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Considering the storage increasing demand of 'multi-variety, small-batch' characteristic goods, we developed a new type of compact warehouse a three-dimensional double-ended compact storage system. Compared with the traditional three-dimensional automated storage and retrieval system (AS/RS) and existing three-dimensional compact AS/RS model, the storage system we designed exhibits excellent characteristics such as high density, high throughput efficiency, and more flexible configuration. There are three key points in our work listed as follows. Firstly, we establish the continuous travel time model under specific operating conditions in this new three-dimensional compact warehouse. Secondly, the three-dimensional size of the storage rack is optimised. The optimal three-dimensional proportion of the storage rack is obtained based on the model's optimal solution. Finally, numerical examples are given to analyse the influence of the I/O port layouts and related parameters on the system throughput efficiency. According to the optimisation results of the system model, a more reasonable rack dimension can be designed, which can provide an effective reference for the construction of a three-dimensional double-ended compact warehouse. [ABSTRACT FROM AUTHOR]

In a platform society, the realization of the public value of platforms is not only affected by goals constructed based on national interest but also closely related to the rights and interests of platform users. In this context, how a platform mediates between the interests of a country, its users, and its businesses becomes a topic worthy of discussion. Through participatory observation and in-depth interviews, this study reveals that online platforms strategically transfer public values that enjoy national policy support and have a broad popular base into their ecosystems, employing techniques such as bridging different parties, gamification management, and the masking effect to produce green users. The findings reveal the unique logic of contemporary China's platform-driven environmental protection practices and mainstream value cultivation while also highlighting the conflicts and contradictions inherent in realizing public values. This study provides a valuable perspective for understanding the Chinese platform society in terms of public value realization. [ABSTRACT FROM AUTHOR]

Oxyntic gland neoplasm (OGN) is a rare subtype of gastric cancer. The aim of this study is to evaluate the prevalence, clinicopathological features, effectiveness and safety of endoscopic treatment, as well as the prognosis of OGN. We retrospectively analyzed the data of patients pathologically diagnosed with OGN at our hospital from November 1, 2019 to May 1, 2023. A total of 36 patients with 45 lesions were identified, resulting in a disease frequency of 0.047% (36/76,832). The mean age was 55.0 ± 7.5 years, with a male-to-female ratio of about 1:1.12. Most lesions were ≤10 mm in size (84.4%), located in the upper third of the stomach (73.3%), exhibited slight elevation (75.5%), appeared whitish (55%), had dilated blood vessels on the surface (75.5%). 16 and 21 lesions were treated by precutting endoscopic mucosal resection (EMR-P) and endoscopic submucosal dissection (ESD), respectively. No significant differences were found between EMR-P and ESD in terms of en bloc resection rate (100% vs 100%, p = 1.000), complete resection rate (100% vs 90.5%, p = 0.495), and curative resection rate (93.8% vs 90.5%, p = 1.000). No complications such as bleeding and perforation were observed. No recurrence or metastasis was observed during the follow-up period. OGN is a rare tumor with unique clinical, endoscopic, and pathological characteristics. EMR-P and ESD are deemed safe and effective for treating OGNs. The relatively faster and easier EMR-P seems at least non-inferior to ESD, especially for removal of smaller OGNs. The overall prognosis is favorable. [ABSTRACT FROM AUTHOR]

Volatile organic compounds (VOCs) are produced by plants responding to biotic and abiotic stresses. According to their biosynthetic sources, induced VOCs are divided into three major classes: terpenoids, phenylpropanoid/benzenoid, and fatty acid derivatives. These compounds with specific aroma characteristics importantly contribute to the aroma quality of oolong tea. Shaking and rocking is the crucial procedure for the aroma formation of oolong tea by exerting mechanical damage to fresh tea leaves. Abundant studies have been carried out to investigate the formation mechanisms of VOCs during oolong tea processing in recent years. This review systematically introduces the biosynthesis of VOCs in plants, and the volatile changes due to biotic and abiotic stresses are summarized and expatiated, using oolong tea as an example. [ABSTRACT FROM AUTHOR]

Due to their advantages in structural stability and versatility, cysteine-rich peptides, which are secreted from the venom glands of venomous animals, constitute a naturally occurring pharmaceutical arsenal. However, the correct folding of disulfide bonds is a challenging task in the prokaryotic expression system like Escherichia coli due to the reducing environment. Here, a secretory expression plasmid pSE-G1M5-SUMO-HWTX-I for the spider neurotoxin huwentoxin-I (HWTX-I) with three disulfides as a model of cysteine-rich peptides was constructed. By utilizing the signal peptide G1M5, the fusion protein 6 × His-SUMO-HWTX-I was successfully secreted into extracellular medium of BL21(DE3). After enrichment using cation-exchange chromatography and purification utilizing the Ni-NTA column, 6 × His-SUMO-HWTX-I was digested via Ulp1 kinase to release recombinant HWTX-I (rHWTX-I), which was further purified utilizing RP-HPLC. Finally, both impurities with low and high molecular weights were completely removed. The molecular mass of rHWTX-I was identified as being 3750.8 Da, which was identical to natural HWTX-I with three disulfide bridges. Furthermore, by utilizing whole-cell patch clamp, the sodium currents of hNav1.7 could be inhibited by rHWTX-I and the IC50 value was 419 nmol/L. [ABSTRACT FROM AUTHOR]

This study aims to explore the effect of nitrification inhibitor combined with urease inhibitor on soil N2O emission under different nitrogen application depths. We carried out a soil column simulation test under 25°C. The combination of 1% N-butyl Phosphorothioate Triamine (NBPT) and 5% Dicyandiamide (DCD) was added to the soil. Anaerobically digested pig slurry (ADPS) was used as a nitrogen source and applied to four soil depths (soil surface (0 cm), 5 cm, 10 cm, and 15 cm, respectively). It was found that the inhibitory effects of NBPT and DCD on the soil N2O emission were significantly affected by different nitrogen application depths. When the ADPS was applied at 15 cm, 10 cm, and on the soil surface, the combination of 1% NBPT and 5% DCD could inhibit soil N2O emission by 46.1%, 21.7%, and 34.6%, respectively. Redundancy analysis (RDA) showed that the addition of inhibitors changed the microbial paths of soil N2O production. The dominant microbial path of soil N2O production after adding inhibitors was from ammonia oxidation dominated by AOB-amoA to denitrification dominated by nirS and nirK. [ABSTRACT FROM AUTHOR]

Flow and work engagement are related concepts, and both are commonly applied and studied in the workplace. This review makes an attempt to define the potential differences and relationships between flow and engagement in the workplace. Based on a systematic review of the extant positive interventions designed to enhance flow and work engagement, meaningful differences between flow and work engagement interventions were found in terms of the mechanisms of the interventions, the types of interventions, and the intervention approach (i.e. personal vs. contextual and deficit-fixing vs. strengths-building). The review concludes that flow interventions can make important contributions above and beyond work engagement interventions. The findings illuminate the conceptual and empirical differences between flow and work engagement interventions, and suggest new directions for flow and engagement intervention research in the workplace. [ABSTRACT FROM AUTHOR]

Drop-weight impact experiments are performed on a thin layer of cyclotetramethylenete tranitramineand cyclotrimethylene trinitramine (RDX) powdery explosives, which were mixed with a few large-sized explosive or NaCl salt granules. The drop-weight impact machine is equipped with the high-speed photographic systems for observing the impact process. It showed that the mixed explosives are more sensitive than pure powdery explosives. Hard salt particles could greatly enhance the burning probability of powdery explosives because frictional heat between salt particles and target explosive powders, stress concentration, and new generated fragments of large granule jointly contribute to heat accumulation at the junction of dissimilar materials. Burning front always initiates at the interface of powdery explosive and additive granule. Adiabatic shear bands were frequently observed in the mixture of ultra-fine RDX powdery explosive with RDX large granules, which mainly resulted from the softening effect of ultra-fine powders once the temperature arises. [ABSTRACT FROM AUTHOR]

In this article, theoretical modeling and vibration characteristics of a spinning double-blade beam assembly restricted by elastic supports are studied. Graphene nanoplatelet (GPL) reinforcement and porous foamed metal matrix are adopted to make up the assembly structure. Due to the nonuniformity of the porosity and graphene nanofillers, the material properties of the attached blades and beam are considered to change along the blade thickness and beam radius, respectively. They are obtained via the rule of mixture, the open-cell scheme and the Halpin-Tsai micromechanics model. These attached blades and beam are modeled in accordance with the Euler-Bernoulli beam theory and the Rayleigh beam theory, respectively. Via employing the Lagrange's equation, the equations of motion of the double-blade beam are derived. Then, the natural frequencies of the spinning nanocomposite double-blade beam are calculated by the substructure modal synthesis method and the assumed modes method. A detailed parameter analysis is performed to study the influences of dimension, distribution pattern and weight fraction of GPLs, distribution and coefficient of porosity, length and location of the blades, stiffness and location of supports, and spinning speed on the mechanical behaviors of the double-blade beam assembly. [ABSTRACT FROM AUTHOR]

Objectives To describe the ultrasonographic appearance of congenital anaplastic astrocytoma, so as to provide diagnostic clues for it. An updated review of the literature was also carried out. Results There was a case of fetal anaplastic astrocytoma detected by ultrasound at 37 + 1 weeks of gestation. It showed that a hypoechoic mass was located in the left hemisphere with a relatively clear margin and subtle color flows. Prenatal magnetic resonance imaging (MRI) which was taken subsequently confirmed the result of ultrasound. Intratumoral hemorrhage was observed in later follow-up and further confirmed by histological examination. The fetus was delivered vaginally at 39 + 6 weeks. The infant died 2 h after delivery due to respiration failure. The histological examination confirmed an anaplastic astrocytoma. Conclusions Congenital anaplastic astrocytoma commonly detected by ultrasound has a relatively better perinatal prognosis, especially compared with glioblastoma. Prenatal ultrasonography diagnosis accurately is of critical importance. The anaplastic astrocytoma should be considered in cases in which fetal images reveal a heterogeneous echogenic mass in the brain, especially in the presence of intratumoral hemorrhage, subtle color flow, and relatively clear margin. [ABSTRACT FROM AUTHOR]

This paper presents an investigation on vibration characteristics of graphene nanoplatelet (GPL) reinforced disk-shaft rotor with eccentric mass resting on elastic supports. The shaft is made of common metal material while the disk is made of graphene nanoplatelet reinforced material. The weight fraction of graphene nanoplatelets (GPLs) is assumed to vary smoothly and continuously along the thickness direction of the disk, which leads to a functionally gradient (FG) structure. The effective properties of the disk are determined via the Halpin-Tsai micromechanics model and the rule of mixture. In accordance with the Timoshenko beam theory and Kirchhoff plate theory, the governing equations which take into account gyroscopic effect due to rotation are derived by using the Lagrange equation. The substructure modal synthesis method and the assumed modes method are utilized to obtain the natural frequencies, and the Runge-Kutta method is adopted to solve the forced vibration response of the rotor system, where the centrifugal force and gravity of an eccentric mass in the shaft are considered as generalized forces. The present analysis is validated through comparison with both experiment and finite element (FE) results. A detailed parametric study is conducted to examine the effects of the rotating speed, GPL weight fraction, GPL distribution pattern, length-to-thickness ratio and length-to-width ratio of GPLs, disk position, disk dimension, and support stiffness on vibration behaviors of the nanocomposite disk-shaft rotor system. [ABSTRACT FROM AUTHOR]

Though some studies have reported navigated high tibial osteotomy (HTO) is a useful procedure to correct knee deformity. There is still great controversy whether navigated HTO can achieve better accuracy of limb alignment and greater clinical outcomes. Current meta-analysis was conducted to investigate whether better radiographic outcomes and clinical outcomes could be acquired in navigated HTO compared with the conventional procedure. We conducted a literature search in the electronic databases, including Medline, Embase, the Cochrane Library, and Web of Science. We identified studies published before August 2020. We also checked the references of the related articles for any relevant studies. We strictly followed the Preferred Reporting Items for Systematics reviews and Meta-Analysis (PRISMA) guidelines in this review. This research was performed using Review Manager 5.4 software. Fourteen articles were included, involving 1399 knees. Our meta-analysis indicated that patients undergoing navigated HTO had significantly better outcomes in outliers of aimed limb alignment (RD=−0.24, 95% CI: =−0.34 to −0.13, p < 0.01), outliers of aimed tibial posterior slope (TPS) (RD=−0.41, 95% CI: −0.51 to −0.30, p < 0.01), Range of Motion (ROM) (MD = 6.37, 95%CI: 0.83–11.91, p = 0.02), and American knee society knee score (AKS knee score) (MD = 3.88, 95%CI: 1.37–6.39, p = 0.002). No significant differences were found in Lysholm score (MD = 1.30, 95%CI: −0.31 to 2.90, p = 0.11), American knee society function score (AKS function score) (RD = 1.42, 95%CI: −0.15 to 2.99, p = 0.08), complications (RD=−0.01, 95% CI: = −0.05 to 0.04, p = 0.77), delayed union (RD=−0.01, 95% CI: = −0.02 to 0.03, p = 0.59), and reoperation (RD = 0, 95% CI: −0.09 to 0.10, p = 0.98) between the two groups. The operation time in the navigated group was 15.46 min longer than in the conventional group. Navigated HTO provided more accurate and reproducible radiographic outcomes in the correction of the malalignment than conventional techniques, and there is no difference in the risk of complications compared with conventional HTO. However, it is unclear whether navigation HTO can achieve better clinical results. More randomized controlled trials (RCTs) with high quality, large sample size, and sufficient follow-up period are required. [ABSTRACT FROM AUTHOR]

Fangcang hospitals, as tentative hospitals built to treat a huge turnover of patients with mild coronavirus disease 2019 (COVID-19) infections, have played a pivotal role to slow down the pandemic spread in China in 2020. However, anxiety and sleep disorders remain tough to address during the treatments. In this study, group psychological intervention in combination with pulmonary rehabilitation exercises were conducted in the trial group for the patients with mild COVID-19 infections in a Fangcang Hospital to mitigate the patients' anxiety and sleep disorders, while conventional nursing methods were done in the control group, with 70 randomly picked patients in each group. Effects were assessed through questionnaire method using state anxiety questionnaire (SAI) and Pittsburgh sleep quality index scale (PQSI) rating investigation. Results showed that both SAI and PSQI scores of the trial group were significantly lower than those of the control group (P < 0.05). The SAI scores of the trial group and the control group were 38.5 ± 13.2 and 45.8 ± 10.4 points (t = 3.600, P < 0.001), respectively, and the PSQI scores were 5.6 ± 3.0 and 7.1 ± 3.0 points (t = 2.982, P < 0.01), respectively. Our methods have significant advantages over conventional nursing methods to mitigate anxiety and sleep disorders for the patients with mild COVID-19 infections in the Fangcang Hospital. [ABSTRACT FROM AUTHOR]

To investigate role and clinical significance of CDK13 in breast cancer patients. A total of 189 cases of breast cancer were enrolled during March 2013 to March 2015. Immunohistochemistry (IHC) was used for measurement of CDK13, HIF-1α and beclin1. Clinical characteristics of age, BMI, TNM stage, pathological types, and tumor diameter, were recorded. Patients' 5-year overall survival and recurrence were followed up. All patients were followed up for 5 years or to the last follow-up. The expression levels of CDK13 and HIF-1αin breast cancer tissues were up-regulated and beclin1 was down-regulated than in the paracancerous non-tumor tissues. CDK13 was positively correlated with HIF-1α and negatively correlated with beclin1 in breast cancer tissues. The patients with higher expression of CDK13 showed significantly higher rates of TNM III–IV, higher rates of lymph node metastasis, distant metastasis and larger tumor size. The mortality and recurrence rates were higher in high expression CDK13 patients than in low CDK13 expression patients, however with no significant difference. K–M curve showed patients with higher CDK13 showed lower 5-year overall survival and lower disease-free survival time, however with no significant difference. CDK13 was overexpressed in breast cancer tissues, and patients with higher CDK13 had poorer clinical outcomes. Further studies are still needed to reveal the clinical significance of CDK13 in breast cancer. [ABSTRACT FROM AUTHOR]

This study aims to perform free vibration and buckling analyses of circular cylindrical shells made of three-dimensional (3D) graphene foam. Three kinds of porosity distribution are considered including two kinds of symmetrical distribution and uniform distribution. The Kirchhoff-Love shell theory is utilized to establish the mathematical model of 3D graphene foam (3D-GF) shells. Natural frequencies and buckling loads of the shells under various boundary conditions are obtained via the Rayleigh-Ritz method in conjunction with Chebyshev polynomials. Results show that the mechanical characteristics of the 3D-GF shells are significantly affected by the porosity coefficient and porosity distribution. Moreover, the effect of porosity coefficient is closely related to boundary conditions of the shells. It is also shown that as the porosity coefficient increases, the porosity distribution effect on the mechanical characteristics of 3D-GF shells becomes increasingly significant. [ABSTRACT FROM AUTHOR]

Objectives: This study was to investigate whether long-term amlodipine-based combination therapy attenuates seasonal variation of office blood pressure (BP) in hypertensive patients. Methods: The data of 206 patients recruited in the Nanchang site of CHIEF trial were retrospectively analyzed. All patients received an amlodipine-based therapy for three years after reaching target BP with a 12-week titration treatment. Among them, 106 patients received amlodipine plus amiloride/hydrochlorothiazide (AA group) and 100 received amlodipine plus telmisartan (AT group) therapies. These patients were followed up every three months. The difference between the highest and lowest values of outdoor temperature in each three months was calculated as the seasonal temperature difference (T-d) and seasonal BP difference was calculated in the similar way. BP control rates in each season were calculated. Results: In the three years, the highest SBP and DBP values occurred in winter and the lowest values in summer. As a result, the BP control rate in summer was the highest and that in winter was the lowest, especially for SBP. Although T-d levels were similar during three following-up years, the seasonal SBP/DBP differences in 2011 were significantly lower than 2009 (10.03 ± 5.74/6.96 ± 3.72 vs 14.36 ± 8.19/9.78 ± 5.21 mmHg, P <.05), suggesting seasonal variation in BP was obviously reduced. Meanwhile, similar change was observed in AA and AT groups. Conclusions: Besides lower BP effectively, long-term amlodipine-based combination therapy could alleviate the seasonal BP variation in high-risk hypertensive patients. [ABSTRACT FROM AUTHOR]

Opisthotropis kuatunensis is classified in the family Natricidae and is widespread in southern China. In this study, we sequenced and analyzed the circular mitochondrial genome of O. kuatunensis from the Fujian Province, China. The complete mitogenome is 17,279 bp in length, and includes 13 protein-coding genes, 2 ribosomal RNAs, 22 transfer RNA, 1 non-coding region of an L-strand replication origin and 2 control regions (D-loop1 and D-loop2). Phylogenetic analysis based on the complete mitochondrial genome supported Opisthotropis as monophyletic and sister to Nerodia and fully resolved O. kuatunensis on a branch with O. latouchii. This study contributes to the systematics, phylogeny and taxonomy of the Natricidae. [ABSTRACT FROM AUTHOR]

We sequenced the complete 17,209 bp mitochondrial genome (mitogenome) of Gonyosoma frenatum (Squamata: Colubridae) using next-generation sequencing. It consists of 13 PCGs, two ribosomal RNA genes, 22 transfer RNA genes, one non-coding region of an L-strand replication origin, and two control regions. The overall nucleotide composition was 34.7% of A, 24.8% of T, 12.3% of G, and 28.1% of C. The result of the phylogenetic analysis showed that G. frenatum, a member of Colubridae, is sister to other New World and Old World ratsnakes. The new data could help better understand the phylogenetic status of the genus Gonyosoma and the evolutionary history of Colubridae species. [ABSTRACT FROM AUTHOR]