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Promoting the hydrogen oxidation reaction (HOR) activity and poisoning tolerance of electrocatalysts is crucial for the large-scale application of hydrogen-oxygen fuel cell. However, it is severely hindered by the scaling relations among different intermediates. Herein, lattice-contracted Pt-Rh in ultrasmall ternary L1 2 -(Pt 0.9 Rh 0.1 ) 3 V intermetallic nanoparticles (~2.2 nm) were fabricated to promote the HOR performances through an oxides self-confined growth strategy. The prepared (Pt 0.9 Rh 0.1 ) 3 V displayed 5.5/3.7 times promotion in HOR mass/specific activity than Pt/C in pure H 2 and dramatically limited activity attenuation in 1000 ppm CO/H 2 mixture. In situ Raman spectra tracked the superior anti-CO* capability as a result of compressive strained Pt, and the adsorption of oxygen-containing species was promoted due to the dual-functional effect. Further assisted by density functional theory calculations, both the adsorption of H* and CO* on (Pt 0.9 Rh 0.1 ) 3 V were reduced compared with that of Pt due to lattice contraction, while the adsorption of OH* was enhanced by introducing oxyphilic Rh sites. This work provides an effective tactic to stimulate the electrocatalytic performances by optimizing the adsorption of different intermediates severally., (© 2024 Wiley-VCH GmbH.)

The short history of research on Li-O 2 batteries has seen a remarkable number of mechanistic U-turns over the years. From the initial use of carbonate electrolytes, that were then found to be entirely unsuitable, to the belief that (su)peroxide was solely responsible for degradation, before the more reactive singlet oxygen was found to form, to the hypothesis that capacity depends on a competing surface/solution mechanism before a practically exclusive solution mechanism was identified. Herein, we argue for an ever-fresh look at the reported data without bias towards supposedly established explanations. We explain how the latest findings on rate and capacity limits, as well as the origin of side reactions, are connected via the disproportionation (DISP) step in the (dis)charge mechanism. Therefrom, directions emerge for the design of electrolytes and mediators on how to suppress side reactions and to enable high rate and high reversible capacity., (© 2023 The Authors. Angewandte Chemie International Edition published by Wiley-VCH GmbH.)

Multi-target histone deacetylase (HDAC) inhibitors can be designed by introducing dominant structures of natural products to enhance activity and efficacy while avoiding the toxicity from other targets. In this study, we reported a series of novel HDAC inhibitors based on erianin and amino erianin upon pharmacophore fusion strategy. Two representative compounds, N-hydroxy-2-(2-methoxy-5- (3,4,5-trimethoxyphenethyl)phenoxy)acetamide and N-Hydroxy-8-((2-methoxy-5- (3,4,5-trimethoxyphenethyl)phenyl)amino)octanamide, possessed good inhibitory effect against five cancer cells tested (IC 50 =0.30-1.29 μΜ, 0.29-1.70 μΜ) with strong HDAC inhibition, and low toxicity toward L02 cells, which were selected for subsequent biological studies in PANC-1 cells. They were also found to promote the intracellular generation of reactive oxygen species, cause DNA damage, block the cell cycle at G2/M phase, and activate the mitochondria-related apoptotic pathway to induce cell apoptosis, which are significant for the discovery of new HDAC inhibitors., (© 2023 Wiley-VCH GmbH.)