Search

Green nanotechnology is an eco-friendly method for the biosynthesis of metallic nanoparticles, which are being used due to their unique features and bio-applications in various fields. World Health Organization (WHO) stated that the use of medicinal plants to treat a variety of disorders, such as diabetes mellitus (DM), cancer, HIV infection, hepatitis, tuberculosis (TB), and malaria is very effective. Green synthesis is a cost-effective, environment- friendly, and safe method. There are a wide variety of native medicinal plants around the world, owing to their unique physical, chemical, and biological characteristics, used for gold and silver nanoparticle (NP) synthesis, and are potent among all metal nanoparticles. However, as an alternative to several traditional techniques to synthesize nanoparticles, green chemistry has arisen. This review covers the green synthesis of AuNPs/AgNPs and its significance as a potent anticancer and antidiabetic agent. All literature surveys will be helpful in terms of further progress as to go from summarizing or concluding data along challenges and future perceptions. [ABSTRACT FROM AUTHOR]

Carboxylic acid supramolecular synthon exhibited dimer or catemer motifs in the crystal lattice depend on the substituent and other functional groups present in the structure. In general, presence of other competing functional groups produced catemer motifs, whereas unsubstituted acids showed dimer. In this manuscript, we have synthesized a new aryl ether amine-based Schiff base with carboxylic acid functionality (1) and demonstrated polymorphic structure via catemer (1a) and dimer (1 b) motifs in the solid state. In both the structure, carboxylic acid group adopted different orientation in the crystal lattice. The different H-bonding lead to modulation of optical properties that was further supported highest occupied molecular orbital (HOMO) and lowest unoccupied molecular orbital (LUMO) calculation. Further the stability calculation indicates that dimer (1 b) structure was more stable by 8.54 kcal/mole relative to catemer (1a) motifs. Further, the supramolecular interactions in catemer (1a) and dimer (1 b) motifs was studied by Hirshfeld surface and fingerprint plots to gain insight and compare the different functional groups contribution for intermolecular interactions in the polymorphic crystals which clearly showed different intermolecular interactions in polymorphs. [ABSTRACT FROM AUTHOR]

Various optoelectronic properties of 10-(1,3-Dithiol-2-ylidene)anthracene based organic light harvesters were probe at solid state bulk surface. Effect of diverse conjugated π-donor-acceptor bridge, 3,4-ethylenedioxythiophene in Comp3 and phenyl for Comps1 and 2, along with two set of electron acceptor entity, an ester moiety for Comp1, a dicyanovinylene moiety for Comp2 and Comp3 was explored on various properties. The 3,4-ethylenedioxythiophene as conjugated π-bridge boost the dielectric constants, conductivity, refractive index and extinction coefficient values significantly. The dicyanovinylene is favorable than the ester group as prior moiety contributes to the p-orbitals from −2.0 to −4.0 eV. The solid states density, relative permittivity's, extinction coefficient, indices of refraction, reflectance, and electrical conductivity displayed that anthracene derivatives may act as proficient objects in multi-purpose organic semiconductors. [ABSTRACT FROM AUTHOR]

Breast cancer (Bca) causes the highest rate of mortality in females owing to the out-of-control cell division in breast cells. In this work, we perform an in-silico screening based on molecular docking and molecular dynamic of curcumin derivatives against ERα. In this study, we carry out, molecular docking of fifty (50) curcumin derivatives having anticancer potential by using virtual screening tools. Ten (10) ligands were selected based on binding energy ranged from (-7.4 kcal/mol to -9 kcal/mol), lower values of inhibition constant (0.23µmol to 3.59µmol), and visualisation of intermolecular interactions. Additionally, we also assess ADMET properties of selected ligands for prediction of their toxicity and drug-likeness. The molecular dynamic simulations (MD) including RMSD, RMSF, Rg, SASA, number of H-bonds and MM-PBSA binding free energy results showed that ligand L2 and L8 bind to estrogen protein ERα more proficiently with good stability over 120 ns. These results suggest lead anticancer compounds L2 (Salicylidenecurcumin) and L8 (Curcumin difluorinated) are the most promising inhibitor against ERα of Bca with ∆Gbind values of (-2.939 and -4.369) kcal/mol. we expect that our findings will evoke the scientific community to further do in-vitro and in-vivo investigations for screened curcumin derivatives against ERα of Bca. [ABSTRACT FROM AUTHOR]

In our research described here nanocomposites containing a newly synthesized methacrylate polymer, poly 2-(4-fluorophenyl)-2-oxoethyl-2-methylprop-2-enoate (PFPAMA) and ZnO nanoparticles in various mass ratios (1, 3 and 5 w %) were synthesized using the hydrothermal method. The synthesized nanocomposites were characterized by Fourier-transform infrared spectroscopy (FTIR), Hydrogen-1 nuclear magnetic resonance (1H-NMR) and X-ray diffraction (XRD) techniques. Both real and imaginary components of the complex dielectric permittivity of pure PFPAMA and the three different PFPAMA/ZnO nanocomposites were measured as a function of frequency. The dielectric study revealed that the ZnO nanoparticles improved the dielectric properties of pure PFPAMA. The variation of electrical conductivity, with frequency showed that the σ value increased linearly with increasing ZnO content. The frequency dependence of the conductivity suggested that the conduction occurs via a barrier hopping process. The obtained results suggest that the ZnO-doped, poly-2-(4-fluorophenyl)-2-oxoethyl-2-methylprop-2-enoate nanocomposites can be used as a dielectric material in dielectric device applications. [ABSTRACT FROM AUTHOR]