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Purpose. As a scientific field, bioinformatics has drawn remarkable attention from various fields, such as information technology, mathematics, and modern biological sciences, in recent years. The topic models originating from the field of natural language processing have become the focus of attention with the rapid accumulation of biological datasets. Thus, this research is aimed at modeling the topic content of the bioinformatics literature presented by Iranian researchers in the Scopus Citation Database. Methodology. This research was a descriptive-exploratory study, and the studied population included 3899 papers indexed in the Scopus database, which had been indexed in this database until March 9, 2022. The topic modeling was then performed on the abstracts and titles of the papers. A combination of LDA and TF-IDF was utilized for topic modeling. Findings. The data analysis with topic modeling resulted in identifying seven main topics "Molecular Modeling," "Gene Expression," "Biomarker," "Coronavirus," "Immunoinformatics," "Cancer Bioinformatics," and "Systems Biology." Moreover, "Systems Biology" and "Coronavirus" had the largest and smallest clusters, respectively. Conclusion. The present investigation demonstrated an acceptable performance for the LDA algorithm in classifying the topics included in this field. The extracted topic clusters indicated excellent consistency and topic connection with each other. [ABSTRACT FROM AUTHOR]

In this paper, we study the problem of gossiping with interference constraint in radio ring networks. Gossiping (or total exchange information) is a protocol where each node in the network has a message and is expected to distribute its own message to every other node in the network. The gossiping problem consists in finding the minimum running time (makespan) of a gossiping protocol and algorithms that attain this makespan. We focus on the case where the transmission network is a ring network. We consider synchronous protocols where it takes one unit of time (step) to transmit a unit-length message. During one step, a node receives at most one message only through one of its two neighbors. We also suppose that, during one step, a node cannot be both a sender and a receiver (half duplex model). Moreover communication is subject to interference constraints. We use a primary node interference model where, if a node receives a message from one of its neighbors, its other neighbor cannot send at the same time. With these assumptions we completely solve the problem for ring networks. We first show lower bounds and then give gossiping algorithms which meet these lower bounds and so are optimal. The number of rounds depends on the congruences of n modulo 12. [ABSTRACT FROM AUTHOR]

Mixed graphs have both directed and undirected edges. We consider mixed graphs that are regular in both directed and undirected degree and with given girth. Araujo-Pardo, Hern'andez-Cruz, andMontellano-Ballesteros recently established a lower bound for regular mixed graphs with directed degree one that generalizes the Moore bound. In this paper we show that, in at least one non-trivial case, their bound can be achieved. For a few other specific values of direct degree, undirected degree and girth we are able to identify graphs (mixed cages) of minimum possible order. We also obtain some fairly tight bounds for a few other cases. [ABSTRACT FROM AUTHOR]

We generalize the familiar notion of periodicity in sequences to a new kind of pseudoperiodicity, and we prove some basic results about it. We revisit the results of a 2012 paper of Shevelev and reprove his results in a simpler and more unified manner, and provide a complete answer to one of his previously unresolved questions. We consider finding words with specific pseudoperiod and having the smallest possible critical exponent. Finally, we consider the problem of determining whether a finite word is pseudoperiodic of a given size, and show that it is NP-complete. [ABSTRACT FROM AUTHOR]

The (bitwise) complement x of a binary word x is obtained by changing each 0 in x to 1 and vice versa. An antisquare is a nonempty word of the form x x. In this paper, we study infinite binary words that do not contain arbitrarily large antisquares. For example, we show that the repetition threshold for the language of infinite binary words containing exactly two distinct antisquares is (5 +√5)/2. We also study repetition thresholds for related classes, where "two" in the previous sentence is replaced by a larger number. We say a binary word is good if the only antisquares it contains are 01 and 10. We characterize the minimal antisquares, that is, those words that are antisquares but all proper factors are good. We determine the growth rate of the number of good words of length n and determine the repetition threshold between polynomial and exponential growth for the number of good words. [ABSTRACT FROM AUTHOR]

Simple Summary: Cancer is basically a tough condition on a patient's body where cell grows uncontrollably. Normal cells are affected, which destroys the health of the patient. The main problem in cancer is spreading from one part to another. Therefore, the mathematical modeling of cancerous tumors integrates to check overall stability. A novel approach is introduced such as Bernstein polynomial with combination of genetic algorithm, sliding mode controller, and synergetic control. The proposed solution has easily eliminated cancerous cells within five days using synergetic control. In addition, five cases are incorporated to evaluate error function. In addition, a brief comparative study is added to contrast the simulation results with theoretical modeling. Cancerous tumor cells divide uncontrollably, which results in either tumor or harm to the immune system of the body. Due to the destructive effects of chemotherapy, optimal medications are needed. Therefore, possible treatment methods should be controlled to maintain the constant/continuous dose for affecting the spreading of cancerous tumor cells. Rapid growth of cells is classified into primary and secondary types. In giving a proper response, the immune system plays an important role. This is considered a natural process while fighting against tumors. In recent days, achieving a better method to treat tumors is the prime focus of researchers. Mathematical modeling of tumors uses combined immune, vaccine, and chemotherapies to check performance stability. In this research paper, mathematical modeling is utilized with reference to cancerous tumor growth, the immune system, and normal cells, which are directly affected by the process of chemotherapy. This paper presents novel techniques, which include Bernstein polynomial (BSP) with genetic algorithm (GA), sliding mode controller (SMC), and synergetic control (SC), for giving a possible solution to the cancerous tumor cells (CCs) model. Through GA, random population is generated to evaluate fitness. SMC is used for the continuous exponential dose of chemotherapy to reduce CCs in about forty-five days. In addition, error function consists of five cases that include normal cells (NCs), immune cells (ICs), CCs, and chemotherapy. Furthermore, the drug control process is explained in all the cases. In simulation results, utilizing SC has completely eliminated CCs in nearly five days. The proposed approach reduces CCs as early as possible. [ABSTRACT FROM AUTHOR]

Let G = (V;E) be a given graph of order n. A function f: V ! f0; 1; 2g is an independent Roman dominating function (IRDF) on G if for every vertex v 2 V with f(v) = 0 there is a vertex u adjacent to v with f(u) = 2 and fv 2 V: f(v) > 0g is an independent set. The weight of an IRDF f on G is the value f(V) = P v2V f(v). The minimum weight of an IRDF among all IRDFs on G is called the independent Roman domination number of G. In this paper, we give algorithms for computing the independent Roman domination number of G in O(jV j) time when G = (V;E) is a tree, unicyclic graph or proper interval graph. [ABSTRACT FROM AUTHOR]

Let k 1 be an integer, and let G be a finite and simple graph with vertex set V (G). A signed total Italian k-dominating function on a graph G is a function f: V (G) ! f1; 1; 2g such that P u2N(v) f(u) ≥ k for every v 2 V (G), where N(v) is the neighborhood of v, and each vertex u with f(u) = 1 is adjacent to a vertex v with f(v) = 2 or to two vertices w and z with f(w) = f(z) = 1. A set ff1; f2;: ::; fdg of distinct signed total Italian k-dominating functions on G with the property that Pd i=1 fi(v) ≤ k for each v 2 V (G), is called a signed total Italian k-dominating family (of functions) on G. The maximum number of functions in a signed total Italian k-dominating family on G is the signed total Italian k-domatic number of G, denoted by dk stI (G). In this paper we initiate the study of signed total Italian k-domatic numbers in graphs, and we present sharp bounds for dk stI (G). In addition, we determine the signed total Italian k-domatic number of some graphs. [ABSTRACT FROM AUTHOR]

With the increasing importance of mathematics in basic education, how to evaluate and analyze the intelligent effect of mathematics teaching classroom through scientific methods has become one of the indicators to evaluate the intelligent classroom. This paper studies the design and application of mathematics teaching intelligent classroom based on the PCA-NN (principal component analysis-neural network) algorithm. Firstly, this paper briefly describes the current research status of mathematics teaching intelligent classroom design and PCA-NN algorithm. Secondly, combined with the key factors of mathematics teaching, it formulates specific standards and puts forward an adaptive strategy of intelligent and personalized intelligent mathematics teaching classroom. Finally, the algorithm is verified by experiments. The results show that, for students with different mathematics basic levels, the mathematics teaching intelligent classroom based on the PCA-NN algorithm can effectively improve the quality of mathematics classroom teaching. Through the research on the factors such as teaching quality, effect, and interaction mode involved in the process of mathematics teaching classroom design, the intelligent classroom design factors affecting teaching quality are determined. This paper analyzes and studies the system from different angles. The research results provide some help for the current quality evaluation of classroom teaching and use the PCA-NN algorithm to make quantitative analysis and multivariate verification of mathematics classroom teaching effect. [ABSTRACT FROM AUTHOR]

Malignant melanoma is one of the most threatening cancers to human health. Only 14% of patients with malignant melanoma have a remaining life span of 5 years. At present, there have been some studies looking for potential prognostic indicators of esophageal cancer from the level of genes and infiltrating immune cells, but there are still some problems that need to be resolved urgently. This paper proposes IGHG3 as the immune infiltration of malignant melanoma, which takes into account the computational mathematics. It aims to deduce the characteristics of immune cell infiltration in malignant melanoma and study the relationship between different immune cell infiltration characteristics and prognosis. The method in this article is to establish a computational mathematical model for the immunotherapy of melanoma, then study the method of identification of the affinity of the IGHG3 reagent, and finally obtain the gene expression of immune infiltration. The functions of these methods are, respectively, to predict the dynamic behavior of T cells with two different specificities through mathematical models and to test the matching degree of different concentrations of IGHG3 reagent with the human body. Then use the ssGSEA algorithm to obtain immune infiltration related data and calculate the difference between the weighted empirical cumulative distribution function of all genes in the effect of IGHG3 on melanoma that was carried out. The experimental results showed the computational mathematical method genome and all the remaining genes. In this study, a computational mathematical method to detect the IGHG3 gene expression had a significant inhibitory effect on A375 cells in the experimental group, and the knockdown efficiency reached 85.6%. [ABSTRACT FROM AUTHOR]

With the rapid development of artificial intelligence (AI) concept technology, it promotes the innovation of educational concept. Mostly for the education information analysis in the class of mathematics in the university, it should be based on a big data-driven system to promote the quality of teaching in the classroom. In the method of teaching math in university, teachers should take full advantage of the benefits of a big data-driven system powered by AI, grow a good teaching model for students, promote education through big data, progressively teach students according to their aptitude, develop in a tailored direction, increase teaching quality and effectiveness, and finally create more great talents for our country. For the sake of improving the resource sharing and the management level of the curriculum which teaches advanced knowledge about mathematics teaching, based on a particle swarm optimization algorithm, an advanced math teaching system is proposed in this paper. The fusion model that can be used in the teaching process of math in university is constructed, the adaptive scheduling of the curriculum which teaches advanced knowledge about mathematics auxiliary teaching resources is realized by an optimization algorithm used for fusion particle swarm, the autocorrelation feature of the curriculum which teaches advanced knowledge about mathematics auxiliary teaching resources is extracted, and the adaptive optimization of the curriculum which teaches advanced knowledge about mathematics auxiliary teaching resource fusion is realized by fuzzy correlation feature matching and statistical analysis. In the process of particle swarm optimization, the combination of statistical features is studied and managed, the resource scheduling and information fusion are realized, and the management capability of the curriculum which teaches advanced knowledge about mathematics auxiliary teaching is promoted, and the experimental results demonstrate that the designed system has a high integration of teaching information resources and strong information scheduling ability and improved the management level of the curriculum which teaches advanced knowledge about mathematics complementary teaching. [ABSTRACT FROM AUTHOR]

In this paper, the theory of viscoelastic material relaxation modulus testing, testing method, and material relaxation modulus parameter solution method is studied. Based on the IoT sensor test devices and the Hertzian mathematics theory, the relationship between the compression amount, pressure, and relaxation modulus of a rigid spherical indenter pressed into a flat viscoelastic material is studied. In combination with the Boltzmann superposition principle, the relaxation modulus test method and theory for viscoelastic materials are proposed. A good fitting curve was obtained to solve the relaxation modulus parameters of various materials under the three-element Maxwell model. The experimental setup and the results of the parameter fitting were analyzed to verify the feasibility and accuracy of the results. [ABSTRACT FROM AUTHOR]

This research aims to improve the rationality and intelligence of AUTOMATICALLY HIGHER MATHEMATICALLY EXAM SYSTEM (AHMES) through some AI algorithms. AHMES is an intelligent and high-quality higher math examination solution for the Department of Computer Engineering at Pai Chai University. This research redesigned the difficulty system of AHMES and used some AI algorithms for initialization and continuous adjustment. This paper describes the multiple linear regression algorithm involved in this research and the AHMES learning (AL) algorithm improved by the Q-learning algorithm. The simulation test results of the upgraded AHMES show the effectiveness of these algorithms. [ABSTRACT FROM AUTHOR]

This paper proposes an innovative statistical method to measure the impact of the class/school on student achievements in multiple subjects. We propose a semiparametric model for a bivariate response variable with random coefficients, that are assumed to follow a discrete distribution with an unknown number of support points, together with an Expectation-Maximization algorithm—called BSPEM algorithm—to estimate its parameters. In the case study, we apply the BSPEM algorithm to data about Italian middle schools, considering students nested within classes, and we identify subpopulations of classes, standing on their effects on student achievements in reading and mathematics. The proposed model is extremely informative in exploring the correlation between multiple class effects, which are typical of the educational production function. The estimated class effects on reading and mathematics student achievements are then explained in terms of various class and school level characteristics selected by means of a LASSO regression. [ABSTRACT FROM AUTHOR]

Grey wolf optimization (GWO) algorithm is a new emerging algorithm that is based on the social hierarchy of grey wolves as well as their hunting and cooperation strategies. Introduced in 2014, this algorithm has been used by a large number of researchers and designers, such that the number of citations to the original paper exceeded many other algorithms. In a recent study by Niu et al., one of the main drawbacks of this algorithm for optimizing real‐world problems was introduced. In summary, they showed that GWO's performance degrades as the optimal solution of the problem diverges from 0. In this paper, by introducing a straightforward modification to the original GWO algorithm, that is, neglecting its social hierarchy, the authors were able to largely eliminate this defect and open a new perspective for future use of this algorithm. The efficiency of the proposed method was validated by applying it to benchmark and real‐world engineering problems. [ABSTRACT FROM AUTHOR]

This paper is concerned with the topological structure, reachability, and stabilization for Boolean control networks (BCNs) with state constraints via event-triggered control (ETC) scheme. In the first part, the topological structure of BCNs with state constraints is studied. Under the framework of state constrain, the definitions of fixed point and cycle are first defined. A novel phenomenon is that there may exist two kinds constrained fixed points, which are, respectively, named as the livelock and deadlock ones. It is different with the traditional fixed point. Accordingly, a formula is presented to calculate the number of constrained fixed points and constrained cycles. In the second part, the constrained reachability and stabilization problem of the event-triggered controlled BCNs are investigated. Two necessary and sufficient criteria are, respectively, obtained. Furthermore, an algorithm is developed to design all feasible controllers. Finally, a reduced model of the lac operon in the Escherichia coli is shown to illustrate the efficiency of the obtained results. [ABSTRACT FROM AUTHOR]