1. Postmortem investigations and identification of multiple causes of child deaths: an analysis of findings from the Child Health and Mortality Prevention Surveillance (CHAMPS) network
- Author
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Pio Vitorino, Ikechukwu U. Ogbuanu, Muntasir Alam, Rosauro Varo, Vicky L. Baillie, Ashka Mehta, Janet Agaya, Afruna Rahman, Victor Akelo, Sana Mahtab, Samba O. Sow, Beth A. Tippett-Barr, Dickson Gethi, Alexander M. Ibrahim, Addisu Alemu, Shabir A. Madhi, Amara Jambai, Nega Assefa, Lola Madrid, Milagritos D. Tapia, Portia Mutevedzi, Atique Iqbal Chowdhury, Nana Bukiwe Thwala, Mischka Garel, Shams El Arifeen, Solomon Samura, Quique Bassat, Inacio Mandomando, Cynthia G. Whitney, Antonio Sitoe, Ima-Abasi Bassey, J. Anthony G. Scott, Adama Mamby Keita, Karen L. Kotloff, Dianna M. Blau, Dickens Onyango, Robert F. Breiman, Julius Ojulong, and Emily S. Gurley
- Subjects
Male ,Pediatrics ,Pulmonology ,Maternal Health ,Global Burden of Disease ,Families ,Medical Conditions ,Risk Factors ,Pregnancy ,Infectious Diseases of the Nervous System ,Cause of Death ,Infant Mortality ,Medicine and Health Sciences ,Public and Occupational Health ,Children ,Cause of death ,Neonatal sepsis ,Medical record ,Age Factors ,Child Health ,Obstetrics and Gynecology ,General Medicine ,Infectious Diseases ,Neurology ,Child, Preschool ,Population Surveillance ,Child Mortality ,Medicine ,Female ,Autopsy ,Neonatal Sepsis ,Infants ,Research Article ,medicine.medical_specialty ,Asia ,Inflammatory Diseases ,Preterm Birth ,Sierra leone ,Respiratory Disorders ,Signs and Symptoms ,Sepsis ,medicine ,Congenital Disorders ,Humans ,Infant Health ,Meningitis ,business.industry ,Infant, Newborn ,Infant ,Biology and Life Sciences ,Neonates ,medicine.disease ,Verbal autopsy ,Infant mortality ,Perinatal asphyxia ,Pregnancy Complications ,Malnutrition ,Age Groups ,Africa ,People and Places ,Respiratory Infections ,Birth ,Women's Health ,Population Groupings ,Clinical Medicine ,business ,Developmental Biology - Abstract
Background The current burden of >5 million deaths yearly is the focus of the Sustainable Development Goal (SDG) to end preventable deaths of newborns and children under 5 years old by 2030. To accelerate progression toward this goal, data are needed that accurately quantify the leading causes of death, so that interventions can target the common causes. By adding postmortem pathology and microbiology studies to other available data, the Child Health and Mortality Prevention Surveillance (CHAMPS) network provides comprehensive evaluations of conditions leading to death, in contrast to standard methods that rely on data from medical records and verbal autopsy and report only a single underlying condition. We analyzed CHAMPS data to characterize the value of considering multiple causes of death. Methods and findings We examined deaths identified from December 2016 through November 2020 from 7 CHAMPS sites (in Bangladesh, Ethiopia, Kenya, Mali, Mozambique, Sierra Leone, and South Africa), including 741 neonatal, 278 infant, and 241 child, In an analysis of data from the Child Health and Mortality Prevention Surveillance (CHAMPS) network, Robert Breiman, Dianna Blau, and colleagues investigate how considering all conditions in the causal chain leading to death informs the identification of deaths attributable to various diagnoses., Author summary Why was this study done? More than 5 million deaths occur annually in children
- Published
- 2022