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Alzheimer's disease (AD) is a progressive and irreversible neurological condition that occurs with age and poses a significant global public health concern, is distinguished by the degeneration of neurons and synapses in various regions of the brain. While the exact processes behind the neurodegeneration in AD are not completely known, it is now acknowledged that inflammation may have a significant impact on the beginning and advancement of AD neurodegeneration. The severity of many neurological illnesses can be influenced by the equilibrium between pro-inflammatory and anti-inflammatory mediators. The IL-1 family of cytokines is linked to innate immune responses, which are present in both acute inflammation and chronic inflammatory diseases. Research on the role of the IL-1 family in chronic neurological disease has been concentrated on AD. In this context, there is indirect evidence suggesting its involvement in the development of the disease. This review aims to provide a summary of the contribution of every IL-1 family member in AD pathogenesis, current immunotherapies in AD disease, and present treatment possibilities for either targeting or boosting these cytokines. [ABSTRACT FROM AUTHOR]

Background: Obesity and sarcopenia are both viewed as pathological body composition issues and indicators of compromised nutritional status. The aim of this study was to evaluate the effects of sarcopenic obesity on short- and long-term clinical outcomes. Methods: The clinical data of patients who underwent radical gastrectomy between 2013 and 2019 were prospectively collected. Sarcopenia is defined by European Working Group on Sarcopenia in Older People (EWGSOP2) and obesity is defined by the body mass index (BMI). To identify the independent predictors of postoperative complications and overall survival, we performed univariate and multivariate logistic and Cox regression analyses. Results: In a total of 508 cases, 372 (73.2%) cases were diagnosed with non-sarcopenia, 112 (22.0%) with non-obese sarcopenia, and 24 (4.7%) with sarcopenic obesity. In the multivariate logistic regression, both of non-obese sarcopenia (OR = 2.305, 95% CI = 1.444–3.679, P < 0.001) and sarcopenic obesity (OR = 2.589, 95% CI = 1.088–6.156, P = 0.031) were independent risk factors for postoperative complications. In the multivariate Cox analysis, only non-obese sarcopenia (HR = 2.614, 95% CI = 1.882–3.631, P < 0.001) was independent risk factor for overall survival. Conclusions: Sarcopenic obesity serves as an independent risk factor for postoperative complications, but not for overall survival. [ABSTRACT FROM AUTHOR]

Mirroring public ideologies and value systems in legislative discourse, stance not only functions as a powerful instrument for legislators to balance legal values and stakeholders' interests but also acts as a valuable reference for individuals to understand legislative texts. This study conducts a corpus-driven analysis of stance expressions in legislative discourse. Using three self-compiled corpora that incorporate data protection laws from the United States, the European Union, and China, we apply Hyland's stance model to contrastively analyse evidence of hedging, boosting, self-mention, and attitude markers across these jurisdictions and eventually propose a specialised research model of stance in law. This study unveils the nature of modesty and sufficient discursive space of data protection laws, as well as legislative values and public ideologies conveyed by different jurisdictions within the broader socio-legal cultural context. Besides uncovering the legal constructiveness of data protection laws, the results also suggest that the overall representation of stance in data protection legislation aligns with its performance in legislative discourse, which showcases a legislative tendency to achieve an overtly neutral appearance through covert stance expressions. [ABSTRACT FROM AUTHOR]

The advancement of laser-induced graphene (LIG) technology has streamlined the fabrications of flexible graphene devices. However, the ultrafast kinetics triggered by laser irradiation generates intrinsic amorphous characteristics, leading to high resistivity and compromised performance in electronic devices. Healing graphene defects in specific patterns is technologically challenging by conventional methods. Herein, we report the rapid rectification of LIG's topological defects by flash Joule heating in milliseconds (referred to as F-LIG), whilst preserving its overall structure and porosity. The F-LIG exhibits a decreased ID/IG ratio from 0.84 – 0.33 and increased crystalline domain from Raman analysis, coupled with a 5-fold surge in conductivity. Pair distribution function and atomic-resolution imaging delineate a broader-range order of F-LIG with a shorter C-C bond of 1.425 Å. The improved crystallinity and conductivity of F-LIG with excellent flexibility enables its utilization in high-performance soft electronics and low-voltage disinfections. Notably, our F-LIG/polydimethylsiloxane strain sensor exhibits a gauge factor of 129.3 within 10% strain, which outperforms pristine LIG by 800%, showcasing significant potential for human-machine interfaces. Laser-induced graphene (LIG) can be obtained via a practically convenient approach, but its amorphous characteristics limit its applications. Here, the authors report a flash Joule heating strategy to improve the crystalline quality and conductivity of LIG, leading to strain sensors with enhanced sensitivity. [ABSTRACT FROM AUTHOR]

This study employs a corpus-assisted critical discourse analysis to demystify the dominant patterns of representations around 5G in the Chinese and British press. Keyword analyses identify four thematic categories around the representation of 5G: the nature of 5G, social actors in 5G discourse, actions around 5G and timing in 5G discourse. Findings suggest that the Chinese press tends to use positive evaluative expressions to depict 5G as a trustworthy and beneficial issue and stress China's strong support for 5G development. In contrast, the British press prefers to frame 5G as a product of geopolitical rivalry and an issue with scientific uncertainties and controversies by repeatedly employing negative language patterns related to 5G risks and conspiracy theories. Besides, a subtle but varying "self versus other" schema is constructed by the two presses. The Chinese press is inclined to use positive predication strategies to construct a positive self-representation, whereas the British press tends to adopt negative predication strategies to portray China as an outgroup and meanwhile use scapegoating strategies to profile Britain as a positive self by using recurrent patterns denoting the pressure exerted on Britain by the United States. Such differences could result from their journalistic ideologies and values and the contrasting socio-political contexts where the two presses are situated. [ABSTRACT FROM AUTHOR]

Time and space, habitually seen as the human psychological background, are increasingly being studied as the cognitive foreground for the development and evolution of matters. Via applying the corpus-based method based on the self-complied corpora of the US, the UK, the EU and Chinese data protection laws, this study examines the basic logic framework of time and space, including human psychological representation, semiotic essence, and function, seeking to present a holistic landscape of tempo-spatial construction in humanity, law and society from the perspective of cognitive semiotics. It finds that the human psychological representations in the tempo-spatial construction process contain cyclical time, linear time, place space and field space; the tempo-spatial essence is to express semiotic meanings through social dialogue and power negotiation among legal subjects in social contexts; and the tempo-spatial functions are manifested in mapping cognitive thinking mode of humanity and constructing law and society. It can be argued that legal discourse is the result of the tempo-spatial dialogue between legal subjects that depends on the interaction between society and its members and the overall evolution of its meaning interpretation; the tempo-spatial construction in human-law-society triangle is thus a typical intersemiotic operation. This study demonstrates the utility of sign of time and sign of space as a cognitive perspective in discourse construction and maps the strong interdependence between humanity, law and society. [ABSTRACT FROM AUTHOR]

Regulating electron transport rate and ion concentrations in the local microenvironment of active site can overcome the slow kinetics and unfavorable thermodynamics of CO2 electroreduction. However, simultaneous optimization of both kinetics and thermodynamics is hindered by synthetic constraints and poor mechanistic understanding. Here we leverage laser-assisted manufacturing for synthesizing CuxO bipyramids with controlled tip angles and abundant nanograins, and elucidate the mechanism of the relationship between electron transport/ion concentrations and electrocatalytic performance. Potassium/OH− adsorption tests and finite element simulations corroborate the contributions from strong electric field at the sharp tip. In situ Fourier transform infrared spectrometry and differential electrochemical mass spectrometry unveil the dynamic evolution of critical *CO/*OCCOH intermediates and product profiles, complemented with theoretical calculations that elucidate the thermodynamic contributions from improved coupling at the Cu+/Cu2+ interfaces. Through modulating the electron transport and ion concentrations, we achieve high Faradaic efficiency of 81% at ~900 mA cm−2 for C2+ products via CO2RR. Similar enhancement is also observed for nitrate reduction reaction (NITRR), achieving 81.83 mg h−1 ammonia yield rate per milligram catalyst. Coupling the CO2RR and NITRR systems demonstrates the potential for valorizing flue gases and nitrate wastes, which suggests a practical approach for carbon-nitrogen cycling. Controlling the kinetics and thermodynamics of electrochemical processes is essential to achieve high-performance multielectron reduction. Here, the authors report laser-induced copper bipyramids with abundant nanograins and controlled tip angles for enhanced multielectron CO2 and nitrate reduction. [ABSTRACT FROM AUTHOR]

Adult skeletal muscle regeneration is mainly driven by muscle stem cells (MuSCs), which are highly heterogeneous. Although recent studies have started to characterize the heterogeneity of MuSCs, whether a subset of cells with distinct exists within MuSCs remains unanswered. Here, we find that a population of MuSCs, marked by Gli1 expression, is required for muscle regeneration. The Gli1+ MuSC population displays advantages in proliferation and differentiation both in vitro and in vivo. Depletion of this population leads to delayed muscle regeneration, while transplanted Gli1+ MuSCs support muscle regeneration more effectively than Gli1− MuSCs. Further analysis reveals that even in the uninjured muscle, Gli1+ MuSCs have elevated mTOR signaling activity, increased cell size and mitochondrial numbers compared to Gli1− MuSCs, indicating Gli1+ MuSCs are displaying the features of primed MuSCs. Moreover, Gli1+ MuSCs greatly contribute to the formation of GAlert cells after muscle injury. Collectively, our findings demonstrate that Gli1+ MuSCs represents a distinct MuSC population which is more active in the homeostatic muscle and enters the cell cycle shortly after injury. This population functions as the tissue-resident sentinel that rapidly responds to injury and initiates muscle regeneration. Adult skeletal muscle regeneration is mainly driven by muscle stem cells (MuSCs), which are highly heterogeneous. Here, the authors found that a population of MuSCs, marked by Gli1 expression, is key contributor to muscle regeneration. [ABSTRACT FROM AUTHOR]

The combined use of walnut meal peptides and ellagic acid demonstrated synergistic anti-inflammatory properties, which could be enhanced through encapsulation into nanoparticles to enhance their bioavailability. However, the specific anti-inflammatory mechanism of these nanoparticles remains unclear. Therefore, this study aimed to investigate the anti-inflammatory mechanism of nanoparticles composed of walnut meal peptides and ellagic acid using ELISA, Western Blot, and qRT-PCR techniques. The ELISA results revealed a significantly reduction in the secretion of nitric oxide and inflammatory factors upon treatment with the nanoparticles. Besides, the findings from the qRT-PCR analysis demonstrated a significant reduction in the mRNA expression of inducible nitric oxide synthase and inflammatory factors in RAW264.7 cells following treatment with the nanoparticles. Additionally, the Western Blot results indicated that the nanoparticles exerted inhibitory effects on the upstream signaling pathway of nuclear factor kappa-B and modulated the mitogen-activated protein kinases signaling pathway, resulting in the suppression of inflammatory factor expression. This study contributes to the foundational understanding of the potential application of these nanoparticles as anti-inflammatory agents in the context of health food. [ABSTRACT FROM AUTHOR]

The Legume family (Leguminosae or Fabaceae), is one of the largest and economically important flowering plants. Heartwood, the core of a tree trunk or branch, is a valuable and renewable resource employed for centuries in constructing sturdy and sustainable structures. Hongmu refers to a category of precious timber trees in China, encompassing 29 woody species, primarily from the legume genus. Due to the lack of genome data, detailed studies on their economic and ecological importance are limited. Therefore, this study generates chromosome-scale assemblies of five Hongmu species in Leguminosae: Pterocarpus santalinus, Pterocarpus macrocarpus, Dalbergia cochinchinensis, Dalbergia cultrata, and Senna siamea, using a combination of short-reads, long-read nanopore, and Hi-C data. We obtained 623.86 Mb, 634.58 Mb, 700.60 Mb, 645.98 Mb, and 437.29 Mb of pseudochromosome level assemblies with the scaffold N50 lengths of 63.1 Mb, 63.7 Mb, 70.4 Mb, 61.1 Mb and 32.2 Mb for P. santalinus, P. macrocarpus, D. cochinchinensis, D. cultrata and S. siamea, respectively. These genome data will serve as a valuable resource for studying crucial traits, like wood quality, disease resistance, and environmental adaptation in Hongmu. [ABSTRACT FROM AUTHOR]

Wood is the most important natural and endlessly renewable source of energy. Despite the ecological and economic importance of wood, many aspects of its formation have not yet been investigated. We performed chromosome-scale genome assemblies of three timber trees (Ochroma pyramidale, Mesua ferrea, and Tectona grandis) which exhibit different wood properties such as wood density, hardness, growth rate, and fiber cell wall thickness. The combination of 10X, stLFR, Hi-Fi sequencing and HiC data led us to assemble high-quality genomes evident by scaffold N50 length of 55.97 Mb (O. pyramidale), 22.37 Mb (M. ferrea) and 14.55 Mb (T. grandis) with >97% BUSCO completeness of the assemblies. A total of 35774, 24027, and 44813 protein-coding genes were identified in M. ferrea, T. grandis and O. pyramidale, respectively. The data generated in this study is anticipated to serve as a valuable genetic resource and will promote comparative genomic analyses, and it is of practical importance in gaining a further understanding of the wood properties in non-model woody species. [ABSTRACT FROM AUTHOR]

Walnut meal is a by-product produced during the production of walnut oil and is often treated as a waste. However, the nutrients in walnut meal mean it has significant potential for development as a plant-based milk. This study investigated the effect of microfluidization on the stability of walnut protein emulsion (WPE) and walnut protein beverage (WPB) produced from walnut meal, compared with conventional homogenization. The particle size, zeta potential, rheological properties, and stability of WPE all significantly improved after microfluidization. The mean particle size and zeta potential of the microfluidized WPE significantly decreased (p < 0.05). The rheological properties demonstrated that the viscosity of the microfluidized WPE decreased by 80%, and that the shear force increased 4.5 times as the shear rate increased. This gave the resulting product the characteristics of non-Newtonian fluid. LUMisizer stability demonstrated that microfluidization improves stability through protein absorption on the oil-water interface. Microfluidization increased the denaturation temperature (Tm) of WPE from 135.65 to 154.87℃. Moreover, microfluidization improved the color, centrifugal precipitation rate, and viscosity in WPB compared to the control at all studied temperatures. The Arrhenius approach was used to establish a shelf-life model, which predicted that microfluidized WPB could be stored for 175 d at 4℃. This study provided a new reference for the widespread application of microfluidization in the production of food-based emulsion and beverage products. [ABSTRACT FROM AUTHOR]

This study is aimed at the preparation and evaluation of walnut meal-derived elastase inhibitory peptide loaded in chitosan-tripolyphosphate (CS-TPP) nanoparticles (NPs). It was shown that the maximum encapsulation efficiency of FFVPF could reach 94.58 ± 0.23%. TEM microphotographs, polydispersity index, and zeta-sizer reports indicated that FFVPF-loaded CS-TPP NPs were in nanometric range and were spherical, discrete, and uniform in size with PDI less than 0.3. FTIR analysis indicated that the peptides interacted with CS-TPP NPs through strong hydrogen bonds and electrostatic interactions. The CS-TPP FFVPF NPs showed better stability with heating treatment, pH treatment, or photochemical treatment. Moreover, the in vitro release profile of peptides was identified. The release rate of encapsulated FFVPF was released explosively to 77.22 ± 2.21% and gradually slowed down. These findings highlighted the prospect of CS-TPP NPs as an oral delivery system, and the application of peptides within food and pharmaceutical products. [ABSTRACT FROM AUTHOR]

The South-to-North Water Diversion Project (SNWDP) is a significant and costly cross-basin mega water project in China, and one aim is to improve water use efficiency. To assess the effect of the SNWDP, this study conducts a quantitative evaluation of the middle route of the SNWDP's impact on water use efficiency through the event analysis method based on panel data from 2010 to 2019 of 14 cities along the middle route. The results show the construction of the SNWDP has had a positive impact on water use efficiency in the areas along the project, and the water use efficiency is constantly improving. Further empirical analysis shows that regional groundwater supply, industrial water consumption, and technical level have a significant positive impact on regional water use efficiency. Regional per-capita GDP has a significant negative impact on water use efficiency. The results can provide a scientific basis and decision-making reference for optimizing the SNWDP. [ABSTRACT FROM AUTHOR]

Defect detection in the textile industry is an important and demanding task. Traditional methods rely on manual inspection, which is costly and damaging to the fabric. The deep learning methods based on semantic segmentation network simply and efficiently implement the fabric defect detection with high accuracy. In this paper, we proposed a Separation Convolution UNet (SCUNet) combined with convolutional down sampling, depth-separable convolution and cross-parallel ratio loss function(IoU Loss), and the number of parameters is only 4.27 M (Million). The location detection of fabric defects is performed by extracting surface features in fabric pictures. We selected a dataset containing 106 fabric grayscale images and performed preprocessing including image cutting and data enhancement. We tested the SCUNet with four metrics on the AITEX dataset, and the results showed that the accuracy, recall, specificity and mIoU are 98.01%, 96.86%, 98.07%, and 34.32%, respectively. [ABSTRACT FROM AUTHOR]

The properties of leachate from refuse transfer stations (RTSs) in rural China were indefinite. In this study, a total of 14 leachate samples from RTSs in nine provinces of China were characterized for their pH, electric conductivity, chromaticity, concentration of organic substances, nitrogen distribution, volatile organic compounds (VOCs), organic phosphorous pesticide, and heavy metals. The structural composition of fluorescent dissolved organic matter (FDOM) was also determined. To evaluate the leachate pollution potential in this study, a leachate pollution index was derived and used. Chromium (Cr) was the most polluting heavy metal present in rural leachate. Ethanol and ethyl acetate were the most frequently detected VOCs at high concentrations. Three-dimensional fluorescence excitation-emission matrix spectra were used to characterize the FDOM. Three components, tryptophan (C1), tyrosine-like (C2), and humic acid– and fulvic acid–like (C3) substances, were identified from all 14 samples. Tryptophan was the major component of FDOM and present in 45.7% of the samples by calculating the fluorescence intensity percentage, on average. Pearson correlations revealed that the fluorescence intensity of C1 and C3 was strongly related to soluble chemical oxygen demand and dissolved oxygen carbon, while C2 had significant positive correlations with ammonia nitrogen and total phosphorus of the solid waste. This study provided detailed data and findings that could serve as a preliminary basis for broadening options for the treatment and management of leachate from rural RTSs in China. [ABSTRACT FROM AUTHOR]

A court judgment is a common legal discourse and the final carrier of court trial activities. From the perspective of socio-cognitive discourse analysis, this study aims to describe and explore the Chinese court judgments in a corpus-based method, concentrating on the interactions among discourse, cognitive, and social dimensions. We have three key findings through an empirical qualitative analysis of the court judgments in China. First, the discourse dimension of Chinese court judgments is both society-oriented and cognition-oriented. The discourse components could mark the cognition sources in court judgments. Second, the cognitive source of faith is a part of social cognition on law and regulation, and induction and paraphrase provide the personal cognition to testimony, documentary, or hearsay evidence. Besides, the cognitive source of inference could change personal cognition into a social consensus through a reasoning process. Third, the social function of court judgments corresponds to the cognitive source and builds the surface structure with various discourse components. Moreover, a probe into the multi-dimensional relationship in court judgments can offer practical insights into the interpretation of legal texts in Chinese judicial decision-making. [ABSTRACT FROM AUTHOR]

Emojis are increasingly being used as digital evidence in courts due to the miscommunication and misinterpretation arising from the high variability of their usage and interpretation. Emojis in courts have been extensively researched in extant studies, but relatively little attention has been paid to the emoji variation phenomena in Chinese courts. Through an empirical qualitative content analysis of the court judgments in China and the United States and some supplementary materials, this study posits that an emoji's meaning in courts can be subject to the following six categories of variations: i. variation across platforms, including devices, operating systems, software programs and clients; ii. temporal variation; iii. variation in court cases under different rules of evidence; iv. variation in individual participants; v. variation across social groups; and vi. linguistic-cultural variation. From a social semiotic perspective, emojis as dynamic signs have great meaning potentials, making their meanings context-dependent and interpreter-dependent. For this reason, it is suggested that legal professionals untangle and weave historical, social, cultural and legal contexts into the interpretation of an emoji's meaning. Moreover, a probe into the contextualized configuration of emojis can offer practical insights into the interpretation of emoji-bearing texts in judicial decision-making as well as the admissibility and investigation of digital evidence in courts. [ABSTRACT FROM AUTHOR]

Skeletal muscle plays a critical role in human health. Muscle stem cells (MuSCs) serve as the major cell type contributing to muscle regeneration by directly differentiating to mature muscle cells. MuSCs usually remain quiescent with occasionally self-renewal and are activated to enter cell cycle for proliferation followed by differentiation upon muscle injury or under pathological conditions. The quiescence maintenance, activation, proliferation, and differentiation of MuSCs are tightly regulated. The MuSC cell-intrinsic regulatory network and the microenvironments work coordinately to orchestrate the fate transition of MuSCs. The heterogeneity of MuSCs further complicates the regulation of MuSCs. This review briefly summarizes the current progress on the heterogeneity of MuSCs and the microenvironments, epigenetic, and transcription regulations of MuSCs. [ABSTRACT FROM AUTHOR]

Wrongful convictions (WC) have been widely studied in law and social sciences, yet, previous research lacks a clear conceptualization and rigorous scientific measurement scale to measure stakeholders' WC perceptions. Given the significance of stakeholders' perceptions in influencing policy reforms and transforming the criminal justice system, developing such a measurement scale offers an effective tool to comprehensively understand the relationship between WC and criminal justice system errors/misconduct and guide policymaking. In this study, based on samples of multiple stakeholders in Pakistan, we adopted qualitative and quantitative techniques for WC perception scale development and empirical testing. The results indicated that WC in the criminal justice system context consists of six dimensions, including perceptions of errors and misconduct by the police, prosecutor, judiciary, defense attorney, eyewitness, and forensics. The resulting WC perception measurement scale demonstrated an acceptable level of reliability and validity. The WC perception latent construct with the six resultant dimensions was tested with a structural equation model to assess the association of each perceived sub-construct with WC perception. The findings indicated that the legal professionals, policymakers, and the general public tend to believe that the prosecutors' and police errors and misconduct are the prime reasons for WC in Pakistan. This study also provides theoretical and practical implications for future studies in relevant fields. [ABSTRACT FROM AUTHOR]

Aging is characterized by a progressive deterioration of physiological integrity, leading to impaired functional ability and ultimately increased susceptibility to death. It is a major risk factor for chronic human diseases, including cardiovascular disease, diabetes, neurological degeneration, and cancer. Therefore, the growing emphasis on "healthy aging" raises a series of important questions in life and social sciences. In recent years, there has been unprecedented progress in aging research, particularly the discovery that the rate of aging is at least partly controlled by evolutionarily conserved genetic pathways and biological processes. In an attempt to bring full-fledged understanding to both the aging process and age-associated diseases, we review the descriptive, conceptual, and interventive aspects of the landscape of aging composed of a number of layers at the cellular, tissue, organ, organ system, and organismal levels. [ABSTRACT FROM AUTHOR]

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Populus euphratica Oliv. response to salinity stress has been mainly studied at a whole-plant level. However, many genes associated with salinity tolerance are constitutively expressed or show strong organ-or tissue-specific, and the relationship between reactive oxygen species (ROS) and the antioxidant system has been rarely investigated. In present work, the effects of salinity treatments (0, 50, 100, 150, and 200 mM NaCl) on cell ultrastructure, ROS, antioxidant enzymes, and relevant gene expressions were investigated to get an overview of salinity stress response of P. euphratica micro-shoots under in vitro conditions. Antioxidant enzymes such as superoxide dismutase (SOD) and ascorbate peroxidase (APX), etc., were activated in the presence of low and moderate salt stress (≤ 150 mM NaCl). Regulation of ROS levels and the cellular redox equilibrium, as well as an increase in glutathione (GSH) and ascorbic acid (AsA) content, were also recorded at 150 mM NaCl. PeCu/ZnSOD upregulation occurred 12 h before PeAPX2 upregulation at 100 mM NaCl. The enzymes SOD, APX, CAT, and POD were inhibited by high salinity stress (200 mM NaCl), whereas the level of H2O2 was significantly increased. PeCu/ZnSOD expression increased after 12 h, whereas PeAPX2 expression increased after 36–72 h at 200 mM NaCl. This resulted in a burst of O2.− and H2O2, which accelerated membrane lipid peroxidation, significantly reduced chlorophyll content, and eventually led to chlorosis and cellular damage. In this study, the bigger contributing markers to salt tolerance were AsA, APX, CAT, and SOD. Our results indicated the coordinated alterations between enzymatic, ROS and gene expressions facilitated the resistance to salinity in P. euphratica micro-shoots under moderate salinity. Key message: The micro-shoots of P. euphratica could endure 150 mM NaCl stress. The coordinated changes in PeCu/ZnSOD and PeAPX2 expression and antioxidative enzymes facilitated in vitro Populus euphratica resistance to salinity stress. [ABSTRACT FROM AUTHOR]

The anti-inflammatory effect of the interaction between ellagic acid (EA) and a bioactive tripeptide (FPL) from walnut meal was investigated in this study. We found that lipopolysaccharide (LPS) -induced expression of nitric oxide, tumor necrosis factor-α, interleukin-6, and interleukin-1β were significantly inhibited by the interaction of EA and FPL in RAW264.7 macrophage cells. Cell viability assays and CompuSyn simulations predicted the highest synergistic effect of the combination at doses of EA-25 µM and FPL-100 µM, with the lowest combination index (CI) values reaching 0.56. Fluorescence spectra revealed the intrinsic fluorescence of phenylalanine in FPL was quenched by interaction with EA. Fourier transform infrared spectroscopy indicated FPL had electrostatic and hydrophobic interactions with EA through N–H, C = O, C-N bonds and the secondary structure of FPL had effectively changed, with a decrease in α-helix when interacting with EA. Our results demonstrated that the synergistic anti-inflammatory effect of EA and FPL as potential inflammatory inhibitors in food industry. [ABSTRACT FROM AUTHOR]

Background: Sarcopenia and cachexia are two predictors of adverse clinical outcomes, but they are partly overlapping. We aimed to compare the characteristics and prognostic value of cachexia and sarcopenia in patients after gastrectomy. Methods: From 2014 to 2019, a total of 1215 gastric cancer patients were enrolled. Cachexia and sarcopenia were diagnosed according to the most recent consensus definitions. Baseline characteristics and clinical outcomes were compared between the two groups. Risk factors of survival were evaluated by Cox regression analysis. Results: Of all patients, 26.5% were diagnosed with cachexia and 19.8% were diagnosed with sarcopenia. Sarcopenia was more prevalent in elderly patients, while cachexia was prone to occur in patients with TMN stage III. Survival curves showed that sarcopenia had adverse effects in patients with TMN stage I and II–III, while cachexia was only associated with poor survival at stages II–III. For the entire cohort, both cachexia and sarcopenia were adverse factors for prognosis. However, for stage I patients, sarcopenia was an independent predictor for overall survival (OS) (HR = 4.939, P < 0.001) and disease-free survival (DFS) (HR = 4.256, P < 0.001), but not cachexia; for stage II–III patients, cachexia was an independent predictor for OS (HR = 1.538, P < 0.001) and DFS (HR = 1.473, P = 0.001), but not sarcopenia. Conclusions: Sarcopenia and cachexia have different clinical characteristics and prognostic values. For patients with early stage gastric cancer, detection for sarcopenia was more meaningful than cachexia. However, the prognostic significance of cachexia exceeded sarcopenia in advanced cancer. [ABSTRACT FROM AUTHOR]