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O carcinoma renal (CR) é uma neoplasia maligna originária do epitélio tubular renal. Este tipo de neoplasia é rara e acomete geralmente cães machos de meia idade. Os sinais clínicos são inespecíficos, podendo se assemelhar a outras doenças e isso acaba dificultando o diagnóstico que é realizado através dos exames de imagem (ultrassonografia e raio-X), da laparotomia exploratória e histopatológico para confirmação. Para o tratamento sugere-se a nefrectomia em casos de carcinoma renal unilateral e quimioterapia, porém não demonstram um aumento na sobrevida dos pacientes. O presente trabalho tem como objetivo relatar o caso de um cão de 8 anos, que foi atendido devido a sinais de cardiopatia e ao retorno apresentou sinais como êmese, anorexia e dor abdominal. Realizou-se exame de ultrassom, onde identificou-se uma estrutura de 7cm do lado esquerdo, realizou-se também exame de raio-X e posterior laparotomia exploratória, seguida de nefrectomia. O material coletado e enviado para histopatológico confirmou carcinoma renal bem diferenciado, padrão papilar. Após diagnóstico, o paciente foi encaminhado para um especialista em oncologia veterinária, que de acordo com os resultados dos exames realizados novamente, optou-se por não entrar com o tratamento quimioterápico.

Thyroid cancer is the most frequent endocrine cancer representing 1-1.5% of all cancers. Approximately 90% of these are differentiated thyroid carcinomas (DTC) with a favorable prognosis and cure rate. DTC has recently witnessed an increase in incidence with a relatively stable mortality rate, mostly due to intensive screening. Despite being considered indolent and the 10-year survival rate being above 90%, local or distant recurrence can be observed in up to 20% of cases. Mutations in BRAF, RET, RAS, NTRK1, PAX8-PPARG are commonly found in DTC but studies show that genetic alterations with apparently no correlation to DTC might improve or aggravate prognosis. Vitamin D deficiency and vitamin D receptor (VDR) gene polymorphisms is consider to be one of these factors, due to the fact that it exerts immunological and antineoplastic functions throught its antiproliferative and prodifferentiating actions. FokI gene polymorphism has been associated with later stage and negative prognosis in different studies. Also, polymorphisms of genes involved in folate metabolism (MTHFR, MTR, RFC1) may be incriminated in carcinogenesis, folate being an extremely important factor in DNA synthesis. Studies suggest that through correction and avoidance of incriminated neoplastic agents, thyroid cancer incidence, evolution and prognosis might improve significantly. For this to be possible we need to be aware of the molecular pathways these environmental factors use to exert their carcinogenic effects [ABSTRACT FROM AUTHOR]

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Renal cell carcinoma represents the most frequent type of kidney cancer and accounts for 2-3% of all adult malignant tumors. Papillary renal cell carcinoma (pRCC) is the second most common type of renal carcinoma. RCC usually metastasizes to the lungs, lymph nodes, bones, brain and liver. Renal carcinoma dissemination to the ovaries is an exceptional occurrence. A 60-yearold woman was admitted in January 2018 due to acute back pain and abdominal discomfort. An abdominal computed tomography (CT) scan with intravenous contrast revealed a solid mass with malignant features located on the left kidney, multiple enlarged lymph nodes, and pulmonary metastases - cT3N1M1(pul). The patient underwent radical left nephrectomy and paraaortic lymphadenectomy followed by treatment with pazopanib. The pathologic study revealed papillary renal cell carcinoma. In June 2018, the patient presented with abdominal pain, postprandial bloating, nausea, vomiting and abdominal distension (ECOG 3). CT imaging showed stable pulmonary metastases and left ovarian mass. An exploratory laparotomy was performed, revealing a 8x7 cm ovarian mass, followed by left adnexectomy. The histopathological report described carcinomatous infiltration of the left ovary and fallopian tube, while the immunohistochemical staining could not clearly differentiate between a primary ovarian tumor and a metastasis. Corroborating the histopathological and immunohistochemical reports with the clinical status, the diagnosis of a synchronous primary ovarian tumor was decided. The treatment was continued with paclitaxel 125 mg/m2 + carboplatin AUC 6, q3w, and pazopanib 800 mg/ daily, with clinical benefit after the first administration, although before the fifth cycle the patient's clinical status rapidly deteriorated. [ABSTRACT FROM AUTHOR]

Copyright of Revista Mexicana de Endocrinología, Metabolismo y Nutrición is the property of Publicidad Permanyer SLU and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Revista Estomatología is the property of Universidad del Valle and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)