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Your search keyword '"Spence, Matthew A."' showing total 2 results
Start Over Author "Spence, Matthew A." Publication Year Range Last 3 years Publisher national academy of sciences
2 results on '"Spence, Matthew A."'

1. A broad-spectrum macrocyclic peptide inhibitor of the SARS-CoV-2 spike protein

Author

Afd Chemical Biology and Drug Discovery, Virologie, Sub Biomol.Mass Spectrometry & Proteom., Infectious Diseases and Immunology - Virology, Thijssen, Vito, Hurdiss, Daniel L, Debski-Antoniak, Oliver J, Spence, Matthew A, Franck, Charlotte, Norman, Alexander, Aggarwal, Anupriya, Mokiem, Nadia J, van Dongen, David A A, Vermeir, Stein W, Liu, Minglong, Li, Wentao, Chatziandreou, Marianthi, Donselaar, Tim, Du, Wenjuan, Drulyte, Ieva, Bosch, Berend-Jan, Snijder, Joost, Turville, Stuart G, Payne, Richard J, Jackson, Colin J, van Kuppeveld, Frank J M, Jongkees, Seino A K, Afd Chemical Biology and Drug Discovery, Virologie, Sub Biomol.Mass Spectrometry & Proteom., Infectious Diseases and Immunology - Virology, Thijssen, Vito, Hurdiss, Daniel L, Debski-Antoniak, Oliver J, Spence, Matthew A, Franck, Charlotte, Norman, Alexander, Aggarwal, Anupriya, Mokiem, Nadia J, van Dongen, David A A, Vermeir, Stein W, Liu, Minglong, Li, Wentao, Chatziandreou, Marianthi, Donselaar, Tim, Du, Wenjuan, Drulyte, Ieva, Bosch, Berend-Jan, Snijder, Joost, Turville, Stuart G, Payne, Richard J, Jackson, Colin J, van Kuppeveld, Frank J M, and Jongkees, Seino A K

Published
2023

2. A broad-spectrum macrocyclic peptide inhibitor of the SARS-CoV-2 spike protein.

Author

Thijssen, Vito, Hurdiss, Daniel L., Debski-Antoniak, Oliver J., Spence, Matthew A., Franck, Charlotte, Norman, Alexander, Aggarwal, Anupriya, Mokiem, Nadia J., van Dongen, David A. A., Vermeir, Stein W., Minglong Liu, Wentao Li, Chatziandreou, Marianthi, Donselaar, Tim, Wenjuan Du, Drulyte, Ieva, Bosch, Berend-Jan, Snijder, Joost, Turville, Stuart G., and Payne, Richard J.

Subjects
SARS-CoV-2, PEPTIDES, SARS-CoV-2 Omicron variant
Abstract

The ongoing COVID-19 pandemic has had great societal and health consequences. Despite the availability of vaccines, infection rates remain high due to immune evasive Omicron sublineages. Broad-spectrum antivirals are needed to safeguard against emerging variants and future pandemics. We used messenger RNA (mRNA) display under a reprogrammed genetic code to find a spike-targeting macrocyclic peptide that inhibits SARS-CoV-2 (severe acute respiratory syndrome coronavirus 2) Wuhan strain infection and pseudoviruses containing spike proteins of SARS-CoV-2 variants or related sarbecoviruses. Structural and bioinformatic analyses reveal a conserved binding pocket between the receptor-binding domain, N-terminal domain, and S2 region, distal to the angiotensin-converting enzyme 2 receptor-interaction site. Our data reveal a hitherto unexplored site of vulnerability in sarbecoviruses that peptides and potentially other drug-like molecules can target. [ABSTRACT FROM AUTHOR]

Published
2023
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