1. Protein Kinase C-Delta Defect in Autoimmune Lymphoproliferative Syndrome-Like Disease: First Case from the National Iranian Registry and Review of the Literature.
- Author
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Sharifinejad, Niusha, Azizi, Gholamreza, Behniafard, Nasrin, Zaki-Dizaji, Majid, Jamee, Mahnaz, Yazdani, Reza, Abolhassani, Hassan, and Aghamohammadi, Asghar
- Subjects
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PROTEIN kinases , *LYMPHOPROLIFERATIVE disorders , *PROTEIN kinase C , *EPSTEIN-Barr virus diseases , *KILLER cells , *AUTOIMMUNE diseases - Abstract
Protein kinase C is a family of serine/threonine kinases that play a key role in the adaptive immune cell signaling, as well as regulation of growth, apoptosis, and differentiation of a variety of cell types. Patients homozygous for a null mutation of the Protein Kinase C Delta (PRKCD) gene, present clinical feature of immune dysregulation with susceptibility to Epstein-Barr virus infection. However, a minority of patients present the autoimmune lymphoproliferative syndrome (ALPS). The data were collected by direct interview and examining the patient's clinical record. Whole-exome sequencing was performed to detect the underlying genetic mutation in the patient. We also conducted electronic searches for ALPS-like reported patients in PubMed, Web of Science, and Scopus databases. In this study, we reported a 13-year-old boy who presented with autoimmunity, lymphoproliferation, recurrent pneumonia, cardiomyopathy, and dermatological manifestations. An elevation of double-negative T cells, CD8+ T cells, serum IgG level, as well as a reduction in NK cells, was observed in the patient. A homozygous frameshift mutation (c.1293_1294insA) in exon 13 of the PRKCD gene was confirmed. The literature search showed 39 ALPS-like patients with monogenic defects which only six (15.3%) of them were due to PRKCD genes. PRKCD should be considered in the context of ALPS clinical manifestations with prominent dermatological involvements. [ABSTRACT FROM AUTHOR]
- Published
- 2022
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