1. Myeloid C-type lectin receptors in host–pathogen interactions and glycan-based targeting.
- Author
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Stegmann, Felix and Lepenies, Bernd
- Subjects
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PATTERN perception receptors , *MYELOID cells , *NATURAL immunity , *IMMUNOREGULATION , *MOLECULAR recognition , *LECTINS - Abstract
Lectin–glycan interactions play a crucial role in the immune system. An important class of lectins in the innate immune system is myeloid C-type lectin receptors (CLRs). Myeloid CLRs act as pattern recognition receptors and are predominantly expressed by myeloid cells, such as macrophages, dendritic cells, and neutrophils. In innate immunity, CLRs contribute to self/non-self discrimination. While the recognition of pathogen-associated molecular patterns (PAMPs) by CLRs may contribute to a protective immune response, CLR engagement can also be exploited by pathogens for immune evasion. Since various CLRs act as endocytic receptors and trigger distinct signaling pathways in myeloid cells, CLR targeting has proven useful for drug/antigen delivery into antigen-presenting cells and the modulation of immune responses. This review covers recent discoveries of pathogen/CLR interactions and novel approaches for CLR targeting within the period of the past two years. [Display omitted] • Myeloid C-type lectin receptors (CLRs) are pathogen sensors in innate immunity. • Myeloid CLRs may be exploited by pathogens for immune evasion. • CLR targeting has proven useful for cell-specific antigen/drug delivery. • Multivalent glycan display on carrier systems facilitates CLR targeting. • This review covers recent studies (mainly in the past two years) on CLR research. [ABSTRACT FROM AUTHOR]
- Published
- 2024
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