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This work was designed to assess the cost-effectiveness of front-line tislelizumab plus chemotherapy (TIS+Chemo) in advanced gastric cancer (GC) or gastroesophageal junction cancer (GEJC) with positive expression of programmed cell death ligand 1 (PD-L1) from the perspective of Chinese healthcare system. A 10-year partitioned survival model was undertaken utilizing clinical data from RATIONALE 305. Costs and utilities were both discounted at an annual rate of 5%. The primary outcome was incremental cost-effectiveness ratios (ICERs) and calculated as the cost per quality-adjusted life years (QALYs). The willingness-to-pay (WTP) threshold was set as $18,625/QALY. Only direct medical costs were considered. Sensitivity analyses and subgroup analyses were performed to evaluate the robustness of the model. In the base-case analysis, the incremental cost and effectiveness associated with TIS+Chemo vs Chemo was 7,361 and 0.38 QALYs, respectively, leading to an ICER of 19,371/QALY. At the WTP threshold of $18,625/QALY, the TIS+Chemo was not a cost-effective first-line treatment option. The model outcomes were robust. TIS+Chemo did not provide a cost-effective approach for PD-L1 positive advanced GC/GEJC in China setting. However, TIS+Chemo might be cost-effective in provinces with higher WTP threshold. RATIONALE 305, , identifier is NCT03777657. [ABSTRACT FROM AUTHOR]

Two new species of nemourid stonefly, Amphinemura bicoloratasp. n. and A. yadongasp. n., are described from Xizang Autonomous Region of south-western China. The relationships between the new species and similar species in the genus are discussed. [ABSTRACT FROM AUTHOR]

Stavsolus shihu sp. n., a new species of stonefly family Perlodidae is described from the Jilin Province of China, illustrated and compared with the related taxa. Habitat data of the new species are given. [ABSTRACT FROM AUTHOR]

International student mobility, taking place within the framework of globalisation, internationalisation and transnationalism, has attained much attention. This paper adopts the Intellectual Migration framework to further our understanding of mobility regarding international higher education. It simultaneously studies China-born students in both China and North America to empirically examine the propensity for student mobility across national borders and the determining factors behind the realisation of such mobility under the same set of geopolitical and international circumstances. The analysis is based on a set of cross-sectional surveys conducted in the 2017–2019 period that yields over 1600 data points. We compare the 'who', 'why' and 'where' aspects of migration between domestic students in China and Chinese international students in North America to delineate the factors underlying international student mobility. By highlighting aspirations and capabilities on mobility outcomes, this paper contributes to differentiating mobility between undergraduate and graduate students and the implications for social inequality. Our analysis also reveals the unequal spatial distributions of educational resources between intellectual gateways and peripheries, and by extension between the Global North and the Global South. The findings of this paper have policy implications on improving the quality, accessibility, and equity of higher education. [ABSTRACT FROM AUTHOR]

Phylloporia, a wood-inhabiting fungal genus, has been used as an anti-inflammatory food taken in the form of tea in Shandong Province, China. The species used in folklore have been clarified as Phylloporia fontanesiae and P. lonicerae. To promote the utilization of Phylloporia and its benefit to human health, sources, medicinal metabolites and functions, safety, and commercial potentials are summarized in this review. The fruiting bodies are the most acceptable sources of Phylloporia, but their shortage makes fermented mycelia a good alternative. Polysaccharides, sterols, acidic components, styryl compounds and polychlorinated compounds are the most well-studied medicinal metabolites extracted from Phylloporia. The main medicinal functions revealed from Phylloporia include antitumor, immunomodulation, antioxidant, neuroprotection, prevention of diabetes and its complications, and antimicrobial activity. The safety of Phylloporia has been demonstrated by experimenting for acute and subchronic oral toxicity of fermented mycelia on animals. A large number of patents even if some are being examined have indicated the commercial potentials of Phylloporia. In the future, increased efforts regarding species identification, artificial cultivation and multi-omics data will contribute to the deeper exploration of the medicinal potential of Phylloporia. [ABSTRACT FROM AUTHOR]

A type of short-pitch rail corrugation on tracks with resilient fasteners called 'Vanguard' fasteners is widely found on different metro lines in China. Field measurements and numerical calculations are used to investigate the cause of the corrugation formation. The corrugation with wavelengths of 30–60 mm occurs on both the curved and straight tracks through field measurements. Corrugation passing frequencies are in the range of 340–700 Hz. The frequencies of pinned-pinned resonance, the P2 resonance and the wheelset torsional resonance are far away from the corrugation passing frequencies. The investigated results show the vertical dynamic characteristic of the track is the main factor for occurrence of the short-pitch rail corrugation. The short-pitch rail corrugation arises by a wavelength-fixing mechanism of rail vertical bouncing on the resilient fasteners. The corrugation wavelength mainly is related to the vertical stiffness of the rail fasteners. Rail corrugation with wavelengths of 25–63 mm easily occurs on tracks with resilient fasteners with the vertical stiffness of less than 20 MN/m. [ABSTRACT FROM AUTHOR]

The Qinling Orogenic Belt was formed by multi-stage convergence and subsequent collision between the North China Block and South China Block during the Palaeozoic to Late Triassic. Following the collision between the South Qinling Belt and the South China Block in the Late Triassic, the whole Qinling Orogenic Belt evolved into an intracontinental orogeny. However, the exact termination time of the Late Mesozoic intracontinental contractional deformation and the tectonic transformation from compression to extension remains unclear. The extensional shear zone developed in the West Qinling Orogenic Belt provides a crucial clue to revealing the tectonic transformation and uplift and exhumation of the orogenic belt. This study focuses on kinematics, deformation temperature, and geochronology of the shear zone in the West Qinling Orogenic Belt through detailed field structural analysis and laboratory analysis. The Taibai shear zone (TBSZ), located in the West Qinling Orogenic Belt, cuts across the Qinling Orogenic Belt along the NE–NEE direction and separates the Taibai pluton in the east from the Baoji pluton in the west. The NE–NEE-striking TBSZ is an extensional shear zone showing a top-to-the-NW sinistral shear sense. The TBSZ was formed under the high greenschist–low amphibolite facies conditions (300–550°C) in the middle-upper crust level (8–15 km). Zircon U–Pb dating and biotite and muscovite 40Ar/39Ar dating indicate that the TBSZ occurred at 120–113 Ma. The extensional TBSZ and normal faults on its hanging wall indicate the tectonic transformation and the extensional collapse of the Mesozoic intracontinental orogenic belt during the late Early Cretaceous. The Cretaceous extensional collapse of the Qinling Orogenic Belt also led to the rapid uplift and exhumation of the Taibai pluton and the North Qinling Belt in the east. [ABSTRACT FROM AUTHOR]

To develop an alarm device for the mechanical compression device displacement (MCD), and further evaluate its effectiveness in clinical use. The alarm device is mainly composed of buzzer, indicator light, magnetic sheet. This is a prospective randomized and controlled study. Four hundred patients who met the inclusion/exclusion criteria were included and randomly assigned to two groups (MCD group vs alarm + MCD group). The primary outcome measures were the sensitivity and specificity of the alarm device to detect MCD displacement, time to hemostasis (TTH), time to ambulation (TTA), time to hospital discharge (TTHD), hospital costs (HC), complication rates, and patient satisfaction. The sensitivity and specificity of the alarm device in detecting MCD displacement were 94.44% and 88.46%, respectively. The study group achieved shorter TTH (p =.034), shorter TTA (p =.021), lower complication rates (p =.025), and better patients' satisfaction (p <.001) compared to the control group. However, no significant difference was observed in TTHD (p =.361) and HC (p =.583). The alarm device is highly sensitive in detecting MCD displacement, while achieving better clinical outcomes compared with artificial monitoring. [ABSTRACT FROM AUTHOR]

This study aims to explore bilateral interactions of social and economic pillars of sustainability in China to reveal if they are synergistic or trade-off. To this end, this research uses the bootstrap method for panel data and an Ordinary Quantile Regression model to estimate the effects of social capital proxies including political identity, family relationship network and trust on economic condition proxy, household income, in different quantiles of Chinese households. This study uses data based on microsurvey data from the China Family Tracking Survey (CFPS) conducted by the China Social Science Research Center of Peking University in 2014, 2016 and 2018. The results show that social capital positively affects economic status implying the synergistic impact of social development on economic pillars of sustainable development. Moreover, further examination reveals that the resulted improvement in economic status is distributed equally among different quantiles of Chinese households. This result implies that the reflective effect of economic development on social pillar is synergistic. Overall, these findings accept the synergistic interactions between social and economic pillars of sustainability which is consistent with the integrated sustainability perspective. These findings suggest that policymakers in both the social and economic sectors to consider the consequences of their own plans and strategies for the other sectors. [ABSTRACT FROM AUTHOR]

The ultra-short-term forecasting of the wind speed in large-scale wind plants not only helps to monitor system operation but also improves the acceptance rate for the power system. The present study establishes a single unit and a regional wind speed forecasting models and achieves the fast prediction of the wind speed in the large-scale wind plant. On the basis, by combining the variational mode decomposition (VMD) and autoregressive integrated moving average (ARIMA) model, an improved VMD-ARIMA model for wind speed forecasting of the single unit is proposed, and the cross-correlation coefficient is presented to determine the number of modes in VMD. Moreover, according to the similarity of wind speed series of different units, the wind plant is divided into several sub-regions based on the correlation of different units. Finally, by calculating the proportion coefficient between the key unit and the non-key one, the wind speed of the whole wind plant is forecasted fast. To assess the performance of the proposed model, it is compared with some forecasting model. Results validated by the actual data sets for Jishanliang wind plant, Shaanxi province, China, show higher efficiency and better reliability of the proposed model in comparison with other forecasting methods. [ABSTRACT FROM AUTHOR]

To enhance resilience for adapting to recent severe issues such as flooding and water shortage, Sponge City (SPC) is being delivered by using Public–Private Partnerships (PPPs) across China. Considering a sustainable implementation, an understanding of and effective management for the environment-related underlying dynamics of the adaptability of SPC PPPs are prerequisite. Therefore, we examined a conceptual model integrated with four external environment dimensions, which is useful for identifying externally environmental effects on the project's adaptability. By utilizing the structural equation modeling techniques, the hypothesized relationships illustrated in the conceptual model were tested and verified. Empirical evidence indicates that the Political Environment has the highest impact followed by the Social, Economic and Natural Environments. Implications generated from the SEM are then discussed for future improvements. This study provides governments with an insight into assessing external environment effects that are significant for (1) improving the adaptability of their projects and then (2) enabling sustainability for infrastructures. [ABSTRACT FROM AUTHOR]

As the rapid increasing of the number of the satellites, the number of facilities of the satellite ground stations is becoming insufficient and the conflicts of serving satellite data missions exist. To make full use of the facilities of the China Remote Sensing Satellite Ground Station (RSGS), scheduling optimization of these facilities was studied in this paper, which was not well-solved by the original method in the operation system of RSGS. The problem is formulated as a continuous time-based mixed integer linear programming (MILP) model. A decomposition optimization algorithm is proposed to solve the large-scale problem, which is difficult to solve using traditional methods. In the first step, the particle swarm optimization (PSO) algorithm is used to optimize the multi-ground station relay tasks, and the multi-ground station optimization problem is transformed into several single ground station optimization problems. Next, in two additional steps, optimization of the facilities at a single ground station is performed to further reduce the size of the model. The proposed method has been applied to operations systems of RSGS, and the approach presented in this article has demonstrated stable performance and sufficient efficiency online, resulting in the automation of facility scheduling. [ABSTRACT FROM AUTHOR]

To compare the efficacy and safety of hyperthermic intrathoracic/intraperitoneal chemotherapy versus conventional intrapleural/intraperitoneal chemotherapy in the treatment of malignant pleural or peritoneal effusion. A randomized clinical trial was carried out in 8 cancer centers across China. Patients with malignant pleural or peritoneal effusion were randomly assigned to the study group or control group. Patients in the study group were treated with cisplatin-based hyperthermic intrathoracic chemotherapy (HITHOC) or hyperthermic intraperitoneal chemotherapy (HIPEC), while the control group was treated with conventional intrapleural or intraperitoneal chemotherapy using same chemotherapeutic regime as the study group. The objective response rate (ORR) was analyzed as primary outcome. Quality-of-life (QOL) score was recorded as secondary outcome using the questionnaire 30 (QLQ-C30) of the European Organization for Research and Treatment of Cancer (EORTC). The efficacy and safety of the two treatments were compared. Total 135 patients were recruited and randomized in this study, with 67 patients in the study group and 68 patients in the control group. The ORR in the study group (80.70%) was significantly higher than that in the control group (31.03%, p < 0.001). However, neither changes of QOL scores, nor incidence rates of adverse events were significantly different between the two groups (p = 0.076 and 0.197, respectively). Efficacy of HITHOC or HIPEC is superior to that of conventional modality for the treatment of malignant effusion with comparable side effects. [ABSTRACT FROM AUTHOR]

The aims of the study were to assess the contribution of resilience, coping style, and COVID-19 stress on the quality of life (QOL) in frontline health care workers (HCWs). The study was a cross-sectional surveyperformed among 309 HCWs in a tertiaryhospital during the outbreak of COVID-19 in China. Data were collected through an anonymous, self-rated questionnaire, including demographic data, a 10-item COVID-19 stress questionnaire, Generic QOL Inventory-74, Connor-Davidson Resilience Scale, and the Simplified Coping Style Questionnaire. Hierarchical regression was used to analyse the relationship between the study variables and the QOL. Among the 309 participants, resilience and active coping were positively correlated with the QOL (P<0.001), whereas, working in confirmed case wards, COVID-19 stress, and passive coping were negatively correlated with the QOL (P<0.001). Resilience and the active coping were negatively correlated with COVID-19 stress (P<0.001). Resilience, coping style,and COVID-19 stressaccounted for 32%, 13%, and 8% of the variance in predicting the Global QOL, respectively. In conclusion, working in confirmed COVID-19 case wards and COVID-19 stress impaired the QOL in HCWs. Psychological intervention to improve the resilience and coping style, and reduce COVID-19 stress are important in improving the QOL and mental health of HCWs. [ABSTRACT FROM AUTHOR]

In our study, patients who had a second delivery were categorised into the following 4 groups. Pelvic floor ultrasound data were compared during the 6th week after the second delivery. The incidence of cystoceles was highest in group A and lowest in group D. In addition, groups A and B had a higher rate of rectoceles or perineum descent. Similarly, the areas of the levator hiatus were higher in Groups A and B during Valsalva manoeuvres. The area of the levator hiatus from the resting state to the Valsalva manoeuvre effect had the greatest change in Group A. A comparison of the PR thickening rates among the four groups did not reveal significant differences. All second delivery methods can cause varying degrees of pelvic organ prolapse and decreased pelvic floor function; however, vaginal delivery as the second delivery mode may have a more significant effect in Chinese women. What is already known on this subject? Different modes of delivery have significantly different effects on female pelvic floor function. Pregnancy beyond 35 weeks of gestation has an effect on female pelvic floor function, irrespective of the mode of delivery. What do the results of this study add? This study analysed the impact of different delivery modes on Chinese female pelvic floor function. Parous women who underwent different modes of second delivery all demonstrated different degrees of pelvic organ prolapse, as well as pelvic floor function decline. What are the implications of these findings for clinical practice and/or further research? Our study will provide basic research of Chinese female pelvic floor function after a second delivery, which will be of clinical significance around the world, as well as in China. China will keep promoting further delivery as the aging population is increasing. If the developing countries want to promote the second delivery around the women, they have basic research and data to instruct the females. [ABSTRACT FROM AUTHOR]

The association between lung cancer and trace element levels, such as serum copper (Cu) and zinc (Zn) levels and the Cu:Zn ratio, vary among different demographic groups; however, it is unknown whether variations in serum Cu and Zn levels and Cu:Zn ratios are related to the prediction and prognosis of lung cancer. We aimed to clarify this relationship in the Han Chinese population of Northeast China. We recruited 146 patients with lung cancer and 146 age- and resident area-matched cancer-free controls. Increased serum Cu and Zn levels and the Cu:Zn ratio were positively associated with lung cancer (OR: 72.243, 95% CI 24.159–216.030; OR: 3.513, 95% CI, 1.476–8.358, and; OR: 58.582, 95% CI, 20.023–171.395, respectively). The critical serum Cu level for the prediction of lung cancer was 1.37 mg/L (sensitivity, 77.4%; specificity, 84.9%), while the critical Cu:Zn ratio was 1.45 (sensitivity, 69.9; specificity, 88.4%). Patients with stage IV non-small-cell lung cancer (NSCLC) had higher serum Cu levels and a higher Cu:Zn ratio than patients with stage I, II, or III NSCLC. The serum Cu level and the Cu:Zn ratio are effective predictive indicators of lung cancer and may help evaluate the prognosis of patients with NSCLC. [ABSTRACT FROM AUTHOR]

This study investigates the impact of accounting firms joining global accounting firm networks and associations (AF N&As) on audit quality and audit pricing in China. We find that after their accounting firms join global AF N&As, client firms' accrual-based earnings management is reduced. However, we find no evidence that audit fees are significantly affected. Cross-sectional analysis suggests that improvements in audit quality resulting from accounting firms joining global AF N&As are more pronounced when auditors have less audit experience, clients have more subsidiaries or auditor tenure is shorter. Additional tests suggest that joining AF N&As reduces the likelihood of accounting firms being dismissed by clients and increases the market share of the accounting firms. [ABSTRACT FROM AUTHOR]

Xanthabraxas hemionata (Guenée, 1858) is a medium-sized and slender-bodied forest pest in China. In this study, we sequenced and analyzed the complete mitochondrial genome (mitogenome) of X. hemionata. This mitogenome was 15,309 bp long and encoded 13 protein-coding genes (PCGs), 22 transfer RNA genes (tRNAs), and 2 ribosomal RNA genes (rRNAs). The gene order was conserved and identical to that of most other previously sequenced Geometridae species. Most of the PCGs of X. hemionata, except for cox1, have the conventional ATN start codon. Except for four genes (cox1, cox2, nad5, and nad4) that end with the incomplete stop codon T−, all other PCGs terminated with the stop codon TAA. Phylogenetic analysis positioned X. hemionata in a well-supported clade with the other Ennominae species. The relationships (Ennominae + (Sterrhinae + Larentiinae)) were supported by Geometridae. [ABSTRACT FROM AUTHOR]

Pinus densiflora var. zhangwuensis S.J.Zhang, C.X.Li & X.Y.Yuan, a tree species with promising afforestation potential in northern China. Here, we assembled and annotated the complete chloroplast (cp) genome of P. densiflora var. zhangwuensis using the Oxford Nanopore sequencing technology. The cp genome was 119,725 bp in length, exhibiting a typical quadripartite structure with a large single-copy (LSC: 65,552 bp) and a small single-copy (SSC: 53,183 bp) separated by a pair of inverted repeats regions (IRA and IRB: each of 495 bp) region. The overall GC content is 37.3%. The genome was predicted to encode 112 distinct genes, including 72 protein-coding, 36 tRNA, and four rRNA genes. Maximum-likelihood (ML) phylogenetic for cp genome sequences of 18 Pinaceae species revealed that P. densiflora var. zhangwuensis was closely related to Pinus sylvestris. [ABSTRACT FROM AUTHOR]