11 results on '"United Kingdom"'
Search Results
2. A Dynamic Disadvantage? Social Perceptions of Dynamic Morphed Emotions Differ from Videos and Photos.
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Becker, Casey, Conduit, Russell, Chouinard, Philippe A., and Laycock, Robin
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FACE , *STATISTICAL power analysis , *RESEARCH funding , *EMOTIONS , *SOCIAL perception , *PHOTOGRAPHY , *COMPARATIVE studies , *FACIAL expression , *FACE perception , *VIDEO recording - Abstract
Dynamic face stimuli are increasingly used in face perception research, as increasing evidence shows they are perceived differently from static photographs. One popular method for creating dynamic faces is the dynamic morph, which can animate the transition between expressions by blending two photographs together. Although morphs offer increased experimental control, their unnatural motion differs from the biological facial motion captured in video recordings. This study aimed to compare ratings of emotion intensity and genuineness in video recordings, dynamic morphs, and static photographs of happy, sad, fearful, and angry expressions. We found that video recordings were perceived to have greater emotional intensity than dynamic morphs, and video recordings of happy expressions were perceived as more genuine compared to happy dynamic morphs. Unexpectedly, static photographs and video recordings had similar ratings for genuineness and intensity. Overall, these results suggest that dynamic morphs may be an inappropriate substitute for video recordings, as they may elicit misleading dynamic effects. [ABSTRACT FROM AUTHOR]
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- 2024
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3. Eplontersen: First Approval.
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Nie, Tina
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LIGANDS (Chemistry) , *CARBOHYDRATES , *HEALTH status indicators , *CARDIAC amyloidosis , *AMYLOIDOSIS , *MEDICATION error prevention , *PATIENT care , *NUCLEOTIDES , *DRUG approval , *MESSENGER RNA , *POLYNEUROPATHIES , *AMYLOID plaque , *QUALITY of life , *DRUG development , *LIVER , *SERUM albumin , *SUBCUTANEOUS injections , *DISEASE progression - Abstract
Eplontersen (Wainua™) is a ligand-conjugated antisense oligonucleotide directed to TTR, which is being developed by Ionis Pharmaceuticals and AstraZeneca for the treatment of TTR-mediated amyloidosis (ATTR). Eplontersen, which is targeted to the liver by a ligand containing three N-acetyl galactosamine residues, binds to wild-type and variant TTR mRNA, thus reducing the levels of circulating TTR protein and amyloid deposition. Subcutaneous eplontersen reduced serum TTR levels, inhibited neuropathy progression and improved health-related quality of life in patients with polyneuropathy of hereditary ATTR (ATTRv-PN; v for variant) in a phase III trial. Based on these results, eplontersen was approved in the USA for the treatment of ATTRv-PN on 21 December 2023 and is currently undergoing regulatory review for a similar indication in the EU, the UK, Switzerland and Canada. Eplontersen is also undergoing phase III development for ATTR cardiomyopathy. This article summarizes the milestones in the development of eplontersen leading to this first approval for ATTRv-PN. [ABSTRACT FROM AUTHOR]
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- 2024
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4. Diverse pharmacovigilance jurisdiction—The right way for global drug safety?
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Zatovkaňuková, Petra and Slíva, Jiří
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DRUG side effects laws , *PUBLIC health laws , *ONLINE information services , *MEDICAL information storage & retrieval systems , *PHARMACOLOGY , *RISK assessment , *DRUG side effects , *MEDLINE - Abstract
Purpose: The purpose of this narrative review is to provide a comparison of several countries with different legislation and approaches to pharmacovigilance and to point out how these impact the number of adverse drug reactions (ADRs) that are reported to national competent authorities. Methods: Legislative and statistical data regarding ADR reporting from various national competent authorities' websites, databases, and pharmacovigilance centers were used. In combination with the WHO pharmacovigilance quantitative indicator that was applied to evaluate the effectiveness of particular national pharmacovigilance systems in our scope. Results: The study compared pharmacovigilance systems in six countries, focusing on ADR reporting from 2010 onwards. All countries required MAHs to report ADRs, while healthcare professionals' obligations varied. Per-capita ADR reports increased in all countries with available data, with the United States having a significantly higher reporting rate, possibly due to FDA campaigns. Despite starting later, China's per-capita reporting rate surpassed that of the Czech Republic and Japan. The study highlighted various measures taken by countries to enhance ADR reporting systems since the inception of their programs, contributing to the overall increase in reporting rates. Conclusions: ADR reporting is a global priority, with efforts made by different countries to strengthen their pharmacovigilance systems. Some success can be seen in gradually improving per-capita ADR reporting rates. The varying reporting rates and measures taken by each country may serve as a basis for further research and exchange of best practices to improve drug safety monitoring worldwide. [ABSTRACT FROM AUTHOR]
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- 2024
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5. Pre- and post-headache phases of migraine: multi-country results from the CaMEO – International Study.
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Lipton, Richard B., Lanteri-Minet, Michel, Leroux, Elizabeth, Manack Adams, Aubrey, Contreras-De Lama, Janette, Reed, Michael L., Fanning, Kristina M., and Buse, Dawn C.
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SCIENTIFIC observation , *NECK pain , *MIGRAINE , *CROSS-sectional method , *HEALTH outcome assessment , *DESCRIPTIVE statistics , *RESEARCH funding , *MENTAL depression , *DISABILITIES , *ANXIETY , *VISION disorders , *SECONDARY analysis , *ALLODYNIA , *SYMPTOMS - Abstract
Background: Individuals with migraine frequently experience pre- and post-headache symptoms. This analysis aimed to characterize the relative frequency and burden of pre- and post-headache symptoms in people with migraine using data collected through the Chronic Migraine Epidemiology and Outcomes – International Study. Methods: This cross-sectional, observational, web-based survey was conducted in 2021–2022 in Canada, France, Germany, Japan, the United Kingdom, and the United States. Respondents who met modified International Classification of Headache Disorders, 3rd edition, criteria were offered the opportunity to participate. Information collected included migraine-related disability, depression/anxiety symptoms, cutaneous allodynia, activity limitations, and acute treatment optimization. Respondents indicated how often they had pre- or post-headache symptoms using a 5-point scale, ranging from 0 to 4, with a rating of 2 or higher classified as a pre- or post-headache symptom case. Modeling was used to examine relationships with monthly headache days (MHDs) and activity limitations during pre-headache and post-headache phases. Results: Among a total of 14,492 respondents, pre-headache symptoms were reported by 66.9%, while post-headache symptoms were reported by 60.2%. Both pre-headache and post-headache symptoms were reported by 49.5% of respondents, only pre-headache by 17.4%, only post-headache by 10.7%, and neither pre- nor post-headache symptoms by 22.4%. Compared with respondents who experienced only pre- or post-headache symptoms, respondents who experienced both pre- and post-headache symptoms had the highest rates of 4–7, 8–14, and ≥ 15 monthly headache days (23.1%, 14.1%, and 10.9%, respectively). Of respondents with both pre- and post-headache symptoms, 58.5% reported moderate-to-severe disability, 47.7% reported clinically significant symptoms of depression, 49.0% reported clinically significant symptoms of anxiety, and 63.8% reported cutaneous allodynia with headache (ASC-12). Moderate-to-severe activity limitations were reported during the pre-headache (29.5%) and post-headache phases (27.2%). For all outcomes modeled, after controlling for covariates, having pre-headache symptoms, post-headache symptoms, or both were associated with worse outcomes than having neither. Conclusions: Pre- and post-headache phases of migraine are common, carry unrecognized burden, and may be a target for treatment. [ABSTRACT FROM AUTHOR]
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- 2023
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6. A Scoping Review of the Relationship Between Physical Activity and Mental Health Among Immigrants in Western Countries: An Integrated Bio-Psycho-Socio-Cultural Lens.
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Elshahat, Sarah, Moffat, Tina, Morshed, Mahira, Alkhawaldeh, Haneen, Madani, Keon, Mohamed, Aya, Nadeem, Naya, Emira, Sara, Newbold, K. Bruce, and Donnelly, Michael
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IMMIGRANTS , *ONLINE information services , *PSYCHOLOGY information storage & retrieval systems , *LEISURE , *RISK-taking behavior , *SPORTS participation , *WELL-being , *COGNITION disorders , *BIOPSYCHOSOCIAL model , *MEDICAL information storage & retrieval systems , *ACCULTURATION , *SYSTEMATIC reviews , *TRAVEL , *SELF-perception , *MENTAL health , *ACTIVITIES of daily living , *PSYCHOSOCIAL functioning , *POST-traumatic stress disorder , *PHYSICAL activity , *CONCEPTUAL structures , *SLEEP , *EXERCISE , *EMPLOYMENT , *MENTAL depression , *AFFECTIVE disorders , *LITERATURE reviews , *MEDLINE , *ANXIETY , *SOMATOFORM disorders , *EAST Asians , *PSYCHOLOGICAL resilience , *PSYCHOLOGICAL distress , *PSYCHOLOGICAL stress - Abstract
Epidemiological evidence suggests that regular physical activity (PA) positively impacts individuals' mental health (MH). The PA-MH relationship may be critical among immigrants owing to psycho-social-cultural influences. This scoping review of 61 studies employed a holistic bio-psycho-socio-cultural framework to thoroughly investigate the complex relationship between PA (across life domains) and immigrants' MH in Western countries. A systematic search of five electronic databases (Medline, PubMed, Embase, PsycINFO and Anthropology Plus) was conducted to locate relevant articles. No limitations were applied to study design, age, gender, home country, MH condition or PA type. A bio-psycho-socio-cultural-informed conceptual model guided the analysis of the multi-domain PA-MH relationship. Immigrant PA-MH studies were conducted and reported most commonly in the USA (38%), Australia (18%), and Canada (11%). Overall, PA was positively related to MH. Each domain-specific PA appeared to be associated with unique MH-promoting pathways/mechanisms. Leisure-related PA may support MH by enhancing self-agency and minimizing risky behaviors, whilst travel- and domestic-related PA may promote self-accomplishment and physical engagement. Ethnic sports appeared to enhance resilience. Occupational-related PA was associated with either positive or negative MH, depending on the type of occupation. A bio-psycho-socio-cultural-informed model is required to gain an encompassing and integrated understanding of immigrants' health. The first iteration of such a model is presented here, along with an illustration of how the model may be used to deepen analysis and understanding of the multi-domain PA-MH relationship among immigrants and inform public health planners and practitioners. [ABSTRACT FROM AUTHOR]
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- 2023
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7. Analysis and Mapping of Scientific Literature on Detention and Deportation of International Migrants (1990–2022).
- Author
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Sweileh, Waleed M.
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NOMADS , *INTERNATIONAL relations , *AUTHORS , *LABOR productivity , *SERIAL publications , *BIBLIOMETRICS , *SOCIAL sciences , *CITATION analysis , *DEPORTATION , *UNIVERSITIES & colleges , *INTELLECT , *DESCRIPTIVE statistics , *INTERPROFESSIONAL relations , *HUMANITIES , *DATA analysis software , *PERIODICAL articles , *MEDICAL literature , *MEDICAL research , *IMPACT factor (Citation analysis) - Abstract
Millions of people cross political borders yearly without having the proper documents. This has led to increased detention and deportation practices in destination countries for reasons related to security and sovereignty. The objective of the current study was to analyze and visualize research publications on the detention and deportation of migrants to identify current research hotspots, research gaps, and potential future research in the field. Relevant research articles were obtained from the Scopus database for the study period from 1900 to December 31, 2022. The analysis included presentations of key contributors to the field and visualization of topics, themes, and international collaboration. In total, 906 articles were found. The earliest was in 1982. The majority of articles were published in journals within the subject areas of social sciences and humanities. The number of publications showed a steep rise from 2011 to 2022. The Journal of Ethnic and Migration Studies was the most prolific, but publications in the Citizenship Studies journal received the highest number of citations per article. Researchers from the United States contributed the most. Mexico ranked fifth in the number of publications. Oxford University was the most prolific institution, followed by three universities in Australia. The majority of articles were single-authored, indicative of limited author-author collaboration. Research hotspots in the field were "human rights" and "mental health". The detention and deportation of Mexican and other Latino migrants in the United States constituted a distinct research theme in the field. International research collaboration was limited by geographical proximity (e.g., the United States and Mexico) or common language (e.g., the United Kingdom and Australia). Future research topics should focus on alternatives to detention, family separation, and healthcare services for detained migrants. Research activity on detention and deportation is required from all world regions, including the source countries of migrants. Future research should promote alternatives to traditional detentions. The contribution of countries in Africa, the Middle East, and South-Eastern Asian regions needs to be encouraged. Future research on the detention and deportation of non-Latino migrants is highly required. [ABSTRACT FROM AUTHOR]
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- 2023
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8. Real-World experience of interictal burden and treatment in migraine: a qualitative interview study.
- Author
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Lo, Siu Hing, Gallop, Katy, Smith, Timothy, Powell, Lauren, Johnston, Karissa, Hubig, Lena T., Williams, Emma, Coric, Vladimir, Harris, Linda, L'Italien, Gilbert, and Lloyd, Andrew J.
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LIFESTYLES , *MIGRAINE , *SELF-evaluation , *RESEARCH methodology , *INTERVIEWING , *CALCITONIN , *MONOCLONAL antibodies , *EXPERIENCE , *PATIENTS' attitudes , *QUALITATIVE research , *QUALITY of life , *QUESTIONNAIRES , *THEMATIC analysis , *SENSITIVITY & specificity (Statistics) - Abstract
Background: The debilitating nature of migraine attacks is widely established; however, less is known about how the interictal burden (i.e., how patients are affected in-between migraine episodes) of migraine impacts on patients' health-related quality of life (HRQL). Acute and preventive treatments may lift the burden of the disease, but they often have unwanted side effects and limited effectiveness. The objective of this study was to understand the interictal burden of migraines, from the patient perspective, and to explore patient experience with migraine treatments. Methods: Participants (n=35) with a self-reported diagnosis of migraine were recruited in the US, UK and Canada, including a subgroup of patients who had taken calcitonin gene-related peptide monoclonal antibody (CGRP mAb) treatment for at least three months. Participants completed a background questionnaire, followed by a semi-structured interview via telephone or video call. The interviews explored patients' migraine symptoms, perception of interictal burden and treatment experience. The interview transcripts were analysed using thematic analysis. Results: The most reported migraine symptom was migraine pain, followed by aura, sensory sensitivity and nausea. Most participants reported interictal impact on HRQL, lifestyle changes they made to avoid triggers or in anticipation of an attack, impacts on work, career, daily activities and relationships. Emotional impacts were reported by all participants, including anger, depression, anxiety and hopelessness. Many participants who took preventive treatments reported improvements in HRQL and functioning but still experienced breakthrough attacks. Among patients who took CGRP mAbs, participants noted varying consistency of treatment effectiveness between treatment administrations. Conclusion: This study detailed the additional HRQL impact of migraine in-between migraine attacks and described the unmet need for effective treatment options to prevent and mitigate migraine attacks. [ABSTRACT FROM AUTHOR]
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- 2022
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9. Differences in Breast Cancer Presentation at Time of Diagnosis for Black and White Women in High Resource Settings.
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Osei-Twum, Jo-Ann, Gedleh, Sahra, Lofters, Aisha, and Nnorom, Onye
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CINAHL database , *MEDICAL information storage & retrieval systems , *BLACK people , *SYSTEMATIC reviews , *EARLY detection of cancer , *DEMOGRAPHY , *WHITE people , *MEDLINE , *BREAST tumors , *WOMEN'S health - Abstract
This paper provides a narrative review of the existing literature on differences in demographic and biological features of breast cancer at time of diagnosis between Black and White women in Canada, the United Kingdom and the United States. Electronic database searches for published peer-reviewed articles on this topic were conducted, and 78 articles were included in the final narrative review. Differences between Black and White women were compared for eight categories including age, tumour stage, size, grade, lymph node involvement, and hormone status. Black women were significantly more likely to present with less favourable tumour features at the time of diagnosis than White women. Significant differences were reported in age at diagnosis, tumour stage, size, grade and hormone status, particularly triple negative breast cancer. Limitations on the generalizability of the review findings are discussed, as well as the implications of these findings on future research, especially within the Canadian context. [ABSTRACT FROM AUTHOR]
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- 2021
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10. Casirivimab/Imdevimab: First Approval.
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Deeks, Emma D.
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THERAPEUTIC use of monoclonal antibodies , *DRUG approval , *DRUG efficacy , *COMBINATION drug therapy , *COVID-19 , *MONOCLONAL antibodies , *SEVERITY of illness index , *THERAPEUTICS - Abstract
Casirivimab/imdevimab (Ronapreve™; REGEN-COV™) is a co-packaged combination of two neutralizing immunoglobulin gamma 1 (IgG1) human monoclonal antibodies (casirivimab and imdevimab) against the spike protein of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the causative agent of coronavirus disease 2019 (COVID-19). Casirivimab/imdevimab received its first emergency use authorization for the treatment of COVID-19 in November 2020 in the USA, with similar authorizations subsequently granted in various other countries, including India, Canada, and Switzerland. In February 2021, casirivimab/imdevimab was granted a positive scientific opinion in the EU for the treatment of COVID-19. In July 2021, casirivimab/imdevimab received its first approval in Japan for the treatment of mild or moderate COVID-19, followed in August 2021 by its conditional approval for the prophylaxis and treatment of acute COVID-19 infection in the UK. The combination was also granted provisional determination in Australia in August 2021, indicating its eligibility to be considered for provisional registration for COVID-19 treatment and prevention. This article summarizes the milestones in the development of casirivimab/imdevimab leading to these first approvals for COVID-19. [ABSTRACT FROM AUTHOR]
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- 2021
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11. Mental health consequences of detaining children and families who seek asylum: a scoping review.
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Mares, Sarah
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IMMIGRATION law , *MENTAL illness risk factors , *PSYCHOLOGY information storage & retrieval systems , *CINAHL database , *WELL-being , *PSYCHOLOGY of refugees , *SYSTEMATIC reviews , *PARENT-child separation , *RISK assessment , *PARENTING , *CHILD psychopathology , *LITERATURE reviews , *MEDLINE , *PARENT-child relationships - Abstract
Almost 80 million people globally are forcibly displaced. A small number reach wealthy western countries and seek asylum. Over half are children. Wealthy reception countries have increasingly adopted restrictive reception practices including immigration detention. There is an expanding literature on the mental health impacts of immigration detention for adults, but less about children. This scoping review identified 22 studies of children detained by 6 countries (Australia, Canada, Hong Kong, Netherlands, the UK and the US) through searches of Medline, PsychINFO, Emcare, CINAHL and Scopus data bases for the period January 1992–May 2019. The results are presented thematically. There is quantitative data about the mental health of children and parents who are detained and qualitative evidence includes the words and drawings of detained children. The papers are predominantly small cross-sectional studies using mixed methodologies with convenience samples. Despite weaknesses in individual studies the review provides a rich and consistent picture of the experience and impact of immigration detention on children's wellbeing, parental mental health and parenting. Displaced children are exposed to peri-migration trauma and loss compounded by further adversity while held detained. There are high rates of distress, mental disorder, physical health and developmental problems in children aged from infancy to adolescence which persist after resettlement. Restrictive detention is a particularly adverse reception experience and children and parents should not be detained or separated for immigration purposes. The findings have implications for policy and practice. Clinicians and researchers have a role in advocacy for reception polices that support the wellbeing of accompanied and unaccompanied children who seek asylum. [ABSTRACT FROM AUTHOR]
- Published
- 2021
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