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2. Building a tuberculosis-free world: The Lancet Commission on tuberculosis

Author

Reid, M.J.A. (Michael J A), Arinaminpathy, N. (Nimalan), Bloom, A. (Amy), Bloom, B.R. (Barry R), Boehme, C. (Catharina), Chaisson, R. (Richard), Chin, D.P. (Daniel P), Churchyard, G. (Gavin), Cox, H. (Helen), Ditiu, L. (Lucica), Dybul, M. (Mark), Farrar, J. (Jeremy), Fauci, A.S. (Anthony S), Fekadu, E. (Endalkachew), Fujiwara, P.I. (Paula I), Hallett, T.B. (Timothy), Hanson, C.L. (Christy L), Harrington, M. (Mark), Herbert, N. (Nick), Hopewell, P.C. (Philip C), Ikeda, C. (Chieko), Jamison, D.T. (Dean T), Khan, A.J. (Aamir J), Koek, I. (Irene), Krishnan, N. (Nalini), Motsoaledi, A. (Aaron), Pai, M. (Madhukar), Raviglione, M.C. (Mario C), Sharman, A. (Almaz), Small, P.M. (Peter M), Swaminathan, S. (Soumya), Temesgen, Z. (Zelalem), Vassall, A. (Anna), Venkatesan, N. (Nandita), van Weezenbeek, K. (Kitty), Yamey, G. (Gavin), Agins, B.D. (Bruce D), Alexandru, S. (Sofia), Andrews, J.R. (Jason R), Beyeler, N. (Naomi), Bivol, S. (Stela), Brigden, G. (Grania), Cattamanchi, A. (Adithya), Cazabon, D. (Danielle), Crudu, V. (Valeriu), Daftary, A. (Amrita), Dewan, P. (Puneet), Doepel, L.K. (Laurie K), Eisinger, R.W. (Robert W), Fan, V. (Victoria), Fewer, S. (Sara), Furin, J. (Jennifer), Goldhaber-Fiebert, J.D. (Jeremy D), Gomez, G.B. (Gabriela B), Graham, S.M. (Stephen M), Gupta, D. (Devesh), Kamene, M. (Maureen), Khaparde, S. (Sunil), Mailu, E.W. (Eunice W), Masini, E.O. (Enos O), McHugh, L. (Lorrie), Mitchell, E.M.H. (Ellen), Moon, S. (Suerie), Osberg, M. (Michael), Pande, T. (Tripti), Prince, L. (Lea), Rade, K. (Kirankumar), Rao, R. (Raghuram), Remme, M. (Michelle), Seddon, J.A. (James A), Selwyn, C. (Casey), Shete, P. (Priya), Sachdeva, K.S. (Kuldeep S), Stallworthy, G. (Guy), Vesga, J.F. (Juan F), Vilc, V. (Valentina), Goosby, E.P. (Eric P), Reid, M.J.A. (Michael J A), Arinaminpathy, N. (Nimalan), Bloom, A. (Amy), Bloom, B.R. (Barry R), Boehme, C. (Catharina), Chaisson, R. (Richard), Chin, D.P. (Daniel P), Churchyard, G. (Gavin), Cox, H. (Helen), Ditiu, L. (Lucica), Dybul, M. (Mark), Farrar, J. (Jeremy), Fauci, A.S. (Anthony S), Fekadu, E. (Endalkachew), Fujiwara, P.I. (Paula I), Hallett, T.B. (Timothy), Hanson, C.L. (Christy L), Harrington, M. (Mark), Herbert, N. (Nick), Hopewell, P.C. (Philip C), Ikeda, C. (Chieko), Jamison, D.T. (Dean T), Khan, A.J. (Aamir J), Koek, I. (Irene), Krishnan, N. (Nalini), Motsoaledi, A. (Aaron), Pai, M. (Madhukar), Raviglione, M.C. (Mario C), Sharman, A. (Almaz), Small, P.M. (Peter M), Swaminathan, S. (Soumya), Temesgen, Z. (Zelalem), Vassall, A. (Anna), Venkatesan, N. (Nandita), van Weezenbeek, K. (Kitty), Yamey, G. (Gavin), Agins, B.D. (Bruce D), Alexandru, S. (Sofia), Andrews, J.R. (Jason R), Beyeler, N. (Naomi), Bivol, S. (Stela), Brigden, G. (Grania), Cattamanchi, A. (Adithya), Cazabon, D. (Danielle), Crudu, V. (Valeriu), Daftary, A. (Amrita), Dewan, P. (Puneet), Doepel, L.K. (Laurie K), Eisinger, R.W. (Robert W), Fan, V. (Victoria), Fewer, S. (Sara), Furin, J. (Jennifer), Goldhaber-Fiebert, J.D. (Jeremy D), Gomez, G.B. (Gabriela B), Graham, S.M. (Stephen M), Gupta, D. (Devesh), Kamene, M. (Maureen), Khaparde, S. (Sunil), Mailu, E.W. (Eunice W), Masini, E.O. (Enos O), McHugh, L. (Lorrie), Mitchell, E.M.H. (Ellen), Moon, S. (Suerie), Osberg, M. (Michael), Pande, T. (Tripti), Prince, L. (Lea), Rade, K. (Kirankumar), Rao, R. (Raghuram), Remme, M. (Michelle), Seddon, J.A. (James A), Selwyn, C. (Casey), Shete, P. (Priya), Sachdeva, K.S. (Kuldeep S), Stallworthy, G. (Guy), Vesga, J.F. (Juan F), Vilc, V. (Valentina), and Goosby, E.P. (Eric P)

Abstract

___Key messages___ The Commission recommends five priority investments to achieve a tuberculosis-free world within a generation. These investments are designed to fulfil the mandate of the UN High Level Meeting on tuberculosis. In addition, they answer t

Published
2019
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3. Building a tuberculosis-free world: The Lancet Commission on tuberculosis

Author

Reid, MJA, Arinaminpathy, N, Bloom, A, Bloom, BR, Boehm, C, Chaisson, R, Chin, DP, Churchyard, G, Cox, H, Ditiu, L, Dybul, M, Farrar, J, Fauci, AS, Fekodu, E, Fujiwara, PI, Hallett, TB, Hanson, CL, Harrington, M, Herbert, N, Hopewell, PC, Ikeda, C, Jamison, DT, Khan, AJ, Koek, I, Krishnan, N, Motsoaledi, A, Pai, M, Raviglione, MC, Sharman, A, Small, PM, Swaminathan, S, Temesgen, Z, Vassall, A, Venkatesan, N, van Weezenbeek, K, Yamey, G, Agins, BD, Arexandru, S, Andrews, JR, Beyeler, N, Bivol, S, Brigden, G, Cattamanchi, A, Cazabon, D, Crudu, V, Daftary, A, Dewan, P, Doepel, LK, Eisinger, RW, Fan, V, Fewer, S, Furin, J, Goldhaber-Fiebert, JD, Gomez, GB, Graham, SM, Gupta, D, Kamene, M, Khaparde, S, Mailu, EW, Masini, EO, McHugh, L, Mitchell, E, Moon, S, Osberg, M, Pande, T, Prince, L, Rade, K, Rao, R, Remme, M, Seddon, JA, Selwyn, C, Shete, P, Sachdeva, KS, Stallworthy, G, Vesga, JF, Vilc, V, Goosby, EP, Reid, MJA, Arinaminpathy, N, Bloom, A, Bloom, BR, Boehm, C, Chaisson, R, Chin, DP, Churchyard, G, Cox, H, Ditiu, L, Dybul, M, Farrar, J, Fauci, AS, Fekodu, E, Fujiwara, PI, Hallett, TB, Hanson, CL, Harrington, M, Herbert, N, Hopewell, PC, Ikeda, C, Jamison, DT, Khan, AJ, Koek, I, Krishnan, N, Motsoaledi, A, Pai, M, Raviglione, MC, Sharman, A, Small, PM, Swaminathan, S, Temesgen, Z, Vassall, A, Venkatesan, N, van Weezenbeek, K, Yamey, G, Agins, BD, Arexandru, S, Andrews, JR, Beyeler, N, Bivol, S, Brigden, G, Cattamanchi, A, Cazabon, D, Crudu, V, Daftary, A, Dewan, P, Doepel, LK, Eisinger, RW, Fan, V, Fewer, S, Furin, J, Goldhaber-Fiebert, JD, Gomez, GB, Graham, SM, Gupta, D, Kamene, M, Khaparde, S, Mailu, EW, Masini, EO, McHugh, L, Mitchell, E, Moon, S, Osberg, M, Pande, T, Prince, L, Rade, K, Rao, R, Remme, M, Seddon, JA, Selwyn, C, Shete, P, Sachdeva, KS, Stallworthy, G, Vesga, JF, Vilc, V, and Goosby, EP

Published
2019

5. Scientific advances and the end of tuberculosis: a report from the Lancet Commission on Tuberculosis.

Author

Reid M, Agbassi YJP, Arinaminpathy N, Bercasio A, Bhargava A, Bhargava M, Bloom A, Cattamanchi A, Chaisson R, Chin D, Churchyard G, Cox H, Denkinger CM, Ditiu L, Dowdy D, Dybul M, Fauci A, Fedaku E, Gidado M, Harrington M, Hauser J, Heitkamp P, Herbert N, Herna Sari A, Hopewell P, Kendall E, Khan A, Kim A, Koek I, Kondratyuk S, Krishnan N, Ku CC, Lessem E, McConnell EV, Nahid P, Oliver M, Pai M, Raviglione M, Ryckman T, Schäferhoff M, Silva S, Small P, Stallworthy G, Temesgen Z, van Weezenbeek K, Vassall A, Velásquez GE, Venkatesan N, Yamey G, Zimmerman A, Jamison D, Swaminathan S, and Goosby E

Subjects
Humans, Global Health, Tuberculosis epidemiology, Tuberculosis prevention & control
Abstract

Competing Interests: Declaration of interests ABe reports a grant through the University of California San Francisco (UCSF) from the US Agency for International Development (USAID) for the SMART4TB Initiative. RC reports a grant from USAID. HC is a member of the Data Safety Monitoring Board for the TRIAD study. CMD reports grants from the US National Institutes of Health (NIH), WHO, German Ministry of Education and Research, German Alliance for Global Health Research, USAID, FIND, German Center for Infection Research, UNAIDS, and Roche Diagnostics; is an academic editor for PLOS Medicine; and is a member of the WHO technical advisory group for tuberculosis diagnostics. EG is a board member for the TB Alliance and reports a grant from USAID for the SMART4TB Initiative. JH reports a grant from the Stop TB Partnership Private Sector Constituency. NH is a member of the British Parliament and co-chair of the Global TB Caucus. PHo reports a grant from USAID for the SMART4TB Initiative. AKi reports personal fees and a contract through UCSF (which also provides travel support) from USAID for the SMART4TB Initiative. IK holds a leadership position at the Save the Children Federation. EL reports personal fees from USAID for the SMART4TB initiative and held a leadership position with Treatment Action Group. PN reports a grant from USAID for the SMART4TB Initiative. MRe reports a grant from USAID for the SMART4TB Initiative. MO reports grants from the Global Fund, Johnson & Johnson, and Cepheid. MP serves as an advisor for the Bill & Melinda Gates Foundation, Foundation for Innovative New Diagnostics, WHO, and Stop TB Partnership. PS reports stock in Hyfe AI. AV reports a grant from Johnson & Johnson. GEV reports grants from the NIH/National Institute of Allergy and Infectious Diseases, Harvard Medical School, Harvard Global Health Institute, Unitaid/Partners in Health, and USAID; and is a protocol co-vice chair for a study with the TB Alliance and for a study with Janssen. GY reports grants from the Gates Foundation and WHO. AZ reports personal fees from Open Consultants. AC reports grants from the US NIH, Global Health Labs, and USAID; and is a member of the Centers for Disease Control and Prevention Advisory Council on Elimination of TB. PHe reports a grant from the Gates Foundation. The remaining authors declare no competing interests.

Published
2023
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6. Global knowledge gaps on antimicrobial resistance in the human health sector: A scoping review.

Author

Hamers RL, Dobreva Z, Cassini A, Tamara A, Lazarus G, Asadinia KS, Burzo S, Olaru ID, Dona D, Emdin F, Van Weezenbeek K, and Bertagnolio S

Subjects
Humans, Drug Resistance, Bacterial, World Health Organization, Bacteria, Anti-Bacterial Agents pharmacology, Anti-Bacterial Agents therapeutic use, Anti-Infective Agents pharmacology
Abstract

Objectives: To identify and summarize existing global knowledge gaps on antimicrobial resistance (AMR) in human health, focusing on the World Health Organization (WHO) bacterial priority pathogens, Mycobacterium tuberculosis, and selected fungi., Methods: We conducted a scoping review of gray and peer-reviewed literature, published in English from January 2012 through December 2021, that reported on the prevention, diagnosis, treatment, and care of drug-resistant infections. We extracted relevant knowledge gaps and, through an iterative process, consolidated those into thematic research questions., Results: Of 8409 publications screened, 1156 were included, including 225 (19.5%) from low- and middle-income countries. A total of 2340 knowledge gaps were extracted, in the following areas: antimicrobial research and development, AMR burden and drivers, resistant tuberculosis, antimicrobial stewardship, diagnostics, infection prevention and control, antimicrobial consumption and use data, immunization, sexually transmitted infections, AMR awareness and education, policies and regulations, fungi, water sanitation and hygiene, and foodborne diseases. The knowledge gaps were consolidated into 177 research questions, including 78 (44.1%) specifically relevant to low- and middle-income countries and 65 (36.7%) targeting vulnerable populations., Conclusion: This scoping review presents the most comprehensive compilation of AMR-related knowledge gaps to date, informing a priority-setting exercise to develop the WHO Global AMR Research Agenda for the human health sector., Competing Interests: Declaration of Competing Interest ZD, KvW, and SBe are World Health Organization (WHO) employees. AC was a WHO employee. SBu and DD are consultants to WHO. RLH was a consultant to WHO and is also supported by the Wellcome Trust (106680/Z/14/Z). The findings and conclusions in this report are those of the authors and do not necessarily represent the official position of WHO or any of the institutions mentioned., (Copyright © 2023. Published by Elsevier Ltd.)

Published
2023
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7. Antimicrobial resistance: Strengthening surveillance for public health action.

Author

Bertagnolio S, Suthar AB, Tosas O, and Van Weezenbeek K

Subjects
Humans, Drug Resistance, Bacterial, World Health Organization, Microbial Sensitivity Tests, Anti-Bacterial Agents pharmacology, Anti-Bacterial Agents therapeutic use, Public Health
Abstract

Competing Interests: We have read the journal’s policy and the authors of this manuscript have the following competing interests: ABS is an Academic Editor on PLOS Medicine’s editorial board.

Published
2023
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8. Building a tuberculosis-free world: The Lancet Commission on tuberculosis.

Author

Reid MJA, Arinaminpathy N, Bloom A, Bloom BR, Boehme C, Chaisson R, Chin DP, Churchyard G, Cox H, Ditiu L, Dybul M, Farrar J, Fauci AS, Fekadu E, Fujiwara PI, Hallett TB, Hanson CL, Harrington M, Herbert N, Hopewell PC, Ikeda C, Jamison DT, Khan AJ, Koek I, Krishnan N, Motsoaledi A, Pai M, Raviglione MC, Sharman A, Small PM, Swaminathan S, Temesgen Z, Vassall A, Venkatesan N, van Weezenbeek K, Yamey G, Agins BD, Alexandru S, Andrews JR, Beyeler N, Bivol S, Brigden G, Cattamanchi A, Cazabon D, Crudu V, Daftary A, Dewan P, Doepel LK, Eisinger RW, Fan V, Fewer S, Furin J, Goldhaber-Fiebert JD, Gomez GB, Graham SM, Gupta D, Kamene M, Khaparde S, Mailu EW, Masini EO, McHugh L, Mitchell E, Moon S, Osberg M, Pande T, Prince L, Rade K, Rao R, Remme M, Seddon JA, Selwyn C, Shete P, Sachdeva KS, Stallworthy G, Vesga JF, Vilc V, and Goosby EP

Subjects
Cost of Illness, Disease Eradication, Global Health statistics & numerical data, Goals, Health Policy, Health Priorities, Humans, Incidence, Leadership, Mortality, Mycobacterium tuberculosis drug effects, Mycobacterium tuberculosis pathogenicity, Political Systems, Quality of Health Care standards, Tuberculosis, Pulmonary drug therapy, Tuberculosis, Pulmonary epidemiology, World Health Organization economics, Global Health legislation & jurisprudence, Quality of Health Care trends, Research economics, Tuberculosis, Pulmonary economics, Tuberculosis, Pulmonary prevention & control
Published
2019
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