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The "2024 ACVIM Forum Research Abstract Program" is a document that provides an index of research abstracts presented at the American College of Veterinary Internal Medicine (ACVIM) Forum. The abstracts cover a wide range of topics in veterinary medicine, including cardiology, equine health, gastroenterology, hematology, hepatology, immunology, infectious disease, nephrology/urology, neurology, kidney disease, feline chronic kidney disease, urinary tract health, and cancer treatment in dogs. It is important to note that the abstracts are not peer-reviewed and the opinions expressed in them are those of the authors and may not represent the views of the ACVIM. The document serves as a valuable resource for researchers and practitioners in the field, providing insights into ongoing research studies. However, further research is needed to confirm and expand upon the findings presented in these abstracts. [Extracted from the article]

This document contains a collection of abstracts summarizing various research studies related to veterinary medicine, specifically focusing on gastrointestinal health in dogs. The studies cover a range of topics including the effects of different diets on gut health, the use of biomarkers for diagnosing and monitoring diseases, and the safety and efficacy of fecal microbiota transplantation. The findings provide valuable insights into the understanding and management of gastrointestinal diseases in companion animals, which can be useful for researchers and pet owners interested in these topics. [Extracted from the article]

Background: The association of gut microbiota with cancer etiology and prognosis has been demonstrated in humans and rodents but has not been studied in dogs with different types of tumors. Hypothesis/Objectives: To analyze microbiome composition according to tumor progression based on metastasis, recurrence, and therapeutic response in canine tumors. Animals: Thirty‐two client‐owned dogs were divided into 3 groups: healthy (n = 9), with lymphoma (n = 12), with nonlymphoid tumors (n = 11). Methods: Retrospective case series included animals were divided into subgroups according to the nature and severity of their tumors. Feces were screened for the 16S rRNA gene. Results: Overall, alpha diversity was significantly reduced in dogs with tumors (n = 23; 12 lymphoid and 11 nonlymphoid) compared to healthy dogs (n = 9). Bacteroides had lower abundance in canine tumors at genus level. Staphylococcus showed significantly reduced abundance in dogs with aggressive tumor progression. Higher white blood cell (WBC) and neutrophil counts and lower hematocrit were significant in dogs with aggressive tumor. Spearman's rank correlation coefficient analysis revealed several measurements that showed moderate to strong correlations, including Coprococcus with total WBC count, neutrophil count, and hematocrit in the aggressive tumor group, and Saccharimonas with serum albumin and sodium concentration in all tumor dogs. Conclusion and Clinical Importance: The diversity of the gut microbiome was significantly reduced in dogs with tumors compared to healthy dogs. Correlations were found between changes in blood measurements and changes in microbiome composition in relation to paraneoplastic syndrome. [ABSTRACT FROM AUTHOR]

Leukaemia cutis (LC) is the infiltration of neoplastic leukocytes into the skin, characterised by haemorrhagic papules, nodules, and plaques. LC has been reported in human leukaemia patients, but it is extremely rare in dogs. A 13‐year‐old spayed female Golden Retriever that was previously diagnosed with chronic lymphocytic leukaemia was managed with chlorambucil (20 mg/m2 orally, every 2 weeks) and prednisolone (2 mg/kg orally, every other day) for 8 months; however, immunosuppression was temporarily discontinued because of a bacterial urinary tract infection. Cutaneous signs, including multifocal ecchymosis and white plaques, appeared 1 month after cessation of chemotherapy. Histopathological examination revealed small‐ to intermediate‐sized lymphocytes with mild atypia in a perivascular to interstitial pattern within the superficial dermis. The bands of atypical cells within the superficial dermis were strongly and extensively positive for CD3 on immunohistochemistry. Polymerase chain reaction analysis of the biopsied skin revealed clonal rearrangement of the T‐cell receptor gamma locus gene. Given the evidence of clinical signs, peripheral immunophenotyping, histopathology, immunohistochemistry, and clonal gene arrangement, LC was diagnosed. The lesions disappeared when chemotherapy was restarted but were occasionally observed when chemotherapy was stopped. To the authors' best knowledge, this is the first case report of LC in a dog. [ABSTRACT FROM AUTHOR]