1. Simulation of the effect of ethanol on DNA damage by ionizing radiation.
- Author
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Barilla, Jiří, Simr, Pavel, and Sýkorová, Květuše
- Abstract
The presence of ethanol in the water solution during irradiation by ionizing radiation decreases the number of
OH andH radicals. Since the living cell is mainly composed of water, this causes less damage to the DNA molecule irradiated by low-LET ionizing radiation where an indirect effect prevails. Ethanol thus acts as a radioprotective substance, scavenging radicalsH andOH . This fact can be used in various practical applications in which living cells are irradiated by ionizing radiation to protect them. We used hybrid Petri nets to simulate all dynamic processes, including chemical reactions and the simultaneous diffusion of radical clusters. The mathematical simulating model enables us to simulate the damage to the DNA molecule by the radical cluster arising at various distances from this molecule. [ABSTRACT FROM AUTHOR]- Published
- 2024
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