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5. Development and validation of prognostic models for anal cancer outcomes using distributed learning: protocol for the international multi-centre atomCAT2 study

Author

Theophanous, Stelios, Lønne, Per-Ivar, Choudhury, Ananya, Berbee, Maaike, Dekker, Andre, Dennis, Kristopher, Dewdney, Alice, Gambacorta, Maria Antonietta, Gilbert, Alexandra, Guren, Marianne Grønlie, Holloway, Lois, Jadon, Rashmi, Kochhar, Rohit, Mohamed, Ahmed Allam, Muirhead, Rebecca, Parés, Oriol, Raszewski, Lukasz, Roy, Rajarshi, Scarsbrook, Andrew, Sebag-Montefiore, David, Spezi, Emiliano, Spindler, Karen-Lise Garm, van Triest, Baukelien, Vassiliou, Vassilios, Malinen, Eirik, Wee, Leonard, and Appelt, Ane L.

Published
2022
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6. Patterns of Care, Tolerability, and Safety of the First Cohort of Patients Treated on a Novel High-Field MR-Linac Within the MOMENTUM Study: Initial Results From a Prospective Multi-Institutional Registry

Author

de Mol van Otterloo, Sophie R., Christodouleas, John P., Blezer, Erwin L.A., Akhiat, Hafid, Brown, Kevin, Choudhury, Ananya, Eggert, Dave, Erickson, Beth A., Daamen, Lois A., Faivre-Finn, Corinne, Fuller, Clifton D., Goldwein, Joel, Hafeez, Shaista, Hall, Emma, Harrington, Kevin J., van der Heide, Uulke A., Huddart, Robert A., Intven, Martijn P.W., Kirby, Anna M., Lalondrelle, Susan, McCann, Claire, Minsky, Bruce D., Mook, Stella, Nowee, Marlies E., Oelfke, Uwe, Orrling, Kristina, Philippens, Marielle E.P., Sahgal, Arjun, Schultz, Christopher J., Tersteeg, Robbert J.H.A., Tijssen, Rob H.N., Tree, Alison C., van Triest, Baukelien, Tseng, Chia-Lin, Hall, William A., and Verkooijen, Helena M.

Published
2021
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9. Trends in epidemiology and primary treatment of anal squamous cell carcinoma in the Netherlands (1990–2021).

Author

Ho, Vincent K. Y., Deijen, Charlotte L., Hemmes, Birgit, van Erning, Felice N., Snaebjornsson, Petur, van Triest, Baukelien, and Grotenhuis, Brechtje A.

Subjects
SQUAMOUS cell carcinoma, POISSON regression, EPIDEMIOLOGY, AGE distribution, DISEASE progression
Abstract

A rapid increase in the incidence of anal squamous cell carcinoma (SCC) was reported in several countries over the past decades. This study assessed trends in epidemiology and primary treatment over a 32‐year period (1990–2021) using the Netherlands Cancer Registry. The study population included 4273 patients, 44.2% male and 55.8% female (median age 63 years). The age‐standardised incidence rate (European Standardised Rate, ESR) increased from 0.5 to 1.6 per 100,000, which entailed an average annual percentage change (AAPC) of 5.0% (95% confidence interval [CI]: 4.5%–5.8%). While incidence among females increased continuously over the total period (AAPC 4.9%; 95%CI: 4.4%–5.6%), to 1.8 per 100,000 ESR in 2021, incidence among males increased until 2016 (annual percentage change [APC] of 6.3%; 95%CI: 5.6%–10.7%), after which it seemed to stabilise (APC −2.1%; 95%CI: −16.8%–4.5%). Significant trends were also observed in distribution of age, tumour stage and primary treatment modalities. Five‐year relative survival (RS) was estimated using the Pohar–Perme estimator, and this improved from 56.1% in 1990–1997 (95%CI: 49.3%–62.4%) to 67.9% in 2014–2021 (95%CI: 64.7%–70.9%), but remained poor for stage IV disease. Evaluation through a multivariable Poisson regression model demonstrated diagnosis in the most recent period to be independently associated with better RS, in addition to female sex, younger age, early disease stage and any treatment. In conclusion, the rising incidence of anal SCC seems to decline in males, but not in females, and advances in diagnostics and therapeutic management have likely contributed to improved prognosis. [ABSTRACT FROM AUTHOR]

Published
2024
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16. A Phase 1 Study of the DNA-PK Inhibitor Peposertib in Combination With Radiation Therapy With or Without Cisplatin in Patients With Advanced Head and Neck Tumors

Author

Samuels, Michael, primary, Falkenius, Johan, additional, Bar-Ad, Voichita, additional, Dunst, Juergen, additional, van Triest, Baukelien, additional, Yachnin, Jeffrey, additional, Rodriguez-Gutierrez, Almudena, additional, Kuipers, Mirjam, additional, You, Xiaoli, additional, Sarholz, Barbara, additional, Locatelli, Giuseppe, additional, Becker, Andreas, additional, and Troost, Esther G.C., additional

Published
2023
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17. Outcomes and potential impact of a virtual hands-on training program on MRI staging confidence and performance in rectal cancer

Author

El Khababi, Najim, primary, Beets-Tan, Regina G. H., additional, Tissier, Renaud, additional, Lahaye, Max J., additional, Maas, Monique, additional, Curvo-Semedo, Luís, additional, Dresen, Raphaëla C., additional, van Griethuysen, Joost J. M., additional, Nougaret, Stephanie, additional, Beets, Geerard L., additional, van Triest, Baukelien, additional, Taylor, Stuart A., additional, and Lambregts, Doenja M. J., additional

Published
2023
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25. Radiotherapy quality assurance for mesorectum treatment planning within the multi-center phase II STAR-TReC trial: Dutch results

Author

van den Ende, Roy P. J., Peters, Femke P., Harderwijk, Ernst, Rütten, Heidi, Bouwmans, Liza, Berbee, Maaike, Canters, Richard A. M., Stoian, Georgiana, Compagner, Kim, Rozema, Tom, de Smet, Mariska, Intven, Martijn P. W., Tijssen, Rob H. N., Theuws, Jacqueline, van Haaren, Paul, van Triest, Baukelien, Eekhout, Dave, Marijnen, Corrie A. M., van der Heide, Uulke A., and Kerkhof, Ellen M.

Published
2020
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27. Supplementary File 6: Pulmonary Function Tests and Pulmonary Adverse Events by Treatment Arm. from Phase I and Pharmacologic Study of Olaparib in Combination with High-dose Radiotherapy with and without Concurrent Cisplatin for Non–Small Cell Lung Cancer

Author

de Haan, Rosemarie, primary, van den Heuvel, Michel M., primary, van Diessen, Judi, primary, Peulen, Heike M.U., primary, van Werkhoven, Erik, primary, de Langen, Adrianus J., primary, Lalezari, Ferry, primary, Pluim, Dick, primary, Verwijs-Janssen, Manon, primary, Vens, Conchita, primary, Schellens, Jan H.M., primary, Steeghs, Neeltje, primary, Verheij, Marcel, primary, and van Triest, Baukelien, primary

Published
2023
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28. Supplementary File 2: Treatment details. from Phase I and Pharmacologic Study of Olaparib in Combination with High-dose Radiotherapy with and without Concurrent Cisplatin for Non–Small Cell Lung Cancer

Author

de Haan, Rosemarie, primary, van den Heuvel, Michel M., primary, van Diessen, Judi, primary, Peulen, Heike M.U., primary, van Werkhoven, Erik, primary, de Langen, Adrianus J., primary, Lalezari, Ferry, primary, Pluim, Dick, primary, Verwijs-Janssen, Manon, primary, Vens, Conchita, primary, Schellens, Jan H.M., primary, Steeghs, Neeltje, primary, Verheij, Marcel, primary, and van Triest, Baukelien, primary

Published
2023
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29. Supplementary File 5: Esophageal Adverse Events. from Phase I and Pharmacologic Study of Olaparib in Combination with High-dose Radiotherapy with and without Concurrent Cisplatin for Non–Small Cell Lung Cancer

Author

de Haan, Rosemarie, primary, van den Heuvel, Michel M., primary, van Diessen, Judi, primary, Peulen, Heike M.U., primary, van Werkhoven, Erik, primary, de Langen, Adrianus J., primary, Lalezari, Ferry, primary, Pluim, Dick, primary, Verwijs-Janssen, Manon, primary, Vens, Conchita, primary, Schellens, Jan H.M., primary, Steeghs, Neeltje, primary, Verheij, Marcel, primary, and van Triest, Baukelien, primary

Published
2023
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30. Supplementary File 3: Dose Limiting Toxicity. from Phase I and Pharmacologic Study of Olaparib in Combination with High-dose Radiotherapy with and without Concurrent Cisplatin for Non–Small Cell Lung Cancer

Author

de Haan, Rosemarie, primary, van den Heuvel, Michel M., primary, van Diessen, Judi, primary, Peulen, Heike M.U., primary, van Werkhoven, Erik, primary, de Langen, Adrianus J., primary, Lalezari, Ferry, primary, Pluim, Dick, primary, Verwijs-Janssen, Manon, primary, Vens, Conchita, primary, Schellens, Jan H.M., primary, Steeghs, Neeltje, primary, Verheij, Marcel, primary, and van Triest, Baukelien, primary

Published
2023
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31. Supplementary File 1: Supplementary Methods. from Phase I and Pharmacologic Study of Olaparib in Combination with High-dose Radiotherapy with and without Concurrent Cisplatin for Non–Small Cell Lung Cancer

Author

de Haan, Rosemarie, primary, van den Heuvel, Michel M., primary, van Diessen, Judi, primary, Peulen, Heike M.U., primary, van Werkhoven, Erik, primary, de Langen, Adrianus J., primary, Lalezari, Ferry, primary, Pluim, Dick, primary, Verwijs-Janssen, Manon, primary, Vens, Conchita, primary, Schellens, Jan H.M., primary, Steeghs, Neeltje, primary, Verheij, Marcel, primary, and van Triest, Baukelien, primary

Published
2023
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32. Supplementary File 4: Adverse Events. from Phase I and Pharmacologic Study of Olaparib in Combination with High-dose Radiotherapy with and without Concurrent Cisplatin for Non–Small Cell Lung Cancer

Author

de Haan, Rosemarie, primary, van den Heuvel, Michel M., primary, van Diessen, Judi, primary, Peulen, Heike M.U., primary, van Werkhoven, Erik, primary, de Langen, Adrianus J., primary, Lalezari, Ferry, primary, Pluim, Dick, primary, Verwijs-Janssen, Manon, primary, Vens, Conchita, primary, Schellens, Jan H.M., primary, Steeghs, Neeltje, primary, Verheij, Marcel, primary, and van Triest, Baukelien, primary

Published
2023
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33. Supplementary File 8: Olaparib Pharmacokinetics. from Phase I and Pharmacologic Study of Olaparib in Combination with High-dose Radiotherapy with and without Concurrent Cisplatin for Non–Small Cell Lung Cancer

Author

de Haan, Rosemarie, primary, van den Heuvel, Michel M., primary, van Diessen, Judi, primary, Peulen, Heike M.U., primary, van Werkhoven, Erik, primary, de Langen, Adrianus J., primary, Lalezari, Ferry, primary, Pluim, Dick, primary, Verwijs-Janssen, Manon, primary, Vens, Conchita, primary, Schellens, Jan H.M., primary, Steeghs, Neeltje, primary, Verheij, Marcel, primary, and van Triest, Baukelien, primary

Published
2023
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34. Supplementary File 7: Loco-regional control and survival. from Phase I and Pharmacologic Study of Olaparib in Combination with High-dose Radiotherapy with and without Concurrent Cisplatin for Non–Small Cell Lung Cancer

Author

de Haan, Rosemarie, primary, van den Heuvel, Michel M., primary, van Diessen, Judi, primary, Peulen, Heike M.U., primary, van Werkhoven, Erik, primary, de Langen, Adrianus J., primary, Lalezari, Ferry, primary, Pluim, Dick, primary, Verwijs-Janssen, Manon, primary, Vens, Conchita, primary, Schellens, Jan H.M., primary, Steeghs, Neeltje, primary, Verheij, Marcel, primary, and van Triest, Baukelien, primary

Published
2023
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35. Radiotherapy, atezolizumab, and bevacizumab in rectal cancers with the aim of organ preservation: The TARZAN study.

Author

Verschoor, Yara L., primary, Lambregts, Doenja M. J., additional, van den Berg, José, additional, Grotenhuis, Brechtje A., additional, Aalbers, Arend, additional, Van Triest, Baukelien, additional, Beets-Tan, Regina G.H., additional, van de Belt, Marieke, additional, Dokter, Simone, additional, Balduzzi, Sara, additional, Voest, Emile E., additional, Haanen, John B. A. G., additional, van Leerdam, Monique E., additional, Beets, Geerard, additional, and Chalabi, Myriam, additional

Published
2023
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37. Features on Endoscopy and MRI after Treatment with Contact X-ray Brachytherapy for Rectal Cancer: Explorative Results

Author

Custers, Petra A., primary, Maas, Monique, additional, Lambregts, Doenja M. J., additional, Beets-Tan, Regina G. H., additional, Beets, Geerard L., additional, Peters, Femke P., additional, Marijnen, Corrie A. M., additional, van Leerdam, Monique E., additional, Huibregtse, Inge L., additional, and van Triest, Baukelien, additional

Published
2022
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39. Additional file 1 of Development and validation of prognostic models for anal cancer outcomes using distributed learning: protocol for the international multi-centre atomCAT2 study

Author

Theophanous, Stelios, Lønne, Per-Ivar, Choudhury, Ananya, Berbee, Maaike, Dekker, Andre, Dennis, Kristopher, Dewdney, Alice, Gambacorta, Maria Antonietta, Gilbert, Alexandra, Guren, Marianne Grønlie, Holloway, Lois, Jadon, Rashmi, Kochhar, Rohit, Mohamed, Ahmed Allam, Muirhead, Rebecca, Parés, Oriol, Raszewski, Lukasz, Roy, Rajarshi, Scarsbrook, Andrew, Sebag-Montefiore, David, Spezi, Emiliano, Spindler, Karen-Lise Garm, van Triest, Baukelien, Vassiliou, Vassilios, Malinen, Eirik, Wee, Leonard, and Appelt, Ane L.

Abstract

Additional file 1: Appendix 1. Data dictionary

Published
2022
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40. Additional file 2 of Development and validation of prognostic models for anal cancer outcomes using distributed learning: protocol for the international multi-centre atomCAT2 study

Author

Theophanous, Stelios, Lønne, Per-Ivar, Choudhury, Ananya, Berbee, Maaike, Dekker, Andre, Dennis, Kristopher, Dewdney, Alice, Gambacorta, Maria Antonietta, Gilbert, Alexandra, Guren, Marianne Grønlie, Holloway, Lois, Jadon, Rashmi, Kochhar, Rohit, Mohamed, Ahmed Allam, Muirhead, Rebecca, Parés, Oriol, Raszewski, Lukasz, Roy, Rajarshi, Scarsbrook, Andrew, Sebag-Montefiore, David, Spezi, Emiliano, Spindler, Karen-Lise Garm, van Triest, Baukelien, Vassiliou, Vassilios, Malinen, Eirik, Wee, Leonard, and Appelt, Ane L.

Abstract

Additional file 2: Appendix 2. Specification of secondary models

Published
2022
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41. Defining near-complete response following (chemo) radiotherapy for rectal cancer: systematic review.

Author

Custers, Petra A., Geubels, Barbara M., Beets, Geerard L., Lambregts, Doenja M. J., van Leerdam, Monique E., van Triest, Baukelien, and Maas, Monique

Subjects
RECTAL cancer, CANCER radiotherapy, DIGITAL rectal examination, DIFFUSION magnetic resonance imaging, WATCHFUL waiting
Abstract

Background: A uniform definition of a clinical near-complete response (near-CR) after neoadjuvant (chemo)radiotherapy for rectal cancer is lacking. A clear definition is necessary for uniformity in clinical practice and trial enrolment for organ-preserving treatments. This review aimed to provide an overview of the terminology, criteria, and features used in the literature to define a near-CR. Methods: A systematic review was performed based on the PRISMA statement. PubMed and Embase were searched up to May 2021 to identify the terminology, criteria, and features used to define a near-CR after (chemo)radiotherapy for rectal cancer. Studies with no clear cut-off point between a cCR and near-CR, studies using Response Evaluation Criteria In Solid Tumours, and studies including only complete responders were excluded. Results: A total of 1876 articles were found, of which 23 were included. Patients were managed by watchful waiting and/or additional local treatment in 11 and 17 of 23 studies respectively. Response evaluation included digital rectal examination (DRE) and/or endoscopy with MRI in 18 studies. The majority of studies used the term 'near-complete response'. In most studies, minor irregularities or a smooth induration with DRE and a small flat ulcer on endoscopy were considered to indicate a near-CR. On MRI, five studies used features (obvious downstaging with or without heterogeneous/irregular fibrosis on T2-weighted MRI or small spot of high signal on diffusion-weighted imaging), five studies used TNM criteria (ycT2), and four used magnetic resonance tumour regression grade (mrTRG) (mrTRG1-2/mrTRG2) to describe a near-CR. Conclusion: The terminology, criteria, and features used to describe a near-CR vary substantially, which can partly be explained by the different treatment strategies patients are selected for (watchful waiting or additional local treatment). A reproducible definition of near-CR is required. [ABSTRACT FROM AUTHOR]

Published
2023
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46. Phase II study of definitive chemoradiation for locally advanced squamous cell cancer of the vulva: An efficacy study

Author

van Triest, Baukelien, primary, Rasing, Marnix, additional, van der Velden, Jacobus, additional, de Hullu, Joanne, additional, Witteveen, Petronella O., additional, Beukema, Jannet C., additional, van der Steen-Banasik, Elsbieta, additional, Westerveld, Henrike, additional, Snyers, An, additional, Peters, Max, additional, Creutzberg, Carien L., additional, Nout, Remi A., additional, Lutgens, Ludy, additional, and Jürgenliemk-Schulz, Ina, additional

Published
2021
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47. Phase I and Pharmacologic Study of Olaparib in Combination with High-dose Radiotherapy with and without Concurrent Cisplatin for Non–Small Cell Lung Cancer

Author

de Haan, Rosemarie, primary, van den Heuvel, Michel M., additional, van Diessen, Judi, additional, Peulen, Heike M.U., additional, van Werkhoven, Erik, additional, de Langen, Adrianus J., additional, Lalezari, Ferry, additional, Pluim, Dick, additional, Verwijs-Janssen, Manon, additional, Vens, Conchita, additional, Schellens, Jan H.M., additional, Steeghs, Neeltje, additional, Verheij, Marcel, additional, and van Triest, Baukelien, additional

Published
2021
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48. The MOMENTUM Study: An International Registry for the Evidence-Based Introduction of MR-Guided Adaptive Therapy

Author

de Mol van Otterloo, Sophie R., primary, Christodouleas, John P., additional, Blezer, Erwin L. A., additional, Akhiat, Hafid, additional, Brown, Kevin, additional, Choudhury, Ananya, additional, Eggert, Dave, additional, Erickson, Beth A., additional, Faivre-Finn, Corinne, additional, Fuller, Clifton D., additional, Goldwein, Joel, additional, Hafeez, Shaista, additional, Hall, Emma, additional, Harrington, Kevin J., additional, van der Heide, Uulke A., additional, Huddart, Robert A., additional, Intven, Martijn P. W., additional, Kirby, Anna M., additional, Lalondrelle, Susan, additional, McCann, Claire, additional, Minsky, Bruce D., additional, Mook, Stella, additional, Nowee, Marlies E., additional, Oelfke, Uwe, additional, Orrling, Kristina, additional, Sahgal, Arjun, additional, Sarmiento, Jeffrey G., additional, Schultz, Christopher J., additional, Tersteeg, Robbert J. H. A., additional, Tijssen, Rob H. N., additional, Tree, Alison C., additional, van Triest, Baukelien, additional, Hall, William A., additional, and Verkooijen, Helena M., additional

Published
2020
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49. Gross tumour volume delineation in anal cancer on T2-weighted and diffusion-weighted MRI – Reproducibility between radiologists and radiation oncologists and impact of reader experience level and DWI image quality

Author

Min, Lisa A., primary, Vacher, Younan J.L., additional, Dewit, Luc, additional, Donker, Mila, additional, Sofia, Carmelo, additional, van Triest, Baukelien, additional, Bos, Paula, additional, van Griethuysen, Joost J.W., additional, Maas, Monique, additional, Beets-Tan, Regina G.H., additional, and Lambregts, Doenja M.J., additional

Published
2020
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