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[Objective] The present paper aimed to provide a reference basis for the safe production in tobacco fields with medium risk of Cd pollution and remediation, the uptake of Cd by tobacco and its distribution pattern in the whole plant were studied. [Method] The tobacco planting soil with medium risk of Cd pollution was selected for pot experiments to explore the remediation potential of 5 tobacco varieties for Cd in the contaminated soil and safety production about of tobacco. [Result] The concentrations of Cd（1.510-2.110 mg/kg) in 5 tobacco varieties were far less than the limit value of Cd（5.0 mg/kg) in Guizhou tobacco leaves. The order of Cd concentration of 5 tobacco varieties was as follows: Guiyan 8 > Yunyan 87 > CF225 > Nanjiang 3 > Bi’na 1.The Cd concerntration of Guiyan 8 was significantly higher than others. There were no significant difference between Bi’na 1 and Nanjiang 3, and they were significantly lower than others. All of 5 tobacco varieties had strong enrichment ability for Cd（127.695%-204.549%), and the order of enrichment ability was as follows: Bi’na 1>Yunyan 87>CF228>Guiyan 8>Nanjiang 3. The accumulation of Cd in Bi’na 1 had 583.102 μg/plant and the remediation efficiency of Cd in soil was 4.113%, more than 4 other tobacco varieties（2.269%-3.262%). The Cd of Bi’na 1 was mainly stored in the unusable parts such as roots, stems and leaf veins in the tobacco. The distribution rate of Cd in leaves of Bi’na 1 was the lowest with 41.03% concentration, which was lower than that of other tobaccos（above 50%). Bi’na 1 reduced the adverse factors（Cd concentration and distribution rate) in the tobacco production. [Conclusion] Among 5 tobacco varieties, Bi’na maximum accumulation amount of Cd, which mainly exists in unusable part, including root, stalk, leave vein, etc. Compared with other four tobacco varieties, Bi’na 1 reduces the disadvantages during tobacco production. Hence, Bi’na 1 has the potential for safe utilization and restoration of tobacco field medium-polluted by Cd. [ABSTRACT FROM AUTHOR]