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A new study conducted at the Public Assistance Hospital of Marseille (AP-HM) has found that caprolactam, a leachable cyclic amide, can be found in plastic bags commonly used in clinical practice for intravenous administration of normal saline (NS) and 5% dextrose in water (D5W). The study found that the contamination levels of caprolactam in these bags were high, with a mean range of 5.43 mg/L to 22.83 mg/L. The researchers suggest that pharmaceutical companies should publicly communicate about the safety of caprolactam, especially considering the possibility of administering it to high-risk patients such as neonates and the elderly. The full study can be accessed in the American Journal of Health-System Pharmacy. [Extracted from the article]

A new report from University Hospital Nancy in Vandoeuvre-les-Nancy, France, provides insights into the physicochemical stability of pevonedistat, a cytotoxic used in the treatment of acute myeloid leukemia and high-risk myelodysplastic syndromes. The study found that diluted solutions of pevonedistat remained physically and chemically stable for 14 days, while the concentrated solution remained stable for 7 days. The research suggests that the concentrated solution can be reused and stored in a commercial glass vial with a Spike in case of non-administration. This information is valuable for healthcare professionals and researchers working with pevonedistat. [Extracted from the article]

In view of these results, osmolality does not seem to be a criterion of choice for the study of drug stability. Keywords: Drugs and Therapies; Hospital Pharmacy EN Drugs and Therapies Hospital Pharmacy 2650 2650 1 03/24/23 20230217 NES 230217 2023 FEB 17 (NewsRx) -- By a News Reporter-Staff News Editor at Drug Week -- New study results on hospital pharmacy have been published. [Extracted from the article]