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Objective: The study aim was to review the economic evaluation literature of commercially available and effective nonsurgical weight‐loss interventions to investigate whether there is evidence to support claims of cost‐effectiveness (i.e., good value for money) or cost savings (i.e., a positive return on investment). Methods: Relevant databases were systematically reviewed to identify economic evaluations of commercially available weight‐loss products and services shown to result in clinically significant weight loss. Five weight‐loss medications (orlistat, liraglutide, naltrexone‐bupropion, semaglutide, and phentermine‐topiramate), two meal replacement programs (Jenny Craig, Optifast), and one behavioral intervention (Weight Watchers [WW]) that met inclusion criteria were identified. After screening, 32 relevant comparisons of cost‐effectiveness or cost savings across 20 studies were identified. Results: Ten of twenty pharmaceutical comparisons showed evidence of cost‐effectiveness based on established thresholds. Four of twelve nonpharmaceutical comparisons provided evidence of cost‐effectiveness, and five made claims of cost savings. However, methodological concerns cast doubt on the robustness of these claims. Conclusions: Evidence of cost‐effectiveness for commercially available, evidence‐based, nonsurgical weight‐loss interventions is mixed. There is no evidence for cost‐saving weight‐loss medications and only weak evidence for behavioral and weight‐loss interventions. Results provide a call to action to generate more robust evidence of the economic value proposition for these interventions. [ABSTRACT FROM AUTHOR]

Alveolar ridge preservation is routinely indicated in clinical practice with the purpose of attenuating postextraction ridge atrophy. Over the past two decades numerous clinical studies and reviews on this topic have populated the literature. In recent years the focus has primarily been on analyzing efficacy outcomes pertaining to postextraction dimensional changes, whereas other relevant facets of alveolar ridge preservation therapy have remained unexplored. With this premise, we carried out a comprehensive evidence‐based assessment of the complications associated with different modalities of alveolar ridge preservation and modeled the cost‐effectiveness of different therapeutic modalities as a function of changes in ridge width and height. We conclude that, among allogeneic and xenogeneic bone graft materials, increased expenditure does not translate into increased effectiveness of alveolar ridge preservation therapy. On the other hand, a significant association between expenditure on a barrier membrane and reduced horizontal and vertical ridge resorption was observed, though only to a certain degree, beyond which the return on investment was significantly diminished. [ABSTRACT FROM AUTHOR]

Purpose: The objective of this systematic literature review was to report the results and complications of recent remnant preservation techniques in posterior cruciate ligament (PCL) reconstruction. Methods: A systematic review was conducted based on the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines. Two independent reviewers searched the PubMed, Scopus, Embase, and Cochrane Library databases using the terms "posterior cruciate ligament" or "PCL" and "remnant preserving." The outcome measures extracted from the studies were the Lysholm score, the International Knee Documentation Committee's (IKDC) subjective and objective scores, Tegner scores, Orthopädische Arbeitsgruppe Knie (OAK) rate of return to sports, and rate of complications. Data were also extracted from studies that used stress radiographs to perform a quantitative assessment of the preoperative and postoperative anteroposterior stability. Results: The systematic review included 13 studies. The patient cohort of consisted of 643 participants (544 [84.6%] men and 99 [15.4%] women) with a mean age of 32.9 ± 4.0 years. The mean postoperative follow-up was 34.5 ± 10.9 months (range: 24–96 months), while the mean time from injury to surgery was 14.4 ± 9.9 months (range: 0–240 months). All studies reported clinically significant improvement at final follow-up, as evident from the measured subjective and objective IKDC scores, Lysholm score, Tegner score, and OAK rate. Only three studies reported return to sports activity, with a mean percentage of 90.8% (99/109). All studies showed a significant improvement in posterior translation, from 11.5 ± 1.2 mm to 3.3 ± 1.1 mm, using radiography (side-to-side difference). This systematic review revealed 13 (2.0%) failures and 33 (5.1%) minor complications: 10 (1.6%) cases of stiffness, 21 (4.9%) screws removal, 1 (0.2%) injury of the peroneal nerve, and 1 (0.2%) fibular fracture. Conclusions: With the currently available data, all studies included in the review on posterior cruciate ligament reconstruction with remnant preservation demonstrated satisfactory outcomes at mid-term follow-up (> 24 months), despite varying surgical techniques and graft types, and intervals from injury to surgery. For clinical relevance, standard PCL reconstruction is a highly effective operation in terms of improvement in functional status, knee stability, quality of life, and cost effectiveness. The remnant preservation technique requires more comprehensive diagnostic assessments of the PCL remnant patterns and more complicated surgical procedures. Given the absence so far of high quality studies with long-term follow-up, the remnant-preserving techniques should be recommended only by experienced knee arthroscopic surgeons. Level of evidence: Level IV. Study registration: reviewregistry1376—www.researchregistry.com. [ABSTRACT FROM AUTHOR]

Despite of being rich in fossil fuels, the Middle East is currently the main energy consumer and is projected to have the highest growth in energy demand in the world. Due to its great potential in the Middle East, solar energy can play an important role in the plans of energy decision-makers in the region. According to the studies done so far, no study has been done to show the potential benefit of using home-scale solar systems in the Middle East. Therefore, in this work for the first time, the potential of solar electricity production in the capitals of Middle Eastern countries has been studied using HOMER V2.81 software. The investigations are technical, economic, energy, and environmental, and the studied solar system is connected to the national electricity grid. The results showed that in Nicosia, due to the sale of electricity to the grid, the levelized cost of electricity (LCOE) is equal to -0.759 $, which is the lowest price for produced electricity and leads to a return on investment time of 5.69 years for this system. The solar fraction for the Nicosia station is 92%, which prevents the emission of more than 8 tons of CO2 pollutants during the year. The highest value of LCOE with the amount of $0.25 is related to Sana'a, whose investment return time, solar fraction, and annual CO2 emission prevention amount are 14.1 years, 53%, and 1162 kg, respectively. Ranking analysis was done on the results of 5 outputs of the HOMER software as well as 3 other influential parameters using 4 multicriteria decision-making (MCDM) methods. TOPSIS, GRA, WSM, and AHP methods were used, and the final ranking of each station was considered the average of the 4 methods. According to the results, Cyprus and Kuwait stations were the best and worst, respectively. [ABSTRACT FROM AUTHOR]

Objectives: Some pregnant women are not ready or do not want to quit smoking completely, and currently there is no support provided for these women in the UK. Offering help to reduce smoking could reduce the health risks associated with smoking and increase the limited reach of the NHS Stop Smoking Services (SSS) for pregnant women. This study aimed to design and evaluate a hypothetical intervention aimed at pregnant women who are not yet ready or do not want to quit smoking entirely.Methods: A hypothetical intervention, the Reduced Smoking During Pregnancy (RSDP) intervention, was conceptualised based on the best available evidence. The intervention was evaluated, using a decision-analytic model developed for SDP interventions. Two different scenarios, a base-case and a cautious-case were developed, and a cost-utility analysis and return on investment analysis were conducted. The uncertainty around the estimates was assessed, using deterministic and probabilistic sensitivity analyses.Results: The RSDP intervention could prevent the loss of 13 foetuses and generate 43 quitters 1 year after delivery per 1000 women. In the lifetime analysis, the intervention was cost-effective in both scenarios, with an incremental cost of £363 (95% CI £29 to £672) and 0.44 (95% CI 0.32 to 0.53) QALYs gained in the base-case.Conclusions: The study found that the hypothetical reduction intervention would produce significant health benefits, reduce smoking and be cost-effective. Offering pregnant smokers help to reduce smoking could reduce health inequalities, widen the reach of SSS and improve health. This economic evaluation of a novel, intensive intervention could inform the piloting of such interventions. [ABSTRACT FROM AUTHOR]

The purpose of this study is to determine the location of the custom workshop business using the criteria of NPV, IRR, PBP, PI and B/C. This research method uses a field research model with the right procedure to use the net present value method, internal rate of return, payback period, profitability index and benefit cost ratio to determine the custome workshop business. The results of the criteria obtained are that NPV>0, IRR is 29.4%, PBP is 2.75 years, PI is 1.1.48 and B/C is 1.1. This level of achievement uses the world every day, there must be activities in the custome workshop to achieve the criteria. The criterion that becomes the dominant factor is the occurrence of an increase in the profitability index. This is a criterion that states there is an increase in the benefits of the specified investment value. What causes an increase in benefits is that assets and production facilities can experience functions that are more suitable for the way they are used. [ABSTRACT FROM AUTHOR]

Pay For Success (PFS) is a financial transaction model used by public entities to access private sector dollars to fund preventative programs for at-risk populations. If predetermined outcomes are met, government agencies pay private investors back with interest. Generally, a PFS feasibility study is conducted that investigates the issue, the target population, and potential evidence-based programs and their outcomes. If a positive return on investment is determined, partners can make a business case for entering into a PFS deal. Through interviews with thirteen stakeholders involved in feasibility studies in Colorado, the costs and benefits of participating in a PFS feasibility studies and barriers to why projects don't move beyond feasibility are examined. Major benefits include increased collaboration between stakeholders, intense focus on a target population and their needs, increased opportunities for funding and data networks, and a focus on paying for outcomes and an opportunity for programmatic self-assessment. [ABSTRACT FROM AUTHOR]

Sustainable Urban Drainage Systems (SuDS) are known to help mitigate flooding whilst simultaneously delivering other positive outcomes, such as the provision of environmental, economic, educational, and business benefits. Despite this, there has been a relatively low uptake of SuDS in new developments and even less of an uptake in the opportunities for retrofitting SuDS in existing buildings. A major barrier to uptake has been a lack of understanding regarding the value of the benefits provided by SuDS. This study presents an appraisal of the costs and benefits derived from the retrofitting of SuDS in existing buildings and reveals some of the key decision-making considerations during the design and installation of such schemes. A qualitative research approach that included a number of case studies of successfully retrofitted SuDS schemes within public buildings was conducted. A novel feature of the research was the use of the Willingness to Pay (WTP) approach to value the tangible and intangible benefits provided by the various schemes from the perspectives of the property owners. The findings revealed that the retrofit provided a net value to the client of over £100,000 over 10 years, a mean CBA ratio of 5.3/10, and a return on investment (ROI) that would be achieved in less than 3 years. The importance of stakeholder engagement during the decision-making process was highlighted in helping to overcome many of the design, installation, and maintenance challenges. The findings demonstrate a significant ROI for these SuDs retrofit schemes and highlight useful approaches to overcoming the barriers in valuing the importance of the intangible benefits. In supporting the uptake of the retrofitting of SuDS, it is recommended that these benefits are given full consideration by property owners, urban planners, and architects during the design of retrofit schemes and throughout the decision-making stage. [ABSTRACT FROM AUTHOR]

Post-traumatic stress disorder (PTSD) leads to significant disability, unemployment, and substantial healthcare costs. The cost-effectiveness of vocational rehabilitation (VR) interventions is important to consider when determining which services to offer. This study assesses the cost-effectiveness and return on investment of Individual Placement and Support (IPS) compared to transitional work (TW) programs. Employment outcomes from a multisite randomized trial comparing IPS to TW in military veterans with PTSD (n = 541) were linked to Veterans Health Administration (VHA) archival medical record databases to examine the comparative cost-effectiveness and return on investment. Effectiveness was defined as hours worked and income earned in competitive jobs. Costs for VR, mental health, and medical care and income earned from competitive sources were annualized and adjusted to 2019 US dollars. The annualized mean cost per person of outpatient (including vocational services) were $3970 higher for IPS compared to TW ($23,245 vs. $19,276, respectively; P = 0.004). When TW income was included in costs, mean grand total costs per person per year were similar between groups ($29,828 IPS vs. $26,772 TW; P = 0.17). The incremental cost-effectiveness analysis showed that while IPS is more costly, it is also more effective. The return on investment (excluding TW income) was 32.9% for IPS ($9762 mean income/$29,691 mean total costs) and 29.6% for TW ($7326 mean income/$24,781 mean total costs). IPS significantly improves employment outcomes for individuals with PTSD with negligible increase in healthcare costs and yields very good return on investment compared to non-IPS VR services. [ABSTRACT FROM AUTHOR]

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This study sought to estimate the net benefits and return on investment (ROI, %) of the Coping and Promoting Strength (CAPS) program to families and insurers, respectively, using data from a multi-year follow up of 136 US families who had participated in a randomized efficacy trial of CAPS. CAPS is a brief parent-focused psychosocial intervention that was compared to information monitoring in the trial. Of the 136 original participants, 113 (83%) completed follow-up interviews 7.1 years, on average, after the CAPS study baseline (mean follow-up age: 15.8 years; range: 13.1 to 20.8 years). Parent-reported willingness-to-pay values and estimates of behavioral healthcare cost savings from delayed onset of anxiety were used to simulate the average net benefits of CAPS to families and insurance plans, respectively, assuming patients pay 20% coinsurance. Psychologists in private offices were expected to charge an average of approximately $195 per CAPS session or $1417 in total in 2020 dollars. The estimated family share of the total CAPS session cost was $283 per youth, while the insurer share was $1134 per youth. Given these costs, the CAPS intervention was estimated to result in average overall net benefits of $1033 per youth (95% CI: -$546 to $2611). Families gained $344 (95% CI: $232 to $455 per family) for an ROI of 121%. Insurance plans on average gained a net savings of $689 per youth (95% CI: -$778 to $2156 per youth) for an average ROI of 61%. In this multiyear follow-up of offspring of anxious parents, exposure to the CAPS pediatric anxiety prevention program was found to be more economically efficient than was waiting for an anxiety disorder to be diagnosed. ClinicalTrials.gov Identifier: NCT00847561. [ABSTRACT FROM AUTHOR]

A case study was conducted on 44 residential homes using both traditional house wrap and ZIP System systems to measure the overall airtightness and compare estimated energy usages. The labor, material, and overhead and profit (O&P) costs were analyzed and used to determine the optimal choice for long-term benefits in terms of cost and performance. The impact of insulation installation is considered a key factor in improving the strategy of reducing energy consumption. Improved installation practices can affect the airtightness of common wall assemblies to reduce the building energy performance gaps and provide insight on how to allocate resources better. A framework was developed to analyze operational costs and building energy performance to address how installation quality is a factor in the return of investment in building construction for heating and cooling systems within the thermal envelope. With this methodology, aggressive energy performance goals will be met while balancing the tradeoff between installation techniques and building systems efficiency based on the introduced probabilistic investment return (PIR) metric. [ABSTRACT FROM AUTHOR]

[Display omitted] • Cost benefit analysis of a municipal solid waste recycling facility. • Internal Rate of Return and Net Present Value of a project. • MATLAB, Python and R-Studio for comparation and validation. Rapid population and economic growth, changes in consumption pattern etc. have become major contributing factors to severe municipal solid waste generation globally. Thus, various methods are being employed to manage the incessant municipal solid waste generation for a sustainable solid waste management and one of the viable approaches is the recycling option. The main objective of this paper is to determine the cost benefit analysis of setting up a recycling facility for the processing of various wastes for use as raw materials by industries. The cost benefit analysis was carried out based on historic data obtained from the municipality and some recent waste composition data. The overall analysis was done using Excel software. From the Excel software analysis, Internal Rate of Return on investment was 42%, Internal Rate of Return on equity was 98% and Net Present Value was R 63, 420,000 (USD$ 4646225.33). In ascertaining the result obtained from the Microsoft Excel, three data analysis and technical computing software (MATLAB, Python, and R-Studio) were employed. This was necessary to compare and validate the cost-benefit indicators (Net Present Value and Internal Rate of Return). Besides, evaluating the performance of each software with regards to the cost-benefit evaluation is ideal for a recycling plant like this to establish the feasibility of the project. Moreover, sensitivity analysis was conducted, and a breakeven point of 211 tons of waste was obtained. In addition, the total benefit of recycling was valued and was given as R 486,008,582.85 (USD$ 35605572.16). From the overall analysis, it was observed that the IRR and Net Present Value were alike, about 677 potential jobs could be created on the project and the Net Present Value > 0. Based on the overall analysis, it was concluded that the project is viable. [ABSTRACT FROM AUTHOR]

Cultural heritage has, for a long time, been considered a source of wealth and well-being for economies. Currently, considerable investments have been allocated for its renewal and maintenance that often surpass the budgets of owners, local communities, and other interested users. Cultural heritage valorisation is expensive and is a great economic challenge. Infrastructural investment, i.e., conservation and restoration, are just one part of the total costs of cultural heritage preservation, while other investments relate to regular operation and maintenance. One of the most difficult decisions for those who design the cultural heritage restoration projects is how to finance them, i.e., what the most efficient financial instruments are for renewal of cultural heritage. These assumptions have instigated interest in the evaluation of services resulting from common good functions of cultural heritage, such as economic, educational, historical, technological, ecological, and climate, as well as tourism and recreational. Therefore, this article starts from the analysis of potential funding sources for cultural heritage through the European Union (EU) funds; a method of economic evaluation of the return on investments and cost-benefit analysis is suggested as a method that should be used in decision making on these interventions. [ABSTRACT FROM AUTHOR]

The article discusses how Return on investment (ROI) is calculated for investments in forecasting software and talent, and the different factors that need to be considered. It mentions investment in demand planning resources; and also mentions labor savings generates the expected financial benefit from the project investment.

In response to our paper, we understand that James Heckman communicated to the journal Editors states that the Heckman Curve does not describe how the average return on investment of programs differs by the age of recipients. This clarification is useful as many people in the policy community have understood the Heckman Curve in this manner. [ABSTRACT FROM AUTHOR]

• Within our partner community, household investments in sanitation and food preparation environments yield a positive net benefit. • Among the four regions we examined, only the state of San Marcos, Guatemala had a positive return on investment for households at year 60. • 'WaSH mobility' is a household's ability to improve its WaSH technology status. • Limited household options for improving WaSH technologies reduces WaSH mobility via reductions in return on investment. • SEM provides a novel method to allocate benefit estimates to multiple WaSH technologies in improving child height-for-age. The child stunting rate (low height-for-age) in Guatemala is the sixth worst in the world. Child stunting is correlated both with short and long-term economic costs. While technologies to improve water, sanitation and hygiene (WaSH) are effective at ameliorating child stunting, current household investment in WaSH technologies is constrained (i.e., self-supply). To understand this constraint, data on household spending priorities and barriers to investment in WaSH technologies must be assessed. We utilize primary data from our partner community in Totonicapán, Guatemala to populate a structural equation model and benefit-cost analysis assessing the association between household WaSH technologies and child height-for-age. To test regional variations, we scale-up our approach to examine four additional regions across western Guatemala. The results suggest there is limited monetary gain for households to invest in WaSH technologies. Among the communities and regions where higher returns on investment for households were identified, significant WaSH technologies were cumulatively low cost and simple to obtain and use. We encourage stakeholders supporting a self-supply model to evaluate that incremental improvements in WaSH technologies financed by the household do not impose large costs without sufficient benefits, facilitating healthy WaSH mobility (a household's ability to improve their WaSH technology status). [ABSTRACT FROM AUTHOR]

Aims: METHODS: RESULTS: We identified nine articles (conducted in Australia (n = 5), Europe (n = 3) and China (n = 1)); three reported healthcare costs associated with excessive sedentary time, whilst six were economic evaluations of interventions targeting sedentary behaviour. Healthcare costs associated with excessive sedentary time as reported in cost of illness studies were substantial; however, none explored non-health sector costs. In contrast, all full economics evaluations adopted a societal perspective; however, costs included differed depending on the intervention context. One sedentary behaviour intervention in children was cost-saving. The five interventions targeting occupational sitting time of adults in office workplaces were cost-effective. Physical environmental changes such as sit-stand desks, active workstations etc., were the key cost driver.Conclusions: Sedentary behaviour is likely associated with excess healthcare costs, although future research should also explore costs across other sectors. Cost-effectiveness evidence of sedentary behaviour reduction interventions in workplaces is limited but consistent. Key gaps relate to the economic credentials of interventions targeting children, and modelling of long-term health benefits of interventions. [ABSTRACT FROM AUTHOR]

Habitat restoration is a key strategy for recovering imperiled species, and planning habitat restoration activities cost effectively can help advance recovery objectives. Habitat restoration planning involves decisions about where and when to undertake restoration, and what type of restoration to undertake. This article focuses on decisions about the amount of restoration to undertake for a given type, location, and time, termed intervention intensity. A return on investment framework is developed for incorporating intervention intensity into habitat restoration planning. The framework is then applied in the context of planning habitat restoration for Pacific salmon recovery as a case study. Results showed that no single intervention type or location dominated, and several returns to scale relationships emerged across the candidate interventions. Scenarios that considered interventions across multiple intensities outperformed single-intensity scenarios in terms of total benefits and cost effectiveness. These findings highlight the usefulness of exploratory return on investment analysis for prioritizing habitat restoration interventions, and underscore the importance of systematically considering how much restoration to undertake, in addition to what to do and where. • Systematically considering the amount of restoration to undertake at a given location and time promotes effective habitat restoration planning. • A return on investment framework is developed for considering intervention intensity when planning habitat restoration. • The framework is applied to prioritizing habitat restoration for endangered Pacific salmon using coupled models of salmon habitat and salmon survival. • The case study results illustrate that considering intervention intensity can promote cost-effective habitat restoration planning. [ABSTRACT FROM AUTHOR]

To foster the development, multiple sources of uncertainty associated with benefits and costs of innovation portfolios from low carbon investment need to be considered. We apply Modern Portfolio Theory to construct efficient portfolios of different low-carbon technology fields. The empirical framework is applied to four countries (i.e., Germany, the United Kingdom, Italy, and France) for six low-carbon technology fields (i.e., renewable energy, smart grid, energy efficiency, sustainable transport, carbon capture and storage, and nuclear power) categorized based on priority areas of the EU's 2008 Strategic Energy Technology Plan. The four main findings are: (1) the highest priority technology fields with the minimum risk portfolio are nuclear power in Germany, renewable energy in the United Kingdom, and energy efficiency in Italy and France, (2) the highest priority technology field with the maximum risk portfolio is sustainable transport in Germany, the United Kingdom, and France, and smart grid in Italy, (3) sustainable transport declines in priority as risk decreases in the portfolios of Germany, the United Kingdom, and France, while smart grid declines in priority as risk decreases in the portfolio in Italy, and (4) the presence of negative correlations over time among expected Return on Investments across energy technology fields improves using the Modern Portfolio Theory framework as risk diversification strategy. Our analysis provides efficient portfolios of low-carbon technologies, which can help shape the overall strategy and coordinate each country's comparative advantage by proposing new laws and policies, monitoring existing ones, and managing budget. • We apply Modern Portfolio Theory to construct efficient portfolios of technologies. • We find the highest priority technology fields with the min and max risk portfolios. • A country has its own strategy for R&D investments based on past information. • The EU should adopt efforts to manage risk inherent in the uncertainties of R&D. [ABSTRACT FROM AUTHOR]