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In excavation engineering, most of the retaining structures are subjected to asymmetrical loads, including in asymmetrical excavation and asymmetrical overloading. However, a theoretical solution to, and deformation-controlling method for, this problem has remained elusive to date. In this work, a semianalytical solution for determining the deformation of retaining structures subjected to asymmetrical loads was derived based on the principle of minimum potential energy. The retaining structures were viewed as flexible, and the overall deformation of the retaining system was evaluated by our proposed theoretical model. This model was verified by comparing it with practical monitoring data. Subsequently, the theoretical solution was applied to analyze the stress and deformation characteristics under the conditions of asymmetrical excavation and asymmetrical overloading, which can be controlled to ensure the safety of a project. Finally, because of the requirement for a small amount of deformation in the foundation pit retaining piles, the earth pressure on the retaining piles is close to the static earth pressure. Reducing the length of the retaining pile on one side had a greater influence on the deformation on that side, but less of an influence on the other side. Thus, the proposed model can be used for optimizing the asymmetrical design of a retaining structure in order to balance the economy and safety of a project. Our design theory can be applied to a variety of engineering projects. A typical case is the Guangzhou Baiyun District Comprehensive Transportation Hub Project in China. The method was used to analyze the status of the subway foundation pit, offering a new design scheme to reduce the design length of the retaining piles, which resulted in great economic benefits in its practical application. The findings provided in this paper can be applied to the engineering of any long, narrow foundation pit that can be simplified into a two-dimensional plane–strain calculation model, being used to realize more accurate deformation control over the foundation pit envelope. The core of this calculation method is that it can accurately describe the magnitude of the earth pressure. The distribution of the earth pressure is worthy of further study. [ABSTRACT FROM AUTHOR]