Search

Obesity is a global public health issue. Obesity-related chronic low-grade inflammation (meta-inflammation) can lead to aberrant adipokine release and promote cardiometabolic diseases and obesity-related tumors. However, the mechanisms involved in the initiation of inflammatory responses in obesity and obesity-related tumors as well as metastasis are not fully understood. In this study, we found that the increased tumor necrosis factor-alpha (TNF-α) in adipocytes promoted the lung metastasis of MC38 colon cancer cells via Fas signaling. The release of TNF-α and interleukin (IL)-6 by Fas signaling in adipocytes was caused by the activation of the nuclear factor-kappa B (NF-κB) and mitogen-activated protein kinase (MAPK) pathways mediated by the interaction of Fas with Bmx, a non-receptor tyrosine kinase. Moreover, the Fas/Bmx complex is involved in the inflammation of adipocytes via Fas at the Tyr189 site and SH2 domain of Bmx. This is the first study to report the interaction between Fas and Bmx in adipocyte inflammation, which may provide clues for the development of potential new treatment strategies for obesity-related diseases. [ABSTRACT FROM AUTHOR]

[Display omitted] • The Early Carboniferous clastic sediments in the North Lhasa Terrane was mainly from the Indian continent and partly from the Australian continent. • The North Lhasa Terrane may be located at the northern margin of the Indian- and Australian continent during the Early Carboniferous. • The reduction of Grenvillian detrital zircons in the Yongzhu Formation might be associated with the Early Carboniferous rifting process in the eastern Lhasa Block. The Lhasa Block was located at the northern margin of East Gondwana before it drifted away, but its exact paleogeographic location in the Late Paleozoic remains controversial. The Late Paleozoic strata in the Lhasa Block, especially the Lower Carboniferous, for which the rock assemblage and sedimentary age have been described but the in-depth research on provenance and tectonic environment are still lacking, may provide vital information about its paleogeographic location. This study presents a systematic field geological survey of the Lower Carboniferous Yongzhu Formation, along with U-Pb dating and Hf isotope analysis of detrital zircons. The detrital zircons U-Pb data revealed major age peaks at 530 and 980 Ma as well as several subordinate age peaks at 784, 890, 1160, 1514, 1690, 2480, and 2600 Ma. The Hf isotopes of the detrital zircons showed similarity with zircons from the Indian continent on the age peaks at 980 and 890 Ma and with those from the Australian continent on the age peaks at 1160 and 2600 Ma, which indicates mixed provenance for the Yongzhu Formation. From this study, we infer that the Lhasa Block might have been located at the northern margin of the Indian and Australian continents during the Early Carboniferous. The weaker age peak at 1160 Ma of the Lower Carboniferous compared to the Pre-Carboniferous and Upper Carboniferous-Lower Permian might be related to the opening of the Sumdo Paleo-Tethys Ocean. [ABSTRACT FROM AUTHOR]

• A fully physical TCAD framework to model the NBTI is validated with differently processes MOSFET measured data. • RD model with ABDWT model for interface trap generation, RDD model for bulk trap generation, ABDWT model for hole trapping is used. • Framework Validation in TCAD in 3D FinFETs and GAA-FETs is in progress. A physics-based framework is incorporated in TCAD to model the primary mechanisms responsible for Negative Bias Temperature Instability (NBTI) in P channel High-K Metal Gate (HKMG) MOSFETs. Three underlying mechanisms are treated including interface trap generation-passivation via a Reaction-Diffusion (RD) model and its charge occupancy via an Activated Barrier Double Well Thermionic (ABDWT) model, hole trapping and de-trapping in pre-existing defects in the gate stack are modeled via an ABDWT model, and bulk trap generation-passivation is modeled via a Reaction-Diffusion-Drift (RDD) model. The framework is used to model measured NBTI time-kinetics for DC stress-recovery and various mixed DC-AC gate pulse segments for planar devices. Furthermore, the same framework is also used to test NBTI behavior in 3D FinFETs. [ABSTRACT FROM AUTHOR]

• Afforestation is affecting widespread sampling deficiency in plant collections. • The big data map the potential artificial and naturals tree coverage of the historical and revisited records of Engelhardia. • The afforestation on historical distribution of recorded plants is blinded by the bright. Against the background of climate change, the booming afforestation is the most effective strategy for climate change mitigation. Also, the rise of the economic forests can bring benefits to eliminate poverty from economic growth. However, it's worth noting that afforestation is affecting widespread sampling deficiency in plant collections. Here, we used the big data to map the potential artificial and naturals tree coverage of the historical and revisited records of Engelhardia. The results show that new collections localities have been discovered in areas with natural forest coverage; on average, the disappearance of recorded localities are likely to be related the increasing artificial forests. Our results highlight the disappearance of recorded species and/or shifts of the biodiversity patterns are blinded by the bright that photosynthetic carbon captured by the afforestation for climate change and the economic values to reduce regional poverty by the economic forests. Therefore, the natural forests are necessary to be valued in biodiversity, ecology and evolution. Also, our study provides insight into the impact of afforestation on historical distribution of recorded plants, which are essential to sustain ecological restoration programs, and will improve ecological managements and policies with the rise of artificial forests across the world. [ABSTRACT FROM AUTHOR]

Zinc (Zn) isotope data for mid-ocean ridge basalts (MORB) are scarce. The possible effects of MORB differentiation and mantle compositional heterogeneity on MORB Zn isotope compositions are poorly understood. In this paper, we report Zn isotope data of MORB lavas from the East Pacific Rise (EPR) at 10°30′N, which are understood to have been derived by a similar extent of melting from a compositionally uniform mantle source but manifest significantly varying extents of magma differentiation (MgO = 7.38–1.76 wt%) to demonstrate unequivocal Zn isotope fractionation during MORB differentiation. These lavas have a small δ66Zn (relative to the JMC-Lyon standard) range of 0.21–0.32‰, with an average of 0.26 ± 0.07‰ (2SD, N = 24), overlapping with literature data. However, δ66Zn values show significant correlations with indices of magma differentiation (e.g., MgO and CaO), with the more differentiated samples having isotopically heavier Zn. We can thus conclude that MORB differentiation can lead to ∼0.1‰ δ66Zn elevation, which is similar to that observed in Hawaiian Kilauea Iki lava lake samples. Fractional crystallization of olivine and clinopyroxene at MgO > ∼3.5 wt% and clinopyroxene and Fe–Ti oxides dominated by ilmenite at MgO < ∼3.5 wt% results in the observed Zn isotope fractionation. The δ66Zn values for primitive N-MORB and MORB source mantle are estimated to be ∼0.22‰ and ∼0.17‰, respectively. Furthermore, we observe a positive correlation between δ66Zn and [La/Sm] N in primitive (MgO = 7.58–9.01 wt%) literature MORB, indicating the existence of possible Zn isotope heterogeneity in the oceanic upper mantle. We thus predict heavy Zn isotope enrichment in mantle sources for E-MORB samples with high [La/Sm] N , which requires future testing. [ABSTRACT FROM AUTHOR]

Redox-driven copper (Cu) isotope fractionation has been widely observed in low-temperature weathering and hydrothermal processes. However, how Cu isotopes may fractionate during magmatic processes remain unknown. To address this issue, we studied MORB samples from the East Pacific Rise (EPR) at 10°30′N to explore the Cu isotope behavior during magma differentiation. These samples are globally ideal because they are generated from a uniformly depleted sub-ridge mantle source but have experienced varying extents of fractional crystallization and sulfide segregation with large variations of MgO (1.76–7.38 wt%) and Cu (16.0–75.2 μg/g). Lavas with MgO ≥ 4.9 wt% involving olivine, clinopyroxene and plagioclase as the major liquidus minerals show homogeneous δ65Cu of 0.05 ± 0.03‰, suggesting little Cu isotope fractionation at this stage of magma differentiation. However, after Fe-Ti oxides appear on the liquidus, melt δ65Cu values first decrease rapidly to –0.41‰ at MgO of 3.9 wt% and then increase with the most evolved sample having δ65Cu of 0.08‰. Such a significant Cu isotope fractionation during magma differentiation has never been reported before. We suggest the large Cu isotope variation at MgO < 4.9 wt% reflect a redox change of MORB melt resulting from fractional crystallization of Fe-Ti oxides. The crystallization of ilmenite (Fe2+TiO 3), which is the first Fe-Ti oxide phase during MORB differentiation, causes a sudden increase of Fe3+/∑Fe in the residual melt and drives the redox reaction Fe3+ + Cu1+ → Fe2+ + Cu2+. As a result, sulfides segregated from the MORB melts have high Cu2+ content and heavy Cu isotope compositions with Δ65Cu Sulfide-Silicate melt > 0 because of the preferential bonding of heavy Cu isotopes (65Cu vs. 63Cu) with Cu2+, whose fractionation rapidly decreases δ65Cu of the residual melts. The increase of Fe3+/∑Fe will quickly drive the melt to be saturated in titanomagnetite (magnetite-Ulvöspinel solid solutions), whose crystallization decreases melt Fe3+/∑Fe and drives the redox reaction Fe2+ + Cu2+ → Fe3+ + Cu1+. As a result, the segregated sulfides after titanomagnetite saturation have decreasing Cu2+ content. These sulfides are also predicted to have low Ni content and exhibit Δ65Cu Sulfide-Silicate melt < 0, whose segregation raises δ65Cu in the residual melts. Therefore, we suggest a significant influence of redox states of Cu and abundance of Ni in the segregated sulfides on the Cu isotope fractionation during MORB differentiation. During mantle melting for MORB at ΔFMQ < 0, Cu isotope fractionation between melt and mantle sulfide is inferred to be limited, and the upper mantle has primitive MORB-like δ65Cu of 0.06 ± 0.05‰. [ABSTRACT FROM AUTHOR]