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Hydrogenation of N‐heteroarenes to saturated N‐heterocycles is an important reaction in organic synthesis. Hydrogen is a green reducing reagent and has been widely applied in industrial production. The development of an appropriate catalyst to realize hydrogenation at low pressure and temperature is desired. In this study, we developed a cobalt‐based catalyst derived from ZIF‐67 that exhibits high activity for N‐heteroarene hydrogenation under 5–20 bar hydrogen, which is a relatively low pressure as compared to reported catalytic systems. This nano‐cobalt catalyst shows broad substrate scope and can be reused without obvious activity loss. [ABSTRACT FROM AUTHOR]

The development of innovative methods for synthesizing silylcyclopentene compounds is particularly important for enriching and improving the synthetical toolbox of organosilicon compounds. Herein, a facile approach has been developed for the synthesis of silylcyclopentenes promoted by mechanochemically generated organolithium species as silicon nucleophiles under ball milling conditions, avoiding the requirement of large amounts of bulk solvent. This operationally simple method demonstrates good functional group compatibility, which provides a great opportunity for further exploration of the synthetic applications of silylcyclopentenes. Density functional theory calculations indicated that the transient lithiosilole intermediates undergo a stepwise nucleophilic addition process, which governs this mechanic‐force‐promoted [4+1] cycloaddition reaction. [ABSTRACT FROM AUTHOR]

Prenatal lethality associated with mouse knockout of Mettl16, a recently identified RNA N6-methyladenosine (m6A) methyltransferase, has hampered characterization of the essential role of METTL16-mediated RNA m6A modification in early embryonic development. Here, using cross-species single-cell RNA sequencing analysis, we found that during early embryonic development, METTL16 is more highly expressed in vertebrate hematopoietic stem and progenitor cells (HSPCs) than other methyltransferases. In Mettl16-deficient zebrafish, proliferation capacity of embryonic HSPCs is compromised due to G1/S cell cycle arrest, an effect whose rescue requires Mettl16 with intact methyltransferase activity. We further identify the cell-cycle transcription factor mybl2b as a directly regulated by Mettl16-mediated m6A modification. Mettl16 deficiency resulted in the destabilization of mybl2b mRNA, likely due to lost binding by the m6A reader Igf2bp1 in vivo. Moreover, we found that the METTL16-m6A-MYBL2-IGF2BP1 axis controlling G1/S progression is conserved in humans. Collectively, our findings elucidate the critical function of METTL16-mediated m6A modification in HSPC cell cycle progression during early embryonic development. Synopsis: METTL16 plays a crucial role in N6-methyladenosine (m6A) modification of RNA. This study sheds light on the significance of this event in early embryonic development and cell cycle progression. METTL16 is highly expressed in hematopoietic stem and progenitor cells (HSPCs) across vertebrates Mettl16 maintains HSPC populations by ensuring G1/S progression in vivo Mettl16-mediated m6A modification of mRNA coding for transcription factor mybl2b enhances its stability The METTL16/m6A/MYBL2/IGF2BP1 axis contributes to G1/S progression in both zebrafish and humans The N6-methyladenosine methyltransferase METTL16 regulates cell cycle progression of HPSCs during embryonic development by stabilizing mybl2b mRNA. [ABSTRACT FROM AUTHOR]

This article discusses a study that aimed to identify specific plasma-derived exosomal microRNA (exo-miRNA) signatures associated with postmenopausal osteoporosis (PMOP) and evaluate their potential as biomarkers for early PMOP detection. The study included 272 postmenopausal women volunteers and used small RNA sequencing to analyze exo-miRNA profiles. The results revealed differentially expressed exo-miRNAs that were associated with PMOP and early-stage PMOP (osteopenia), suggesting their potential as biomarkers for detecting these conditions. The study also identified three exo-miRNAs (hsa-let-7d-3p, hsa-miR-24-3p, and hsa-miR-550a-3-5p) as potential biomarkers for PMOP detection and demonstrated their discriminative power in distinguishing PMOP and early-stage PMOP from healthy controls. The findings suggest that plasma-derived exo-miRNA profiling could be a minimally invasive and effective strategy for early PMOP detection. [Extracted from the article]

BACKGROUND: A new enzymatic hydrolysis‐based process inspired by the Maillard reaction can produce strong flavored, high‐value rapeseed oil that meets safety requirements. In the present study, the effect of reaction time (10–30 min) and temperature (130–160 °C) on the physicochemical properties, nutritional status, fatty acids composition and key aroma compounds of fragrant rapeseed oil (FRO) was investigated. RESULTS: An increasing reaction time and temperature substantially decreased the total tocopherol, polyphenol and sterol contents of FRO, but increased benzo[a]pyrene content, as well as the acid and peroxide values, which did not exceed the European Union legislation limit. Among the volatile components, 2,5‐dimethyl was the main substance contributing to the barbecue flavor of FRO. The 150 °C for 30 min reaction conditions produced a FRO with a strong, fragrant flavor, with high total tocopherol (560.15 mg kg−1), polyphenol (6.82 mg kg−1) and sterol (790.65 mg kg−1) contents; acceptable acid (1.60 mg g−1) and peroxide values (4.78 mg g−1); and low benzo[a]pyrene (1.39 mg g−1) content. These were the optimal conditions for the enzymatic Maillard reaction, according to the principal component analysis. Furthermore, hierarchical cluster analysis showed that reaction temperature had a stronger effect on FRO than reaction time. CONCLUSION: The optimal enzymatic Maillard reaction conditions for the production of FRO are heating at 150 °C for 30 min. These findings provide new foundations for better understanding the composition and flavor profile of FRO, toward guiding its industrial production. © 2023 Society of Chemical Industry. [ABSTRACT FROM AUTHOR]

Predicting the crystal structure is essential to address the reliance on serendipity for facilitating the discovery and design of high‐performance high‐entropy oxides (HEOs). Here, three classic algorithms‐based machine learning models to predict the crystal structure of HEOs are successfully established and analyzed by combining five metrics, and the XGBoost classifier shows excellent accuracy and robustness with ACC and F1 scores up to 0.977 and 0.975, respectively. SHAP summary plot indicates that the anion‐to‐cation radius ratio (rA/rC) has the greatest impact on crystal structure, followed by difference in Pauling and Mulliken electronegativities (ΔχPauling and ΔχMulliken). It is noteworthy that the rA/rC, ΔχPauling, and ΔχMulliken lower than 0.35, 0.1, and 0.2, respectively, tend to lead to a fluorite crystal structure, whereas rock‐salt and spinel crystal structures are always formed. This work is expected to facilitate the discovery and design of HEOs with tailorable crystal structures and properties. [ABSTRACT FROM AUTHOR]

During the Corona Virus Disease-2019 (COVID-19) pandemic, among men infected with SARS-CoV-2, little attention has been given to reduced libido and its associations with decreased erectile function, even though there may be physical and psychological factors that contribute to the two. So the purpose of the study is to determine the correlation between decreased erectile function and reduced libido in SARS-CoV-2 infected people during the COVID-19 pandemic and to describe the associated clinical, psychic, and lifestyle parameters. We recruited 321 eligible men with SARS-CoV-2 infection in the urology clinic of our hospital. We used the International Index of Erectile Function-5 (IIEF-5), the Patient Health Questionnaire-9 (PHQ-9), 7-item Generalized Anxiety Disorder (GAD-7) module, and Pittsburgh Sleep Quality Index to independently evaluate the subjects, collect relevant data, and analyze the data. In this study, we show that both libido and erectile function were decreased after SARS-CoV-2 infection (p < 0.0001), and reduced libido was strongly correlated with decreased erectile function (p < 0.0001 ; odds ratio (OR) = 11.33). In addition, anxiety (OR = 2.41, CI = 1.13–5.23), (p < 0.05), symptomatic infection (OR = 3.293, CI = 1.11–11.48), (p < 0.05), and body mass index (OR = 0.88, CI = 0.83–0.92), (p < 0.05) were also associated with decreased erectile function. So, we think that during the COVID-19 pandemic, for erectile dysfunction patients who decreased erectile function after SARS-CoV-2 infection, we should not only pay attention to patients' erectile function status but also to patients' reduced libido status. [ABSTRACT FROM AUTHOR]

The utilization of aryl radicals as open‐shelled intermediates has become an essential tool for both conventional and state‐of‐the‐art synthetic chemistry. However, the current methods for generating aryl radicals are still inefficient, greatly impeding their practical applications. Encouragingly, sulfonium salts have emerged as appealing sources of aryl radicals for a wide range of transformations aimed at creating novel chemical bonds driven by their distinctive structural attributes and chemical tendencies. This review primarily focuses on the specific reaction mechanisms underlying the cleavage of C−S bonds in sulfonium salts, leading to the generation of corresponding aryl radicals within diverse reaction conditions. [ABSTRACT FROM AUTHOR]

Stabilisation of metal species using hydroxyl‐rich dealuminated zeolites is a promising method for catalysis. However, insights into the interactions between the hydroxyl groups in zeolite and noble metals and their effects on catalysis are not yet fully understood. Herein, comparative studies were conducted using Pt catalysts supported on hydroxyl‐rich dealuminated Beta (deAl‐Beta) and the pristine proton‐form Beta (H‐Beta) for catalytic oxidation of toluene. The findings suggest that during impregnation the Pt precursor (i. e., Pt(NH3)4(NO3)2) interacted with different sites on deAl‐Beta and H‐Beta, leading to the formation of supported Pt nanoparticles with different physicochemical properties. In detail, for H‐Beta, the Pt precursor interacted with Al‐OH and isolated external Si‐OH sites, yielding Pt NPs with a higher Pt0 proportion of ~71 % compared to ~57 % Pt0 on deAl‐Beta. Comparatively, abundant hydroxyl groups on deAl‐Beta such as silanol nest and isolated internal Si‐OH stabilised highly active Pt‐O species. The resulting Pt/deAl‐Beta exhibited improved activity and anti‐coking ability than Pt/H‐Beta in catalytic toluene oxidation. For example, the temperature for 50 % toluene conversion was 193 °C for Pt/deAl‐Beta vs. 232 °C for Pt/H‐Beta, and the coke deposition was 1.7 % vs. 6.7 % (after the 24‐h longevity test), respectively. According to the toluene‐temperature programmed desorption (toluene‐TPD), 1H nuclear magnetic resonance (1H NMR) relaxation and in situ diffuse reflection Fourier transform spectroscopy (in situ DRIFTS) characterisation, the enhanced performance of Pt/deAl‐Beta could be ascribed to (i) the active Pt‐O sites stabilised by hydroxyl groups, which interact with toluene easily for conversion, and (ii) the acid‐free feature of the deAl‐Beta support, which avoids the formation of coke precursors (such as benzoate species) on the catalyst surface. Findings of the work can serve as the design guidelines for making effective supported metal catalysts using zeolitic carriers. [ABSTRACT FROM AUTHOR]

Here, the limitations of characteristic length‐based (Lchb) and grain size‐based (Gb) criteria with two or three parameters were pointed out employing the apparent toughness tests of 12 different ceramics at a large span range of U‐notch root radius (ρ) values. After comprehensively considering the potential influencing factors of stress intensity factor (Kc), ρ divided by critical notch tip radius (ρc) was proposed as the independent variable, and the data of 21 materials (covering ceramics, plastics, resins, rocks, and metals) was summarized and discussed to establish a simple and more applicable Kc prediction model. Results indicated that Kc/KIc was a power function of ρ/ρc with a power exponent n of 0.5 for ideal materials and less than 0.5 for actual materials. It was also found that ρc can be calculated simply by KIc2/(πσ02), where σ0 represented the inherent strength. This semiempirical criterion succeeded in unifying the Lchb and Gb criteria without introducing more parameters to increase the prediction accuracy of the Kc at the U‐notch root for brittle materials like ceramics. [ABSTRACT FROM AUTHOR]

Background: Recently, dapoxetine has been widely accepted to treat premature ejaculation by fast‐inhibiting 5‐hydroxytryptamine reuptake. However, dapoxetine is not suitable for all premature ejaculation patients in clinical treatment. We need to investigate and reveal the mechanism deeply to solve this problem. Objectives: To investigate and reveal the function of dopamine D4 receptor in dapoxetine medicated premature ejaculation treatment. Materials and methods: A rat model was used to screen rapid ejaculators. The molecular mechanisms of histone serotonylation‐mediated regulation of dopamine D4 receptor were demonstrated by chromatin immunoprecipitation, DNA pull‐down, mass spectrometry analysis, and coimmunoprecipitation experiments. The biological function of dopamine D4 receptor was investigated through in vivo experiments by intrathecal injection of shDRD4 to knockdown dopamine D4 receptor. Results: In this study, we found that dapoxetine increased expression of 5‐hydroxytryptamine and dopamine D4 receptor. We demonstrated that dapoxetine increased levels of 5‐hydroxytryptamine, which promoted histone serotonylation (H3K4me3Q5ser) and transcription factor myeloid zinc‐finger 1 complex binding on the dopamine D4 receptor promoter, upregulated the expression of dopamine D4 receptor and thus delayed ejaculation. Discussion: In this study, we demonstrated that dapoxetine increased the levels of 5‐hydroxytryptamine, which promoted histone serotonylation and myeloid zinc‐finger 1 complex binding to the dopamine D4 receptor promoter and upregulated the expression of dopamine D4 receptor, thus delaying ejaculation. Conclusion: It is a novel mechanism that dapoxetine take effect of premature ejaculation treatment through upregulating the dopamine D4 receptor, which indicated that upregulated dopamine D4 receptor would enhance the dapoxetine effect in premature ejaculation treatment. This may lead to the development of novel therapeutic interventions for premature ejaculation. [ABSTRACT FROM AUTHOR]

This study aimed to investigate the quality of hotpot oil from various hotpot seasonings. For this, 12 representative hotpot seasonings with beef tallow (BT) and flavored rapeseed oil (FRO) were collected before the hotpot oil was extracted. The oil content, sensory evaluation scores, physiochemical properties, fatty acid composition, harmful substances, and nutrient content of the hotpot oil were subsequently analyzed. The results showed that the oil content of the hotpot seasoning was 38.3%–58.2%. Furthermore, the BT hotpot oils produced better sensory scores (7–8.5), and their oxidative stability (12.08–13.17 h) was higher on average than that of the FRO hotpot oils. Additionally, the FRO hotpot oils had higher contents of unsaturated fatty acid (81.70%–97.32%), phytosterol (3466.07–6110.37 ppm), tocopherol (182.91–1276.17 mg kg−1), and polyphenol (34.48–61.94 mg kg−1). The factor analyses revealed that the FRO and BT hotpot oils were significantly different and were affected by the iodine value, acid value, and linoleic acid and phytosterol contents. Practical applications: It is necessary to improve the nutritional value and taste of hotpot oils to facilitate rapid development in the hotpot seasoning industry. This study showed FRO was a positive mediator of antioxidant, anti‐inflammatory, and anticancer effects owing to its richness of nutritional compounds, such as polyphenols, phytosterols, and tocopherols. In comparison, BT was found to have a lower nutritional value than FRO but added a unique taste and aroma to the hotpot. The use of blended oil as raw oil could also improve the quality of hotpot oil. This information will provide an important guide to the nutritional value and industrial production of hotpot oil. Blended oil is a promising raw oil for future use in hotpot seasoning processing to meet consumer demands for nutritious and pleasantly flavored hotpot oil. [ABSTRACT FROM AUTHOR]

Radicals can be formed expeditiously through the direct irradiation of an electron donor‐acceptor (EDA) complex. Herein, we show a photocatalyst‐free strategy for gem‐difluoroalkenes synthesis realized by photo‐irradiation of the EDA complexes, which can be generated in situ between N‐alkylpyridinium salts and Hantzsch ester without any other additives. A wide variety of readily available alkylamines underwent deaminative defluoroalkylation to provide the corresponding gem‐difluoroalkenes. This reaction system exhibits high reactivity and good functional group tolerance and provides a practical and effective entry to a broad range of α‐alkyl‐substituted gem‐difluoroalkenes. [ABSTRACT FROM AUTHOR]

A simple and cost‐effective direct radical‐radical cross‐coupling reaction of N‐hydroxyphthalimides with azo compounds under metal‐free conditions has been developed without any external oxidant or additive. The protocol provides phthalimidooxy compounds in moderate to excellent yields (up to 92 %). This transformation shows good tolerance toward both nitrile‐containing and non‐nitrile‐containing azo compounds. Furthermore, mechanistic investigations indicate that the reaction proceeds through the radical pathway. [ABSTRACT FROM AUTHOR]

An effective and practical synthesis of α‐ketothioesters has been reported for direct oxidative thioesterification of substitutional acetophenones with dimethyl sulfoxide and iodine in the presence of boric acid and acetic anhydride in high yields. According to the control experiments and literatures, the reaction mechanism was proposed to undergo via Pummerer rearrangement. [ABSTRACT FROM AUTHOR]

Cyclic GMP‐AMP synthase (cGAS) is essential for fighting against viruses and bacteria, but how cGAS is involved in host immune response remains largely elusive. Here, we uncover the crucial role of cGAS in host immunity based on a Pseudomonas aeruginosa pulmonary infection model. cGAS−/− mice showed more heavy bacterial burdens and serious lung injury accompanied with exorbitant proinflammatory cytokines than wild‐type mice. cGAS deficiency caused an accumulation of mitochondrial DNA in the cytoplasm, which, in turn, induced excessive secretion of proinflammatory factors by activating inflammasome and TLR9 signalling. Mechanistically, cGAS deficiency inhibited the recruitment of LC3 by reducing the binding capacity of TBK‐1 to p62, leading to impaired mitophagy and augmented release of mitochondrial DNA. Importantly, cytoplasmic mitochondrial DNA also acted as a feedback signal that induced the activation of cGAS. Altogether, these findings identify protective and homeostasis functions of cGAS against Pseudomonas aeruginosa infection, adding significant insight into the pathogenesis of bacterial infectious diseases. [ABSTRACT FROM AUTHOR]

Summary: Sphingosine‐1‐phosphate (S1P) is a bioactive sphingolipid metabolite. The past decade has witnessed exponential growth in the field of S1P research, partly attributed to drugs targeting its receptors or kinases. Accumulating evidence indicates that changes in the S1P axis (i.e., S1P production, transport, and receptors) may modify metabolism and eventually mediate metabolic diseases. Dysfunction of the mitochondria on a master monitor of cellular metabolism is considered the leading cause of metabolic diseases, with aberrations typically induced by abnormal biogenesis, respiratory chain complex disorders, reactive oxygen species overproduction, calcium deposition, and mitophagy impairment. Accordingly, we discuss decades of investigation into changes in the S1P axis and how it controls mitochondrial function. Furthermore, we summarize recent scientific advances in disorders associated with the S1P axis and their involvement in the pathogenesis of metabolic diseases in humans, including type 2 diabetes mellitus and cardiovascular disease, from the perspective of mitochondrial function. Finally, we review potential challenges and prospects for S1P axis application to the regulation of mitochondrial function and metabolic diseases; these data may provide theoretical guidance for the treatment of metabolic diseases. [ABSTRACT FROM AUTHOR]

It is reported the alkenylation of cyclic ethers via radical addition to β‐nitrostyrenes in the presence of AMBN without any other additives under mild conditions. A wide range of β‐nitrostyrenes and various ethers are tested in this reaction, most cases are happed smoothly with excellent to good yields. Cyclohexane also could be reacted under the conditions with moderate yield. According to the control experiments, the reaction mechanism was proposed. It is found that AMBN could induce to hydrogen abstraction from sp3 carbon under oxygen atmosphere. This reaction system possesses the advantages of very high reactivity, stability, and convenient preparation method. Especially, it is very useful in the pharmacy industry due to the metal‐free and easy treatment conditions. [ABSTRACT FROM AUTHOR]

Background: Although there was some evidence to suggest that the serotonergic system in the brain played an important role in premature ejaculation (PE), tryptophan hydroxylase‐2 (TPH2) is considered to be the key enzyme for the synthesis of 5‐hydroxytryptamine (5‐HT) and few studies have reported that brain TPH2 is involved in the regulation of ejaculation. Objectives: This study aimed to investigate whether changes in brain TPH2 levels were associated with PE and to explore the effects of acute administration of dapoxetine on TPH2 expression in the brain of rats with rapid ejaculation. Materials and methods: Based on the ejaculation frequency, the male rats were split into three groups: "rapid," "normal," and "sluggish" ejaculators. The level of 5‐HT in the brain was determined by an enzyme‐linked immunosorbent assay. TPH2 expression was detected by western blot analysis and immunohistochemistry. Results: The results showed that the concentration of 5‐HT and the expression of TPH2 in rapid rats were the lowest, while those in sluggish rats were the highest. Correlation analysis also indicated the level of TPH2 was positively correlated with ejaculation latency (r = 0.8633, p < 0.0001) and negatively correlated with ejaculation frequency (r = –0.874, p < 0.001). In addition, dapoxetine acute administration to rapid rats resulted in upregulation of TPH2 expression in the brain. Discussion: There was an important link between the level of TPH2 and the change of ejaculation behaviors. Decreased expression of TPH2 in relevant brain regions will lead to rapid ejaculation. Moreover, the effect of dapoxetine on prolonging ejaculation may be due to the upregulation of TPH2 expression. Conclusion: We found the correlation between the level of TPH2 in the brain and PE. The findings in this study will open up a novel way for future research in PE therapy. [ABSTRACT FROM AUTHOR]

A visible‐light‐driven and room temperature photo‐Wolff‐Kischner reaction of sulfur ylides and N‐tosylhydrazones has been developed for the first time to provide modular access to alkene synthesis. The high functional group tolerance and broad substrate scope were demonstrated by more than 60 examples. Both E‐ and Z‐olefinic stereochemistry in the products could be controlled with excellent stereoselectivity. A series of mechanistic studies support that the reaction should proceed through a radical‐carbanion crossover pathway, specifically involving addition of photo‐generated sulfur ylide radical cations to N‐tosylhydrazones to form carbanions and subsequent Wolff‐Kischner process. [ABSTRACT FROM AUTHOR]

This study was to explore whether serotonin transporter gene‐linked polymorphic region polymorphisms (5‐HTTLPR+rs25531) influence the response to dapoxetine treatment in a Chinese population with premature ejaculation (PE). 112 patients with PE re‐enrolled from our previous study received dapoxetine monotherapy. At the endpoint, patients with S'S' had a significant increased risk of nonresponse compared with L' carriers (p <.001). The improvement in S'S' genotype was significantly lower in premature ejaculation profile (PEP) items of 'control over ejaculation' (p =.035) and 'distress related to ejaculation' (p =.017) than that in L' carriers. As to clinical global impression of change (CGIC), results in S'S' subjects showed significantly lower scores (p =.008) and a less satisfaction rate reporting at least 'better' (p =.020) compared with L' carriers. Moreover, our findings suggested that patients with S'S' were more likely to develop adverse effects (AEs) compared with L' carriers (p =.040). This study suggests that PE patients bearing the S'S' genotype have an inferior comprehensive efficacy and safety of dapoxetine treatment, which consist of poorer response in IELTs, less improvement in patient‐reported outcome (PRO) measures and greater incidence of AEs, than L' carriers. Variants of triallelic 5‐HTTLPR may play a major role as a predictor of treatment response to dapoxetine. [ABSTRACT FROM AUTHOR]

By using this operationally simple method, Koji Kubota, Hajime Ito, and co-workers developed a novel cross-electrophile-coupling reaction mediated by arylcalcium nucleophiles in their Research Article (e202207118), which is typically difficult using conventional Grignard reagents. Keywords: Ball Mill; Calcium; Cross-Electrophile Coupling; Mechanochemistry; Solid-State Reaction EN Ball Mill Calcium Cross-Electrophile Coupling Mechanochemistry Solid-State Reaction 1 1 1 10/04/22 20221010 NES 221010 B A ball-milling approach b allows the efficient activation of calcium metal and thus makes the direct generation of calcium-based heavy Grignard reagents feasible without complicated pre-activation processes. Inside Cover: Mechanochemically Generated Calcium-Based Heavy Grignard Reagents and Their Application to Carbon-Carbon Bond-Forming Reactions (Angew. [Extracted from the article]

Ball Mill, Calcium, Cross-Electrophile Coupling, Mechanochemistry, Solid-State Reaction Keywords: Ball Mill; Calcium; Cross-Electrophile Coupling; Mechanochemistry; Solid-State Reaction EN Ball Mill Calcium Cross-Electrophile Coupling Mechanochemistry Solid-State Reaction 1 1 1 10/04/22 20221010 NES 221010 B Ein Kugelmahlverfahren b ermöglicht die effiziente Aktivierung von Calciummetall und damit die direkte Herstellung von schweren Grignard-Reagenzien auf Calciumbasis ohne komplizierte Voraktivierungsprozesse. Mithilfe dieser einfachen Methode entwickelten Koji Kubota, Hajime Ito et al. in ihrem Forschungsartikel (e202207118) eine neuartige, durch Arylcalcium-Nucleophile vermittelte gekreuzte Elektrophil-Kupplung, die mittels herkömmlicher Grignard-Reagenzien schwierig durchzuführen ist. [Extracted from the article]

Background Objective Methods Results Conclusion Sleep deprivation (SD) can cause damage to the male reproductive system. However, the duration required for such damage and the specific sequence and severity of damage to the testis and epididymis remain unclear.To investigate the effects of different durations of SD on different parts of the testis and epididymis caput, corpus, and cauda.Adult ICR mice were randomly assigned to five groups: the SD group (SD for 18 h/day for 1, 2, 3, or 4 weeks), the SD + Vit E group (supplemented with Vit E 50 mg/kg/d during 4 weeks of SD, the SD+NS group (saline supplementation during 4 weeks of SD), the SD + RS group (5 weeks of recovery sleep after 4 weeks of SD), and a normal sleep control (Ctrl) group. Following the interventions, sperm parameters, testicular and epididymal histopathology, inflammatory response, and oxidative stress markers were compared between the groups.Compared to the Ctrl group, the SD group showed a decrease in sperm motility and concentration from SD 2 W and SD 3 W, respectively. Decreases in sperm concentration and motility were more pronounced in the cauda compared to the caput and corpus. Pathological damage was less severe in the epididymis caput than in the corpus and cauda. After 4 weeks of SD, inflammation and oxidative stress increased in both testes and epididymis. Both sleep recovery and vitamin E supplementation showed significant improvements, though they did not fully reach the level of the Ctrl group.Chronic SD for more than 2 weeks causes varying degrees of damage to the testis, epididymis caput, corpus, and cauda in male mice. This damage is not fully reversible after 5 weeks of sleep recovery and antioxidant stress treatment. These findings help us to identify and prevent SD damage to the male reproduction at an early stage. [ABSTRACT FROM AUTHOR]

Background Objectives Materials and methods Results Discussion: Conclusion: Since the outbreak of coronavirus disease 2019, it has had a serious impact on people's physical and mental health. However, in our clinical work, we have found that the erectile function of coronavirus disease 2019 patients with neurological decline was often seriously affected.To further explore the relationship between erectile dysfunction and neurological dysfunction caused by coronavirus disease 2019.We conducted a survey from August 2022 to February 2023 at the First Affiliated Hospital of Anhui Medical University and the Third People's Hospital of Linyi City. A total of 251 subjects with a history of coronavirus disease 2019 infection were included. Symptoms and changes in erectile function after the coronavirus disease 2019 infection were collected and assessed using the International Index of Erectile Function‐5 scale and several targeted questions.In this study, we found that in patients infected with novel coronavirus, the proportion of erectile dysfunction was higher in those with neurological manifestations such as olfactory and taste impairment or psychological symptoms such as anxiety.We found that neurological decline and psychological factors were independent and significant risk factors for erectile dysfunction caused by coronavirus disease 2019.Patients with neurological damage or psychiatric symptoms are more likely to have erectile dysfunction, suggesting that the 2019 novel coronavirus may affect erectile function by damaging nerves. This provides a new insight into the mechanism of erectile dysfunction [ABSTRACT FROM AUTHOR]