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Wind shear has important implications for Kelvin–Helmholtz instability (KHI) and gravity waves (GWs) in the mesosphere–lower thermosphere (MLT) region where its momentum transport process is dominated by short-period (<1 h) GWs. However, the sub-hourly variation in wind shear is still not well quantified. This study aims to improve current understanding of vertical wind shear by analyzing multi-year meteor radar measurements at the Mohe (MH, 53.5°N, 122.3°E), Beijing (BJ, 40.3 ° N , 116.2 ° E ), Wuhan (WH, 30.5 ° N , 114.6 ° E ), and Fuke (FK, 19.5°N, 109.1°E) stations in China. The wind field is estimated by a new algorithm, e.g., the damped least squares fitting. Taking the wind shear estimated by normal products as a criterion, the shear produced by the new algorithm has more statistical convergence as compared to the traditional algorithm, e.g., the least squares fitting. Therefore, we argue that the 10 min DLSA wind probably produces a more reasonable vertical shear. Both intensive wind shears and GW kinetic energy can be simultaneously captured during the 0600–1600 UTs of May at MH and during the 1300–2400 UTs of March at FK, possibly implying that the up-propagation of GWs could contribute to the production of large wind shears. The sub-hourly variation in wind shears is potentially valuable for understanding the interrelationship between shear (or KHI) and GWs. [ABSTRACT FROM AUTHOR]

This study presents the observations of midlatitude plasma irregularities over Eastern Asia during a moderate magnetic storm on 16 July 2003. Multi-instrumental observations, including the ground-based ionosondes, the GNSS networks, and the CHAMP and ROCSAT-1 satellites, were utilized to investigate the occurrence and characteristics of midlatitude plasma irregularities. The midlatitude strong spread F (SSF) mainly occurred in the midnight–morning sector as observed by ionosondes over Japan during this storm. SSF was related to plasma depletions, which is also recorded by GNSS network in the form of the enhancement of the rate of total electron content (TEC) change index (ROTI). The possible mechanism for the generation of SSF is that the enhanced eastward electric fields, associated with the prompt penetration electric fields and disturbance dynamo electric fields, cause the uplift and latitudinal extension of equatorial plasma bubbles (EPBs) to generate the observed midlatitude SSF further. Meanwhile, plasma density increased significantly under the influence of this storm. In addition, other common type of spread F, frequency spread F (FSF), was observed over Japan on the non-storm day and/or at high latitude station WK545, which seems to be closely related to the coupling of medium-scale traveling ionospheric disturbances (MSTIDs) and sporadic E (Es) layer. The above results indicate that various types of midlatitude spread F can be produced by different physical mechanisms. It is found that SSF can significantly affect the performance of radio wave propagation compared with FSF. Our results show that space weather events have a significant influence on the day-to-day variability of the occurrence and characteristics of ionospheric F-region irregularities at midlatitudes. [ABSTRACT FROM AUTHOR]

Atmospheric gravity waves (GWs) in the mesosphere-lower thermosphere (MLT) are crucial for the understanding of general circulation. However, their dynamical characteristics are hardly retrieved due to the difficulty in the high-resolution observation of wind. Therefore, this paper uses eight years (2013–2020) of meteor radar measurements in the MLT region at Mohe station (53.5°N, 122.3°E), China, to retrieve high-temporal-resolution mesospheric wind data and further evaluate the temporal variation of GW kinetic energy. As the detected meteor trails exceed 6, the wind velocity is recalculated using the least square algorithm method, significantly increasing the temporal resolution of wind from 1 h up to 5 min. This resolution is sufficiently high for the investigation of GW kinetic energy, which exhibits a high spatial-temporal variability. For instance, it is enhanced in the winter season during the period of 0200–1400 UT and in the spring season during the period of 0800–1300 UT. The similarity between the climatological characteristics of GWs in MLT and the seasonal variation of GW total energy in the troposphere, determined from high-resolution radiosondes near to Mohe station, suggests that the meteorology in the lower atmosphere could be an important source of GWs in the MLT region. [ABSTRACT FROM AUTHOR]

A GO pathway enrichment analysis of PDAC cells with knockdown of I TBK1 i or I BACH1 i suggested that I TBK1 i and I BACH1 i both regulate cellular iron ion homeostasis and cell migration. Using our previously published data of RNA-seq in AsPC-1 cells with or without I BACH1 i knockdown [[46]], there were 102 common upregulated genes and 181 common downregulated genes in I TBK1 i -silenced and I BACH1 i -silenced AsPC-1 cells (Figure 2A,B). The expression of these genes is also reduced upon I BACH1 i knockdown in these cells [[46]], suggesting that I TBK1 i promotes metastatic process including cell migration via enhancing the function of I BACH1 i . 3.3. TBK1-BACH1 Pathway Regulates Iron Homeostasis and Cell Migration To further investigate the regulatory relationship between I TBK1 i and I BACH1 i , we knocked down I TBK1 i in AsPC-1 cells and carried out an RNA-seq analysis. [Extracted from the article]