LMIF and provide a closer look at the experimental process. We introduce new experimental results by running the reproducibility protocol introduced herein and discussing the differences with the results reported in our primary work (Antol et al., 2021). Finally, we make an argument that these results can be considered weakly reproducible (in both of the performance metrics), since they point to the same conclusions derived in the primary paper. [ABSTRACT FROM AUTHOR]

Wireless and mobile sensing technologies, including mixed reality capture technologies (e.g., lidar, RGB-D, and vision), wireless infrastructure sensors, wearable sensors, robotics, and unmanned aerial systems (UASs), have generated large amounts of high-resolution data on infrastructure construction and management. The special collection on Future of Smart Construction and Infrastructure is available in the ASCE Library (https://ascelibrary.org/jccee5/future smart construction conference). This special collection supports a broader discussion regarding the future of smart construction and infrastructure enabled by advanced sensing technologies and data analytics. [Extracted from the article]

Introduction: Open science initiatives have enabled sharing of large amounts of already collected data. However, significant gaps remain regarding how to find appropriate data, including underutilized data that exist in the long tail of science. We demonstrate the NeuroBridge prototype and its ability to search PubMed Central full-text papers for information relevant to neuroimaging data collected from schizophrenia and addiction studies. Methods: The NeuroBridge architecture contained the following components: (1) Extensible ontology for modeling study metadata: subject population, imaging techniques, and relevant behavioral, cognitive, or clinical data. Details are described in the companion paper in this special issue; (2) A natural-language based document processor that leveraged pre-trained deep-learning models on a small-sample document corpus to establish efficient representations for each article as a collection of machine-recognized ontological terms; (3) Integrated search using ontology-driven similarity to query PubMed Central and NeuroQuery, which provides fMRI activation maps along with PubMed source articles. Results: The NeuroBridge prototype contains a corpus of 356 papers from 2018 to 2021 describing schizophrenia and addiction neuroimaging studies, of which 186 were annotated with the NeuroBridge ontology. The search portal on the NeuroBridge website https://neurobridges.org/provides an interactive Query Builder, where the user builds queries by selecting NeuroBridge ontology terms to preserve the ontology tree structure. For each return entry, links to the PubMed abstract as well as to the PMC full-text article, if available, are presented. For each of the returned articles, we provide a list of clinical assessments described in the Section "Methods" of the article. Articles returned from NeuroQuery based on the same search are also presented. Conclusion: The NeuroBridge prototype combines ontology-based search with natural-language text-mining approaches to demonstrate that papers relevant to a user's research question can be identified. The NeuroBridge prototype takes a first step toward identifying potential neuroimaging data described in fulltext papers. Toward the overall goal of discovering "enough data of the right kind," ongoing work includes validating the document processor with a larger corpus, extending the ontology to include detailed imaging data, and extracting information regarding data availability from the returned publications and incorporating XNAT-based neuroimaging databases to enhance data accessibility. [ABSTRACT FROM AUTHOR]

Copyright of Lijecnicki Vjesnik is the property of Croatian Medical Association and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

This digital art history project analyzes the display of Native American pottery and weavings from the US Southwest in the Washington, DC, home of a wealthy, wellconnected, worldly, and intellectually curious couple, Isabel and Larz Anderson, in the first decade of the twentieth century. It contends that these objects were presented by the Andersons in eclectic arrangements designed to authenticate their cosmopolitanism and to facilitate their advancement in white, elite social and political circles. The article, which analyzes how the Andersons refigured the pots and blankets in their home, is expanded and more fully illustrated in an interactive digital tour of Anderson House that reveals the broader domestic and social context in which the Native objects appeared. [ABSTRACT FROM AUTHOR]

The graphic edition of Snyder's On Tyranny (2021) states "truth dies in four modes," which is a contemporary synthesis connected to Klemperer's Language of the Third Reich (1957). The researchers connected these four modes to information literacy (IL) instruction--but would others? The researchers surveyed academic librarians engaged in IL instruction on whether they felt they addressed any of the modes in their work. The researchers also asked whether they believe the ACRL Framework for Information Literacy for Higher Education works to circumvent any of the four modes. Nearly 150 librarians responded and, while most respondents were unfamiliar with the two texts referenced and their thoughts were mixed, many saw their work and the Framework as antagonistically related to Mode 1 (Open Hostility to Verifiable Reality). This paper discusses survey results and their implications for better understanding of how academic librarians engaged in IL instruction view their work in a socio-political context. [ABSTRACT FROM AUTHOR]

This study explores the case study of two Quaker nuns, Ms Catherine Evans and Ms Sarah Cheevers. Their coincidental connection with the Mediterranean island of Malta caught the attention of several researchers, primarily interested in the micro history of the Quakers movement. Originally, Evans and Cheevers were entrusted to travel to Jerusalem, expecting to convert Christians at the epicentre of Christianity to Quakerism. After their ship called into the port of Malta en route to the Holy Land, their mission was interrupted due to their polarising and confrontational behaviour towards the Holy Office of the Roman Inquisition. Their intended short stay was turned into an incarcerated pilgrimage for about three and a half years. Based on the Quaker nuns' criminal proceedings of the Inquisition Tribunal located in the Mdina Cathedral Archives of Malta and other published literature, various interpretations are explored regarding their missionary-pilgrimage experience in seventeenth-century Malta. The challenging situation experienced by these Quaker nuns during their detainment, their confined pilgrimage presents an intriguing opportunity to explore their experience as a spiritual and physical phenomenon, turning their mission into a missionary-pilgrimage experience. Considering the context within which this experience unfolds, and the complicated circumstances that dominated this situation, this study throws light on the historical context of how believers used temporal experiences, in this case the human body, as an attempt to navigate and communicate the spiritual world. Although the original missionary objectives could be easily regarded as an outright failure, it is here argued that the Quaker nuns continued their missionary purpose of preaching Quakerism. Conversely, their incarceration-turned-pilgrimage could be viewed as a resounding success, whereby the two nuns were able to reinforce their own understanding and beliefs in Quaker ideology while perpetuating their experiences among other Quaker communities. [ABSTRACT FROM AUTHOR]

Post-wildfire debris flows (PFDF) threaten life and property in western North America. They are triggered by short-duration, high-intensity rainfall. Following a wildfire, rainfall thresholds are developed that, if exceeded, indicate high likelihood of a PFDF. Existing weather forecast products allow forecasters to identify favorable atmospheric conditions for rainfall intensities that may exceed established thresholds at lead times needed for decision-making (e.g., =24 h). However, at these lead times, considerable uncertainty exists regarding rainfall intensity and whether the high-intensity rainfall will intersect the burn area. The approach of messaging on potential hazards given favorable conditions is generally effective in avoiding unanticipated PFDF impacts, but may lead to "messaging fatigue" if favorable triggering conditions are forecast numerous times, yet no PFDF occurs (i.e., false alarm). Forecasters and emergency managers need additional tools that increase their confidence regarding occurrence of short-duration, high-intensity rainfall as well as tools that tie rainfall forecasts to potential PFDF outcomes. We present a concept for probabilistic tools that evaluate PFDF hazards by coupling a high-resolution (1-km), large (100-member) ensemble 24-h precipitation forecast at 5-min resolution with PFDF likelihood and volume models. The observed 15-min maximum rainfall intensities are captured within the ensemble spread, though in highest ~10% of members. We visualize the model output in several ways to demonstrate most likely and most extreme outcomes and to characterize uncertainty. Our experiment highlights the benefits and limitations of this approach, and provides an initial step toward further developing situational awareness and impact-based decision-support tools for forecasting PFDF hazards. [ABSTRACT FROM AUTHOR]

In the evening of 24 December 1789, 2100 km southeast of Cape Town and after encountering three icebergs, the HMS Guardian under Captain Edward Riou collided with the submerged foot of a large iceberg. Despite severe damage to the ship and its abandonment by many of its crew and passengers, Riou sailed the hulk back to Cape Town, arriving on 22 February 1790. From present-day research and field studies, the formation of the foot in the collision is consistent with the above-freezing seawater temperatures inferred from Riou's commentary. Further, the observed 60 m iceberg height suggests that it calved from the Filchner Ice Shelf in the Weddell Sea. Comparison of the positions of Riou's icebergs with historic sightings, satellite observations and iceberg drift and fracture models also shows that they originated in the Weddell Sea and that their likelihood of occurrence in the collision region is small. [ABSTRACT FROM AUTHOR]

Background: Chronic non-specific neck pain (CNNP) is a prevalent musculoskeletal disorder known for its significant disability and economic burden, ranking second only to low back pain in musculoskeletal conditions. Physical therapy offers effective interventions for CNNP, including low-level laser therapy (LLLT). High-intensity laser therapy (HILT) is a recent treatment for musculoskeletal pain, but studies that support its use in CNNP are limited. The objective of this study is to assess the effect of high-intensity laser therapy on pain intensity in patients with CNNP, given the existing evidence on LLLT for this condition. Methods: This is a 2-arm, randomized, placebo-controlled trial with blinded evaluators. The research will be carried out in the laboratory of physical agents at the Andrés Bello University, Campus Casona de las Condes. Eligible participants include the entire internal and external community associated with Andrés Bello University suffering from chronic non-specific NP. Participants will be stratified by sex (4 subgroups) and randomized into 2 study groups: group 1 (HILT and stretching exercises) and group 2 (sham HILT and stretching exercises). Treatments will be performed twice a week for 4 weeks with 3 assessments: before treatment (T0), at the end of treatment (T1), and 12 weeks after treatment (follow-up) (T2). The main outcomes will be pain intensity at rest, pain intensity at movement (active cervical movements: flexion, extension, right and left side bending, and right and left rotation), and pain pressure threshold (average obtained for six evaluation points). Secondary outcome measures will include neck range of motion in the sagittal, coronal, and transverse planes and neck disability. Discussion: In this study, HILT's effects on patients with non-specific NP will be compared to those of a sham laser intervention. This RCT will offer new evidence regarding the potential benefits of HILT in terms of pain intensity, range of movement, and disability in people suffering with non-specific NP. Trial registration: ClinicalTrials.gov NCT05689788. January 19, 2023. [ABSTRACT FROM AUTHOR]

Ocean dynamics at the submesoscale play a key role in mediating upper‐ocean energy dissipation and dispersion of tracers. Observations of ocean currents from synoptic mesoscale surveys at submesoscale resolution (250 m–100 km) from a novel airborne instrument (MASS DoppVis) reveal that the kinetic energy spectrum in the California Current System is nearly continuous from 100 km to sub‐kilometer scales, with a k−2 spectral slope. Although there is not a transition in the kinetic energy spectral slope, there is a transition in the dynamics to non‐linear ageostrophic interactions at scales of O $\mathcal{O}$(1 km). Kinetic energy transfer across spatial scales is enabled by interactions between the rotational and divergent components of the flow field at the submesoscale. Kinetic energy flux is patchy and localized at submesoscale fronts. Kinetic energy is transferred both downscale and upscale from 1 km in the observations of a cold filament. Plain Language Summary: Ocean dynamics at scales of 100 m–10 km, called the submesoscale, are important because they are associated with large velocity gradients and non‐linear interactions. Large gradients lead to vertical velocity, which facilitates ocean‐atmosphere interactions and ocean biological processes. Velocity gradients and non‐linear processes combine to transfer kinetic energy from the large‐scale flow to small‐scale perturbations. This can lead to instabilities that dissipate energy in the ocean surface layer (rather than the seafloor). Here we analyze novel observations that provide insight into ocean dynamics through the distributions of velocity gradients and energy transfer at 1 km scale. Dynamics at these scales have previously been modeled, but have not been observed directly. We observe a transition where non‐linear dynamics become more important at scales of order 10 km. We also introduce new interpretations of spectral analysis (analysis of energy and correlations across scales). Moreover, we analyze covariance of velocity gradient quantities and flow energetics to demonstrate that energy flux is episodic and localized at fronts. Together, these observations demonstrate that fronts play an important role in boundary‐layer kinetic energy processes and highlight the evolution of upwelling filaments. Key Points: Remote sensing observations reveal a kinetic energy spectrum with a continuous slope from 100 to 1 km in an eastern boundary regionBetween 1 and 10 km, ageostrophic non‐linear interactions become dynamically importantCross‐scale kinetic energy transfers computed from 2D velocity observations are associated with shear strain in the observed front [ABSTRACT FROM AUTHOR]

The storage process of Baijiu is an integral part of its production (the quality undergoes substantial changes during the aging process of Baijiu). As the storage time extends, the flavor compounds in Baijiu tend to undergo coordinated transformation, thereby enhancing the quality of Baijiu. Among them, long-chain fatty acid ethyl esters (LCFAEEs) were widely distributed in Baijiu and have been shown to have potential contributions to the quality of Baijiu. However, the current research on LCFAEEs in Baijiu predominantly focuses on the olfactory sensation aspect, while there is a lack of systematic investigation into their influence on taste and evaluation after drinking Baijiu during the aging process. In light of this, the present study investigates the distribution of LCFAEEs in Baijiu over different years. We have combined modern flavor sensory analysis with multivariate chemometrics to comprehensively and objectively explore the influence of LCFAEEs on Baijiu quality. The results demonstrate a significant positive correlation between the concentration of LCFAEEs and the fruity aroma (p < 0.05, r = 0.755) as well as the aged aroma (p < 0.05, r = 0.833) of Baijiu within a specific range; they can effectively reduce the off-flavors and spicy sensation of Baijiu. Furthermore, additional experiments utilizing a single variable suggest that LCFAEEs were crucial factors influencing the flavor of Baijiu, with Ethyl Palmitate (EP) being the most notable LCFAEE that merits further systematic investigation. [ABSTRACT FROM AUTHOR]

Tranexamic acid (TXA) is a synthetic derivative of the amino acid lysine and is commonly used as an antifibrinolytic agent in large joint surgery, such as knee arthroplasty, to minimize blood loss and its associated complications. Some studies have suggested that perioperative intravenous TXA application lowers the incidence of postoperative infections after hip and knee arthroplasty. While its effects on bacteria are not its primary purpose, more research is needed further to elucidate the extent of TXA's impact on bacterial inhibition and its clinical relevance. In order to determine possible inhibitory effects, 22 clinically relevant bacterial strains were exposed to different TXA concentrations. Two different assays were performed: a microdilution assay with traditional endpoint measurements and a kinetic growth assay for a time-dependent susceptibility assessment. With the microdilution technique, a growth inhibitory effect became evident at higher TXA concentrations (50 and 100 mg/mL) on eight tested bacterial strains, of which four demonstrated absence of growth at 100 mg/mL, suggesting minimal inhibitory concentration. However, the kinetic growth assay revealed more specific TXA-induced dynamic changes in the bacterial growth of all tested bacterial strains. This study showed that TXA affects the growth dynamics of bacteria by altering their lag phase duration, exponential growth rate, and population density and may contribute to the prevention of implant-associated infections. [ABSTRACT FROM AUTHOR]

The ability to manipulate objects with limbs has evolved repeatedly among land tetrapods. Several selective forces have been proposed to explain the emergence of forelimb manipulation, however, work has been largely restricted to mammals, which prevents the testing of evolutionary hypotheses in a comprehensive evolutionary framework. In birds, forelimbs have gained the exclusive function of flight, with grasping transferred predominantly to the beak. In some birds, the feet are also used in manipulative tasks and appear to share some features with manual grasping and prehension in mammals, but this has not been systematically investigated. Here we use large online repositories of photographs and videos to quantify foot manipulative skills across a large sample of bird species (>1000 species). Our results show that a complex interaction between niche, diet and phylogeny drive the evolution of manipulative skills with the feet in birds. Furthermore, we provide strong support for the proposition that an arboreal niche is a key element in the evolution of manipulation in land vertebrates. Our systematic comparison of foot use in birds provides a solid base for understanding morphological and neural adaptations for foot use in birds, and for studying the convergent evolution of manipulative skills in birds and mammals. A large-scale citizen science approach reveals that a complex interaction between niche, diet and phylogeny drive the evolution of manipulative skill with the feet in birds. [ABSTRACT FROM AUTHOR]

While the use of semantic technologies is now commonplace in the cultural heritage sector and several semantically annotated cultural heritage datasets are publicly available, there are few examples of cultural portals that exploit these datasets and technologies to improve the experience of visitors to their online collections. Aiming to address this gap, this paper explores methods for semantics-based recommendations aimed at visitors to cultural portals who want to explore online collections. The proposed methods exploit the rich semantic metadata in a cultural heritage dataset and the capabilities of a graph database system to improve the accuracy of searches through the collection and the quality of the recommendations provided to the user. The methods were developed and tested with the Archive of the Art Textbooks of Elementary and Public Schools in the Japanese Colonial Period. However, they can easily be adapted to any cultural heritage collection dataset modelled in RDF. [ABSTRACT FROM AUTHOR]

Having a large number of device connections provides attackers with multiple ways to attack a network. This situation can lead to distributed denial-of-service (DDoS) attacks, which can cause fiscal harm and corrupt data. Thus, irregularity detection in traffic data is crucial in detecting malicious behavior in a network, which is essential for network security and the integrity of modern Cyber–Physical Systems (CPS). Nevertheless, studies have shown that current techniques are ineffective at detecting DDoS attacks on networks, especially in the case of high-speed networks (HSN), as detecting attacks on the latter is very complex due to their fast packet processing. This review aims to study and compare different approaches to detecting DDoS attacks, using machine learning (ML) techniques such as k-means, K-Nearest Neighbors (KNN), and Naive Bayes (NB) used in intrusion detection systems (IDSs) and flow-based IDSs, and expresses data paths for packet filtering for HSN performance. This review highlights the high-speed network accuracy evaluation factors, provides a detailed DDoS attack taxonomy, and classifies detection techniques. Moreover, the existing literature is inspected through a qualitative analysis, with respect to the factors extracted from the presented taxonomy of irregular traffic pattern detection. Different research directions are suggested to support researchers in identifying and designing the optimal solution by highlighting the issues and challenges of DDoS attacks on high-speed networks. [ABSTRACT FROM AUTHOR]

The polycystic ovarian syndrome (PCOS) is closely associated with enhanced apoptosis of granulosa cells, which have a vital role in maturation of oocytes. p53 plays a critical role in the regulation of apoptosis and cell cycle arrest, metabolism and insulin resistance. The aim of this study was to investigate the impact of p53 pathway in enhancing apoptosis and abnormal function of granulosa cells. In this study, microarray analysis and RNA sequencing were downloaded from the GEO and used as datasets. Principal Component Analysis (PCA) and online SSizer tool were applied to evaluate the experiment quality control and sample sufficiency, respectively. Bioinformatics' analyses were performed on the selected datasets, and validated by qRT-PCR and western blot analyses. Three datasets out of five ones were chosen for re-analyzing based on the PCA outcomes. 21 deregulated genes were identified via filters including p < 0.05 and |log2FC|≥ 1. Functional enrichment analysis confirmed the relevance of cell cycle regulation and apoptosis as common biological hallmarks in PCOS. Results have shown differentially expressed p53 target genes involved in apoptosis (BAX, FAS, PMAIP1, and CASP8), cell cycle (Cyclins, Cyclin dependent kinases), glucose metabolism and insulin resistance (THBS1), and p53 regulation (MDM2). Subsequently, the relative mRNA expression of FAS, PMAIP1 and MDM2 genes, and protein levels of p53 and MDM2 were confirmed using granulosa cells collected from 20 PCOS women and 18 control individuals by qRT-PCR and western blot, respectively. Results of this study represent the possible role of p53 pathway in pathogenesis of PCOS particularly, through the enhancement of apoptosis in granulosa cells. [ABSTRACT FROM AUTHOR]

Machine learning components are essential for today's software systems, causing a need to adapt traditional software engineering practices when developing machine-learning-based systems. This need is pronounced due to many development-related challenges of machine learning components such as asset, experiment, and dependency management. Recently, many asset management tools addressing these challenges have become available. It is essential to understand the support such tools offer to facilitate research and practice on building new management tools with native supports for machine learning and software engineering assets. This article positions machine learning asset management as a discipline that provides improved methods and tools for performing operations on machine learning assets.We present a feature-based survey of 18 stateof- practice and 12 state-of-research tools supporting machine-learning assetmanagement.We overview their features for managing the types of assets used in machine learning experiments. Most state-of-research tools focus on tracking, exploring, and retrieving assets to address development concerns such as reproducibility, while the state-of-practice tools also offer collaboration and workflow-execution-related operations. In addition, assets are primarily tracked intrusively from the source code through APIs and managed via web dashboards or command-line interfaces (CLIs).We identify asynchronous collaboration and asset reusability as directions for new tools and techniques. [ABSTRACT FROM AUTHOR]

Glioblastoma (GBM) is the most lethal intracranial tumor. Sequencing technologies have supported personalized therapy for precise diagnosis and optimal treatment of GBM by revealing clinically actionable molecular characteristics. Although accumulating sequence data from brain tumors and matched normal tissues have facilitated a comprehensive understanding of genomic features of GBM, these in silico evaluations could gain more biological credibility when they are verified with in vitro and in vivo models. From this perspective, GBM cell lines with whole exome sequencing (WES) datasets of matched tumor tissues and normal blood are suitable biological platforms to not only investigate molecular markers of GBM but also validate the applicability of druggable targets. Here, we provide a complete WES dataset of 26 GBM patient-derived cell lines along with their matched tumor tissues and blood to demonstrate that cell lines can mostly recapitulate genomic profiles of original tumors such as mutational signatures and copy number alterations. [ABSTRACT FROM AUTHOR]

This research aimed to investigate the properties of bio rayeb milk that results from goats fed on feed supplemented with different concentrations of coriander oil. The study design included a control treatment (C) and two coriander oil concentrations, a low level of (0.95%) T1 and a high level of (1.9%) T2. A probiotic starter culture, Direct Vat Set (DVS) of lactobacillus delbrueckii ssp. bulgaricus and streptococcus salivarius ssp. thermophilus in the ratio (1:1) was used to prepare bio rayeb. All treatments were stored at 4 °C for 2 weeks and analyzed on day one and at the end of storage. Results showed that the coagulation time during bio rayeb manufacturing remained consistent at almost 6 h for all batches. However, using a high coriander oil level (1.90%) significantly decreased the apparent viscosity and the content of monounsaturated fatty acids. The DPPH inhibition and the content of monounsaturated fatty acids increased. The electrophoresis chromatogram exhibited a high degree of proteolysis in T2 compared to the control and T1. Microbiologically, yeast, molds, and coliforms were absent in all treatments. Feeding goats on provender supplemented with a low concentration of coriander oil may positively impact the resultant milk's technological and sensorial properties. [ABSTRACT FROM AUTHOR]

Imagery still plays a crucial role in a world of various languages and dialects. However, during the Middle Ages, when the masses were illiterate and the outside world often unknown and incomprehensible, images and visuality created a safe and coherent support for those who witnessed it. Iconography as a mode of non-verbal communication was often used by the Church, but people communicated among themselves through images, too. One of the popular modes of visual communication in the Middle Ages were badges - small objects, usually made to be worn pinned to the front of clothing or hats, or suspended. The badges existed in both the religious and secular spheres of human life and were meant to communicate an individual's personal or business affiliations, religious beliefs or even jokes. The following paper will focus on the religious badges using the example of the pilgrim badges of Wilsnack. It will analyse the levels on which these badges communicated not only visually, but also as indirect mediators of information, agents of private conversations with God and saints, and as tools of surprising unification of pilgrims during the times of Wilsnack controversy. [ABSTRACT FROM AUTHOR]

The purpose of this study is to investigate what semiotic analysis can reveal about how welcoming and inclusive a science library space is for patrons. A space was examined in terms of its messaging to patrons of various genders, abilities, races, ethnicities, nationalities, and disciplines. Findings are presented about the space's messaging regarding the disciplines it serves, inclusion of patrons from minoritized demographics, and general expectations of visitors. Recommendations for library practice and future research are discussed. [ABSTRACT FROM AUTHOR]

The objective of this paper is to study possible relationships of the text of Pierre Bersuire's Ovidius moralizatus with other medieval works departing from two illuminated passages in two different manuscripts: Bergamo, Biblioteca Civica Angelo Mai, Cassaforte 3.4, and Treviso, Biblioteca Comunale, 344. Therefore, analyzing the texts on which the two illustrations are based, we try to determine which works can be the source for them, and we also try to understand the figures represented in the illustrations. So, the figure of Vanity from the Treviso manuscript seems to be unique in its representation, but the text, with some distinctive features, seems to be based on the Ymagines Fulgencii. The representation of the story of Bacchus in the Bergamo manuscript is found in other illustrations, and its accompanied text seems to rely on the mythographical tradition present in an anonymous Liber de natura deorum of the twelfth century. [ABSTRACT FROM AUTHOR]

The article examines U.S. Supreme Court Justice Samuel Alito's conservatism. Topics discussed include his view on Burkean constitutionalism, formative moment in the young Alito's civic education, and evolution of American political conservatism. It also mentions conservatism's cautious embrace of populism, and role of conservatism's shift on executive power in the conservative legal movement.

This study aims to explore the influence of national music lessons on university students' subjective well-being, self-esteem, and national identity. A Chinese university provided four national music courses spanning 8 weeks. The students' subjective well-being, self-esteem, and national identity were measured before the commencement of the courses (T1), the fourth week of the courses (T2), and post the completion of the courses (T3). A total of 362 participants completed the Positive and Negative Affect Scales, the Satisfaction with Life Scale, the Rosenberg Self-Esteem Scale, and the National Identity Scale at T1, T2, and T3. Results indicated that national music lessons could improve university students' subjective well-being, yet there was no effect on their national identity or selfesteem. Although high national identity and high self-esteem predicted a greater level of subjective well-being, self-esteem and national identity did not affect the influence of national music lessons on subjective well-being. National music lessons were particularly beneficial to students with low and middle levels of subjective well-being, in comparison to those with higher levels of subjective well-being. This paper verifies an efficient method to bolster students' subjective well-being that can be conducted in educational practices. [ABSTRACT FROM AUTHOR]

AKT (also known as PKB) is a serine/threonine kinase that plays a pivotal regulatory role in the PI3K/AKT/mTOR signaling pathway. Dysregulation of AKT activity, especially its hyperactivation, is closely associated with the development of various human cancers and resistance to chemotherapy. Over the years, a wide array of AKT inhibitors has been discovered through experimental and computational approaches. In this regard, herein we present a comprehensive overview of AKT inhibitors identified using computer-assisted drug design methodologies (including docking-based and pharmacophore-based virtual screening, machine learning, and quantitative structure–activity relationships) and successfully validated small molecules endowed with anticancer activity. Thus, this review provides valuable insights to support scientists focused on AKT inhibition for cancer treatment and suggests untapped directions for future computer-aided drug discovery efforts. [ABSTRACT FROM AUTHOR]

Copyright of Agathon: International Journal of Architecture, Art & Design is the property of DEMETRA CE.RI.MED and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Comic media exists in historical and geocultural variations. The historically dynamic identity formation of comic media in some geocultural versions is accompanied by the emergence of mediatic hybridisations that manifest themselves in a street art activity. In this article, we examine these comics-based hybrid media and their use from a media theoretical perspective in the context of two different media cities of the Francophone bande dessinée. In Brussels and Geneva, the institutionalisation of comics has been partially different, but both cities have seen a significant role in hybrid media related to street art. In Brussels, this is the case with comic murals, which have a canonising function and also generate tourist activity. In the case of Geneva, the importance of comic posters and comic-style street signs linked to political communication, civic education, and campaigns by NGOs is striking. [ABSTRACT FROM AUTHOR]

This article examines several libraries assembled by the Society of Jesus in their college and missions in Northern Mexico (in the present-day Mexican State of Chihuahua), where Jesuits have been a constant presence from the seventeenth century, interrupted only temporarily by the Society's suppression. All their bibliographic collections were transferred, dispersed, or looted after the general expulsion of 1767. Archival materials preserved in repositories such as the Archivo General de la Nación in Mexico City, however, enable a reconstruction of these libraries. This essay argues that these collections constituted a sort of "cultural oasis" (Michael Mathes). They provided arsenals of knowledge for missionaries in distant places with harsh living conditions and show the strong and lasting bond between Jesuits and print culture even in the most remote and adverse of conditions. [ABSTRACT FROM AUTHOR]

The province of Jaén (Andalusia, Spain), despite being declared the European territory with the largest number of defensive constructions (castles, fortifications, etc.), has few conservation plans, with many remains included on the Red List of Spanish Heritage lying abandoned. This poses a challenge for landscape conservation and the optimal use of the province's tourism potential. In this paper, we present the early implementation of an ongoing methodological approach designed to alleviate this situation. It takes advantage of data from the Sentinel 2A and 2B satellites, HBIM, RPAS, GIS, and fieldwork that will be applied across five archaeological case studies. It was tested for the first time in the village of Magaña. Three main objectives and phases of this methodological approach were designed: 1. Preparation of an environmental risk chart with which to answer such questions as "How have climate change, anthropic alterations and environmental characteristics affected the state of conservation of certain heritage sites?" 2. Preparation of HBIM models to foster monitorisation and conservation policies for the main archaeological remains and improving their protection based on digital and technological tools. 3. Building a smart tourism app for mobile devices aimed at promoting smart tourism by digitalising and virtualising tourist itineraries and archaeological remains. Finally, public administrations will be apprised of the need to implement a conservation policy for cultural assets and their surroundings in a simple, quick, and cost-effective manner. [ABSTRACT FROM AUTHOR]

Immunoproteasome inhibition is a promising strategy for the treatment of hematological malignancies, autoimmune diseases, and inflammatory diseases. The design of non-covalent inhibitors of the immunoproteasome β1i/β5i catalytic subunits could be a novel approach to avoid the drawbacks of the known covalent inhibitors, such as toxicity due to off-target binding. In this work, we report the biological evaluation of thirty-four compounds selected from a commercially available collection. These hit compounds are the outcomes of a virtual screening strategy including a dynamic pharmacophore modeling approach onto the β1i subunit and a pharmacophore/docking approach onto the β5i subunit. The computational studies were first followed by in vitro enzymatic assays at 100 μM. Only compounds capable of inhibiting the enzymatic activity by more than 50% were characterized in detail using Tian continuous assays, determining the dissociation constant (Ki) of the non-covalent complex where Ki is also the measure of the binding affinity. Seven out of thirty-four hits showed to inhibit β1i and/or β5i subunit. Compound 3 is the most active on the β1i subunit with Ki = 11.84 ± 1.63 µM, and compound 17 showed Ki = 12.50 ± 0.77 µM on the β5i subunit. Compound 2 showed inhibitory activity on both subunits (Ki = 12.53 ± 0.18 and Ki = 31.95 ± 0.81 on the β1i subunit and β5i subunit, respectively). The induced fit docking analysis revealed interactions with Thr1 and Phe31 of β1i subunit and that represent new key residues as reported in our previous work. Onto β5i subunit, it interacts with the key residues Thr1, Thr21, and Tyr169. This last hit compound identified represents an interesting starting point for further optimization of β1i/β5i dual inhibitors of the immunoproteasome. [ABSTRACT FROM AUTHOR]

The concept of digital preservation is explored in this article, delving into the challenges and best practices involved in safeguarding and conserving digital materials within library settings. It explores the importance of preserving digital collections in order to ensure their availability for future generations and the various technologies and tools used to preserve and conserve digital materials. It also highlights the role of libraries in preserving digital cultural heritage and the importance of collaboration and partnerships in digital preservation and conservation. The article concludes by emphasizing the constant evolution of the field and the need for libraries to stay adaptable to new technologies and challenges. Overall, the article is useful for librarians, library professionals, and researchers to understand the challenges and best practices of digital preservation and conservation in libraries. [ABSTRACT FROM AUTHOR]

Purpose: This study assessed the use of electronic resources by the faculty members who are currently employed in two government colleges in capital of Sikkim. The purpose of this paper is to explain readers about many kinds of electronic resources, as well as the benefits, frequency, barriers, and of using them. Methodology: Out the 167 questionnaires that were developed for this study, only 157 were completed and returned by a faculty member of two government institutions with a response. The data was analysed using a table and chart. Findings: Since many faculty members are engaged in research programme there has been a noticeable rise in the usage of e-journals. In addition to instructional activities, research activities have also been enhanced. These include conducting literature reviews, writing reports, locating research, and turning in reports on time. Faculty members use these tools mostly from home because it is always available and accessible. Furthermore, it was discovered that two government colleges' faculties are well-versed in e-resources. Originality / Value: The study's conclusions will be instructive and useful in determining the best course for making greater use of electronic resources. The study concludes that faculty members of government colleges, Sikkim are currently depending heavily on electronic resources for their information needs. The findings and technique can be used to make comparisons. [ABSTRACT FROM AUTHOR]

Colleges are the gateways to the higher education. College is the door step which leads a student to the treasure of knowledge. Up to the college level main focus of education lies at preparing the student to understand how to study. True education begins only after a student steps in a college. Colleges open new vistas of knowledge for the students and make them practical in responding to the problems at individual as well as social level. Apart from teaching the respective subjects, colleges are supposed to develop and enhance the creativity and learning ability among the students as well. Students are taught and trained to develop research aptitude to enter the university level. The role of library in a college is as good as of blood in our body. Besides providing stimulus to reading by procuring materials for study and research, college libraries also feed the intellect of the student, and thus serve the teaching and research needs of the faculty. No academic institute can achieve its goals without a well equipped and up to date library. Teacher as a nation builder should be highly skilled and professional with good knowledge and skills of all the latest developments at global level and such an intellect is formed and shaped only in the library. The significance of a library in an educational institution is highlighted by NKC (2007) as, “A library is not a building stacked with books – it is a repository and source of information and ideas, a place for learning and enquiry, and for the generation of thought and the creation of new knowledge.” [ABSTRACT FROM AUTHOR]

The storage of data documentation for Myanmar pagodas has various issues, and its retrieval method causes problems for users and libraries. This study utilized a mixed-methods approach, combining qualitative and quantitative methods to investigate pagoda data management in Myanmar libraries. The study aims to achieve the following objectives: to study the library collection management of pagodas in Myanmar, to investigate the management of pagoda data in Myanmar libraries, and to identify the pagoda data requirements for metadata development from the library professional perspective. The study findings revealed several challenges facing librarians and library users in accessing and managing Myanmar pagoda data, including limited stocks and retrieval tools, difficulty in accessing all available data online, and a lack of a centralized database or repository for storing and retrieving pagoda data. The study recommends the establishment of metadata criteria for managing a set of pagoda data and improving access to technology to address these challenges. [ABSTRACT FROM AUTHOR]

Humans possess an intuitive understanding of the environment's physical properties and dynamics, which allows them to predict the outcomes of physical scenarios and successfully interact with the physical world. This predictive ability is thought to rely on mental simulations and has been shown to involve frontoparietal areas. Here, we investigate whether such mental simulations may be accompanied by visual imagery of the predicted physical scene. We designed an intuitive physical inference task requiring participants to infer the parabolic trajectory of an occluded ball falling in accordance with Newtonian physics. Participants underwent fMRI while (i) performing the physical inference task alternately with a visually matched control task, and (ii) passively observing falling balls depicting the trajectories that had to be inferred during the physical inference task. We found that performing the physical inference task activates early visual areas together with a frontoparietal network when compared with the control task. Using multivariate pattern analysis, we show that these regions contain information specific to the trajectory of the occluded ball (i.e., fall direction), despite the absence of visual inputs. Using a cross‐classification approach, we further show that in early visual areas, trajectory‐specific activity patterns evoked by the physical inference task resemble those evoked by the passive observation of falling balls. Together, our findings suggest that participants simulated the ball trajectory when solving the task, and that the outcome of these simulations may be represented in form of the perceivable sensory consequences in early visual areas. [ABSTRACT FROM AUTHOR]

This article looks at the role of formal grammatical analysis in the writings of Moses ibn Chiquitilla; tracing the adoption of triliteralism among grammarians in Iberia. One of the enduring difficulties of recounting a history of the major developments in the study of Hebrew grammar is the patchwork nature of the material available. With the availability of the Firkovitch collection at the Russian National Library (RNL), source material from the 11th-century grammarian, translator, and exegete, Moses ibn Chiquitilla, is now available. Of what little survives of Ibn Chiquitilla’s writings, a large portion of his biblical commentary on Psalms is preserved in one manuscript, Evr-Arab. I 3583 alongside smaller portions belonging to other libraries. In this article, I trace the development of debates among grammarians as portrayed in the writings of Ibn Chiquitilla. I reach the conclusion that among the circles of grammarians in Saragossa in the 11th and 12th centuries, Ibn Chiquitilla tends towards the opinions of Judah Ḥayyūj, accepting the theoretical underpinnings of his system of grammar. He rejects any except

There is a need for novel chemical matter for phenotypic and target-based screens to find starting points for drug discovery programmes in neglected infectious diseases and non-hormonal contraceptives that disproportionately affect Low- and Middle-Income Countries (LMICs). In some disease areas multiple screens of corporate and other libraries have been carried out, giving rise to some valuable starting points and leading to preclinical candidates. Whilst in other disease areas, little screening has been carried out. Much screening against pathogens has been conducted phenotypically as there are few robustly validated protein targets. However, many of the active compound series identified share the same molecular targets. To address the need for new chemical material, in this article we describe the design of a new library, designed for screening in drug discovery programmes for neglected infectious diseases. The compounds have been selected from the Enamine REAL (REadily AccessibLe) library, a virtual library which contains approximately 4.5 billion molecules. The molecules theoretically can be synthesized quickly using commercially available intermediates and building blocks. The vast majority of these have not been prepared before, so this is a source of novel compounds. In this paper we describe the design of a diverse library of 30,000 compounds from this collection (graphical abstract). The new library will be made available to laboratories working in neglected infectious diseases, subject to a review process. The project has been supported by the Bill & Melinda Gates Foundation and the Wellcome Trust (Wellcome).