44 results on '"van Rij, Andre M."'
Search Results
2. The lower limb perforator veins in normal subjects
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Hill, Brigid G. and van Rij, André M.
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- 2022
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3. Guidelines for management of actual or suspected inadvertent intra-arterial injection of sclerosants.
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Parsi, Kurosh, De Maeseneer, Marianne, van Rij, Andre M, Rogan, Christopher, Bonython, Wendy, Devereux, John A, Lekich, Christopher K, Amos, Michael, Bozkurt, Ahmet Kursat, Connor, David E, Davies, Alun H, Gianesini, Sergio, Gibson, Kathleen, Gloviczki, Peter, Grabs, Anthony, Grillo, Lorena, Hafner, Franz, Huber, David, Iafrati, Mark, and Jackson, Mark
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ISCHEMIA treatment ,THROMBOSIS prevention ,HEMORRHAGE risk factors ,PERIPHERAL vascular disease treatment ,MEDICAL protocols ,CONSENSUS (Social sciences) ,ANTICOAGULANTS ,RISK assessment ,AMPUTATION ,WOUND healing ,UNNECESSARY surgery ,VASODILATORS ,SKIN diseases ,CHRONIC pain ,NEUROLOGIC manifestations of general diseases ,MENTAL health ,DIFFERENTIAL diagnosis ,EXTRAVASATION ,NECROSIS ,DIGITAL subtraction angiography ,ENDOVASCULAR surgery ,FIBRINOLYTIC agents ,SCLEROTHERAPY ,THROMBECTOMY ,INTRA-arterial injections ,HEALTH care teams ,SKIN ulcers ,DRUG dosage ,DRUG administration - Abstract
Background: Inadvertent intra-arterial injection of sclerosants is an uncommon adverse event of both ultrasound-guided and direct vision sclerotherapy. This complication can result in significant tissue or limb loss and significant long-term morbidity. Objectives: To provide recommendations for diagnosis and immediate management of an unintentional intra-arterial injection of sclerosing agents. Methods: An international and multidisciplinary expert panel representing the endorsing societies and relevant specialities reviewed the published biomedical, scientific and legal literature and developed the consensus-based recommendations. Results: Actual and suspected cases of an intra-arterial sclerosant injection should be immediately transferred to a facility with a vascular/interventional unit. Digital Subtraction Angiography (DSA) is the key investigation to confirm the diagnosis and help select the appropriate intra-arterial therapy for tissue ischaemia. Emergency endovascular intervention will be required to manage the risk of major limb ischaemia. This includes intra-arterial administration of vasodilators to reduce vasospasm, and anticoagulants and thrombolytic agents to mitigate thrombosis. Mechanical thrombectomy, other endovascular interventions and even open surgery may be required. Lumbar sympathetic block may be considered but has a high risk of bleeding. Systemic anti-inflammatory agents, anticoagulants, and platelet inhibitors and modifiers would complement the intra-arterial endovascular procedures. For risk of minor ischaemia, systemic oral anti-inflammatory agents, anticoagulants, vasodilators and antiplatelet treatments are recommended. Conclusion: Inadvertent intra-arterial injection is an adverse event of both ultrasound-guided and direct vision sclerotherapy. Medical practitioners performing sclerotherapy must ensure completion of a course of formal training (specialty or subspecialty training, or equivalent recognition) in the management of venous and lymphatic disorders (phlebology), and be personally proficient in the use of duplex ultrasound in vascular (both arterial and venous) applications, to diagnose and provide image guidance to venous procedure. Expertise in diagnosis and immediate management of an intra-arterial injection is essential for all practitioners performing sclerotherapy. [ABSTRACT FROM AUTHOR]
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- 2024
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4. Popliteal vein compression, obesity, and chronic venous disease
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Millen, Rebecca N., Thomas, Kate N., Versteeg, Matthew P.T., and van Rij, Andre M.
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- 2022
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5. Both Small and Large Infrarenal Aortic Size is Associated with an Increased Prevalence of Ischaemic Heart Disease
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Jones, Gregory T., Drinkwater, Ben, Blake-Barlow, Ashton, Hill, Geraldine B., Williams, Michael J.A., Krysa, Jolanta, van Rij, Andre M., and Coffey, Sean
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- 2020
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6. Triage of patients with venous and lymphatic diseases during the COVID-19 pandemic – The Venous and Lymphatic Triage and Acuity Scale (VELTAS):: A consensus document of the International Union of Phlebology (UIP), Australasian College of Phlebology (ACP), American Vein and Lymphatic Society (AVLS), American Venous Forum (AVF), European College of Phlebology (ECoP), European Venous Forum (EVF), Interventional Radiology Society of Australasia (IRSA), Latin American Venous Forum, Pan-American Society of Phlebology and Lymphology and the Venous Association of India (VAI)
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Parsi, Kurosh, van Rij, Andre M., Meissner, Mark H., Davies, Alun H., De Maeseneer, Marianne, Gloviczki, Peter, Benson, Stephen, Bottini, Oscar, Manuel Canata, Victor, Dinnen, Paul, Gasparis, Antonios, Gianesini, Sergio, Huber, David, Jenkins, David, Lal, Brajesh K., Kabnick, Lowell, Lim, Adrian, Marston, William, Granados, Alberto Martinez, Morrison, Nick, Nicolaides, Andrew, Paraskevas, Peter, Patel, Malay, Roberts, Stefania, Rogan, Christopher, Schul, Marlin W., Komlos, Pedro, Stirling, Andrew, Thibault, Simon, Varghese, Roy, Welch, Harold J., and Wittens, Cees H.A.
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- 2020
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7. Correcting for Body Surface Area Identifies the True Prevalence of Abdominal Aortic Aneurysm in Screened Women
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Jones, Gregory T., Sandiford, Peter, Hill, Geraldine B., Williams, Michael J.A., Khashram, Manar, Tilyard, Murray W., Hammond-Tooke, Graeme D., Krysa, Jolanda, and van Rij, Andre M.
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- 2019
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8. Microvenous Reflux in the Skin of Limbs with Superficial Venous Incompetence
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Govind, Darshna, Thomas, Kate N., Hill, Brigid G., and van Rij, Andre M.
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- 2018
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9. Publisher Correction: Dysregulation of ghrelin in diabetes impairs the vascular reparative response to hindlimb ischemia in a mouse model; clinical relevance to peripheral artery disease
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Neale, Joshua P. H., Pearson, James T., Thomas, Kate N., Tsuchimochi, Hirotsugu, Hosoda, Hiroshi, Kojima, Masayasu, Sato, Takahiro, Jones, Gregory T., Denny, Adam P., Daniels, Lorna J., Chandrasekera, Dhananjie, Liu, Ping, van Rij, Andre M., Katare, Rajesh, and Schwenke, Daryl O.
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- 2020
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10. Dysregulation of ghrelin in diabetes impairs the vascular reparative response to hindlimb ischemia in a mouse model; clinical relevance to peripheral artery disease
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Neale, Joshua P. H., Pearson, James T., Thomas, Kate N., Tsuchimochi, Hirotsugu, Hosoda, Hiroshi, Kojima, Masayasu, Sato, Takahiro, Jones, Gregory T., Denny, Adam P., Daniels, Lorna J., Chandrasekera, Dhananjie, Liu, Ping, van Rij, Andre M., Katare, Rajesh, and Schwenke, Daryl O.
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- 2020
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11. The natural history of ultrasound-detected recurrence in the groin following saphenofemoral treatment for varicose veins
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Versteeg, Matthew P.T., Macfarlane, Josie, Hill, Geraldine B., and van Rij, André M.
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- 2016
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12. A variant of the castor zinc finger 1 (CASZ1) gene is differentially associated with the clinical classification of chronic venous disease
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Jones, Gregory T., Marsman, Judith, Pardo, Luba M., Nijsten, Tamar, De Maeseneer, Marianne, Phillips, Vicky, Lynch-Sutherland, Chi, Horsfield, Julia, Krysa, Jolanda, and van Rij, Andre M.
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- 2019
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13. Reliability of Contrast-Enhanced Ultrasound for the Assessment of Muscle Perfusion in Health and Peripheral Arterial Disease
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Thomas, Kate N., Cotter, James D., Lucas, Samuel J.E., Hill, Brigid G., and van Rij, André M.
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- 2015
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14. Nonsynonymous Polymorphism in Guanine Monophosphate Synthetase Is a Risk Factor for Unfavorable Thiopurine Metabolite Ratios in Patients With Inflammatory Bowel Disease
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Roberts, Rebecca L, Wallace, Mary C, Seinen, Margien L, van Bodegraven, Adriaan A, Krishnaprasad, Krupa, Jones, Gregory T, van Rij, Andre M, Baird, Angela, Lawrance, Ian C, Prosser, Ruth, Bampton, Peter, Grafton, Rachel, Simms, Lisa A, Studd, Corrie, Bell, Sally J, Kennedy, Martin A, Halliwell, Jacob, Gearry, Richard B, Radford-Smith, Graham, Andrews, Jane M, McHugh, Patrick C, and Barclay, Murray L
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- 2018
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15. Corrigendum to “European Society for Vascular Surgery (ESVS) 2022 Clinical Practice Guidelines on the Management of Chronic Venous Disease of the Lower Limbs. [Eur J Vasc Endovasc Surg (2022) 63, 184-267]”
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De Maeseneer, Marianne G., primary, Kakkos, Stavros K., additional, Aherne, Thomas, additional, Baekgaard, Niels, additional, Black, Stephen, additional, Blomgren, Lena, additional, Giannoukas, Athanasios, additional, Gohel, Manjit, additional, de Graaf, Rick, additional, Hamel-Desnos, Claudine, additional, Jawien, Arkadiusz, additional, Jaworucka-Kaczorowska, Aleksandra, additional, Lattimer, Christopher R., additional, Mosti, Giovanni, additional, Noppeney, Thomas, additional, Josee van Rijn, Marie, additional, Stansby, Gerry, additional, Kolh, Philippe, additional, Goncalves, Frederico Bastos, additional, Chakfé, Nabil, additional, Coscas, Raphael, additional, de Borst, Gert J., additional, Dias, Nuno V., additional, Hinchliffe, Robert J., additional, Koncar, Igor B., additional, Lindholt, Jes S., additional, Trimarchi, Santi, additional, Tulamo, Riikka, additional, Twine, Christopher P., additional, Vermassen, Frank, additional, Wanhainen, Anders, additional, Björck, Martin, additional, Labropoulos, Nicos, additional, Lurie, Fedor, additional, Mansilha, Armando, additional, Nyamekye, Isaac K., additional, Ortega, Marta Ramirez, additional, Ulloa, Jorge H., additional, Urbanek, Tomasz, additional, van Rij, Andre M., additional, and Vuylsteke, Marc E., additional
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- 2022
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16. Pulsatile flow in venous perforators of the lower limb
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Thomas, Kate N., primary, Gibbons, Travis D., additional, Campbell, Holly A., additional, Cotter, James D., additional, and van Rij, Andre M., additional
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- 2022
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17. Variant ASGR1 Associated with a Reduced Risk of Coronary Artery Disease
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Nioi, Paul, Sigurdsson, Asgeir, Thorleifsson, Gudmar, Helgason, Hannes, Agustsdottir, Arna B., Norddahl, Gudmundur L., Helgadottir, Anna, Magnusdottir, Audur, Jonasdottir, Aslaug, Gretarsdottir, Solveig, Jonsdottir, Ingileif, Steinthorsdottir, Valgerdur, Rafnar, Thorunn, Swinkels, Dorine W., Galesloot, Tessel E., Grarup, Niels, Jørgensen, Torben, Vestergaard, Henrik, Hansen, Torben, Lauritzen, Torsten, Linneberg, Allan, Friedrich, Nele, Krarup, Nikolaj T., Fenger, Mogens, Abildgaard, Ulrik, Hansen, Peter R., Galløe, Anders M., Braund, Peter S., Nelson, Christopher P., Hall, Alistair S., Williams, Michael J.A., van Rij, Andre M., Jones, Gregory T., Patel, Riyaz S., Levey, Allan I., Hayek, Salim, Shah, Svati H., Reilly, Muredach, Eyjolfsson, Gudmundur I., Sigurdardottir, Olof, Olafsson, Isleifur, Kiemeney, Lambertus A., Quyyumi, Arshed A., Rader, Daniel J., Kraus, William E., Samani, Nilesh J., Pedersen, Oluf, Thorgeirsson, Gudmundur, Masson, Gisli, Holm, Hilma, Gudbjartsson, Daniel, Sulem, Patrick, Thorsteinsdottir, Unnur, and Stefansson, Kari
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- 2016
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18. European society for vascular surgery (ESVS) 2022 clinical practice guidelines on the management of chronic venous disease of the lower limbs
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De Maeseneer, Marianne G., Kakkos, Stavros K., Aherne, Thomas, Baekgaard, Niels, Black, Stephen, Blomgren, Lena, Giannoukas, Athanasios, Gohel, Manjit, de Graaf, Rick, Hamel-Desnos, Claudine, Jawien, Arkadiusz, Jaworucka-Kaczorowska, Aleksandra, Lattimer, Christopher R., Mosti, Giovanni, Noppeney, Thomas, Josee van Rijn, Marie, Stansby, Gerry, Kolh, Philippe, Bastos Goncalves, Frederico, Chakfe, Nabil, Coscas, Raphael, de Borst, Gert J., Dias, Nuno, V, Hinchliffe, Robert J., Koncar, Igor B., Lindholt, Jes S., Trimarchi, Santi, Tulamo, Riikka, Twine, Christopher P., Vermassen, Frank, Wanhainen, Anders, Bjorck, Martin, Labropoulos, Nicos, Lurie, Fedor, Mansilha, Armando, Nyamekye, Isaac K., Ramirez Ortega, Marta, Ulloa, Jorge H., Urbanek, Tomasz, van Rij, Andre M., Vuylsteke, Marc E., De Maeseneer, Marianne G., Kakkos, Stavros K., Aherne, Thomas, Baekgaard, Niels, Black, Stephen, Blomgren, Lena, Giannoukas, Athanasios, Gohel, Manjit, de Graaf, Rick, Hamel-Desnos, Claudine, Jawien, Arkadiusz, Jaworucka-Kaczorowska, Aleksandra, Lattimer, Christopher R., Mosti, Giovanni, Noppeney, Thomas, Josee van Rijn, Marie, Stansby, Gerry, Kolh, Philippe, Bastos Goncalves, Frederico, Chakfe, Nabil, Coscas, Raphael, de Borst, Gert J., Dias, Nuno, V, Hinchliffe, Robert J., Koncar, Igor B., Lindholt, Jes S., Trimarchi, Santi, Tulamo, Riikka, Twine, Christopher P., Vermassen, Frank, Wanhainen, Anders, Bjorck, Martin, Labropoulos, Nicos, Lurie, Fedor, Mansilha, Armando, Nyamekye, Isaac K., Ramirez Ortega, Marta, Ulloa, Jorge H., Urbanek, Tomasz, van Rij, Andre M., and Vuylsteke, Marc E.
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- 2022
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19. Editor's Choice - European Society for Vascular Surgery (ESVS) 2022 Clinical Practice Guidelines on the Management of Chronic Venous Disease of the Lower Limbs
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Zorgeenheid Vaatchirurgie Medisch, Brain, Circulatory Health, Regenerative Medicine and Stem Cells, De Maeseneer, Marianne G, Kakkos, Stavros K, Aherne, Thomas, Baekgaard, Niels, Black, Stephen, Blomgren, Lena, Giannoukas, Athanasios, Gohel, Manjit, de Graaf, Rick, Hamel-Desnos, Claudine, Jawien, Arkadiusz, Jaworucka-Kaczorowska, Aleksandra, Lattimer, Christopher R, Mosti, Giovanni, Noppeney, Thomas, van Rijn, Marie Josee, Stansby, Gerry, Esvs Guidelines Committee, Guidelines Committee, Kolh, Philippe, Bastos Goncalves, Frederico, Chakfé, Nabil, Coscas, Raphael, de Borst, Gert J, Dias, Nuno V, Hinchliffe, Robert J, Koncar, Igor B, Lindholt, Jes S, Trimarchi, Santi, Tulamo, Riikka, Twine, Christopher P, Vermassen, Frank, Wanhainen, Anders, Document Reviewers, Reviewers, Björck, Martin, Labropoulos, Nicos, Lurie, Fedor, Mansilha, Armando, Nyamekye, Isaac K, Ramirez Ortega, Marta, Ulloa, Jorge H, Urbanek, Tomasz, van Rij, Andre M, Vuylsteke, Marc E, Zorgeenheid Vaatchirurgie Medisch, Brain, Circulatory Health, Regenerative Medicine and Stem Cells, De Maeseneer, Marianne G, Kakkos, Stavros K, Aherne, Thomas, Baekgaard, Niels, Black, Stephen, Blomgren, Lena, Giannoukas, Athanasios, Gohel, Manjit, de Graaf, Rick, Hamel-Desnos, Claudine, Jawien, Arkadiusz, Jaworucka-Kaczorowska, Aleksandra, Lattimer, Christopher R, Mosti, Giovanni, Noppeney, Thomas, van Rijn, Marie Josee, Stansby, Gerry, Esvs Guidelines Committee, Guidelines Committee, Kolh, Philippe, Bastos Goncalves, Frederico, Chakfé, Nabil, Coscas, Raphael, de Borst, Gert J, Dias, Nuno V, Hinchliffe, Robert J, Koncar, Igor B, Lindholt, Jes S, Trimarchi, Santi, Tulamo, Riikka, Twine, Christopher P, Vermassen, Frank, Wanhainen, Anders, Document Reviewers, Reviewers, Björck, Martin, Labropoulos, Nicos, Lurie, Fedor, Mansilha, Armando, Nyamekye, Isaac K, Ramirez Ortega, Marta, Ulloa, Jorge H, Urbanek, Tomasz, van Rij, Andre M, and Vuylsteke, Marc E
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- 2022
20. Meta-Analysis of Genome-Wide Association Studies for Abdominal Aortic Aneurysm Identifies Four New Disease-Specific Risk Loci
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Jones, Gregory T., Tromp, Gerard, Kuivaniemi, Helena, Gretarsdottir, Solveig, Baas, Annette F., Giusti, Betti, Strauss, Ewa, van‘t Hof, Femke N.G., Webb, Thomas R., Erdman, Robert, Ritchie, Marylyn D., Elmore, James R., Verma, Anurag, Pendergrass, Sarah, Kullo, Iftikhar J., Ye, Zi, Peissig, Peggy L., Gottesman, Omri, Verma, Shefali S., Malinowski, Jennifer, Rasmussen-Torvik, Laura J., Borthwick, Kenneth M., Smelser, Diane T., Crosslin, David R., de Andrade, Mariza, Ryer, Evan J., McCarty, Catherine A., Böttinger, Erwin P., Pacheco, Jennifer A., Crawford, Dana C., Carrell, David S., Gerhard, Glenn S., Franklin, David P., Carey, David J., Phillips, Victoria L., Williams, Michael J.A., Wei, Wenhua, Blair, Ross, Hill, Andrew A., Vasudevan, Thodor M., Lewis, David R., Thomson, Ian A., Krysa, Jo, Hill, Geraldine B., Roake, Justin, Merriman, Tony R., Oszkinis, Grzegorz, Galora, Silvia, Saracini, Claudia, Abbate, Rosanna, Pulli, Raffaele, Pratesi, Carlo, Saratzis, Athanasios, Verissimo, Ana R., Bumpstead, Suzannah, Badger, Stephen A., Clough, Rachel E., Cockerill, Gillian, Hafez, Hany, Scott, D. Julian A., Futers, T. Simon, Romaine, Simon P.R., Bridge, Katherine, Griffin, Kathryn J., Bailey, Marc A., Smith, Alberto, Thompson, Matthew M., van Bockxmeer, Frank M., Matthiasson, Stefan E., Thorleifsson, Gudmar, Thorsteinsdottir, Unnur, Blankensteijn, Jan D., Teijink, Joep A.W., Wijmenga, Cisca, de Graaf, Jacqueline, Kiemeney, Lambertus A., Lindholt, Jes S., Hughes, Anne, Bradley, Declan T., Stirrups, Kathleen, Golledge, Jonathan, Norman, Paul E., Powell, Janet T., Humphries, Steve E., Hamby, Stephen E., Goodall, Alison H., Nelson, Christopher P., Sakalihasan, Natzi, Courtois, Audrey, Ferrell, Robert E., Eriksson, Per, Folkersen, Lasse, Franco-Cereceda, Anders, Eicher, John D., Johnson, Andrew D., Betsholtz, Christer, Ruusalepp, Arno, Franzén, Oscar, Schadt, Eric E., Björkegren, Johan L.M., Lipovich, Leonard, Drolet, Anne M., Verhoeven, Eric L., Zeebregts, Clark J., Geelkerken, Robert H., van Sambeek, Marc R., van Sterkenburg, Steven M., de Vries, Jean-Paul, Stefansson, Kari, Thompson, John R., de Bakker, Paul I.W., Deloukas, Panos, Sayers, Robert D., Harrison, Seamus C., van Rij, Andre M., Samani, Nilesh J., and Bown, Matthew J.
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- 2017
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21. European Society for Vascular Surgery (ESVS) 2022 Clinical Practice Guidelines on the Management of Chronic Venous Disease of the Lower Limbs
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De Maeseneer, Marianne G, Kakkos, Stavros K, Aherne, Thomas, Baekgaard, Niels, Black, Stephen, Blomgren, Lena, Giannoukas, Athanasios, Gohel, Manjit, de Graaf, Rick, Hamel-Desnos, Claudine, Jawien, Arkadiusz, Jaworucka-Kaczorowska, Aleksandra, Lattimer, Christopher R, Mosti, Giovanni, Noppeney, Thomas, Josee van Rijn, Marie, Stansby, Gerry, Kolh, Philippe, Bastos Goncalves, Frederico, Chakfe, Nabil, Coscas, Raphael, de Borst, Gert J, Dias, Nuno, Hinchliffe, Robert J, Koncar, Igor B, Lindholt, Jes S, Trimarchi, Santi, Tulamo, Riikka, Twine, Christopher P, Vermassen, Frank, Wanhainen, Anders, Bjorck, Martin, Labropoulos, Nicos, Lurie, Fedor, Mansilha, Armando, Nyamekye, Isaac K, Ramirez Ortega, Marta, Ulloa, Jorge H, Urbanek, Tomasz, van Rij, Andre M, and Vuylsteke, Marc E
- Subjects
Science & Technology ,ELASTIC COMPRESSION STOCKINGS ,STRAIN-GAUGE PLETHYSMOGRAPHY ,Kirurgi ,RANDOMIZED CONTROLLED-TRIAL ,HEAT-INDUCED THROMBOSIS ,GUIDED FOAM SCLEROTHERAPY ,RECURRENT VARICOSE-VEINS ,TRANSILLUMINATED POWERED PHLEBECTOMY ,Peripheral Vascular Disease ,QUALITY-OF-LIFE ,GREAT SAPHENOUS-VEIN ,Cardiovascular System & Cardiology ,Surgery ,ENDOVENOUS LASER-ABLATION ,Life Sciences & Biomedicine - Abstract
ispartof: EUROPEAN JOURNAL OF VASCULAR AND ENDOVASCULAR SURGERY vol:63 issue:2 pages:184-267 ispartof: location:England status: published
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- 2022
22. Plasma heat shock protein 27 is associated with coronary artery disease, abdominal aortic aneurysm and peripheral artery disease
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Jin, Cao, Phillips, Victoria L, Williams, Michael JA, van Rij, Andre M, and Jones, Gregory T
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- 2014
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23. Exercise, Bulging Veins and Venous Disease
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van Rij, André M. and Thomas, Kate N.
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- 2023
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24. Triage of patients with venous and lymphatic diseases during the COVID-19 pandemic – The Venous and Lymphatic Triage and Acuity Scale (VELTAS)
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Parsi, Kurosh, primary, van Rij, Andre M, additional, Meissner, Mark H, additional, Davies, Alun H, additional, Maeseneer, Marianne De, additional, Gloviczki, Peter, additional, Benson, Stephen, additional, Bottini, Oscar, additional, Canata, Victor Manuel, additional, Dinnen, Paul, additional, Gasparis, Antonios, additional, Gianesini, Sergio, additional, Huber, David, additional, Jenkins, David, additional, Lal, Brajesh K, additional, Kabnick, Lowell, additional, Lim, Adrian, additional, Marston, William, additional, Granados, Alberto Martinez, additional, Morrison, Nick, additional, Nicolaides, Andrew, additional, Paraskevas, Peter, additional, Patel, Malay, additional, Roberts, Stefania, additional, Rogan, Christopher, additional, Schul, Marlin W, additional, Komlos, Pedro, additional, Stirling, Andrew, additional, Thibault, Simon, additional, Varghese, Roy, additional, Welch, Harold J, additional, and Wittens, Cees HA, additional
- Published
- 2020
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25. Heat therapy vs. supervised exercise therapy for peripheral arterial disease: a 12-wk randomized, controlled trial
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Akerman, Ashley P., primary, Thomas, Kate N., additional, van Rij, Andre M., additional, Body, E. Dianne, additional, Alfadhel, Mesfer, additional, and Cotter, James D., additional
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- 2019
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26. Genetic Association of Lipids and Lipid Drug Targets With Abdominal Aortic Aneurysm : A Meta-analysis
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Harrison, Seamus C., Holmes, Michael V., Burgess, Stephen, Asselbergs, Folkert W., Jones, Gregory T., Baas, Annette F., Van't Hof, F. N., De Bakker, Paul I.W., Blankensteijn, Jan D., Powell, Janet T., Saratzis, Athanasios, De Borst, Gert J., Swerdlow, Daniel I., Van Der Graaf, Yolanda, Van Rij, Andre M., Carey, David J., Elmore, James R., Tromp, Gerard, Kuivaniemi, Helena, Sayers, Robert D., Samani, Nilesh J., Bown, Matthew J., Humphries, Steve E., Harrison, Seamus C., Holmes, Michael V., Burgess, Stephen, Asselbergs, Folkert W., Jones, Gregory T., Baas, Annette F., Van't Hof, F. N., De Bakker, Paul I.W., Blankensteijn, Jan D., Powell, Janet T., Saratzis, Athanasios, De Borst, Gert J., Swerdlow, Daniel I., Van Der Graaf, Yolanda, Van Rij, Andre M., Carey, David J., Elmore, James R., Tromp, Gerard, Kuivaniemi, Helena, Sayers, Robert D., Samani, Nilesh J., Bown, Matthew J., and Humphries, Steve E.
- Published
- 2018
27. Genetic Association of Lipids and Lipid Drug Targets With Abdominal Aortic Aneurysm: A Meta-analysis
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Team Medisch, Circulatory Health, Genetica Klinische Genetica, CMM Groep Kaaij, Zorgeenheid Vaatchirurgie Medisch, Cardiovasculaire Epi Team 5, Cardiovasculaire Epi Team 7, JC onderzoeksprogramma Cardiovasculaire Epidemiologie, Harrison, Seamus C., Holmes, Michael V., Burgess, Stephen, Asselbergs, Folkert W., Jones, Gregory T., Baas, Annette F., Van't Hof, F. N., De Bakker, Paul I.W., Blankensteijn, Jan D., Powell, Janet T., Saratzis, Athanasios, De Borst, Gert J., Swerdlow, Daniel I., Van Der Graaf, Yolanda, Van Rij, Andre M., Carey, David J., Elmore, James R., Tromp, Gerard, Kuivaniemi, Helena, Sayers, Robert D., Samani, Nilesh J., Bown, Matthew J., Humphries, Steve E., Team Medisch, Circulatory Health, Genetica Klinische Genetica, CMM Groep Kaaij, Zorgeenheid Vaatchirurgie Medisch, Cardiovasculaire Epi Team 5, Cardiovasculaire Epi Team 7, JC onderzoeksprogramma Cardiovasculaire Epidemiologie, Harrison, Seamus C., Holmes, Michael V., Burgess, Stephen, Asselbergs, Folkert W., Jones, Gregory T., Baas, Annette F., Van't Hof, F. N., De Bakker, Paul I.W., Blankensteijn, Jan D., Powell, Janet T., Saratzis, Athanasios, De Borst, Gert J., Swerdlow, Daniel I., Van Der Graaf, Yolanda, Van Rij, Andre M., Carey, David J., Elmore, James R., Tromp, Gerard, Kuivaniemi, Helena, Sayers, Robert D., Samani, Nilesh J., Bown, Matthew J., and Humphries, Steve E.
- Published
- 2018
28. Open retrieval of an inferior vena cava filter penetrating into a horseshoe kidney
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Taylor, Sam G., primary, Jung, Hong K., additional, Gerson, David, additional, and van Rij, Andre M., additional
- Published
- 2018
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29. Accuracy and repeatability of the Dopplex Ability
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Millen, Rebecca N., primary, Thomas, Kate N., additional, Majumder, Arunesh, additional, Hill, Brigid G., additional, Van Rij, Andre M., additional, and Krysa, Jo, additional
- Published
- 2018
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30. Genetic Association of Lipids and Lipid Drug Targets With Abdominal Aortic Aneurysm
- Author
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Harrison, Seamus C., primary, Holmes, Michael V., additional, Burgess, Stephen, additional, Asselbergs, Folkert W., additional, Jones, Gregory T., additional, Baas, Annette F., additional, van ’t Hof, F. N., additional, de Bakker, Paul I. W., additional, Blankensteijn, Jan D., additional, Powell, Janet T., additional, Saratzis, Athanasios, additional, de Borst, Gert J., additional, Swerdlow, Daniel I., additional, van der Graaf, Yolanda, additional, van Rij, Andre M., additional, Carey, David J., additional, Elmore, James R., additional, Tromp, Gerard, additional, Kuivaniemi, Helena, additional, Sayers, Robert D., additional, Samani, Nilesh J., additional, Bown, Matthew J., additional, and Humphries, Steve E., additional
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- 2018
- Full Text
- View/download PDF
31. Meta-Analysis of Genome-Wide Association Studies for Abdominal Aortic Aneurysm Identifies Four New Disease-Specific Risk Loci
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Jones, Gregory T, Tromp, Gerard, Kuivaniemi, Helena, Gretarsdottir, Solveig, Baas, Annette F, Giusti, Betti, Strauss, Ewa, Van't Hof, Femke N G, Webb, Thomas R, Erdman, Robert, Ritchie, Marylyn D, Elmore, James R, Verma, Anurag, Pendergrass, Sarah, Kullo, Iftikhar J, Ye, Zi, Peissig, Peggy L, Gottesman, Omri, Verma, Shefali S, Malinowski, Jennifer, Rasmussen-Torvik, Laura J, Borthwick, Kenneth M, Smelser, Diane T, Crosslin, David R, de Andrade, Mariza, Ryer, Evan J, McCarty, Catherine A, Böttinger, Erwin P, Pacheco, Jennifer A, Crawford, Dana C, Carrell, David S, Gerhard, Glenn S, Franklin, David P, Carey, David J, Phillips, Victoria L, Williams, Michael J A, Wei, Wenhua, Blair, Ross, Hill, Andrew A, Vasudevan, Thodor M, Lewis, David R, Thomson, Ian A, Krysa, Jo, Hill, Geraldine B, Roake, Justin, Merriman, Tony R, Oszkinis, Grzegorz, Galora, Silvia, Saracini, Claudia, Abbate, Rosanna, Pulli, Raffaele, Pratesi, Carlo, Saratzis, Athanasios, Verissimo, Ana R, Bumpstead, Suzannah, Badger, Stephen A, Clough, Rachel E, Cockerill, Gillian, Hafez, Hany, Scott, D Julian A, Futers, T Simon, Romaine, Simon P R, Bridge, Katherine, Griffin, Kathryn J, Bailey, Marc A, Smith, Alberto, Thompson, Matthew M, van Bockxmeer, Frank M, Matthiasson, Stefan E, Thorleifsson, Gudmar, Thorsteinsdottir, Unnur, Blankensteijn, Jan D, Teijink, Joep A W, Wijmenga, Cisca, de Graaf, Jacqueline, Kiemeney, Lambertus A, Lindholt, Jes S, Hughes, Anne, Bradley, Declan T, Stirrups, Kathleen, Golledge, Jonathan, Norman, Paul E, Powell, Janet T, Humphries, Steve E, Hamby, Stephen E, Goodall, Alison H, Nelson, Christopher P, Sakalihasan, Natzi, Courtois, Audrey, Ferrell, Robert E, Eriksson, Per, Folkersen, Lasse, Franco-Cereceda, Anders, Eicher, John D, Johnson, Andrew D, Betsholtz, Christer, Ruusalepp, Arno, Franzén, Oscar, Schadt, Eric E, Björkegren, Johan L M, Lipovich, Leonard, Drolet, Anne M, Verhoeven, Eric L, Zeebregts, Clark J, Geelkerken, Robert H, van Sambeek, Marc R, van Sterkenburg, Steven M, de Vries, Jean-Paul, Stefansson, Kari, Thompson, John R, de Bakker, Paul I W, Deloukas, Panos, Sayers, Robert D, Harrison, Seamus C, van Rij, Andre M, Samani, Nilesh J, Bown, Matthew J, Jones, Gregory T, Tromp, Gerard, Kuivaniemi, Helena, Gretarsdottir, Solveig, Baas, Annette F, Giusti, Betti, Strauss, Ewa, Van't Hof, Femke N G, Webb, Thomas R, Erdman, Robert, Ritchie, Marylyn D, Elmore, James R, Verma, Anurag, Pendergrass, Sarah, Kullo, Iftikhar J, Ye, Zi, Peissig, Peggy L, Gottesman, Omri, Verma, Shefali S, Malinowski, Jennifer, Rasmussen-Torvik, Laura J, Borthwick, Kenneth M, Smelser, Diane T, Crosslin, David R, de Andrade, Mariza, Ryer, Evan J, McCarty, Catherine A, Böttinger, Erwin P, Pacheco, Jennifer A, Crawford, Dana C, Carrell, David S, Gerhard, Glenn S, Franklin, David P, Carey, David J, Phillips, Victoria L, Williams, Michael J A, Wei, Wenhua, Blair, Ross, Hill, Andrew A, Vasudevan, Thodor M, Lewis, David R, Thomson, Ian A, Krysa, Jo, Hill, Geraldine B, Roake, Justin, Merriman, Tony R, Oszkinis, Grzegorz, Galora, Silvia, Saracini, Claudia, Abbate, Rosanna, Pulli, Raffaele, Pratesi, Carlo, Saratzis, Athanasios, Verissimo, Ana R, Bumpstead, Suzannah, Badger, Stephen A, Clough, Rachel E, Cockerill, Gillian, Hafez, Hany, Scott, D Julian A, Futers, T Simon, Romaine, Simon P R, Bridge, Katherine, Griffin, Kathryn J, Bailey, Marc A, Smith, Alberto, Thompson, Matthew M, van Bockxmeer, Frank M, Matthiasson, Stefan E, Thorleifsson, Gudmar, Thorsteinsdottir, Unnur, Blankensteijn, Jan D, Teijink, Joep A W, Wijmenga, Cisca, de Graaf, Jacqueline, Kiemeney, Lambertus A, Lindholt, Jes S, Hughes, Anne, Bradley, Declan T, Stirrups, Kathleen, Golledge, Jonathan, Norman, Paul E, Powell, Janet T, Humphries, Steve E, Hamby, Stephen E, Goodall, Alison H, Nelson, Christopher P, Sakalihasan, Natzi, Courtois, Audrey, Ferrell, Robert E, Eriksson, Per, Folkersen, Lasse, Franco-Cereceda, Anders, Eicher, John D, Johnson, Andrew D, Betsholtz, Christer, Ruusalepp, Arno, Franzén, Oscar, Schadt, Eric E, Björkegren, Johan L M, Lipovich, Leonard, Drolet, Anne M, Verhoeven, Eric L, Zeebregts, Clark J, Geelkerken, Robert H, van Sambeek, Marc R, van Sterkenburg, Steven M, de Vries, Jean-Paul, Stefansson, Kari, Thompson, John R, de Bakker, Paul I W, Deloukas, Panos, Sayers, Robert D, Harrison, Seamus C, van Rij, Andre M, Samani, Nilesh J, and Bown, Matthew J
- Published
- 2017
32. Meta-Analysis of Genome-Wide Association Studies for Abdominal Aortic Aneurysm Identifies Four New Disease-Specific Risk Loci
- Author
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Genetica Klinische Genetica, Circulatory Health, CMM Groep Kaaij, Brain, Infection & Immunity, Jones, Gregory T, Tromp, Gerard, Kuivaniemi, Helena, Gretarsdottir, Solveig, Baas, Annette F, Giusti, Betti, Strauss, Ewa, Van't Hof, Femke N G, Webb, Thomas R, Erdman, Robert, Ritchie, Marylyn D, Elmore, James R, Verma, Anurag, Pendergrass, Sarah, Kullo, Iftikhar J, Ye, Zi, Peissig, Peggy L, Gottesman, Omri, Verma, Shefali S, Malinowski, Jennifer, Rasmussen-Torvik, Laura J, Borthwick, Kenneth M, Smelser, Diane T, Crosslin, David R, de Andrade, Mariza, Ryer, Evan J, McCarty, Catherine A, Böttinger, Erwin P, Pacheco, Jennifer A, Crawford, Dana C, Carrell, David S, Gerhard, Glenn S, Franklin, David P, Carey, David J, Phillips, Victoria L, Williams, Michael J A, Wei, Wenhua, Blair, Ross, Hill, Andrew A, Vasudevan, Thodor M, Lewis, David R, Thomson, Ian A, Krysa, Jo, Hill, Geraldine B, Roake, Justin, Merriman, Tony R, Oszkinis, Grzegorz, Galora, Silvia, Saracini, Claudia, Abbate, Rosanna, Pulli, Raffaele, Pratesi, Carlo, Saratzis, Athanasios, Verissimo, Ana R, Bumpstead, Suzannah, Badger, Stephen A, Clough, Rachel E, Cockerill, Gillian, Hafez, Hany, Scott, D Julian A, Futers, T Simon, Romaine, Simon P R, Bridge, Katherine, Griffin, Kathryn J, Bailey, Marc A, Smith, Alberto, Thompson, Matthew M, van Bockxmeer, Frank M, Matthiasson, Stefan E, Thorleifsson, Gudmar, Thorsteinsdottir, Unnur, Blankensteijn, Jan D, Teijink, Joep A W, Wijmenga, Cisca, de Graaf, Jacqueline, Kiemeney, Lambertus A, Lindholt, Jes S, Hughes, Anne, Bradley, Declan T, Stirrups, Kathleen, Golledge, Jonathan, Norman, Paul E, Powell, Janet T, Humphries, Steve E, Hamby, Stephen E, Goodall, Alison H, Nelson, Christopher P, Sakalihasan, Natzi, Courtois, Audrey, Ferrell, Robert E, Eriksson, Per, Folkersen, Lasse, Franco-Cereceda, Anders, Eicher, John D, Johnson, Andrew D, Betsholtz, Christer, Ruusalepp, Arno, Franzén, Oscar, Schadt, Eric E, Björkegren, Johan L M, Lipovich, Leonard, Drolet, Anne M, Verhoeven, Eric L, Zeebregts, Clark J, Geelkerken, Robert H, van Sambeek, Marc R, van Sterkenburg, Steven M, de Vries, Jean-Paul, Stefansson, Kari, Thompson, John R, de Bakker, Paul I W, Deloukas, Panos, Sayers, Robert D, Harrison, Seamus C, van Rij, Andre M, Samani, Nilesh J, Bown, Matthew J, Genetica Klinische Genetica, Circulatory Health, CMM Groep Kaaij, Brain, Infection & Immunity, Jones, Gregory T, Tromp, Gerard, Kuivaniemi, Helena, Gretarsdottir, Solveig, Baas, Annette F, Giusti, Betti, Strauss, Ewa, Van't Hof, Femke N G, Webb, Thomas R, Erdman, Robert, Ritchie, Marylyn D, Elmore, James R, Verma, Anurag, Pendergrass, Sarah, Kullo, Iftikhar J, Ye, Zi, Peissig, Peggy L, Gottesman, Omri, Verma, Shefali S, Malinowski, Jennifer, Rasmussen-Torvik, Laura J, Borthwick, Kenneth M, Smelser, Diane T, Crosslin, David R, de Andrade, Mariza, Ryer, Evan J, McCarty, Catherine A, Böttinger, Erwin P, Pacheco, Jennifer A, Crawford, Dana C, Carrell, David S, Gerhard, Glenn S, Franklin, David P, Carey, David J, Phillips, Victoria L, Williams, Michael J A, Wei, Wenhua, Blair, Ross, Hill, Andrew A, Vasudevan, Thodor M, Lewis, David R, Thomson, Ian A, Krysa, Jo, Hill, Geraldine B, Roake, Justin, Merriman, Tony R, Oszkinis, Grzegorz, Galora, Silvia, Saracini, Claudia, Abbate, Rosanna, Pulli, Raffaele, Pratesi, Carlo, Saratzis, Athanasios, Verissimo, Ana R, Bumpstead, Suzannah, Badger, Stephen A, Clough, Rachel E, Cockerill, Gillian, Hafez, Hany, Scott, D Julian A, Futers, T Simon, Romaine, Simon P R, Bridge, Katherine, Griffin, Kathryn J, Bailey, Marc A, Smith, Alberto, Thompson, Matthew M, van Bockxmeer, Frank M, Matthiasson, Stefan E, Thorleifsson, Gudmar, Thorsteinsdottir, Unnur, Blankensteijn, Jan D, Teijink, Joep A W, Wijmenga, Cisca, de Graaf, Jacqueline, Kiemeney, Lambertus A, Lindholt, Jes S, Hughes, Anne, Bradley, Declan T, Stirrups, Kathleen, Golledge, Jonathan, Norman, Paul E, Powell, Janet T, Humphries, Steve E, Hamby, Stephen E, Goodall, Alison H, Nelson, Christopher P, Sakalihasan, Natzi, Courtois, Audrey, Ferrell, Robert E, Eriksson, Per, Folkersen, Lasse, Franco-Cereceda, Anders, Eicher, John D, Johnson, Andrew D, Betsholtz, Christer, Ruusalepp, Arno, Franzén, Oscar, Schadt, Eric E, Björkegren, Johan L M, Lipovich, Leonard, Drolet, Anne M, Verhoeven, Eric L, Zeebregts, Clark J, Geelkerken, Robert H, van Sambeek, Marc R, van Sterkenburg, Steven M, de Vries, Jean-Paul, Stefansson, Kari, Thompson, John R, de Bakker, Paul I W, Deloukas, Panos, Sayers, Robert D, Harrison, Seamus C, van Rij, Andre M, Samani, Nilesh J, and Bown, Matthew J
- Published
- 2017
33. Meta-Analysis of Genome-Wide Association Studies for Abdominal Aortic Aneurysm Identifies Four New Disease-Specific Risk Loci
- Author
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Jones, Gregory T, Tromp, Gerard, Kuivaniemi, Helena, Gretarsdottir, Solveig, Baas, Annette F, Giusti, Betti, Strauss, Ewa, Van't Hof, Femke N G, Webb, Thomas R, Erdman, Robert, Ritchie, Marylyn D, Elmore, James R, Verma, Anurag, Pendergrass, Sarah, Kullo, Iftikhar J, Ye, Zi, Peissig, Peggy L, Gottesman, Omri, Verma, Shefali S, Malinowski, Jennifer, Rasmussen-Torvik, Laura J, Borthwick, Kenneth M, Smelser, Diane T, Crosslin, David R, de Andrade, Mariza, Ryer, Evan J, McCarty, Catherine A, Böttinger, Erwin P, Pacheco, Jennifer A, Crawford, Dana C, Carrell, David S, Gerhard, Glenn S, Franklin, David P, Carey, David J, Phillips, Victoria L, Williams, Michael J A, Wei, Wenhua, Blair, Ross, Hill, Andrew A, Vasudevan, Thodor M, Lewis, David R, Thomson, Ian A, Krysa, Jo, Hill, Geraldine B, Roake, Justin, Merriman, Tony R, Oszkinis, Grzegorz, Galora, Silvia, Saracini, Claudia, Abbate, Rosanna, Pulli, Raffaele, Pratesi, Carlo, Saratzis, Athanasios, Verissimo, Ana R, Bumpstead, Suzannah, Badger, Stephen A, Clough, Rachel E, Cockerill, Gillian, Hafez, Hany, Scott, D Julian A, Futers, T Simon, Romaine, Simon P R, Bridge, Katherine, Griffin, Kathryn J, Bailey, Marc A, Smith, Alberto, Thompson, Matthew M, van Bockxmeer, Frank M, Matthiasson, Stefan E, Thorleifsson, Gudmar, Thorsteinsdottir, Unnur, Blankensteijn, Jan D, Teijink, Joep A W, Wijmenga, Cisca, de Graaf, Jacqueline, Kiemeney, Lambertus A, Lindholt, Jes S, Hughes, Anne, Bradley, Declan T, Stirrups, Kathleen, Golledge, Jonathan, Norman, Paul E, Powell, Janet T, Humphries, Steve E, Hamby, Stephen E, Goodall, Alison H, Nelson, Christopher P, Sakalihasan, Natzi, Courtois, Audrey, Ferrell, Robert E, Eriksson, Per, Folkersen, Lasse, Franco-Cereceda, Anders, Eicher, John D, Johnson, Andrew D, Betsholtz, Christer, Ruusalepp, Arno, Franzén, Oscar, Schadt, Eric E, Björkegren, Johan L M, Lipovich, Leonard, Drolet, Anne M, Verhoeven, Eric L, Zeebregts, Clark J, Geelkerken, Robert H, van Sambeek, Marc R, van Sterkenburg, Steven M, de Vries, J.P.P.M., Stefansson, Kari, Thompson, John R, de Bakker, Paul I W, Deloukas, Panos, Sayers, Robert D, Harrison, Seamus C, van Rij, Andre M, Samani, Nilesh J, Bown, Matthew J, Surgery, ICaR - Ischemia and repair, ACS - Microcirculation, and ACS - Atherosclerosis & ischemic syndromes
- Subjects
Cardiac & Cardiovascular Systems ,aortic aneurysm abdominal ,computational biology ,Cardiac and Cardiovascular Systems ,genetics ,Aortic Aneurysm, Abdominal/diagnosis ,genome-wide association study ,matrix metalloproteinases ,meta-analysis ,Aortic Aneurysm, Abdominal ,Genetic Loci ,Genetic Predisposition to Disease ,Genetic Variation ,Genome-Wide Association Study ,Humans ,Physiology ,Cardiology and Cardiovascular Medicine ,Kardiologi ,Hematology ,C-REACTIVE PROTEIN ,TRANSCRIPTION FACTORS ,Genetic Variation/genetics ,DENSITY-LIPOPROTEIN CHOLESTEROL ,Genetic Loci/genetics ,Genome-Wide Association Study/methods ,ComputingMethodologies_DOCUMENTANDTEXTPROCESSING ,abdominal ,cardiovascular system ,CORONARY-ARTERY-DISEASE ,aortic aneurysm ,Life Sciences & Biomedicine ,aortic aneurysm, abdominal ,SUSCEPTIBILITY LOCI ,1102 Cardiovascular Medicine And Haematology ,Article ,SDG 3 - Good Health and Well-being ,Genetic Predisposition to Disease/epidemiology ,Journal Article ,CANDIDATE GENE ASSOCIATION ,Hematologi ,cardiovascular diseases ,Science & Technology ,genome-wide association study ■ matrix metalloproteinases ,ELECTRONIC MEDICAL-RECORDS ,HUMAN PREFRONTAL CORTEX ,1103 Clinical Sciences ,Atherosclerosis ,Peripheral Vascular Disease ,Cardiovascular System & Hematology ,SEQUENCE VARIANT ,RECEPTOR-RELATED PROTEIN-1 ,Cardiovascular System & Cardiology ,Clinical Track - Abstract
Supplemental Digital Content is available in the text., Rationale: Abdominal aortic aneurysm (AAA) is a complex disease with both genetic and environmental risk factors. Together, 6 previously identified risk loci only explain a small proportion of the heritability of AAA. Objective: To identify additional AAA risk loci using data from all available genome-wide association studies. Methods and Results: Through a meta-analysis of 6 genome-wide association study data sets and a validation study totaling 10 204 cases and 107 766 controls, we identified 4 new AAA risk loci: 1q32.3 (SMYD2), 13q12.11 (LINC00540), 20q13.12 (near PCIF1/MMP9/ZNF335), and 21q22.2 (ERG). In various database searches, we observed no new associations between the lead AAA single nucleotide polymorphisms and coronary artery disease, blood pressure, lipids, or diabetes mellitus. Network analyses identified ERG, IL6R, and LDLR as modifiers of MMP9, with a direct interaction between ERG and MMP9. Conclusions: The 4 new risk loci for AAA seem to be specific for AAA compared with other cardiovascular diseases and related traits suggesting that traditional cardiovascular risk factor management may only have limited value in preventing the progression of aneurysmal disease.
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- 2016
- Full Text
- View/download PDF
34. Shared Genetic Risk Factors of Intracranial, Abdominal, and Thoracic Aneurysms
- Author
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van 't Hof, Femke N G, Ruigrok, Ynte M, Lee, Cue Hyunkyu, Ripke, Stephan, Anderson, Graig, de Andrade, Mariza, Baas, Annette F, Blankensteijn, Jan D, Böttinger, Erwin P, Bown, Matthew J, Broderick, Joseph, Bijlenga, Philippe, Carrell, David S, Crawford, Dana C, Crosslin, David R, Ebeling, Christian, Eriksson, Johan G, Fornage, Myriam, Foroud, Tatiana, von Und Zu Fraunberg, Mikael, Friedrich, Christoph M, Gaál, Emília I, Gottesman, Omri, Guo, Dong-Chuan, Harrison, Seamus C, Hernesniemi, Juha, Hofman, Albert, Inoue, Ituro, Jääskeläinen, Juha E, Jones, Gregory T, Kiemeney, Lambertus A L M, Kivisaari, Riku, Ko, Nerissa, Koskinen, Seppo, Kubo, Michiaki, Kullo, Iftikhar J, Kuivaniemi, Helena, Kurki, Mitja I, Laakso, Aki, Lai, Dongbing, Leal, Suzanne M, Lehto, Hanna, LeMaire, Scott A, Low, Siew-Kee, Malinowski, Jennifer, McCarty, Catherine A, Milewicz, Dianna M, Mosley, Thomas H, Nakamura, Yusuke, Nakaoka, Hirofumi, Niemelä, Mika, Pacheco, Jennifer, Peissig, Peggy L, Pera, Joanna, Rasmussen-Torvik, Laura, Ritchie, Marylyn D, Rivadeneira, Fernando, van Rij, Andre M, Santos-Cortez, Regie Lyn P, Saratzis, Athanasios, Slowik, Agnieszka, Takahashi, Atsushi, Tromp, Gerard, Uitterlinden, André G, Verma, Shefali S, Vermeulen, Sita H, Wang, Gao T, Han, Buhm, Rinkel, Gabriël J E, de Bakker, Paul I W, Aneurysm Consortium; Vascular Research Consortium of New Zealand, van 't Hof, Femke N G, Ruigrok, Ynte M, Lee, Cue Hyunkyu, Ripke, Stephan, Anderson, Graig, de Andrade, Mariza, Baas, Annette F, Blankensteijn, Jan D, Böttinger, Erwin P, Bown, Matthew J, Broderick, Joseph, Bijlenga, Philippe, Carrell, David S, Crawford, Dana C, Crosslin, David R, Ebeling, Christian, Eriksson, Johan G, Fornage, Myriam, Foroud, Tatiana, von Und Zu Fraunberg, Mikael, Friedrich, Christoph M, Gaál, Emília I, Gottesman, Omri, Guo, Dong-Chuan, Harrison, Seamus C, Hernesniemi, Juha, Hofman, Albert, Inoue, Ituro, Jääskeläinen, Juha E, Jones, Gregory T, Kiemeney, Lambertus A L M, Kivisaari, Riku, Ko, Nerissa, Koskinen, Seppo, Kubo, Michiaki, Kullo, Iftikhar J, Kuivaniemi, Helena, Kurki, Mitja I, Laakso, Aki, Lai, Dongbing, Leal, Suzanne M, Lehto, Hanna, LeMaire, Scott A, Low, Siew-Kee, Malinowski, Jennifer, McCarty, Catherine A, Milewicz, Dianna M, Mosley, Thomas H, Nakamura, Yusuke, Nakaoka, Hirofumi, Niemelä, Mika, Pacheco, Jennifer, Peissig, Peggy L, Pera, Joanna, Rasmussen-Torvik, Laura, Ritchie, Marylyn D, Rivadeneira, Fernando, van Rij, Andre M, Santos-Cortez, Regie Lyn P, Saratzis, Athanasios, Slowik, Agnieszka, Takahashi, Atsushi, Tromp, Gerard, Uitterlinden, André G, Verma, Shefali S, Vermeulen, Sita H, Wang, Gao T, Han, Buhm, Rinkel, Gabriël J E, de Bakker, Paul I W, and Aneurysm Consortium; Vascular Research Consortium of New Zealand
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- 2016
35. Shared Genetic Risk Factors of Intracranial, Abdominal, and Thoracic Aneurysms
- Author
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University of Helsinki, Clinicum, University of Helsinki, Institute for Molecular Medicine Finland (FIMM), University of Helsinki, Neurokirurgian yksikkö, van't Hof, Femke N. G., Ruigrok, Ynte M., Lee, Cue Hyunkyu, Ripke, Stephan, Anderson, Graig, de Andrade, Mariza, Baas, Annette F., Blankensteijn, Jan D., Bottinger, Erwin P., Bown, Matthew J., Broderick, Joseph, Bijlenga, Philippe, Carrell, David S., Crawford, Dana C., Crosslin, David R., Ebeling, Christian, Eriksson, Johan G., Fornage, Myriam, Foroud, Tatiana, von und zu Fraunberg, Mikael, Friedrich, Christoph M., Gaal, Emilia I., Gottesman, Omri, Guo, Dong-Chuan, Harrison, Seamus C., Hernesniemi, Juha, Hofman, Albert, Inoue, Ituro, Jaaskelainen, Juha E., Jones, Gregory T., Kiemeney, Lambertus A. L. M., Kivisaari, Riku, Ko, Nerissa, Koskinen, Seppo, Kubo, Michiaki, Kullo, Iftikhar J., Kuivaniemi, Helena, Kurki, Mitja I., Laakso, Aki, Lai, Dongbing, Leal, Suzanne M., Lehto, Hanna, LeMaire, Scott A., Low, Siew-Kee, Malinowski, Jennifer, McCarty, Catherine A., Milewicz, Dianna M., Mosley, Thomas H., Nakamura, Yusuke, Nakaoka, Hirofumi, Niemela, Mika, Pacheco, Jennifer, Peissig, Peggy L., Pera, Joanna, Rasmussen-Torvik, Laura, Ritchie, Marylyn D., Rivadeneira, Fernando, van Rij, Andre M., Santos-Cortez, Regie Lyn P., Saratzis, Athanasios, Slowik, Agnieszka, Takahashi, Atsushi, Tromp, Gerard, Uitterlinden, Andre G., Verma, Shefali S., Vermeulen, Sita H., Wang, Gao T., Han, Buhm, Rinkel, Gabriel J. E., de Bakker, Paul I. W., Aneurysm Consortium, Vasc Res Consortium New Zealand, University of Helsinki, Clinicum, University of Helsinki, Institute for Molecular Medicine Finland (FIMM), University of Helsinki, Neurokirurgian yksikkö, van't Hof, Femke N. G., Ruigrok, Ynte M., Lee, Cue Hyunkyu, Ripke, Stephan, Anderson, Graig, de Andrade, Mariza, Baas, Annette F., Blankensteijn, Jan D., Bottinger, Erwin P., Bown, Matthew J., Broderick, Joseph, Bijlenga, Philippe, Carrell, David S., Crawford, Dana C., Crosslin, David R., Ebeling, Christian, Eriksson, Johan G., Fornage, Myriam, Foroud, Tatiana, von und zu Fraunberg, Mikael, Friedrich, Christoph M., Gaal, Emilia I., Gottesman, Omri, Guo, Dong-Chuan, Harrison, Seamus C., Hernesniemi, Juha, Hofman, Albert, Inoue, Ituro, Jaaskelainen, Juha E., Jones, Gregory T., Kiemeney, Lambertus A. L. M., Kivisaari, Riku, Ko, Nerissa, Koskinen, Seppo, Kubo, Michiaki, Kullo, Iftikhar J., Kuivaniemi, Helena, Kurki, Mitja I., Laakso, Aki, Lai, Dongbing, Leal, Suzanne M., Lehto, Hanna, LeMaire, Scott A., Low, Siew-Kee, Malinowski, Jennifer, McCarty, Catherine A., Milewicz, Dianna M., Mosley, Thomas H., Nakamura, Yusuke, Nakaoka, Hirofumi, Niemela, Mika, Pacheco, Jennifer, Peissig, Peggy L., Pera, Joanna, Rasmussen-Torvik, Laura, Ritchie, Marylyn D., Rivadeneira, Fernando, van Rij, Andre M., Santos-Cortez, Regie Lyn P., Saratzis, Athanasios, Slowik, Agnieszka, Takahashi, Atsushi, Tromp, Gerard, Uitterlinden, Andre G., Verma, Shefali S., Vermeulen, Sita H., Wang, Gao T., Han, Buhm, Rinkel, Gabriel J. E., de Bakker, Paul I. W., Aneurysm Consortium, and Vasc Res Consortium New Zealand
- Abstract
Background-Intracranial aneurysms (IAs), abdominal aortic aneurysms (AAAs), and thoracic aortic aneurysms (TAAs) all have a familial predisposition. Given that aneurysm types are known to co-occur, we hypothesized that there may be shared genetic risk factors for IAs, AAAs, and TAAs. Methods and Results-We performed a mega-analysis of 1000 Genomes Project-imputed genome-wide association study (GWAS) data of 4 previously published aneurysm cohorts: 2 IA cohorts (in total 1516 cases, 4305 controls), 1 AAA cohort (818 cases, 3004 controls), and 1 TAA cohort (760 cases, 2212 controls), and observed associations of 4 known IA, AAA, and/or TAA risk loci (9p21, 18q11, 15q21, and 2q33) with consistent effect directions in all 4 cohorts. We calculated polygenic scores based on IA-, AAA-, and TAA-associated SNPs and tested these scores for association to case-control status in the other aneurysm cohorts; this revealed no shared polygenic effects. Similarly, linkage disequilibrium-score regression analyses did not show significant correlations between any pair of aneurysm subtypes. Last, we evaluated the evidence for 14 previously published aneurysm risk single-nucleotide polymorphisms through collaboration in extended aneurysm cohorts, with a total of 6548 cases and 16 843 controls (IA) and 4391 cases and 37 904 controls (AAA), and found nominally significant associations for IA risk locus 18q11 near RBBP8 to AAA (odds ratio [OR]= 1.11; P=4.1 x 10(-5)) and for TAA risk locus 15q21 near FBN1 to AAA (OR=1.07; P=1.1 x 10(-3)). Conclusions-Although there was no evidence for polygenic overlap between IAs, AAAs, and TAAs, we found nominally significant effects of two established risk loci for IAs and TAAs in AAAs. These two loci will require further replication.
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- 2016
36. Duodenal obstruction associated with an abdominal aortic aneurysm
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Taylor, Sam G., primary, van Rij, Andre M., additional, and Woodfield, John C., additional
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- 2016
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37. VariantASGR1Associated with a Reduced Risk of Coronary Artery Disease
- Author
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Nioi, Paul, primary, Sigurdsson, Asgeir, additional, Thorleifsson, Gudmar, additional, Helgason, Hannes, additional, Agustsdottir, Arna B., additional, Norddahl, Gudmundur L., additional, Helgadottir, Anna, additional, Magnusdottir, Audur, additional, Jonasdottir, Aslaug, additional, Gretarsdottir, Solveig, additional, Jonsdottir, Ingileif, additional, Steinthorsdottir, Valgerdur, additional, Rafnar, Thorunn, additional, Swinkels, Dorine W., additional, Galesloot, Tessel E., additional, Grarup, Niels, additional, Jørgensen, Torben, additional, Vestergaard, Henrik, additional, Hansen, Torben, additional, Lauritzen, Torsten, additional, Linneberg, Allan, additional, Friedrich, Nele, additional, Krarup, Nikolaj T., additional, Fenger, Mogens, additional, Abildgaard, Ulrik, additional, Hansen, Peter R., additional, Galløe, Anders M., additional, Braund, Peter S., additional, Nelson, Christopher P., additional, Hall, Alistair S., additional, Williams, Michael J.A., additional, van Rij, Andre M., additional, Jones, Gregory T., additional, Patel, Riyaz S., additional, Levey, Allan I., additional, Hayek, Salim, additional, Shah, Svati H., additional, Reilly, Muredach, additional, Eyjolfsson, Gudmundur I., additional, Sigurdardottir, Olof, additional, Olafsson, Isleifur, additional, Kiemeney, Lambertus A., additional, Quyyumi, Arshed A., additional, Rader, Daniel J., additional, Kraus, William E., additional, Samani, Nilesh J., additional, Pedersen, Oluf, additional, Thorgeirsson, Gudmundur, additional, Masson, Gisli, additional, Holm, Hilma, additional, Gudbjartsson, Daniel, additional, Sulem, Patrick, additional, Thorsteinsdottir, Unnur, additional, and Stefansson, Kari, additional
- Published
- 2016
- Full Text
- View/download PDF
38. Two C‐C Family Chemokines, Eotaxin and RANTES, Are Novel Independent Plasma Biomarkers for Abdominal Aortic Aneurysm
- Author
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Jones, Gregory T., primary, Phillips, L. Victoria, additional, Williams, Michael J.A., additional, van Rij, Andre M., additional, and Kabir, Tasnuva D., additional
- Published
- 2016
- Full Text
- View/download PDF
39. Hot-water immersion increases popliteal artery shear stress in Peripheral Arterial Disease
- Author
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Thomas, Kate N, primary, Van Rij, Andre M, additional, Lucas, Samuel JE, additional, and Cotter, James D, additional
- Published
- 2015
- Full Text
- View/download PDF
40. Shared Genetic Risk Factors of Intracranial, Abdominal, and Thoracic Aneurysms
- Author
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van ’t Hof, Femke N. G., Ruigrok, Ynte M., Lee, Cue Hyunkyu, Ripke, Stephan, Anderson, Graig, de Andrade, Mariza, Baas, Annette F., Blankensteijn, Jan D., Böttinger, Erwin P., Bown, Matthew J., Broderick, Joseph, Bijlenga, Philippe, Carrell, David S., Crawford, Dana C., Crosslin, David R., Ebeling, Christian, Eriksson, Johan G., Fornage, Myriam, Foroud, Tatiana, von und zu Fraunberg, Mikael, Friedrich, Christoph M., Gaál, Emília I., Gottesman, Omri, Guo, Dong‐Chuan, Harrison, Seamus C., Hernesniemi, Juha, Hofman, Albert, Inoue, Ituro, Jääskeläinen, Juha E., Jones, Gregory T., Kiemeney, Lambertus A. L. M., Kivisaari, Riku, Ko, Nerissa, Koskinen, Seppo, Kubo, Michiaki, Kullo, Iftikhar J., Kuivaniemi, Helena, Kurki, Mitja I., Laakso, Aki, Lai, Dongbing, Leal, Suzanne M., Lehto, Hanna, LeMaire, Scott A., Low, Siew‐Kee, Malinowski, Jennifer, McCarty, Catherine A., Milewicz, Dianna M., Mosley, Thomas H., Nakamura, Yusuke, Nakaoka, Hirofumi, Niemelä, Mika, Pacheco, Jennifer, Peissig, Peggy L., Pera, Joanna, Rasmussen‐Torvik, Laura, Ritchie, Marylyn D., Rivadeneira, Fernando, van Rij, Andre M., Santos‐Cortez, Regie Lyn P., Saratzis, Athanasios, Slowik, Agnieszka, Takahashi, Atsushi, Tromp, Gerard, Uitterlinden, André G., Verma, Shefali S., Vermeulen, Sita H., Wang, Gao T., Han, Buhm, Rinkel, Gabriël J. E., de Bakker, Paul I. W., Verissimo, Ana, Wright, Benjamin J., Bumpstead, Suzannah, Gretarsdottir, Solveig, Badger, Stephen A., Child, Anne H., Clough, Rachel E., Cockerill, Gillian, Hafez, Hany, Scott, D. Julian A., Futers, Simon, Sohrabi, Soroush, Smith, Alberto, Thompson, Matthew M., van Bockxmeer, Frank M., Matthiasson, Stefan E., Thorleifsson, Gudmar, Thorsteinsdottir, Unnur, Teijink, Joep A. W., Wijmenga, Cisca, de Graaf, Jacqueline, Kiemeney, Lambertus A., Palmen, Jutta, Smith, Andrew J., Lindholt, Jes S., Bradley, Declan T., Waltham, Matthew, Edkins, Sarah, Gwilliam, Rhian, Hunt, Sarah E., Potter, Simon, Golledge, Jonathan, Eriksson, Per, Norman, Paul E., Powell, Janet T., Stefansson, Kari, Thompson, John R., Humphries, Steve E., Sayers, Robert D., Deloukas, Panos, Samani, Nilesh J., Phillip, L. Victoria, Hill, Geraldine B., Williams, Michael J. A., Thomson, Ian A., Krysa, Jo, Wilkins, Gerard T., Merriman, Tony R., Vasudevan, Thodor M., Lewis, David R., Blair, Ross D., and Hill, Andrew A.
- Subjects
abdominal aortic aneurysm ,genome wide association study ,intracranial aneurysm ,thoracic aortic aneurysm ,Inflammation ,Vascular Biology ,Ischemic Stroke - Abstract
Background: Intracranial aneurysms (IAs), abdominal aortic aneurysms (AAAs), and thoracic aortic aneurysms (TAAs) all have a familial predisposition. Given that aneurysm types are known to co‐occur, we hypothesized that there may be shared genetic risk factors for IAs, AAAs, and TAAs. Methods and Results: We performed a mega‐analysis of 1000 Genomes Project‐imputed genome‐wide association study (GWAS) data of 4 previously published aneurysm cohorts: 2 IA cohorts (in total 1516 cases, 4305 controls), 1 AAA cohort (818 cases, 3004 controls), and 1 TAA cohort (760 cases, 2212 controls), and observed associations of 4 known IA, AAA, and/or TAA risk loci (9p21, 18q11, 15q21, and 2q33) with consistent effect directions in all 4 cohorts. We calculated polygenic scores based on IA‐, AAA‐, and TAA‐associated SNPs and tested these scores for association to case‐control status in the other aneurysm cohorts; this revealed no shared polygenic effects. Similarly, linkage disequilibrium–score regression analyses did not show significant correlations between any pair of aneurysm subtypes. Last, we evaluated the evidence for 14 previously published aneurysm risk single‐nucleotide polymorphisms through collaboration in extended aneurysm cohorts, with a total of 6548 cases and 16 843 controls (IA) and 4391 cases and 37 904 controls (AAA), and found nominally significant associations for IA risk locus 18q11 near RBBP8 to AAA (odds ratio [OR]=1.11; P=4.1×10−5) and for TAA risk locus 15q21 near FBN1 to AAA (OR=1.07; P=1.1×10−3). Conclusions: Although there was no evidence for polygenic overlap between IAs, AAAs, and TAAs, we found nominally significant effects of two established risk loci for IAs and TAAs in AAAs. These two loci will require further replication.
- Published
- 2016
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41. Pulsatile flow in venous perforators of the lower limb.
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Thomas KN, Gibbons TD, Campbell HA, Cotter JD, and van Rij AM
- Subjects
- Blood Flow Velocity physiology, Humans, Pulsatile Flow, Water, Leg blood supply, Lower Extremity
- Abstract
Teaching traditionally asserts that the arterial pressure pulse is dampened across the capillary bed to the extent that pulsatility is nonexistent in the venous circulation of the lower limbs. Herein, we present evidence of transmission of arterial pulsations across the capillary network into perforator veins in the lower limbs of healthy, heat-stressed humans. Perforator veins are connections from the superficial veins that drain into the deep veins. When assessed using ultrasound at rest, they infrequently demonstrate flow, and a pulsatile flow waveform is not described. We investigated perforator vein pulsatility in 10 young, healthy volunteers who underwent passive heating by +2°C core body temperature via a hot-water-perfused suit, and 5 who also underwent active heating by +2°C via low-intensity cycling while wearing the hot-water-perfused suit. At +0.5°C increments in temperature, blood velocity in an ankle perforator vein was measured using duplex ultrasound. In all perforators with heating, sustained flow was demonstrated, with a pulsatile waveform that was synchronous with the cardiac cycle. The maximum velocity was 30 ± 13 cm/s with passive heating and approximately half with active heating ( P = 0.04). The small veins of the skin at the ankle also demonstrated increased perfusion with pulsatility, seen with low-velocity microvascular imaging technology. We consider explanations for this pulsatility and conclude that it is propagated from the arterial inflow through the skin microcirculation as a result of increased dilatation and flow volume and that this is a normal response to increased skin blood flow.
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- 2022
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- View/download PDF
42. Editor's Choice - European Society for Vascular Surgery (ESVS) 2022 Clinical Practice Guidelines on the Management of Chronic Venous Disease of the Lower Limbs.
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De Maeseneer MG, Kakkos SK, Aherne T, Baekgaard N, Black S, Blomgren L, Giannoukas A, Gohel M, de Graaf R, Hamel-Desnos C, Jawien A, Jaworucka-Kaczorowska A, Lattimer CR, Mosti G, Noppeney T, van Rijn MJ, Stansby G, Esvs Guidelines Committee, Kolh P, Bastos Goncalves F, Chakfé N, Coscas R, de Borst GJ, Dias NV, Hinchliffe RJ, Koncar IB, Lindholt JS, Trimarchi S, Tulamo R, Twine CP, Vermassen F, Wanhainen A, Document Reviewers, Björck M, Labropoulos N, Lurie F, Mansilha A, Nyamekye IK, Ramirez Ortega M, Ulloa JH, Urbanek T, van Rij AM, and Vuylsteke ME
- Subjects
- Europe, Humans, Lower Extremity blood supply, Vascular Surgical Procedures standards, Societies, Medical standards, Vascular Diseases surgery, Vascular Surgical Procedures methods, Veins surgery
- Published
- 2022
- Full Text
- View/download PDF
43. The acute effect of resistance exercise on limb blood flow.
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Thomas KN, Kissling LS, Gibbons TD, Akerman AP, van Rij AM, and Cotter JD
- Subjects
- Adaptation, Physiological physiology, Adult, Blood Flow Velocity physiology, Blood Pressure physiology, Brachial Artery physiology, Endothelium, Vascular physiology, Female, Hemodynamics physiology, Humans, Male, Muscle, Skeletal physiology, Resistance Training methods, Stress, Mechanical, Vasodilation physiology, Young Adult, Exercise physiology, Extremities physiology, Regional Blood Flow physiology
- Abstract
New Findings: What is the central question of this study? How does resistance exercise affect peripheral haemodynamics in the active and inactive limb? What is the main finding and its importance? Preliminary data indicate that resistance exercise increases flow and shear rate in the active limb transiently. The same exercise has minimal, short-lasting influence on peripheral haemodynamics in the inactive limb, but further research is required to elaborate on resistance exercise-mediated changes in vascular function in active and inactive limbs., Abstract: Current evidence indicates that to achieve maximum health benefits, regular resistance exercise should be a key component of structured physical activity. Several studies have revealed that regular resistance exercise may be associated with impaired vascular function, although this finding is inconsistent. Proposed explanations for impairment include substantial increases in blood pressure and increased retrograde blood flow in active limbs promoted by resistance exercise. However, few studies have examined the acute haemodynamics of resistance exercise in active - and even fewer in inactive - limbs. The purpose of this study was to characterise the haemodynamic responses in peripheral arteries in active and inactive limbs in response to resistance exercise using upper and lower limbs. Ten participants (five male, five female) familiar with resistance training performed three sets of 10 isotonic repetitions of right-sided bicep curls or knee extensions on separate days. Blood flow, shear rate and muscle oxygenation in the active and inactive limb, and blood pressure were measured before and for 3 min after each set. Blood flow increased in response to resistance exercise in the active limb (∼8-fold and ∼6-fold for the upper and lower limb respectively), with concurrent significant increases in mean and antegrade shear rate. In the inactive limb, blood flow more than doubled for both upper and lower limb exercise, transiently, with no significant change in retrograde shear rate. These acute blood flow profiles following resistance exercise are not indicative of long-term vessel impairment based on current understanding of blood flow and shear stress patterns., (© 2020 The Authors. Experimental Physiology © 2020 The Physiological Society.)
- Published
- 2020
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44. Heat therapy vs. supervised exercise therapy for peripheral arterial disease: a 12-wk randomized, controlled trial.
- Author
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Akerman AP, Thomas KN, van Rij AM, Body ED, Alfadhel M, and Cotter JD
- Subjects
- Aged, Aged, 80 and over, Blood Pressure, Exercise Tolerance, Female, Humans, Male, Middle Aged, New Zealand, Peripheral Arterial Disease diagnosis, Peripheral Arterial Disease physiopathology, Quality of Life, Recovery of Function, Time Factors, Treatment Outcome, Walking, Exercise Therapy, Hot Temperature, Hydrotherapy, Peripheral Arterial Disease therapy
- Abstract
Peripheral arterial disease (PAD) is characterized by lower limb atherosclerosis impairing blood supply and causing walking-induced leg pain or claudication. Adherence to traditional exercise training programs is poor due to these symptoms despite exercise being a mainstay of conservative treatment. Heat therapy improves many cardiovascular health outcomes, so this study tested if this was a viable alternative cardiovascular therapy for PAD patients. Volunteers with PAD were randomized to 12 wk of heat ( n = 11; mean age 76 ± 8 yr, BMI 28.7 ± 3.5 kg/m
2 , 4 females) or exercise ( n = 11; 74 ± 10 yr, 28.5 ± 6.8 kg/m2 , 3 females). Heat involved spa bathing at ∼39°C, 3-5 days/wk for ≤30 min, followed by ≤30 min of callisthenics. Exercise involved ≤90 min of supervised walking and gym-based exercise, 1-2 days/wk. Following the interventions, total walking distance during a 6-min walk test increased (from ∼350 m) by 41 m (95% CI: [13, 69], P = 0.006) regardless of group, and pain-free walking distance increased (from ∼170 m) by 43 m ([22, 63], P < 0.001). Systolic blood pressure was reduced more following heat (-7 mmHg, [-4, -10], P < 0.001) than following exercise (-3 mmHg, [0, -6], P = 0.078), and diastolic and mean arterial pressure decreased by 4 mmHg in both groups ( P = 0.002). There were no significant changes in blood volume, ankle-brachial index, or measures of vascular health. There were no differences in the improvement in functional or blood pressure outcomes between heat and exercise in individuals with PAD. NEW & NOTEWORTHY Heat therapy via hot-water immersion and supervised exercise both improved walking distance and resting blood pressure in peripheral arterial disease (PAD) patients over 12 wk. Adherence to heat therapy was excellent, and the heat intervention was well tolerated. The results of the current study indicate that heat therapy can improve functional ability and has potential as an effective cardiovascular conditioning tool for individuals with PAD.- Published
- 2019
- Full Text
- View/download PDF
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